• 14105 Citations
1978 …2023

Research output per year

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Personal profile

Research Interests

My lab's primary research interest is on Siglec-8, a receptor expressed on human eosinophils and mast cells, how it signals and functions, what are its natural sialoside ligands, and whether it can be leveraged as a therapeutic target. Regarding the latter, we have generated Siglec-8 knock-in mice for preclinical studies of Siglec-8 biology and targeting in mouse models. We have also initiated studies on Siglec-6 function in human mast cells, and how pharmacologic inhibition of Bruton's tyrosine kinase (BTK) in mast cells and basophils protects from anaphylaxis in vitro and in vivo.

My primary clinical interests are in eosinophil- and mast-cell associated diseases, including hypereosinophilic syndromes and systemic mastocytosis. I am also interested in anaphylaxis and other allergic diseases.

My primary clinical interests are in eosinophil- and mast-cell associated diseases.

Certifications and Licenses

Internal Medicine
Allergy & Immunology

Training Experience

1985Residency, University of Illinois Medical Center
1988Fellowship, Johns Hopkins University School of Medicine

Education/Academic qualification

MD, University of Illinois at Chicago

… → 1982

Research interests

  • Allergies
  • Asthma
  • Eosinophilic Esophagitis
  • Eosinophilic Gastrointestinal Disease
  • Food Allergy
  • Inflammation

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Grants

  • Research Output

    Contributions of Eosinophils to Human Health and Disease

    Klion, A. D., Ackerman, S. J. & Bochner, B. S., Jan 24 2020, In : Annual Review of Pathology: Mechanisms of Disease. 15, p. 179-209 31 p.

    Research output: Contribution to journalReview article

  • 2 Scopus citations

    Eosinophil and mast cell Siglecs: From biology to drug target

    O'Sullivan, J. A., Chang, A. T., Youngblood, B. A. & Bochner, B. S., Jan 1 2020, (Accepted/In press) In : Journal of Leukocyte Biology.

    Research output: Contribution to journalReview article

  • Fibrinogen is a specific trigger for cytolytic eosinophil degranulation

    Coden, M. E., Loffredo, L. F., Walker, M. T., Jeong, B. M., Nam, K., Bochner, B. S., Abdala-Valencia, H. & Berdnikovs, S., Jan 1 2020, In : Journal of Immunology. 204, 2, p. 438-448 11 p.

    Research output: Contribution to journalArticle

  • A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and-F on Immune Cells

    Nycholat, C. M., Duan, S., Knuplez, E., Worth, C., Elich, M., Yao, A., O'Sullivan, J., McBride, R., Wei, Y., Fernandes, S. M., Zhu, Z., Schnaar, R. L., Bochner, B. S. & Paulson, J. C., Sep 11 2019, In : Journal of the American Chemical Society. 141, 36, p. 14032-14037 6 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity

    Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.

    Research output: Contribution to journalArticle