Bruce Scott Bochner

  • 13507 Citations
1978 …2023
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Research Output 1978 2019

2019

Mast cell-specific expression of human siglec-8 in conditional knock-in mice

Wei, Y., Chhiba, K. D., Zhang, F., Ye, X., Wang, L., Zhang, L., Robida, P. A., Moreno-Vinasco, L., Schnaar, R. L., Roers, A., Hartmann, K., Lee, C. M., Demers, D., Zheng, T., Bochner, B. S. & Zhu, Z., Jan 1 2019, In : International journal of molecular sciences. 20, 1, 19.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Mast Cells
mice
acids
Acids

Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

Legrand, F., Cao, Y., Wechsler, J. B., Zhu, X., Zimmermann, N., Rampertaap, S., Monsale, J., Romito, K., Youngblood, B. A., Brock, E. C., Makiya, M. A., Tomasevic, N., Bebbington, C., Maric, I., Metcalfe, D. D., Bochner, B. S. & Klion, A. D., Jan 1 2019, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Saliva
Eosinophils
Lectins
Immunoglobulins
Antibodies
2018
1 Citation (Scopus)

Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency

Kumagai, T., Kiwamoto, T., Brummet, M. E., Wu, F., Aoki, K., Zhu, Z., Bochner, B. S. & Tiemeyer, M., Jun 1 2018, In : Glycobiology. 28, 6, p. 406-417 12 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Glycomics
Keratan Sulfate
Sulfotransferases
Galactose
1 Citation (Scopus)

Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge

Johansson, M. W., Kelly, E. A., Nguyen, C. L., Jarjour, N. N. & Bochner, B. S., Aug 1 2018, In : International archives of allergy and immunology. 177, 1, p. 16-28 13 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Therapeutic Irrigation
Allergens
Eosinophils
Lung
3 Citations (Scopus)
Routine Diagnostic Tests
Eosinophils
Referral and Consultation
Eosinophilia
Physical Examination
4 Citations (Scopus)

Diagnosis and Novel Approaches to the Treatment of Hypereosinophilic Syndromes

Dispenza, M. C. & Bochner, B. S., Jun 1 2018, In : Current Hematologic Malignancy Reports. 13, 3, p. 191-201 11 p.

Research output: Contribution to journalReview article

Hypereosinophilic Syndrome
Biological Products
Eosinophils
Protein-Tyrosine Kinases
Sialic Acid Binding Immunoglobulin-like Lectins
1 Citation (Scopus)

Enhanced antigen presenting and T cell functions during late-phase allergic responses in the lung

Liu, M. C., Xiao, H. Q., Breslin, L. M., Bochner, B. S. & Schroeder, J. T., Mar 1 2018, In : Clinical and Experimental Allergy. 48, 3, p. 334-342 9 p.

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Allergens
Neuropilin-1
Bronchoalveolar Lavage
T-Lymphocytes
8 Citations (Scopus)

Eosinophils and eosinophil-associated diseases: An update

O'Sullivan, J. A. & Bochner, B. S., Feb 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 2, p. 505-517 13 p.

Research output: Contribution to journalArticle

Eosinophils
Allergy and Immunology
2 Citations (Scopus)

Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

O'Sullivan, J. A., Wei, Y., Carroll, D. J., Moreno-Vinasco, L., Cao, Y., Zhang, F., Lee, J. J., Zhu, Z. & Bochner, B. S., Jul 1 2018, In : Journal of Leukocyte Biology. 104, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Eosinophils
Mast Cells
CXCR3 Receptors
Death Domain Receptors
2 Citations (Scopus)

Human eosinophils and mast cells: Birds of a feather flock together

Robida, P. A., Puzzovio, P. G., Pahima, H., Levi-Schaffer, F. & Bochner, B. S., Mar 1 2018, In : Immunological Reviews. 282, 1, p. 151-167 17 p.

Research output: Contribution to journalReview article

Feathers
Eosinophils
Mast Cells
Birds
Phenotype
1 Citation (Scopus)

Identification of a Siglec-F+ granulocyte-macrophage progenitor

Bolden, J. E., Lucas, E. C., Zhou, G., O'Sullivan, J. A., de Graaf, C. A., McKenzie, M. D., Di Rago, L., Baldwin, T. M., Shortt, J., Alexander, W. S., Bochner, B. S., Ritchie, M. E., Hilton, D. J. & Fairfax, K. A., Jul 1 2018, In : Journal of Leukocyte Biology. 104, 1, p. 123-133 11 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Granulocyte-Macrophage Progenitor Cells
Interleukin-5 Receptors
Eosinophils
Population
11 Citations (Scopus)

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

O'Sullivan, J. A., Carroll, D. J., Cao, Y., Salicru, A. N. & Bochner, B. S., May 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1774-1785.e7

Research output: Contribution to journalArticle

Saliva
Eosinophils
Lectins
Mast Cells
Immunoglobulins

Mepolizumab use: Post-approval academic practice experience

Benjamin, M. R., Bochner, B. S. & Peters, A. T., Jul 1 2018, In : Annals of Allergy, Asthma and Immunology. 121, 1, p. 126-128 3 p.

Research output: Contribution to journalArticle

mepolizumab

Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD)

Khoury, P., Akuthota, P., Ackerman, S. J., Arron, J. R., Bochner, B. S., Collins, M. H., Kahn, J. E., Fulkerson, P. C., Gleich, G. J., Gopal-Srivastava, R., Jacobsen, E. A., Leiferman, K. M., Francesca, L. S., Mathur, S. K., Minnicozzi, M., Prussin, C., Rothenberg, M. E., Roufosse, F., Sable, K., Simon, D. & 7 othersSimon, H. U., Spencer, L. A., Steinfeld, J., Wardlaw, A. J., Wechsler, M. E., Weller, P. F. & Klion, A. D., Jul 1 2018, In : Journal of Leukocyte Biology. 104, 1, p. 69-83 15 p.

Research output: Contribution to journalReview article

Eosinophils
Research
Biomarkers
Clinical Trials
Drug Approval
4 Citations (Scopus)

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease

Abdala-Valencia, H., Coden, M. E., Chiarella, S. E., Jacobsen, E. A., Bochner, B. S., Lee, J. J. & Berdnikovs, S., Jul 1 2018, In : Journal of Leukocyte Biology. 104, 1, p. 95-108 14 p.

Research output: Contribution to journalReview article

Eosinophils
Homeostasis
Hematopoiesis
Thromboplastin
Phenotype
Nut Hypersensitivity
Basophils
Skin Tests
Immunoglobulin E
Therapeutics
7 Citations (Scopus)

Sialic acid–binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin–dependent function in human eosinophils

Carroll, D. J., O'Sullivan, J. A., Nix, D. B., Cao, Y., Tiemeyer, M. & Bochner, B. S., Jun 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 6, p. 2196-2207 12 p.

Research output: Contribution to journalArticle

Saliva
Eosinophils
Lectins
Immunoglobulins
Sialic Acid Binding Immunoglobulin-like Lectins
3 Citations (Scopus)

Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways

Gonzalez-Gil, A., Porell, R. N., Fernandes, S. M., Wei, Y., Yu, H., Carroll, D. J., McBride, R., Paulson, J. C., Tiemeyer, M., Aoki, K., Bochner, B. S. & Schnaar, R. L., Jan 1 2018, In : Glycobiology. 28, 10, p. 786-801 16 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Keratan Sulfate
Proteoglycans
Ligands
keratan-sulfate endo-1,4-beta-galactosidase
3 Citations (Scopus)

The eosinophil: For better or worse, in sickness and in health

Bochner, B. S., Aug 1 2018, In : Annals of Allergy, Asthma and Immunology. 121, 2, p. 150-155 6 p.

Research output: Contribution to journalReview article

Eosinophils
Health
2017
8 Citations (Scopus)

Glycobiology of eosinophilic inflammation: Contributions of siglecs, glycans, and other glycan-binding proteins

O'Sullivan, J. A., Carroll, D. J. & Bochner, B. S., Jan 1 2017, In : Frontiers in Medicine. 4, AUG, 116.

Research output: Contribution to journalReview article

Open Access
Sialic Acid Binding Immunoglobulin-like Lectins
Glycomics
Polysaccharides
Eosinophils
Carrier Proteins
1 Citation (Scopus)

Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils

Banuelos, J., Cao, Y., Shin, S. C., Bochner, B. S., Avila, P., Li, S., Jiang, X., Lingen, M. W., Schleimer, R. P. & Lu, N. Z., May 1 2017, In : PloS one. 12, 5, e0177884.

Research output: Contribution to journalArticle

granulocyte colony-stimulating factor
Granulocyte Colony-Stimulating Factor
dexamethasone
lipopolysaccharides
Dexamethasone
8 Citations (Scopus)
Lymphoproliferative Disorders
Basophils
Skin Tests
Agammaglobulinaemia tyrosine kinase
PCI 32765

In lasting tribute: Dr James J. Lee (1958-2017)

Rosenberg, H. F., Jacobsen, E. A., Bochner, B. S. & Weller, P. F., Jan 1 2017, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

In Memory and Celebration: Dr. James J. Lee

Rosenberg, H. F., Fryer, A. D., Munitz, A., Bochner, B. S., Jacoby, D. B., Levi-Schaffer, F., Gleich, G. J., Furuta, G. T., Rothenberg, M. E., Lacy, P., Fulkerson, P. C., Hogan, S. P., Ackerman, S. J. & Foster, P. S., Jul 1 2017, In : Clinical and Experimental Allergy. 47, 7, p. 980-981 2 p.

Research output: Contribution to journalLetter

6 Citations (Scopus)
Nasal Lavage Fluid
Nasal Polyps
Aspirin
Biomarkers
Basophils
2 Citations (Scopus)

Potential applications of Bruton’s tyrosine kinase inhibitors for the prevention of allergic reactions

Dispenza, M. C., Regan, J. A. & Bochner, B. S., Oct 3 2017, In : Expert Review of Clinical Immunology. 13, 10, p. 921-923 3 p.

Research output: Contribution to journalEditorial

5 Citations (Scopus)

Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases

Kano, G., Bochner, B. S. & Zimmermann, N., Feb 1 2017, In : Immunobiology. 222, 2, p. 343-349 7 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
src-Family Kinases
Eosinophils
Reactive Oxygen Species
Cell Death
2016
17 Citations (Scopus)

BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis

Banuelos, J., Shin, S., Cao, Y., Bochner, B. S., Morales-Nebreda, L., Budinger, G. R. S., Zhou, L., Li, S., Xin, J., Lingen, M. W., Dong, C., Schleimer, R. P. & Lu, N. Z., May 1 2016, In : Allergy: European Journal of Allergy and Clinical Immunology. 71, 5, p. 640-650 11 p.

Research output: Contribution to journalArticle

Th17 Cells
Glucocorticoids
Apoptosis
Interleukin-17
Asthma
13 Citations (Scopus)

Control of lung defence by mucins and macrophages: Ancient defence mechanisms with modern functions

Janssen, W. J., Stefanski, A. L., Bochner, B. S. & Evans, C. M., Oct 1 2016, In : European Respiratory Journal. 48, 4, p. 1201-1214 14 p.

Research output: Contribution to journalArticle

Mucins
Macrophages
Mucus
Phagocytosis
Lung
20 Citations (Scopus)

Eosinophilic bioactivities in severe asthma

Carr, T. F., Berdnikovs, S., Simon, H. U., Bochner, B. S. & Rosenwasser, L. J., Jun 27 2016, In : World Allergy Organization Journal. 9, 1, 112.

Research output: Contribution to journalReview article

Eosinophils
Asthma
Eosinophilia
Biomarkers
Cytokines
9 Citations (Scopus)

Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis

Lynch, K. L., Dhalla, S., Chedid, V., Ravich, W. J., Stein, E. M., Montgomery, E. A., Bochner, B. S. & Clarke, J. O., Feb 1 2016, In : Diseases of the Esophagus. 29, 2, p. 174-178 5 p.

Research output: Contribution to journalArticle

Eosinophilic Esophagitis
Heartburn
Deglutition Disorders
Chest Pain
Esophageal Motility Disorders
10 Citations (Scopus)

Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression

Schleimer, R. P., Schnaar, R. L. & Bochner, B. S., Jan 1 2016, In : Current Opinion in Allergy and Clinical Immunology. 16, 1, p. 24-30 7 p.

Research output: Contribution to journalReview article

Sialic Acid Binding Immunoglobulin-like Lectins
Ligands
Inflammation
Eosinophils
Mast Cells
15 Citations (Scopus)

"siglec"ting the allergic response for therapeutic targeting

Bochner, B. S., Jun 23 2016, In : Glycobiology. 26, 6, p. 546-552 7 p.

Research output: Contribution to journalReview article

Sialic Acid Binding Immunoglobulin-like Lectins
Tolnaftate
Eosinophils
Basophils
Mast Cells
2015
40 Citations (Scopus)

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

Kiwamoto, T., Katoh, T., Evans, C. M., Janssen, W. J., Brummet, M. E., Hudson, S. A., Zhu, Z., Tiemeyer, M. & Bochner, B. S., May 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 5, p. 1329-1340.e9

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Mucins
Eosinophils
Polysaccharides
Apoptosis
24 Citations (Scopus)

Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells

Jia, Y., Yu, H., Fernandes, S. M., Wei, Y., Gonzalez-Gil, A., Motari, M. G., Vajn, K., Stevens, W., Peters, A. T., Bochner, B. S., Kern, R. C., Schleimer, R. P. & Schnaar, R. L., Mar 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 3, p. 799-810.e7

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Ligands
Mucin-5B
Inflammation
15 Citations (Scopus)

Novel Therapies for Eosinophilic Disorders

Bochner, B. S., Aug 1 2015, In : Immunology and Allergy Clinics of North America. 35, 3, p. 577-598 22 p.

Research output: Contribution to journalReview article

Eosinophils
Off-Label Use
Controlled Clinical Trials
Biological Products
Glucocorticoids
3 Citations (Scopus)

Out of the orphanage and into the clinic - Therapeutic targeting of GATA3

Bochner, B. S. & Schleimer, R. P., May 21 2015, In : New England Journal of Medicine. 372, 21, p. 2060-2061 2 p.

Research output: Contribution to journalEditorial

GATA3 Transcription Factor
Orphanages
Catalytic DNA
Anti-Asthmatic Agents
Asthma
1 Citation (Scopus)

Reply

Bochner, B. S., Kiwamoto, T., Katoh, T., Zhu, Z. & Tiemeyer, M., Jun 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 6, p. 1662-1663 2 p.

Research output: Contribution to journalLetter

Sialic Acid Binding Immunoglobulin-like Lectins
Mucins
Eosinophils
Polysaccharides
Apoptosis
41 Citations (Scopus)

Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

Bochner, B. S. & Zimmermann, N., Mar 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 3, p. 598-608 11 p.

Research output: Contribution to journalReview article

Sialic Acid Binding Immunoglobulin-like Lectins
Polysaccharides
Carrier Proteins
Glycomics
Selectins
38 Citations (Scopus)

The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

Schneider, C., Smith, D. F., Cummings, R. D., Boligan, K. F., Hamilton, R. G., Bochner, B. S., Miescher, S., Simon, H. U., Pashov, A., Vassilev, T. & Von Gunten, S., Jan 1 2015, In : Science Translational Medicine. 7, 269, 269ra1.

Research output: Contribution to journalArticle

Polysaccharides
Immunoglobulin G
Carbohydrates
Antibodies
Microbiological Attachment Sites
2014
32 Citations (Scopus)

Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation

Kiwamoto, T., Brummet, M. E., Wu, F., Motari, M. G., Smith, D. F., Schnaar, R. L., Zhu, Z. & Bochner, B. S., Jan 1 2014, In : Journal of Allergy and Clinical Immunology. 133, 1

Research output: Contribution to journalArticle

beta-galactoside alpha-2,3-sialyltransferase
Sialic Acid Binding Immunoglobulin-like Lectins
Sialyltransferases
Inflammation
Ovalbumin
2013
9 Citations (Scopus)

Advances in mechanisms of allergy and clinical immunology in 2012

Bochner, B. S., Rothenberg, M. E., Boyce, J. A. & Finkelman, F., Mar 1 2013, In : Journal of Allergy and Clinical Immunology. 131, 3, p. 661-667 7 p.

Research output: Contribution to journalReview article

Allergy and Immunology
Immunologic Desensitization
Anti-Allergic Agents
Manuscripts
Immune System Diseases
11 Citations (Scopus)

Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis

Kim, Y. H., Park, C. S., Lim, D. H., Son, B. K., Kim, J. H., Ahn, S. H., Bochner, B. S., Na, K. & Jang, T. Y., May 1 2013, In : American Journal of Rhinology and Allergy. 27, 3, p. 187-191 5 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Anti-Allergic Agents
Inflammation
Ovalbumin
Bronchoalveolar Lavage Fluid

Antieosinophil Therapeutics

Straumann, A., Haldar, P., Pavord, I. D., Wardlaw, A. J., Busse, W. W., Molfino, N. A., Kolbeck, R., Shin, M. K., Bochner, B. S. & Cools, J., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 577-605 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Therapeutics
5 Citations (Scopus)
Eosinophils
5 Citations (Scopus)

Biology of Eosinophils

Kita, H. & Bochner, B. S., Oct 18 2013, Middleton's Allergy: Principles and Practice: Eighth Edition. Adkinson, NF., Bochner, BS., Busse, WW., Holgate, ST., Lemanske, R. & O’Hehir, R. (eds.). Philadelphia: Elsevier Inc., p. 265-279

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophils
1 Citation (Scopus)

CD Molecules

von Gunten, S., Ghanim, V., Valent, P. & Bochner, B. S., Oct 18 2013, Middleton's Allergy: Principles and Practice: Eighth Edition. Elsevier Inc, Vol. 2-2. p. 1663-1687 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophil Trafficking

Wennerås, C., Matsumoto, K., Bochner, B. S., Cook-Mills, J. M., Asosingh, K., Erzurum, S. C., Rao, S. P. & Sriramarao, P., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc, p. 121-166 46 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophils

High-dose cyclophosphamide used to treat aplastic anemia in a patient with respiratory and food allergies has a prolonged effect on serum IgE levels

Cook, M. L., Brodsky, R. A., Hamilton, R., Wood, R. A. & Bochner, B. S., Jan 1 2013, In : Journal of Allergy and Clinical Immunology. 132, 1, p. 237-239 3 p.

Research output: Contribution to journalArticle

Food Hypersensitivity
Aplastic Anemia
Cyclophosphamide
Immunoglobulin E
Serum
47 Citations (Scopus)

Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: Role for reactive oxygen species-enhanced MEK/ERK activation

Kano, G., Almanan, M., Bochner, B. S. & Zimmermann, N., Aug 1 2013, In : Journal of Allergy and Clinical Immunology. 132, 2, p. 437-445 9 p.

Research output: Contribution to journalArticle

Sialic Acid Binding Immunoglobulin-like Lectins
Interleukin-5
Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Eosinophils