Grants per year
Personal profile
Research Interests
My lab's primary research interest is on Siglec-8, a receptor expressed on human eosinophils and mast cells, how it signals and functions, what are its natural sialoside ligands, and whether it can be leveraged as a therapeutic target. Regarding the latter, we have generated Siglec-8 knock-in mice for preclinical studies of Siglec-8 biology and targeting in mouse models. We have also initiated studies on Siglec-6 function in human mast cells, and how pharmacologic inhibition of Bruton's tyrosine kinase (BTK) in mast cells and basophils protects from anaphylaxis in vitro and in vivo.
My primary clinical interests are in eosinophil- and mast-cell associated diseases, including hypereosinophilic syndromes and systemic mastocytosis. I am also interested in anaphylaxis and other allergic diseases.
My primary clinical interests are in eosinophil- and mast-cell associated diseases.
Certifications and Licenses
| Internal Medicine | |
| Allergy & Immunology |
Training Experience
| 1985 | Residency, University of Illinois Medical Center |
| 1988 | Fellowship, Johns Hopkins University School of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Illinois at Chicago
… → 1982
Research interests keywords
- Allergies
- Asthma
- Eosinophilic Esophagitis
- Eosinophilic Gastrointestinal Disease
- Food Allergy
- Inflammation
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Understanding Anaphylaxis to Platinum-Based Cancer Chemotherapy and Rapid Drug Desensitization that Enables its Use in Allergic Patients
Stevens, W. (PD/PI), Berin, C. (Other), Bochner, B. S. (Other), Kircher, S. M. (Other) & Roque, D. R. (Other)
American Academy of Allergy, Asthma and Immunology
10/1/24 → 9/30/25
Project: Research project
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Modulation and exploitation of Siglec-6 function to broadly impede mast cell activation
O'Sullivan, J. A. (PD/PI) & Bochner, B. S. (Other)
National Institute of Allergy and Infectious Diseases
3/7/24 → 1/31/29
Project: Research project
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Project 3 for Unraveling the Mechanisms of HIV Persistence and Rebound
Martinelli, E. (PD/PI), Martinelli, E. (PD/PI), Bochner, B. S. (Co-PD/PI), Martinelli, E. (Co-PD/PI), O'Sullivan, J. A. (Co-PD/PI), Bochner, B. S. (Co-Investigator), Bochner, B. S. (Co-Investigator) & O'Sullivan, J. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
7/15/22 → 4/30/27
Project: Research project
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Northwestern University Allergy and Immunology Research (NUAIR) Program
Berdnikovs, S. (PD/PI), Eisenbarth, S. C. (PD/PI), Schleimer, R. P. (PD/PI), Berdnikovs, S. (Co-Investigator), Bochner, B. S. (Co-Investigator) & Saltoun, C. A. (Other)
National Institute of Allergy and Infectious Diseases
8/1/20 → 7/31/25
Project: Research project
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Northwestern University Allergy and Immunology Research (NUAIR) Program
Bochner, B. S. (PD/PI), Schleimer, R. P. (PD/PI), Berdnikovs, S. (Other) & Saltoun, C. A. (Other)
National Institute of Allergy and Infectious Diseases
8/1/20 → 7/31/25
Project: Research project
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Analysis of human neutrophils from nasal polyps by single-cell RNA sequencing reveals roles of neutrophils in chronic rhinosinusitis
Iwasaki, N., Poposki, J. A., Kidoguchi, M., Oka, A., Klingler, A. I., Stevens, W. W., Suh, L. A., Bai, J., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Bochner, B. S., Schleimer, R. P., Kern, R. C., Tan, B. K. & Kato, A., 2024, (Accepted/In press) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
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Controlled adsorption of multiple bioactive proteins enables targeted mast cell nanotherapy
Du, F., Rische, C. H., Li, Y., Vincent, M. P., Krier-Burris, R. A., Qian, Y., Yuk, S. A., Almunif, S., Bochner, B. S., Qiao, B. & Scott, E. A., May 2024, In: Nature nanotechnology. 19, 5, p. 698-704 7 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Little to no mRNA for the α- or β-chains of FcεRI in human eosinophils
Chhiba, K. D., Kuang, F. L., Berdnikovs, S., Kato, A. & Bochner, B. S., Feb 2024, In: Journal of Allergy and Clinical Immunology. 153, 2, p. 533-534 2 p.Research output: Contribution to journal › Letter › peer-review
Open Access1 Scopus citations -
Prevention of allergic reactions during oxaliplatin desensitization through inhibition of Bruton tyrosine kinase
Erickson, K. A., Norton, J. E., Law, J., Soriano, N., Strojny, M., Gentry, N., Fried, M., Bochner, B. S., Kircher, S. & Stevens, W. W., Jul 2024, In: Journal of Allergy and Clinical Immunology. 154, 1, p. 222-228.e4Research output: Contribution to journal › Article › peer-review
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Single cell RNA sequencing of human eosinophils from nasal polyps reveals eosinophil heterogeneity in chronic rhinosinusitis tissue
Iwasaki, N., Poposki, J. A., Oka, A., Kidoguchi, M., Klingler, A. I., Suh, L. A., Bai, J., Stevens, W. W., Peters, A. T., Grammer, L. C., Welch, K. C., Smith, S. S., Conley, D. B., Schleimer, R. P., Kern, R. C., Bochner, B. S., Tan, B. K. & Kato, A., 2024, (Accepted/In press) In: Journal of Allergy and Clinical Immunology. 154, 4, p. 952-964 13 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations