• 14357 Citations
1978 …2020

Research output per year

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Research Output

2020

Contributions of Eosinophils to Human Health and Disease

Klion, A. D., Ackerman, S. J. & Bochner, B. S., Jan 24 2020, In : Annual Review of Pathology: Mechanisms of Disease. 15, p. 179-209 31 p.

Research output: Contribution to journalReview article

7 Scopus citations

Eosinophil and mast cell Siglecs: From biology to drug target

O'Sullivan, J. A., Chang, A. T., Youngblood, B. A. & Bochner, B. S., Jul 1 2020, In : Journal of Leukocyte Biology. 108, 1, p. 73-81 9 p.

Research output: Contribution to journalReview article

3 Scopus citations

Fibrinogen is a specific trigger for cytolytic eosinophil degranulation

Coden, M. E., Loffredo, L. F., Walker, M. T., Jeong, B. M., Nam, K., Bochner, B. S., Abdala-Valencia, H. & Berdnikovs, S., Jan 1 2020, In : Journal of Immunology. 204, 2, p. 438-448 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls

Knuplez, E., Krier-Burris, R., Cao, Y., Marsche, G., O'Sullivan, J. & Bochner, B. S., Jul 1 2020, In : Journal of Leukocyte Biology. 108, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features

Dong, Z. M., Lin, E., Wechsler, M. E., Weller, P. F., Klion, A. D., Bochner, B. S., Delker, D. A., Hazel, M. W., Fairfax, K., Khoury, P., Akuthota, P., Merkel, P. A., Dyer, A. M., Langford, C., Specks, U., Gleich, G. J., Chinchilli, V. M., Raby, B., Yandell, M. & Clayton, F., Jul 2020, In : American Journal of Pathology. 190, 7, p. 1438-1448 11 p.

Research output: Contribution to journalArticle

Open Access
2019

A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and-F on Immune Cells

Nycholat, C. M., Duan, S., Knuplez, E., Worth, C., Elich, M., Yao, A., O'Sullivan, J., McBride, R., Wei, Y., Fernandes, S. M., Zhu, Z., Schnaar, R. L., Bochner, B. S. & Paulson, J. C., Sep 11 2019, In : Journal of the American Chemical Society. 141, 36, p. 14032-14037 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity

Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.

Research output: Contribution to journalArticle

Mast cell-specific expression of human siglec-8 in conditional knock-in mice

Wei, Y., Chhiba, K. D., Zhang, F., Ye, X., Wang, L., Zhang, L., Robida, P. A., Moreno, L., Schnaar, R. L., Roers, A., Hartmann, K., Lee, C. M., Demers, D., Zheng, T., Bochner, B. S. & Zhu, Z., Jan 2019, In : International journal of molecular sciences. 20, 1, 19.

Research output: Contribution to journalArticle

5 Scopus citations

Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

Legrand, F., Cao, Y., Wechsler, J. B., Zhu, X., Zimmermann, N., Rampertaap, S., Monsale, J., Romito, K., Youngblood, B. A., Brock, E. C., Makiya, M. A., Tomasevic, N., Bebbington, C., Maric, I., Metcalfe, D. D., Bochner, B. S. & Klion, A. D., Jun 2019, In : Journal of Allergy and Clinical Immunology. 143, 6, p. 2227-2237.e10

Research output: Contribution to journalArticle

13 Scopus citations

Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis

Youngblood, B. A., Brock, E. C., Leung, J., Falahati, R., Bochner, B. S., Rasmussen, H. S., Peterson, K., Bebbington, C. & Tomasevic, N., Jan 1 2019, In : JCI Insight. 4, 19, e126219.

Research output: Contribution to journalArticle

13 Scopus citations

Workup for eosinophilia

Guo, C. & Bochner, B. S., Nov 1 2019, In : Allergy and asthma proceedings. 40, 6, p. 429-432 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency

Kumagai, T., Kiwamoto, T., Brummet, M. E., Wu, F., Aoki, K., Zhu, Z., Bochner, B. S. & Tiemeyer, M., Jun 1 2018, In : Glycobiology. 28, 6, p. 406-417 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge

Johansson, M. W., Kelly, E. A., Nguyen, C. L., Jarjour, N. N. & Bochner, B. S., Aug 1 2018, In : International archives of allergy and immunology. 177, 1, p. 16-28 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
7 Scopus citations

Diagnosis and Novel Approaches to the Treatment of Hypereosinophilic Syndromes

Dispenza, M. C. & Bochner, B. S., Jun 1 2018, In : Current Hematologic Malignancy Reports. 13, 3, p. 191-201 11 p.

Research output: Contribution to journalReview article

6 Scopus citations

Enhanced antigen presenting and T cell functions during late-phase allergic responses in the lung

Liu, M. C., Xiao, H. Q., Breslin, L. M., Bochner, B. S. & Schroeder, J. T., Mar 2018, In : Clinical and Experimental Allergy. 48, 3, p. 334-342 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Eosinophils and eosinophil-associated diseases: An update

O'Sullivan, J. A. & Bochner, B. S., Feb 2018, In : Journal of Allergy and Clinical Immunology. 141, 2, p. 505-517 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

O'Sullivan, J. A., Wei, Y., Carroll, D. J., Moreno, L., Cao, Y., Zhang, F., Lee, J. J., Zhu, Z. & Bochner, B. S., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Human eosinophils and mast cells: Birds of a feather flock together

Robida, P. A., Puzzovio, P. G., Pahima, H., Levi-Schaffer, F. & Bochner, B. S., Mar 2018, In : Immunological Reviews. 282, 1, p. 151-167 17 p.

Research output: Contribution to journalReview article

17 Scopus citations

Identification of a Siglec-F+ granulocyte-macrophage progenitor

Bolden, J. E., Lucas, E. C., Zhou, G., O'Sullivan, J. A., de Graaf, C. A., McKenzie, M. D., Di Rago, L., Baldwin, T. M., Shortt, J., Alexander, W. S., Bochner, B. S., Ritchie, M. E., Hilton, D. J. & Fairfax, K. A., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 123-133 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

O'Sullivan, J. A., Carroll, D. J., Cao, Y., Salicru, A. N. & Bochner, B. S., May 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1774-1785.e7

Research output: Contribution to journalArticle

21 Scopus citations

Mepolizumab use: Post-approval academic practice experience

Benjamin, M. R., Bochner, B. S. & Peters, A. T., Jul 2018, In : Annals of Allergy, Asthma and Immunology. 121, 1, p. 126-128 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD)

Khoury, P., Akuthota, P., Ackerman, S. J., Arron, J. R., Bochner, B. S., Collins, M. H., Kahn, J. E., Fulkerson, P. C., Gleich, G. J., Gopal-Srivastava, R., Jacobsen, E. A., Leiferman, K. M., Francesca, L. S., Mathur, S. K., Minnicozzi, M., Prussin, C., Rothenberg, M. E., Roufosse, F., Sable, K., Simon, D. & 7 others, Simon, H. U., Spencer, L. A., Steinfeld, J., Wardlaw, A. J., Wechsler, M. E., Weller, P. F. & Klion, A. D., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 69-83 15 p.

Research output: Contribution to journalReview article

8 Scopus citations

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Abdala-Valencia, H., Coden, M. E., Chiarella, S. E., Jacobsen, E. A., Bochner, B. S., Lee, J. J. & Berdnikovs, S., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 95-108 14 p.

Research output: Contribution to journalReview article

26 Scopus citations

Sialic acid–binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin–dependent function in human eosinophils

Carroll, D. J., O'Sullivan, J. A., Nix, D. B., Cao, Y., Tiemeyer, M. & Bochner, B. S., Jun 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 6, p. 2196-2207 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways

Gonzalez-Gil, A., Porell, R. N., Fernandes, S. M., Wei, Y., Yu, H., Carroll, D. J., McBride, R., Paulson, J. C., Tiemeyer, M., Aoki, K., Bochner, B. S. & Schnaar, R. L., Jan 1 2018, In : Glycobiology. 28, 10, p. 786-801 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

The eosinophil: For better or worse, in sickness and in health

Bochner, B. S., Aug 2018, In : Annals of Allergy, Asthma and Immunology. 121, 2, p. 150-155 6 p.

Research output: Contribution to journalReview article

11 Scopus citations
2017

Glycobiology of eosinophilic inflammation: Contributions of siglecs, glycans, and other glycan-binding proteins

O'Sullivan, J. A., Carroll, D. J. & Bochner, B. S., Jan 1 2017, In : Frontiers in Medicine. 4, AUG, 116.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations

Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils

Banuelos, J., Cao, Y., Shin, S. C., Bochner, B. S., Avila, P. C., Li, S., Jiang, X., Lingen, M. W., Schleimer, R. P. & Lu, N. Z., May 2017, In : PloS one. 12, 5, e0177884.

Research output: Contribution to journalArticle

2 Scopus citations

In Memory and Celebration: Dr. James J. Lee

Rosenberg, H. F., Fryer, A. D., Munitz, A., Bochner, B. S., Jacoby, D. B., Levi-Schaffer, F., Gleich, G. J., Furuta, G. T., Rothenberg, M. E., Lacy, P., Fulkerson, P. C., Hogan, S. P., Ackerman, S. J. & Foster, P. S., Jul 2017, In : Clinical and Experimental Allergy. 47, 7, p. 980-981 2 p.

Research output: Contribution to journalLetter

13 Scopus citations

Potential applications of Bruton’s tyrosine kinase inhibitors for the prevention of allergic reactions

Dispenza, M. C., Regan, J. A. & Bochner, B. S., Oct 3 2017, In : Expert Review of Clinical Immunology. 13, 10, p. 921-923 3 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases

Kano, G., Bochner, B. S. & Zimmermann, N., Feb 1 2017, In : Immunobiology. 222, 2, p. 343-349 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis

Banuelos, J., Shin, S., Cao, Y., Bochner, B. S., Morales-Nebreda, L., Budinger, G. R. S., Zhou, L., Li, S., Xin, J., Lingen, M. W., Dong, C., Schleimer, R. P. & Lu, N. Z., May 1 2016, In : Allergy: European Journal of Allergy and Clinical Immunology. 71, 5, p. 640-650 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Control of lung defence by mucins and macrophages: Ancient defence mechanisms with modern functions

Janssen, W. J., Stefanski, A. L., Bochner, B. S. & Evans, C. M., Oct 1 2016, In : European Respiratory Journal. 48, 4, p. 1201-1214 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Eosinophilic bioactivities in severe asthma

Carr, T. F., Berdnikovs, S., Simon, H. U., Bochner, B. S. & Rosenwasser, L. J., Jun 27 2016, In : World Allergy Organization Journal. 9, 1, 112.

Research output: Contribution to journalReview article

31 Scopus citations

Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis

Lynch, K. L., Dhalla, S., Chedid, V., Ravich, W. J., Stein, E. M., Montgomery, E. A., Bochner, B. S. & Clarke, J. O., Feb 1 2016, In : Diseases of the Esophagus. 29, 2, p. 174-178 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression

Schleimer, R. P., Schnaar, R. L. & Bochner, B. S., Jan 1 2016, In : Current Opinion in Allergy and Clinical Immunology. 16, 1, p. 24-30 7 p.

Research output: Contribution to journalReview article

13 Scopus citations

"siglec"ting the allergic response for therapeutic targeting

Bochner, B. S., Jun 23 2016, In : Glycobiology. 26, 6, p. 546-552 7 p.

Research output: Contribution to journalReview article

19 Scopus citations
2015

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

Kiwamoto, T., Katoh, T., Evans, C. M., Janssen, W. J., Brummet, M. E., Hudson, S. A., Zhu, Z., Tiemeyer, M. & Bochner, B. S., May 2015, In : Journal of Allergy and Clinical Immunology. 135, 5, p. 1329-1340.e9

Research output: Contribution to journalArticle

44 Scopus citations

Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells

Jia, Y., Yu, H., Fernandes, S. M., Wei, Y., Gonzalez-Gil, A., Motari, M. G., Vajn, K., Stevens, W. W., Peters, A. T., Bochner, B. S., Kern, R. C., Schleimer, R. P. & Schnaar, R. L., Mar 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 3, p. 799-810.e7

Research output: Contribution to journalArticle

30 Scopus citations

Novel Therapies for Eosinophilic Disorders

Bochner, B. S., Aug 1 2015, In : Immunology and Allergy Clinics of North America. 35, 3, p. 577-598 22 p.

Research output: Contribution to journalReview article

20 Scopus citations

Out of the orphanage and into the clinic - Therapeutic targeting of GATA3

Bochner, B. S. & Schleimer, R. P., May 21 2015, In : New England Journal of Medicine. 372, 21, p. 2060-2061 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Reply

Bochner, B. S., Kiwamoto, T., Katoh, T., Zhu, Z. & Tiemeyer, M., Jun 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 6, p. 1662-1663 2 p.

Research output: Contribution to journalLetter

2 Scopus citations

Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

Bochner, B. S. & Zimmermann, N., Mar 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 3, p. 598-608 11 p.

Research output: Contribution to journalReview article

59 Scopus citations

The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

Schneider, C., Smith, D. F., Cummings, R. D., Boligan, K. F., Hamilton, R. G., Bochner, B. S., Miescher, S., Simon, H. U., Pashov, A., Vassilev, T. & Von Gunten, S., Jan 1 2015, In : Science Translational Medicine. 7, 269, 269ra1.

Research output: Contribution to journalArticle

55 Scopus citations
2014

Biology of Eosinophils

Kita, H. & Bochner, B. S., Jan 1 2014, Middleton's Allergy: Principles and Practice: Eighth Edition. Elsevier Inc, Vol. 1-2. p. 265-279 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations