Grants per year
Personal profile
Research Interests
My lab's primary research interest is on Siglec-8, a receptor expressed on human eosinophils and mast cells, how it signals and functions, what are its natural sialoside ligands, and whether it can be leveraged as a therapeutic target. Regarding the latter, we have generated Siglec-8 knock-in mice for preclinical studies of Siglec-8 biology and targeting in mouse models. We have also initiated studies on Siglec-6 function in human mast cells, and how pharmacologic inhibition of Bruton's tyrosine kinase (BTK) in mast cells and basophils protects from anaphylaxis in vitro and in vivo.
My primary clinical interests are in eosinophil- and mast-cell associated diseases, including hypereosinophilic syndromes and systemic mastocytosis. I am also interested in anaphylaxis and other allergic diseases.
My primary clinical interests are in eosinophil- and mast-cell associated diseases.
Certifications and Licenses
| Internal Medicine | |
| Allergy & Immunology |
Training Experience
| 1985 | Residency, University of Illinois Medical Center |
| 1988 | Fellowship, Johns Hopkins University School of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Illinois at Chicago
… → 1982
Research interests keywords
- Allergies
- Asthma
- Eosinophilic Esophagitis
- Eosinophilic Gastrointestinal Disease
- Food Allergy
- Inflammation
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Project 3 Elena Martinelli for Unraveling the Mechanisms of HIV Persistence and Rebound
Martinelli, E., Bochner, B. S. & O'Sullivan, J. A.
National Institute of Allergy and Infectious Diseases
7/15/22 → 4/30/27
Project: Research project
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Northwestern University Allergy and Immunology Research (NUAIR) Program
Bochner, B. S., Schleimer, R. P., Berdnikovs, S. & Saltoun, C. A.
National Institute of Allergy and Infectious Diseases
8/1/20 → 7/31/25
Project: Research project
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Targeting Mast Cells through Siglec-6
O'Sullivan, J. A., Bochner, B. S. & Bochner, B. S.
American Academy of Allergy, Asthma and Immunology
7/1/17 → 6/30/19
Project: Research project
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Glucocorticoid induced G-CSF in lung inflammation
Lu, N., Bochner, B. S., Budinger, G. S. & Schleimer, R. P.
National Heart, Lung, and Blood Institute
9/15/16 → 1/31/17
Project: Research project
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A Cell-Free Protein Synthesis Platform to Produce a Clinically Relevant Allergen Panel
Thames, A. H., Rische, C. H., Cao, Y., Krier-Burris, R. A., Kuang, F. L., Hamilton, R. G., Bronzert, C., Bochner, B. S. & Jewett, M. C., Aug 18 2023, In: ACS synthetic biology. 12, 8, p. 2252-2261 10 p.Research output: Contribution to journal › Article › peer-review
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A phase II study of Bruton’s tyrosine kinase inhibition for the prevention of anaphylaxis
Suresh, R. V., Dunnam, C., Vaidya, D., Wood, R. A., Bochner, B. S., MacGlashan, D. W. & Dispenza, M. C., Aug 15 2023, In: Journal of Clinical Investigation. 133, 16, e172335.Research output: Contribution to journal › Article › peer-review
Open Access -
Drug delivery targets and strategies to address mast cell diseases
Rische, C. H., Thames, A. N., Krier-Burris, R. A., O’Sullivan, J. A., Bochner, B. S. & Scott, E. A., 2023, In: Expert Opinion on Drug Delivery. 20, 2, p. 205-222 18 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
GlycoCAP: A Cell-Free, Bacterial Glycosylation Platform for Building Clickable Azido-Sialoglycoproteins
Thames, A. H., Moons, S. J., Wong, D. A., Boltje, T. J., Bochner, B. S. & Jewett, M. C., Apr 21 2023, In: ACS synthetic biology. 12, 4, p. 1264-1274 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Leukocyte–Blood Vessel Interactions
Davenpeck, K. L. & Bochner, B. S., Jan 1 2023, Inflammatory Mechanisms in Allergic Diseases. CRC Press, p. 125-141 17 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter