Grants per year
Personal profile
Research Interests
I am a physician-scientist who specializes in pediatric critical care medicine. I received my MD from the University of Washington and completed my Residency in Pediatrics and Fellowship in Critical Care Medicine at Northwestern University. I joined the faculty in the Pediatric Critical Care Division in 2011.
My research explores differences in the inflammatory response to viral respiratory infections in children and adults. Although young children and elderly adults bear a disproportionate burden of morbidity and mortality associated with viral respiratory infections, little is known about the mechanisms placing these populations at increased risk. My lab is currently investigating the role of innate immune responses in influenza infection. Elucidation of the mechanisms underlying age-related susceptibility and resistance to disease may contribute to the broader understanding of innate immunity and its role in critical illness.
My clinical focus is the care for critically ill children in the Pediatric Intensive Care Unit (PICU). I am particularly interested in acute respiratory failure, acute respiratory distress syndrome, and mechanical ventilation.
Certifications and Licenses
Pediatric Critical Care Medicine | |
General Pediatrics |
Training Experience
2008 | Internship, Northwestern University, McGaw Medical Center |
2011 | Residency, Northwestern University, McGaw Medical Center |
Education/Academic qualification
MD, University of Washington
… → 2005
Research interests
- Critical Care
- Immune Regulation
- Infectious Diseases in Children
- Inflammation
- Lung Injury
- Virus Diseases
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Grants
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Pathophysiology of Influenza A Virus-induced Lung Injury in Juveniles
National Heart, Lung, and Blood Institute
8/6/18 → 6/30/22
Project: Research project
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Pathophysiology of Influenza A Virus-induced Lung Injury in Juveniles
National Heart, Lung, and Blood Institute
8/6/18 → 6/30/22
Project: Research project
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Pathophysiology of Influenza A Virus-induced Lung Injury in Juveniles
National Heart, Lung, and Blood Institute
8/6/18 → 6/30/22
Project: Research project
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Research Output
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Age-dependent differences in t-cell responses to influenza a virus
Prigge, A. D., Ma, R., Coates, B. M., Singer, B. D. & Ridge, K. M., Oct 2020, In: American journal of respiratory cell and molecular biology. 63, 4, p. 415-423 9 p.Research output: Contribution to journal › Review article › peer-review
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Exuberant fibroblast activity compromises lung function via ADAMTS4
PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators, Nov 19 2020, In: Nature. 587, 7834, p. 466-471 6 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Prognostic relevance and inter-observer reliability of chest-imaging in pediatric ARDS: a pediatric acute respiratory distress incidence and epidemiology (PARDIE) study
the Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology (PARDIE) V3 Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Jul 1 2020, In: Intensive Care Medicine. 46, 7, p. 1382-1393 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Paediatric acute respiratory distress syndrome incidence and epidemiology (PARDIE): an international, observational study
Pediatric Acute Respiratory Distress syndrome Incidence and Epidemiology (PARDIE) Investigators & Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Feb 2019, In: The Lancet Respiratory Medicine. 7, 2, p. 115-128 14 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations -
Inflammatory monocytes drive influenza A virus-mediated lung injury in juvenile mice
Coates, B. M., Staricha, K. L., Koch, C. M., Cheng, Y., Shumaker, D. K., Budinger, G. R. S., Perlman, H., Misharin, A. V. & Ridge, K. M., Apr 1 2018, In: Journal of Immunology. 200, 7, p. 2391-2404 14 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations