• 13757 Citations
1978 …2023
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Personal profile

Research Interests

My lab's primary research interest is on Siglec-8, a receptor expressed on human eosinophils and mast cells, how it signals and functions, what are its natural sialoside ligands, and whether it can be leveraged as a therapeutic target. Regarding the latter, we have generated Siglec-8 knock-in mice for preclinical studies of Siglec-8 biology and targeting in mouse models. We have also initiated studies on Siglec-6 function in human mast cells, and how pharmacologic inhibition of Bruton's tyrosine kinase (BTK) in mast cells and basophils protects from anaphylaxis in vitro and in vivo.

My primary clinical interests are in eosinophil- and mast-cell associated diseases, including hypereosinophilic syndromes and systemic mastocytosis. I am also interested in anaphylaxis and other allergic diseases.

My primary clinical interests are in eosinophil- and mast-cell associated diseases.

Certifications and Licenses

Internal Medicine
Allergy & Immunology

Training Experience

1985Residency, University of Illinois Medical Center
1988Fellowship, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, University of Illinois - Chicago

… → 1982

Research interests

  • Allergies
  • Asthma
  • Eosinophilic Esophagitis
  • Eosinophilic Gastrointestinal Disease
  • Food Allergy
  • Inflammation

Fingerprint Dive into the research topics where Bruce Scott Bochner is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 20 Similar Profiles
Eosinophils Medicine & Life Sciences
Sialic Acid Binding Immunoglobulin-like Lectins Medicine & Life Sciences
Basophils Medicine & Life Sciences
Mast Cells Medicine & Life Sciences
Leukocytes Medicine & Life Sciences
Vascular Cell Adhesion Molecule-1 Medicine & Life Sciences
Integrins Medicine & Life Sciences
Hypersensitivity Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2013 2023

Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
Eosinophils
Sialic Acid Binding Ig-like Lectin 1
Ligands
Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
Eosinophils
Sialic Acid Binding Ig-like Lectin 1
Ligands
Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
Ligands
Eosinophils
Sialic Acid Binding Ig-like Lectin 1
Food Hypersensitivity
Anaphylaxis
Mast Cells
Allergens
Epithelial Cells
Food Hypersensitivity
Anaphylaxis
Peanut Hypersensitivity
Food
Epinephrine

Research Output 1978 2019

A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and -F on Immune Cells

Nycholat, C. M., Duan, S., Knuplez, E., Worth, C., Elich, M., Yao, A., O'Sullivan, J. A., McBride, R., Wei, Y., Fernandes, S. M., Zhu, Z., Schnaar, R. L., Bochner, B. S. & Paulson, J. C., Sep 11 2019, In : Journal of the American Chemical Society. 141, 36, p. 14032-14037 6 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Sulfonamides
Ligands
Liposomes
Display devices

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity

Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 1 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.

Research output: Contribution to journalArticle

Mast Cells
Cell Movement
Actins
Secretory Vesicles
Phenotype
1 Citation (Scopus)

Mast cell-specific expression of human siglec-8 in conditional knock-in mice

Wei, Y., Chhiba, K. D., Zhang, F., Ye, X., Wang, L., Zhang, L., Robida, P. A., Moreno-Vinasco, L., Schnaar, R. L., Roers, A., Hartmann, K., Lee, C. M., Demers, D., Zheng, T., Bochner, B. S. & Zhu, Z., Jan 1 2019, In : International journal of molecular sciences. 20, 1, 19.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
mice
acids
Acids
2 Citations (Scopus)

Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

Legrand, F., Cao, Y., Wechsler, J. B., Zhu, X., Zimmermann, N., Rampertaap, S., Monsale, J., Romito, K., Youngblood, B. A., Brock, E. C., Makiya, M. A., Tomasevic, N., Bebbington, C., Maric, I., Metcalfe, D. D., Bochner, B. S. & Klion, A. D., Jun 1 2019, In : Journal of Allergy and Clinical Immunology. 143, 6, p. 2227-2237.e10

Research output: Contribution to journalArticle

Saliva
Eosinophils
Lectins
Immunoglobulins
Antibodies
1 Citation (Scopus)

Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency

Kumagai, T., Kiwamoto, T., Brummet, M. E., Wu, F., Aoki, K., Zhu, Z., Bochner, B. S. & Tiemeyer, M., Jun 1 2018, In : Glycobiology. 28, 6, p. 406-417 12 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Glycomics
Keratan Sulfate
Sulfotransferases
Galactose