Research Output 1978 2017

2017

Eosinophils and eosinophil-associated diseases: An update

O'Sullivan, J. A. & Bochner, B. S. Jan 1 2017 (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Research - peer-reviewArticle

Eosinophils
Allergy and Immunology
Surveys and Questionnaires

Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils

Banuelos, J., Cao, Y., Shin, S. C., Bochner, B. S., Avila, P., Li, S., Jiang, X., Lingen, M. W., Schleimer, R. P. & Lu, N. Z. May 1 2017 In : PLoS ONE. 12, 5, e0177884

Research output: Research - peer-reviewArticle

granulocyte colony-stimulating factor
dexamethasone
lipopolysaccharides
neutrophils
lungs
2 Citations
Lymphoproliferative Disorders
Basophils
Skin Tests
Agammaglobulinaemia tyrosine kinase
PCI 32765

In lasting tribute: Dr James J. Lee (1958-2017)

Rosenberg, H. F., Jacobsen, E. A., Bochner, B. S. & Weller, P. F. 2017 (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Research - peer-reviewArticle

In Memory and Celebration: Dr. James J. Lee

Rosenberg, H. F., Fryer, A. D., Munitz, A., Bochner, B. S., Jacoby, D. B., Levi-Schaffer, F., Gleich, G. J., Furuta, G. T., Rothenberg, M. E., Lacy, P., Fulkerson, P. C., Hogan, S. P., Ackerman, S. J. & Foster, P. S. Jul 1 2017 In : Clinical and Experimental Allergy. 47, 7, p. 980-981 2 p.

Research output: Research - peer-reviewLetter

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

O'Sullivan, J. A., Carroll, D. J., Cao, Y., Salicru, A. N. & Bochner, B. S. 2017 (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Research - peer-reviewArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Eosinophils
Mast Cells
Endocytosis
Cell Line
Nasal Lavage Fluid
Nasal Polyps
Aspirin
Biomarkers
Basophils

Potential applications of Bruton’s tyrosine kinase inhibitors for the prevention of allergic reactions

Dispenza, M. C., Regan, J. A. & Bochner, B. S. Oct 3 2017 In : Expert Review of Clinical Immunology. 13, 10, p. 921-923 3 p.

Research output: Research - peer-reviewEditorial

2 Citations

Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases

Kano, G., Bochner, B. S. & Zimmermann, N. Feb 1 2017 In : Immunobiology. 222, 2, p. 343-349 7 p.

Research output: Research - peer-reviewArticle

Sialic Acid Binding Immunoglobulin-like Lectins
src-Family Kinases
Eosinophils
Reactive Oxygen Species
Cell Death
2016
8 Citations

BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis

Banuelos, J., Shin, S., Cao, Y., Bochner, B. S., Morales-Nebreda, L., Budinger, G. R. S., Zhou, L., Li, S., Xin, J., Lingen, M. W., Dong, C., Schleimer, R. P. & Lu, N. Z. May 1 2016 In : Allergy: European Journal of Allergy and Clinical Immunology. 71, 5, p. 640-650 11 p.

Research output: Research - peer-reviewArticle

Th17 Cells
Glucocorticoids
Apoptosis
Interleukin-17
Asthma
3 Citations

Control of lung defence by mucins and macrophages: Ancient defence mechanisms with modern functions

Janssen, W. J., Stefanski, A. L., Bochner, B. S. & Evans, C. M. Oct 1 2016 In : European Respiratory Journal. 48, 4, p. 1201-1214 14 p.

Research output: Research - peer-reviewArticle

Mucins
Macrophages
Lung
Mucus
Phagocytosis
6 Citations

Eosinophilic bioactivities in severe asthma

Carr, T. F., Berdnikovs, S., Simon, H. U., Bochner, B. S. & Rosenwasser, L. J. Jun 27 2016 In : World Allergy Organization Journal. 9, 1, 112

Research output: Research - peer-reviewReview article

Eosinophils
Asthma
Eosinophilia
Biomarkers
Cytokines
5 Citations

Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis

Lynch, K. L., Dhalla, S., Chedid, V., Ravich, W. J., Stein, E. M., Montgomery, E. A., Bochner, B. S. & Clarke, J. O. Feb 1 2016 In : Diseases of the Esophagus. 29, 2, p. 174-178 5 p.

Research output: Research - peer-reviewArticle

Eosinophilic Esophagitis
Heartburn
Deglutition Disorders
Chest Pain
Guidelines
5 Citations
Sialic Acid Binding Immunoglobulin-like Lectins
Ligands
Inflammation
Eosinophils
Mast Cells
4 Citations

"siglec"ting the allergic response for therapeutic targeting

Bochner, B. S. Jun 23 2016 In : Glycobiology. 26, 6, p. 546-552 7 p.

Research output: Research - peer-reviewReview article

Sialic Acid Binding Immunoglobulin-like Lectins
Tolnaftate
Eosinophils
Therapeutics
Basophils
2015
23 Citations

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

Kiwamoto, T., Katoh, T., Evans, C. M., Janssen, W. J., Brummet, M. E., Hudson, S. A., Zhu, Z., Tiemeyer, M. & Bochner, B. S. May 1 2015 In : Journal of Allergy and Clinical Immunology. 135, 5, p. 1329-1340e9

Research output: Research - peer-reviewArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Mucins
Eosinophils
Polysaccharides
Apoptosis
12 Citations

Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells

Jia, Y., Yu, H., Fernandes, S. M., Wei, Y., Gonzalez-Gil, A., Motari, M. G., Vajn, K., Stevens, W. W., Peters, A. T., Bochner, B. S., Kern, R. C., Schleimer, R. P. & Schnaar, R. L. Jan 1 2015 In : Journal of Allergy and Clinical Immunology. 135, 3, p. 799-810.e7

Research output: Research - peer-reviewArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Ligands
Inflammation
Mucin-5B
Turbinates
9 Citations

Novel Therapies for Eosinophilic Disorders

Bochner, B. S. Aug 1 2015 In : Immunology and Allergy Clinics of North America. 35, 3, p. 577-598 22 p.

Research output: Research - peer-reviewReview article

Therapeutics
Eosinophils
Off-Label Use
Controlled Clinical Trials
Biological Products
2 Citations

Out of the orphanage and into the clinic - Therapeutic targeting of GATA3

Bochner, B. S. & Schleimer, R. P. May 21 2015 In : New England Journal of Medicine. 372, 21, p. 2060-2061 2 p.

Research output: Research - peer-reviewEditorial

GATA3 Transcription Factor
Orphanages
Catalytic DNA
Anti-Asthmatic Agents
Asthma

Reply

Bochner, B. S., Kiwamoto, T., Katoh, T., Zhu, Z. & Tiemeyer, M. Jun 1 2015 In : Journal of Allergy and Clinical Immunology. 135, 6, p. 1662-1663 2 p.

Research output: Research - peer-reviewLetter

Sialic Acid Binding Immunoglobulin-like Lectins
Mucins
Eosinophils
Polysaccharides
Apoptosis
30 Citations

Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

Bochner, B. S. & Zimmermann, N. Mar 1 2015 In : Journal of Allergy and Clinical Immunology. 135, 3, p. 598-608 11 p.

Research output: Research - peer-reviewReview article

Sialic Acid Binding Immunoglobulin-like Lectins
Polysaccharides
Carrier Proteins
Glycomics
Selectins
22 Citations

The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

Schneider, C., Smith, D. F., Cummings, R. D., Boligan, K. F., Hamilton, R. G., Bochner, B. S., Miescher, S., Simon, H. U., Pashov, A., Vassilev, T. & Von Gunten, S. Jan 1 2015 In : Science Translational Medicine. 7, 269, 269ra1

Research output: Research - peer-reviewArticle

Polysaccharides
Immunoglobulin G
Carbohydrates
Antibodies
T-Lymphocytes
2014
23 Citations

Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation

Kiwamoto, T., Brummet, M. E., Wu, F., Motari, M. G., Smith, D. F., Schnaar, R. L., Zhu, Z. & Bochner, B. S. Jan 1 2014 In : Journal of Allergy and Clinical Immunology. 133, 1

Research output: Research - peer-reviewArticle

beta-galactoside alpha-2,3-sialyltransferase
Sialic Acid Binding Immunoglobulin-like Lectins
Sialyltransferases
Inflammation
Genes
2013
5 Citations

Advances in mechanisms of allergy and clinical immunology in 2012

Bochner, B. S., Rothenberg, M. E., Boyce, J. A. & Finkelman, F. Mar 1 2013 In : Journal of Allergy and Clinical Immunology. 131, 3, p. 661-667 7 p.

Research output: Research - peer-reviewReview article

Allergy and Immunology
Immunologic Desensitization
Anti-Allergic Agents
Manuscripts
Immune System Diseases
6 Citations

Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis

Kim, Y. H., Park, C. S., Lim, D. H., Son, B. K., Kim, J. H., Ahn, S. H., Bochner, B. S., Na, K. & Jang, T. Y. May 2013 In : American Journal of Rhinology and Allergy. 27, 3, p. 187-191 5 p.

Research output: Research - peer-reviewArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Anti-Allergic Agents
Inflammation
Allergic Rhinitis
Antibodies

Antieosinophil Therapeutics

Straumann, A., Haldar, P., Pavord, I. D., Wardlaw, A. J., Busse, W. W., Molfino, N. A., Kolbeck, R., Shin, M. K., Bochner, B. S. & Cools, J. 2013 Eosinophils in Health and Disease. Elsevier Inc., p. 577-605 29 p.

Research output: ResearchChapter

Therapeutics
3 Citations

Biology of Eosinophils

Kita, H. & Bochner, B. S. Oct 18 2013 Middleton's Allergy: Principles and Practice: Eighth Edition. Adkinson, N. F., Bochner, B. S., Busse, W. W., Holgate, S. T., Lemanske, R. & O’Hehir, R. (eds.). Philadelphia: Elsevier Inc., p. 265-279

Research output: ResearchChapter

Eosinophils
1 Citations

CD Molecules

von Gunten, S., Ghanim, V., Valent, P. & Bochner, B. S. Oct 18 2013 Middleton's Allergy: Principles and Practice: Eighth Edition. Elsevier Inc., Vol. 2-2, p. 1663-1687 25 p.

Research output: ResearchChapter

Eosinophil Trafficking

Wennerås, C., Matsumoto, K., Bochner, B. S., Cook-Mills, J. M., Asosingh, K., Erzurum, S. C., Rao, S. P. & Sriramarao, P. Aug 29 2013 Eosinophils in Health and Disease. Elsevier Inc., p. 121-166 46 p.

Research output: ResearchChapter

Eosinophils

High-dose cyclophosphamide used to treat aplastic anemia in a patient with respiratory and food allergies has a prolonged effect on serum IgE levels

Cook, M. L., Brodsky, R. A., Hamilton, R., Wood, R. A. & Bochner, B. S. Jan 1 2013 In : Journal of Allergy and Clinical Immunology. 132, 1, p. 237-239 3 p.

Research output: Research - peer-reviewLetter

Food Hypersensitivity
Aplastic Anemia
Cyclophosphamide
Immunoglobulin E
Serum
37 Citations

Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: Role for reactive oxygen species-enhanced MEK/ERK activation

Kano, G., Almanan, M., Bochner, B. S. & Zimmermann, N. Aug 2013 In : Journal of Allergy and Clinical Immunology. 132, 2, p. 437-445 9 p.

Research output: Research - peer-reviewArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Interleukin-5
Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Eosinophils
15 Citations

Mechanisms of Siglec-F-Induced Eosinophil Apoptosis: A Role for Caspases but Not for SHP-1, Src Kinases, NADPH Oxidase or Reactive Oxygen

Mao, H., Kano, G., Hudson, S. A., Brummet, M., Zimmermann, N., Zhu, Z. & Bochner, B. S. Jun 28 2013 In : PLoS ONE. 8, 6, e68143

Research output: Research - peer-reviewArticle

caspases
eosinophils
phosphotransferases (kinases)
apoptosis
oxygen
2 Citations

Middleton's Allergy: Principles and Practice: Eighth Edition

Adkinson, N. F., Bochner, B. S., Burks, A. W., Busse, W. W., Holgate, S. T., Lemanske, R. F. & O'Hehir, R. E. Oct 18 2013 Elsevier Inc.1764 p.

Research output: ResearchBook

Allergy and Immunology
Hypersensitivity
Research Personnel

Preface to the Eighth Edition

Adkinson, N. F., Bochner, B. S., Burks, A. W., Busse, W. W., Holgate, S. T., Lemanske, R. F. & O'Hehir, R. E. Oct 18 2013 Middleton's Allergy: Principles and Practice: Eighth Edition. Elsevier Inc., Vol. 1-2, p. ix-x

Research output: ResearchForeword/postscript

18 Citations

The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation

Kiwamoto, T., Katoh, T., Tiemeyer, M. & Bochner, B. S. Feb 2013 In : Current Opinion in Allergy and Clinical Immunology. 13, 1, p. 106-111 6 p.

Research output: Research - peer-reviewReview article

Sialic Acid Binding Immunoglobulin-like Lectins
Ligands
Inflammation
Lung
Eosinophils
2012
36 Citations

Advances in mechanisms of asthma, allergy, and immunology in 2011

Boyce, J. A., Bochner, B., Finkelman, F. D. & Rothenberg, M. E. Feb 1 2012 In : Journal of Allergy and Clinical Immunology. 129, 2, p. 335-341 7 p.

Research output: Research - peer-reviewReview article

Allergy and Immunology
Allergens
Asthma
Immunologic Desensitization
Cytokines

Anti-eosinophil therapeutics. Therapeutic Approaches Targeting Siglecs

Shin, M. K. & Bochner, B. S. 2012 Eosinophils in Health and Disease. Lee, J. J. & Rosenberg, H. F. (eds.). Amsterdam: Elsevier Sanders, p. 592-599

Research output: ResearchChapter

12 Citations
Sialic Acid Binding Immunoglobulin-like Lectins
Eosinophils
Biomarkers
Serum
Proteins
8 Citations

Controversies and open questions in the definitions and classification of the hypereosinophilic syndromes and eosinophilic leukemias

Valent, P., Horny, H. P., Bochner, B. S., Haferlach, T. & Reiter, A. Apr 1 2012 In : Seminars in Hematology. 49, 2, p. 171-181 11 p.

Research output: Research - peer-reviewArticle

Hypereosinophilic Syndrome
Eosinophils
Neoplasms
Eosinophilia
Adjustment Disorders

Davos declaration: Allergy as a global problem (Allergy: European Journal of Allergy and Clinical Immunology (2012) 67, (141-143))

Ring, J. , Akdis, C. , Behrendt, H. , Lauener, R. P. , Schäppi, G. , Akdis, M. , Ammann, W. , De Beaumont, O. , Bieber, T. , Bienenstock, J. , Blaser, K. , Bochner, B. , Bousquet, J. , Crameri, R. , Custovic, A. , Czerkinsky, C. , Darsow, U. , Denburg, J. , Drazen, J. , De Villiers, E. M. & 29 others Fire, A., Galli, S., Haahtela, T., Zur Hausen, H., Hildemann, S., Holgate, S., Holt, P., Jakob, T., Jung, A., Kemeny, M., Koren, H., Leung, D., Lockey, R., Marone, G., Mempel, M., Menné, B., Menz, G., Mueller, U., Von Mutius, E., Ollert, M., O'Mahony, L., Pawankar, R., Renz, H., Platts-Mills, T., Roduit, C., Schmidt-Weber, C., Traidl-Hoffmann, C., Wahn, U. & Rietschel, E. May 2012 In : Allergy: European Journal of Allergy and Clinical Immunology. 67, 5, 1 p.

Research output: Research - peer-reviewComment/debate

Eosinophil trafficking. Adhesion Molecules

K, M., BS, B. & Bochner, B. S. 2012 Eosinophils in Health and Disease. JJ, L. & HF, R. (eds.). Elsevier Sanders

Research output: ResearchChapter

Eosinophil trafficking. Adhesion Molecules

Matsumoto, K. & Bochner, B. S. 2012 Eosinophils in Health and Disease. Lee, J. J. & Rosenberg, H. F. (eds.). Amsterdam: Elsevier Sanders, p. 131-139

Research output: ResearchChapter

15 Citations

Glycomic analysis of human mast cells, eosinophils and basophils

North, S. J., Von Gunten, S., Antonopoulos, A., Trollope, A., MacGlashan, D. W., Jang-Lee, J., Dell, A., Metcalfe, D. D., Kirshenbaum, A. S., Bochner, B. S. & Haslam, S. M. Jan 1 2012 In : Glycobiology. 22, 1, p. 12-22 11 p.

Research output: Research - peer-reviewArticle

Glycomics
Basophils
Eosinophils
Mast Cells
Polysaccharides
13 Citations

ICON: Eosinophil disorders

Valent, P. , Klion, A. D. , Rosenwasser, L. J. , Arock, M. , Bochner, B. S. , Butterfield, J. H. , Gotlib, J. , Haferlach, T. , Hellmann, A. , Horny, H. P. , Leiferman, K. M. , Metzgeroth, G. , Matsumoto, K. , Reiter, A. , Roufosse, F. , Rothenberg, M. E. , Simon, H. U. , Sotlar, K. , Vandenberghe, P. , Weller, P. F. & 1 others Gleich, G. J. 2012 In : World Allergy Organization Journal. 5, 12, p. 174-181 8 p.

Research output: Research - peer-reviewArticle

Allergy and Immunology
Eosinophils
Consensus
Asthma
Hypersensitivity
31 Citations

IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils

Na, H. J., Hudson, S. A. & Bochner, B. S. Jan 1 2012 In : Cytokine. 57, 1, p. 169-174 6 p.

Research output: Research - peer-reviewArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Interleukin-5
Eosinophils
Apoptosis
Interleukin-33
56 Citations

Novel targeted therapies for eosinophilic disorders

Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., Ortega, H., Patel, J., Prussin, C., Renzi, P., Rothenberg, M. E., Roufosse, F., Simon, D., Simon, H. U., Wardlaw, A., Weller, P. F. & Klion, A. D. Sep 1 2012 In : Journal of Allergy and Clinical Immunology. 130, 3, p. 563-571 9 p.

Research output: Research - peer-reviewReview article

Hypereosinophilic Syndrome
Therapeutics
Eosinophils
Eosinophilia
Quality of Life
63 Citations

Pathogenesis and classification of eosinophil disorders: A review of recent developments in the field

Valent, P., Gleich, G. J., Reiter, A., Roufosse, F., Weller, P. F., Hellmann, A., Metzgeroth, G., Leiferman, K. M., Arock, M., Sotlar, K., Butterfield, J. H., Cerny-Reiterer, S., Mayerhofer, M., Vandenberghe, P., Haferlach, T., Bochner, B. S., Gotlib, J., Horny, H. P., Simon, H. U. & Klion, A. D. Oct 26 2012 In : Expert Review of Hematology. 5, 2, p. 157-176 20 p.

Research output: Research - peer-reviewReview article

Eosinophils
Eosinophilia
Therapeutics
Adjustment Disorders
Reducing Agents
59 Citations

Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions

Kiwamoto, T., Kawasaki, N., Paulson, J. C. & Bochner, B. S. Sep 1 2012 In : Pharmacology and Therapeutics. 135, 3, p. 327-336 10 p.

Research output: Research - peer-reviewArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Eosinophils
Mast Cells
Polysaccharides
Ligands
18 Citations

Workshop report from the national institutes of health taskforce on the research needs of eosinophil-associated diseases (TREAD)

Bochner, B. S., Book, W., Busse, W. W., Butterfield, J., Furuta, G. T., Gleich, G. J., Klion, A. D., Lee, J. J., Leiferman, K. M., Minnicozzi, M., Moqbel, R., Rothenberg, M. E., Schwartz, L. B., Simon, H. U., Wechsler, M. E. & Weller, P. F. Sep 2012 In : Journal of Allergy and Clinical Immunology. 130, 3, p. 587-596 10 p.

Research output: Research - peer-reviewArticle

National Institutes of Health (U.S.)
Eosinophils
Education
Research
Patient Advocacy
2011
45 Citations

Advances in mechanisms of asthma, allergy, and immunology in 2010

Broide, D. H., Finkelman, F., Bochner, B. S. & Rothenberg, M. E. Mar 1 2011 In : Journal of Allergy and Clinical Immunology. 127, 3, p. 689-695 7 p.

Research output: Research - peer-reviewArticle

Allergy and Immunology
Asthma
Inflammation
Food Hypersensitivity
Mast Cells