• 1609 Citations
20022023

Research output per year

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Personal profile

Research Interests

Cilia Polarity. The ability of ciliated epithelia to generate directed fluid flow is an important aspect of diverse developmental and physiological processes including proper respiratory function. To achieve directed flow, ciliated cells must generate 100-200 cilia that are polarized along a common axis both within and between cells. My lab is currently working towards understanding the molecular mechanisms for how cell polarity is coordinated as well as how individual cilia interpret the cells polarity. Centriole Duplication. Centrioles are microtubule based structures with nine fold symmetry that are involved in both centrosome organization and aster formation during cell division. During the normal cell cycle centrioles duplicate once, generating a mother / daughter pair, and in most post-mitotic vertebrate cells the mother centriole then goes on to form the basal body of a sensory cilium. Abnormalities in the duplication of centrioles (and centrosomes) are prevalent in many cancers suggesting a link between centriole duplication and cancer progression. My laboratory is addressing this fundamental question in cell biology from a novel direction with the use of Xenopus motile ciliated cells. Ciliated cells are unique among vertebrate cells in that they naturally generate hundreds of centrioles therefore providing a great system for studying the regulation of centriole duplication. Understanding how nature has overcome the typically tight regulation of centriole duplication will lend insight into the molecular mechanisms of cancer progression.

Education/Academic qualification

PhD, University of North Carolina

… → 2001

Research interests

  • Cancer Biology
  • Cell Biology
  • Cell Imaging
  • Developmental Biology
  • Respiratory Diseases

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Grants

  • Research Output

    Centriole Number and the Accumulation of Microtubules Modulate the Timing of Apical Insertion during Radial Intercalation

    Collins, C., Majekodunmi, A. & Mitchell, B., May 18 2020, In : Current Biology. 30, 10, p. 1958-1964.e3

    Research output: Contribution to journalArticle

    Open Access
  • Functional Architecture of Deleterious Genetic Variants in the Genome of a Wrangel Island Mammoth

    Fry, E., Kim, S. K., Chigurapti, S., Mika, K. M., Ratan, A., Dammermann, A., Mitchell, B. J., Miller, W., Lynch, V. J. & Baer, C., Mar 17 2020, In : Genome biology and evolution. 12, 3, p. 48-58 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance

    Bustamante-Marin, X. M., Yin, W. N., Sears, P. R., Werner, M. E., Brotslaw, E. J., Mitchell, B. J., Jania, C. M., Zeman, K. L., Rogers, T. D., Herring, L. E., Refabért, L., Thomas, L., Amselem, S., Escudier, E., Legendre, M., Grubb, B. R., Knowles, M. R., Zariwala, M. A. & Ostrowski, L. E., Feb 7 2019, In : American journal of human genetics. 104, 2, p. 229-245 17 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Massive centriole production can occur in the absence of deuterosomes in multiciliated cells

    Mercey, O., Levine, M. S., LoMastro, G. M., Rostaing, P., Brotslaw, E., Gomez, V., Kumar, A., Spassky, N., Mitchell, B. J., Meunier, A. & Holland, A. J., Dec 1 2019, In : Nature Cell Biology. 21, 12, p. 1544-1552 9 p.

    Research output: Contribution to journalArticle

  • Scribble, Erbin, and Lano redundantly regulate epithelial polarity and apical adhesion complex

    Choi, J., Troyanovsky, R. B., Indra, I., Mitchell, B. J. & Troyanovsky, S. M., Jan 1 2019, In : Journal of Cell Biology. 218, 7, p. 2277-2293 17 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations