Brian Joseph Popko

  • 8407 Citations
1984 …2019

Research output per year

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Research Output

2019

Molecular Control of Oligodendrocyte Development

Elbaz, B. & Popko, B., Apr 2019, In : Trends in Neurosciences. 42, 4, p. 263-277 15 p.

Research output: Contribution to journalReview article

13 Scopus citations

Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis

Chen, Y., Podojil, J. R., Kunjamma, R. B., Jones, J., Weiner, M., Lin, W., Miller, S. D. & Popko, B., Feb 1 2019, In : Brain. 142, 2, p. 344-361 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

The UPR-PERK pathway is not a promising therapeutic target for mutant SOD1-induced ALS

Dzhashiashvili, Y., Monckton, C. P., Shah, H. S., Kunjamma, R. B. & Popko, B., Jul 2019, In : Neurobiology of Disease. 127, p. 527-544 18 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Cholesterol crystals impede nerve repair: Cholesterol deposits in phagocytic cells disrupt the repair of demyelinated axons

Chen, Y. & Popko, B., Feb 9 2018, In : Science. 359, 6376, p. 635-636 2 p.

Research output: Contribution to journalReview article

1 Scopus citations

Detecting Demyelination by PET: The Lesion as Imaging Target

Brugarolas, P., Reich, D. S. & Popko, B., Jul 19 2018, In : Molecular Imaging. 17

Research output: Contribution to journalComment/debate

Open Access
3 Scopus citations

Development of a PET radioligand for potassium channels to image CNS demyelination

Brugarolas, P., Sánchez-Rodríguez, J. E., Tsai, H. M., Basuli, F., Cheng, S. H., Zhang, X., Caprariello, A. V., Lacroix, J. J., Freifelder, R., Murali, D., DeJesus, O., Miller, R. H., Swenson, R. E., Chen, C. T., Herscovitch, P., Reich, D. S., Bezanilla, F. & Popko, B., Dec 1 2018, In : Scientific reports. 8, 1, 607.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation

Elbaz, B., Aaker, J. D., Isaac, S., Kolarzyk, A., Brugarolas, P., Eden, A. & Popko, B., May 22 2018, In : Cell reports. 23, 8, p. 2254-2263 10 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017

Activation of the integrated stress response and metabolic dysfunction in a murine model of sleep apnea

Khalyfa, A., Qiao, Z., Gileles-Hillel, A., Khalyfa, A. A., Akbarpour, M., Popko, B. & Gozal, D., Oct 2017, In : American journal of respiratory cell and molecular biology. 57, 4, p. 477-486 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Integrated stress response activation by sleep fragmentation during late gestation in mice leads to emergence of adverse metabolic phenotype in offspring

Trzepizur, W., Khalyfa, A., Qiao, Z., Popko, B. & Gozal, D., Apr 1 2017, In : Metabolism: Clinical and Experimental. 69, p. 188-198 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease

McKenzie, A. T., Moyon, S., Wang, M., Katsyv, I., Song, W. M., Zhou, X., Dammer, E. B., Duong, D. M., Aaker, J., Zhao, Y., Beckmann, N., Wang, P., Zhu, J., Lah, J. J., Seyfried, N. T., Levey, A. I., Katsel, P., Haroutunian, V., Schadt, E. E., Popko, B. & 2 others, Casaccia, P. & Zhang, B., Nov 6 2017, In : Molecular neurodegeneration. 12, 1, 82.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Neonatal Hypoxia Results in Peripheral Nerve Abnormalities

Clayton, B. L. L., Huang, A., Dukala, D., Soliven, B. & Popko, B., Feb 1 2017, In : American Journal of Pathology. 187, 2, p. 245-251 7 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The integrated stress response in hypoxia-induced diffuse white matter injury

Clayton, B. L., Huang, A., Kunjamma, R. B., Solanki, A. & Popko, B., Aug 2 2017, In : Journal of Neuroscience. 37, 31, p. 7465-7480 16 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2016

Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS

Elbaz, B., Traka, M., Kunjamma, R. B., Dukala, D., Lutz, A. B., Anton, E. S., Barres, B. A., Soliven, B. & Popko, B., Jul 1 2016, In : Development (Cambridge). 143, 13, p. 2356-2366 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Connexin23 deletion does not affect lens transparency

Berthoud, V. M., Minogue, P. J., Snabb, J. I., Dzhashiashvili, Y., Novak, L. A., Zoltoski, R. K., Popko, B. & Beyer, E. C., May 1 2016, In : Experimental eye research. 146, p. 283-288 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia

Clayton, B. L. L. & Popko, B., Oct 1 2016, In : Brain research. 1648, p. 594-602 9 p.

Research output: Contribution to journalReview article

42 Scopus citations

Harnessing the integrated stress response for the treatment of multiple sclerosis

Way, S. W. & Popko, B., Apr 1 2016, In : The Lancet Neurology. 15, 4, p. 434-443 10 p.

Research output: Contribution to journalReview article

26 Scopus citations

Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

De Rossi, P., Buggia-Prévot, V., Clayton, B. L. L., Vasquez, J. B., Van Sanford, C., Andrew, R. J., Lesnick, R., Botté, A., Deyts, C., Salem, S., Rao, E., Rice, R. C., Parent, A., Kar, S., Popko, B., Pytel, P., Estus, S. & Thinakaran, G., Aug 3 2016, In : Molecular neurodegeneration. 11, 1, 59.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice

Aaker, J. D., Elbaz, B., Wu, Y., Looney, T. J., Zhang, L., Lahn, B. T. & Popko, B., Sep 1 2016, In : ASN Neuro. 8, 5

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2015

ER chaperone BiP/GRP78 is required for myelinating cell survival and provides protection during experimental autoimmune encephalomyelitis

Hussien, Y., Podojil, J. R., Robinson, A. P., Lee, A. S., Miller, S. D. & Popko, B., Dec 2 2015, In : Journal of Neuroscience. 35, 48, p. 15921-15933 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Oligodendrocyte death results in immune-mediated CNS demyelination

Traka, M., Podojil, J. R., Mccarthy, D. P., Miller, S. D. & Popko, B., Dec 29 2015, In : Nature Neuroscience. 19, 1, p. 65-74 10 p.

Research output: Contribution to journalArticle

75 Scopus citations

Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic

Way, S. W., Podojil, J. R., Clayton, B. L., Zaremba, A., Collins, T. L., Kunjamma, R. B., Robinson, A., Brugarolas, P., Miller, R. H., Miller, S. D. & Popko, B., 2015, In : Nature communications. 6, 6532.

Research output: Contribution to journalArticle

54 Scopus citations
2014

An enhanced integrated stress response ameliorates mutant SOD1-induced ALS

Wang, L., Popko, B. & Roos, R. P., May 2014, In : Human molecular genetics. 23, 10, p. 2629-2638 10 p., ddt658.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

Genetic inactivation of PERK signaling in mouse oligodendrocytes: Normal developmental myelination with increased susceptibility to inflammatory demyelination

Hussien, Y., Cavener, D. R. & Popko, B., May 2014, In : Glia. 62, 5, p. 680-691 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis

Wang, L., Popko, B., Tixier, E. & Roos, R. P., Nov 1 2014, In : Neurobiology of Disease. 71, p. 317-324 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Remyelination therapy goes to trial for multiple sclerosis

Brugarolas, P. & Popko, B., Aug 2014, In : Neurology: Neuroimmunology and NeuroInflammation. 1, 2, p. e26

Research output: Contribution to journalEditorial

Open Access
9 Scopus citations
2013

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis

Lin, W., Lin, Y., Li, J., Fenstermaker, A. G., Way, S. W., Clayton, B., Jamison, S., Harding, H. P., Ron, D. & Popko, B., Apr 3 2013, In : Journal of Neuroscience. 33, 14, p. 5980-5991 12 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

WDR81 is necessary for Purkinje and photoreceptor cell survival

Traka, M., Millen, K. J., Collins, D., Elbaz, B., Kidd, G. J., Gomez, C. M. & Popko, B., Apr 17 2013, In : Journal of Neuroscience. 33, 16, p. 6834-6844 11 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
2012

Peripheral Neuropathy: Neurochemical and Molecular Mechanisms

Soliven, B. & Popko, B., Dec 1 2012, Basic Neurochemistry. Elsevier, p. 679-690 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2011

Animal models in the study of the unfolded protein response

Bommiasamy, H. & Popko, B., 2011, Methods in Enzymology. Academic Press Inc, p. 91-109 19 p. (Methods in Enzymology; vol. 491).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Downregulating DR6 to drive remyelination

Popko, B., Jul 1 2011, In : Nature Medicine. 17, 7, p. 779-780 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations

The unfolded protein response in familial amyotrophic lateral sclerosis

Wang, L., Popko, B. & Roos, R. P., Mar 1 2011, In : Human molecular genetics. 20, 5, p. 1008-1015 8 p., ddq546.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations
2010

Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice

Saadat, L., Dupree, J. L., Kilkus, J., Han, X., Traka, M., Proia, R. L., Dawson, G. & Popko, B., Mar 1 2010, In : Glia. 58, 4, p. 391-398 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

A G-coupled receptor protein critical for peripheral nerve myelination

Howng, S. Y. B., Douglas, D. S. & Popko, B., Dec 1 2010, In : Journal of Molecular Cell Biology. 2, 3, p. 105-106 2 p.

Research output: Contribution to journalArticle

Open Access

A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination

Traka, M., Arasi, K., Avila, R. L., Podojil, J. R., Christakos, A., Miller, S. D., Soliven, B. & Popko, B., Oct 2010, In : Brain. 133, 10, p. 3017-3029 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Myelin maintenance: Axonal support required

Popko, B., Mar 1 2010, In : Nature Neuroscience. 13, 3, p. 275-277 3 p.

Research output: Contribution to journalShort survey

11 Scopus citations

ZFP191 is required by oligodendrocytes for CNS myelination

Howng, S. Y. B., Avila, R. L., Emery, B., Traka, M., Lin, W., Watkins, T., Cook, S., Bronson, R., Davisson, M., Barres, B. A. & Popko, B., Feb 1 2010, In : Genes and Development. 24, 3, p. 301-311 11 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations
2009

Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis

Douglas, D. S., Moran, J. L., Bermingham, J. R., Chen, X. J., Brindley, D. N., Soliven, B., Beier, D. R. & Popko, B., Sep 30 2009, In : Journal of Neuroscience. 29, 39, p. 12089-12100 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Endoplasmic reticulum stress in disorders of myelinating cells

Lin, W. & Popko, B., Apr 1 2009, In : Nature Neuroscience. 12, 4, p. 379-385 7 p.

Research output: Contribution to journalReview article

153 Scopus citations

Mouse forward genetics in the study of the peripheral nervous system and human peripheral neuropathy

Douglas, D. S. & Popko, B., Jan 1 2009, In : Neurochemical Research. 34, 1, p. 124-137 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008

A subgenomic segment of Theiler's murine encephalomyelitis virus RNA causes demyelination

Baida, G., Popko, B., Wollmann, R. L., Stavrou, S., Lin, W., Tretiakova, M., Krausz, T. N. & Roos, R. P., Jun 1 2008, In : Journal of virology. 82, 12, p. 5879-5886 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-γ

Lin, W., Kunkler, P. E., Harding, H. P., Ron, D., Kraig, R. P. & Popko, B., Nov 2008, In : American Journal of Pathology. 173, 5, p. 1508-1517 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Epigenetic control of myelin repair

Popko, B., Sep 1 2008, In : Nature Neuroscience. 11, 9, p. 987-988 2 p.

Research output: Contribution to journalShort survey

9 Scopus citations

Nur7 is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS

Traka, M., Wollmann, R. L., Cerda, S. R., Dugas, J., Barres, B. A. & Popko, B., Nov 5 2008, In : Journal of Neuroscience. 28, 45, p. 11537-11549 13 p.

Research output: Contribution to journalArticle

Open Access
54 Scopus citations

Spinal glioma: Platelet-derived growth factor B-mediated oncogenesis in the spinal cord

Hitoshi, Y., Harris, B. T., Liu, H., Popko, B. & Israel, M. A., Oct 15 2008, In : Cancer Research. 68, 20, p. 8507-8515 9 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Spinal glioma: Platelet-derived growth factor B-mediated oncogenesis in the spinal cord (Cancer Research (2008) 68, (8507-8515))

Hitoshi, Y., Harris, B. T., Liu, H., Popko, B. & Israel, M. A., Nov 15 2008, In : Cancer Research. 68, 22, 1 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations
2007

Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic dynein heavy chain 1 gene

Chen, X. J., Levedakou, E. N., Millen, K. J., Wollmann, R. L., Soliven, B. & Popko, B., Dec 26 2007, In : Journal of Neuroscience. 27, 52, p. 14515-14524 10 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex

Ghashghaei, H. T., Weimer, J. M., Schmid, R. S., Yokota, Y., McCarthy, K. D., Popko, B. & Anton, E. S., Dec 15 2007, In : Genes and Development. 21, 24, p. 3258-3271 14 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage

Lin, W., Bailey, S. L., Ho, H., Harding, H. P., Ron, D., Miller, S. D. & Popko, B., Feb 1 2007, In : Journal of Clinical Investigation. 117, 2, p. 448-456 9 p.

Research output: Contribution to journalArticle

127 Scopus citations
2006

Interferon-γ inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

Lin, W., Kemper, A., Dupree, J. L., Harding, H. P., Ron, D. & Popko, B., May 2006, In : Brain. 129, 5, p. 1306-1318 13 p.

Research output: Contribution to journalArticle

Open Access
143 Scopus citations

Nmf11 is a novel ENU-induced mutation in the mouse glycine receptor alpha 1 subunit

Traka, M., Seburn, K. L. & Popko, B., Sep 1 2006, In : Mammalian Genome. 17, 9, p. 950-955 6 p.

Research output: Contribution to journalArticle

13 Scopus citations