Grants per year
Personal profile
Research Interests
An area of research is the determination of the catalytic mechanisms of metalloenzymes through the development and implementation of electron-nuclear double resonance (ENDOR) spectroscopy, a combination of NMR and EPR. A second area of research is the study of long-range electron transfer between proteins. The focus is on the central question: how do conformational dynamics at a protein-protein interface control inter-protein electron transfer?
Education/Academic qualification
PhD, California Institute of Technology
BS, The University of Chicago
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Dive into the research topics where Brian M Hoffman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Biophysical Studies of Metalloenzymes
Hoffman, B. M. (PD/PI)
4/1/24 → 3/31/28
Project: Research project
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Biological Transition Metals
Hoffman, B. M. (PD/PI), Hoffman, B. M. (PD/PI), Doan, P. E. (Other) & Doan, P. E. (Other)
National Institute of General Medical Sciences
2/1/22 → 1/31/26
Project: Research project
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Towards the Mechanism of N2 Fixation by Nitrogenase
Hoffman, B. M. (PD/PI), Hoffman, B. M. (PD/PI) & Hoffman, B. M. (PD/PI)
9/1/18 → 8/31/27
Project: Research project
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Biophysical Studies of Metalloenzymes
Hoffman, B. M. (PD/PI)
8/1/19 → 7/31/24
Project: Research project
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Biological Transition Metals
Hoffman, B. M. (PD/PI)
National Institute of General Medical Sciences
8/1/18 → 1/31/22
Project: Research project
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Discovery of a New Class of Aminoacyl Radical Enzymes Expands Nature's Known Radical Chemistry
Fu, B., Yang, H., Kountz, D. J., Lundahl, M. N., Beller, H. R., Broderick, W. E., Broderick, J. B., Hoffman, B. H. & Balskus, E. P., Oct 30 2024, In: Journal of the American Chemical Society. 146, 43, p. 29645-29655 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
ENDOR Spectroscopy Reveals the “Free” 5′-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site Actually is Chaperoned by Close Interaction with the Methionine-Bound [4Fe-4S]2+ Cluster
Yang, H., Ho, M. B., Lundahl, M. N., Mosquera, M. A., Broderick, W. E., Broderick, J. B. & Hoffman, B. M., Feb 14 2024, In: Journal of the American Chemical Society. 146, 6, p. 3710-3720 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Erratum: Correction to "Terminal Hydride Complex of High-Spin Mn" (Journal of the American Chemical Society (2024) 146 27 DOI: 10.1021/jacs.4c03310)
Drena, A., Fraker, A., Thompson, N. B., Doan, P. E., Hoffman, B. M. & McSkimming, A., Oct 2 2024, In: Journal of the American Chemical Society. 146, 39, p. 27213 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Impact of N-Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C-H Activation in the M. oryzae Lipoxygenase
Whittington, C., Sharma, A., Hill, S. G., Iavarone, A. T., Hoffman, B. M. & Offenbacher, A. R., May 21 2024, In: Biochemistry. 63, 10, p. 1335-1346 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Role of ammonia-lyases in the synthesis of the dithiomethylamine ligand during [FeFe]-hydrogenase maturation
Pagnier, A., Balci, B., Shepard, E. M., Yang, H., Drena, A., Holliday, G. L., Hoffman, B. M., Broderick, W. E. & Broderick, J. B., Oct 2024, In: Journal of Biological Chemistry. 300, 10, 107760.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Crystal Structure of Horse heart ferric myoglobin; K45E/K63E/K96E mutant
Trana, E. N. (Contributor), Nocek, J. M. (Contributor), Woude, J. V. (Contributor), Span, I. (Contributor), Smith, S. M. (Contributor), Rosenzweig, A. C. (Contributor) & Hoffman, B. M. (Contributor), Protein Data Bank (PDB), May 9 2012
DOI: 10.2210/pdb3RJ6/pdb, https://www.wwpdb.org/pdb?id=pdb_00003rj6
Dataset
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CCDC 888347: Experimental Crystal Structure Determination
Chiang, K. P. (Creator), Scarborough, C. C. (Creator), Horitani, M. (Creator), Lees, N. S. (Creator), Ding, K. (Creator), Dugan, T. R. (Creator), Brennessel, W. W. (Creator), Bill, E. (Creator), Hoffman, B. M. (Creator) & Holland, P. L. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/ccytdch, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccytdch&sid=DataCite
Dataset
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Crystal structure of oxy-I107E CuB myoglobin (I107E L29H F43H sperm whale myoglobin; partial occupancy)
Petrik, I. D. (Contributor), Davydov, R. (Contributor), Kahle, M. (Contributor), Sandoval, B. (Contributor), Dwaraknath, S. (Contributor), Adelroth, P. (Contributor), Hoffman, B. (Contributor) & Lu, Y. (Contributor), Protein Data Bank (PDB), Feb 3 2021
DOI: 10.2210/pdb7L3Y/pdb, https://www.wwpdb.org/pdb?id=pdb_00007l3y
Dataset
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Methanobactin biosynthetic protein complex of MbnB and MbnC from Methylosinus trichosporium OB3b at 2.31 Angstrom resolution
Park, Y. J. (Contributor), Jodts, R. J. (Contributor), Slater, J. W. (Contributor), Reyes, R. M. (Contributor), Winton, V. J. (Contributor), Montaser, R. A. (Contributor), Thomas, P. M. (Contributor), Dowdle, W. B. (Contributor), Ruiz, A. (Contributor), Kelleher, N. L. (Contributor), Bollinger, J. M. (Contributor), Krebs, C. (Contributor), Hoffman, B. M. (Contributor) & Rosenzweig, A. C. (Contributor), Protein Data Bank (PDB), Mar 23 2022
DOI: 10.2210/pdb7TCU/pdb, https://www.wwpdb.org/pdb?id=pdb_00007tcu
Dataset
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2IN4 : Crystal Structure of Myoglobin with Charge Neutralized Heme, ZnDMb-dme
Wheeler, K. E. (Contributor), Nocek, J. M. (Contributor), Cull, D. A. (Contributor), Yatsunyk, L. A. (Contributor), Rosenzweig, A. C. (Contributor) & Hoffman, B. M. (Contributor), RCSB-PDB, 2006
DOI: 10.2210/pdb2in4/pdb, https://www.rcsb.org/structure/2IN4
Dataset