Bruce Scott Bochner

  • 13537 Citations
1978 …2023
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Personal profile

Research Interests

My lab's primary research interest is on Siglec-8, a receptor expressed on human eosinophils and mast cells, how it signals and functions, what are its natural sialoside ligands, and whether it can be leveraged as a therapeutic target. Regarding the latter, we have generated Siglec-8 knock-in mice for preclinical studies of Siglec-8 biology and targeting in mouse models. We have also initiated studies on Siglec-6 function in human mast cells, and how pharmacologic inhibition of Bruton's tyrosine kinase (BTK) in mast cells and basophils protects from anaphylaxis in vitro and in vivo.

My primary clinical interests are in eosinophil- and mast-cell associated diseases, including hypereosinophilic syndromes and systemic mastocytosis. I am also interested in anaphylaxis and other allergic diseases.

My primary clinical interests are in eosinophil- and mast-cell associated diseases.

Certifications and Licenses

Allergy & Immunology
Internal Medicine

Training Experience

1985Residency, University of Illinois Medical Center
1988Fellowship, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, University of Illinois - Chicago

… → 1982

Keywords

  • Allergies
  • Asthma
  • Eosinophilic Esophagitis
  • Eosinophilic Gastrointestinal Disease
  • Food Allergy
  • Inflammation

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Grants 2013 2023

Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
Ligands
Eosinophils
Sialic Acid Binding Ig-like Lectin 1
Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
Eosinophils
Sialic Acid Binding Ig-like Lectin 1
Ligands
Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
Eosinophils
Sialic Acid Binding Ig-like Lectin 1
Ligands
Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
Endocytosis
Systemic Mastocytosis
Cell Surface Receptors

Research Output 1978 2019

Mast cell-specific expression of human siglec-8 in conditional knock-in mice

Wei, Y., Chhiba, K. D., Zhang, F., Ye, X., Wang, L., Zhang, L., Robida, P. A., Moreno-Vinasco, L., Schnaar, R. L., Roers, A., Hartmann, K., Lee, C. M., Demers, D., Zheng, T., Bochner, B. S. & Zhu, Z., Jan 1 2019, In : International journal of molecular sciences. 20, 1, 19.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
mice
acids
Acids

Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

Legrand, F., Cao, Y., Wechsler, J. B., Zhu, X., Zimmermann, N., Rampertaap, S., Monsale, J., Romito, K., Youngblood, B. A., Brock, E. C., Makiya, M. A., Tomasevic, N., Bebbington, C., Maric, I., Metcalfe, D. D., Bochner, B. S. & Klion, A. D., Jan 1 2019, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Saliva
Eosinophils
Lectins
Immunoglobulins
Antibodies
1 Citation (Scopus)

Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency

Kumagai, T., Kiwamoto, T., Brummet, M. E., Wu, F., Aoki, K., Zhu, Z., Bochner, B. S. & Tiemeyer, M., Jun 1 2018, In : Glycobiology. 28, 6, p. 406-417 12 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Glycomics
Keratan Sulfate
Sulfotransferases
Galactose
1 Citation (Scopus)

Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge

Johansson, M. W., Kelly, E. A., Nguyen, C. L., Jarjour, N. N. & Bochner, B. S., Aug 1 2018, In : International archives of allergy and immunology. 177, 1, p. 16-28 13 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Therapeutic Irrigation
Allergens
Eosinophils
Lung
3 Citations (Scopus)
Routine Diagnostic Tests
Eosinophils
Referral and Consultation
Eosinophilia
Physical Examination