• 14357 Citations
1978 …2020

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Article
2020

Fibrinogen is a specific trigger for cytolytic eosinophil degranulation

Coden, M. E., Loffredo, L. F., Walker, M. T., Jeong, B. M., Nam, K., Bochner, B. S., Abdala-Valencia, H. & Berdnikovs, S., Jan 1 2020, In : Journal of Immunology. 204, 2, p. 438-448 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls

Knuplez, E., Krier-Burris, R., Cao, Y., Marsche, G., O'Sullivan, J. & Bochner, B. S., Jul 1 2020, In : Journal of Leukocyte Biology. 108, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pulmonary Eosinophilic Granulomatosis with Polyangiitis Has IgG4 Plasma Cells and Immunoregulatory Features

Dong, Z. M., Lin, E., Wechsler, M. E., Weller, P. F., Klion, A. D., Bochner, B. S., Delker, D. A., Hazel, M. W., Fairfax, K., Khoury, P., Akuthota, P., Merkel, P. A., Dyer, A. M., Langford, C., Specks, U., Gleich, G. J., Chinchilli, V. M., Raby, B., Yandell, M. & Clayton, F., Jul 2020, In : American Journal of Pathology. 190, 7, p. 1438-1448 11 p.

Research output: Contribution to journalArticle

Open Access
2019

A Sulfonamide Sialoside Analogue for Targeting Siglec-8 and-F on Immune Cells

Nycholat, C. M., Duan, S., Knuplez, E., Worth, C., Elich, M., Yao, A., O'Sullivan, J., McBride, R., Wei, Y., Fernandes, S. M., Zhu, Z., Schnaar, R. L., Bochner, B. S. & Paulson, J. C., Sep 11 2019, In : Journal of the American Chemical Society. 141, 36, p. 14032-14037 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity

Klein, O., Krier-Burris, R. A., Lazki-Hagenbach, P., Gorzalczany, Y., Mei, Y., Ji, P., Bochner, B. S. & Sagi-Eisenberg, R., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1074-1090 17 p.

Research output: Contribution to journalArticle

Mast cell-specific expression of human siglec-8 in conditional knock-in mice

Wei, Y., Chhiba, K. D., Zhang, F., Ye, X., Wang, L., Zhang, L., Robida, P. A., Moreno, L., Schnaar, R. L., Roers, A., Hartmann, K., Lee, C. M., Demers, D., Zheng, T., Bochner, B. S. & Zhu, Z., Jan 2019, In : International journal of molecular sciences. 20, 1, 19.

Research output: Contribution to journalArticle

5 Scopus citations

Sialic acid–binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

Legrand, F., Cao, Y., Wechsler, J. B., Zhu, X., Zimmermann, N., Rampertaap, S., Monsale, J., Romito, K., Youngblood, B. A., Brock, E. C., Makiya, M. A., Tomasevic, N., Bebbington, C., Maric, I., Metcalfe, D. D., Bochner, B. S. & Klion, A. D., Jun 2019, In : Journal of Allergy and Clinical Immunology. 143, 6, p. 2227-2237.e10

Research output: Contribution to journalArticle

13 Scopus citations

Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis

Youngblood, B. A., Brock, E. C., Leung, J., Falahati, R., Bochner, B. S., Rasmussen, H. S., Peterson, K., Bebbington, C. & Tomasevic, N., Jan 1 2019, In : JCI Insight. 4, 19, e126219.

Research output: Contribution to journalArticle

13 Scopus citations

Workup for eosinophilia

Guo, C. & Bochner, B. S., Nov 1 2019, In : Allergy and asthma proceedings. 40, 6, p. 429-432 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency

Kumagai, T., Kiwamoto, T., Brummet, M. E., Wu, F., Aoki, K., Zhu, Z., Bochner, B. S. & Tiemeyer, M., Jun 1 2018, In : Glycobiology. 28, 6, p. 406-417 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of Siglec-8 Expression on Lavage Cells after Segmental Lung Allergen Challenge

Johansson, M. W., Kelly, E. A., Nguyen, C. L., Jarjour, N. N. & Bochner, B. S., Aug 1 2018, In : International archives of allergy and immunology. 177, 1, p. 16-28 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Enhanced antigen presenting and T cell functions during late-phase allergic responses in the lung

Liu, M. C., Xiao, H. Q., Breslin, L. M., Bochner, B. S. & Schroeder, J. T., Mar 2018, In : Clinical and Experimental Allergy. 48, 3, p. 334-342 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Eosinophils and eosinophil-associated diseases: An update

O'Sullivan, J. A. & Bochner, B. S., Feb 2018, In : Journal of Allergy and Clinical Immunology. 141, 2, p. 505-517 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils

O'Sullivan, J. A., Wei, Y., Carroll, D. J., Moreno, L., Cao, Y., Zhang, F., Lee, J. J., Zhu, Z. & Bochner, B. S., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of a Siglec-F+ granulocyte-macrophage progenitor

Bolden, J. E., Lucas, E. C., Zhou, G., O'Sullivan, J. A., de Graaf, C. A., McKenzie, M. D., Di Rago, L., Baldwin, T. M., Shortt, J., Alexander, W. S., Bochner, B. S., Ritchie, M. E., Hilton, D. J. & Fairfax, K. A., Jul 2018, In : Journal of Leukocyte Biology. 104, 1, p. 123-133 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells

O'Sullivan, J. A., Carroll, D. J., Cao, Y., Salicru, A. N. & Bochner, B. S., May 2018, In : Journal of Allergy and Clinical Immunology. 141, 5, p. 1774-1785.e7

Research output: Contribution to journalArticle

21 Scopus citations

Mepolizumab use: Post-approval academic practice experience

Benjamin, M. R., Bochner, B. S. & Peters, A. T., Jul 2018, In : Annals of Allergy, Asthma and Immunology. 121, 1, p. 126-128 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sialic acid–binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin–dependent function in human eosinophils

Carroll, D. J., O'Sullivan, J. A., Nix, D. B., Cao, Y., Tiemeyer, M. & Bochner, B. S., Jun 1 2018, In : Journal of Allergy and Clinical Immunology. 141, 6, p. 2196-2207 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways

Gonzalez-Gil, A., Porell, R. N., Fernandes, S. M., Wei, Y., Yu, H., Carroll, D. J., McBride, R., Paulson, J. C., Tiemeyer, M., Aoki, K., Bochner, B. S. & Schnaar, R. L., Jan 1 2018, In : Glycobiology. 28, 10, p. 786-801 16 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils

Banuelos, J., Cao, Y., Shin, S. C., Bochner, B. S., Avila, P. C., Li, S., Jiang, X., Lingen, M. W., Schleimer, R. P. & Lu, N. Z., May 2017, In : PloS one. 12, 5, e0177884.

Research output: Contribution to journalArticle

2 Scopus citations
13 Scopus citations

Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases

Kano, G., Bochner, B. S. & Zimmermann, N., Feb 1 2017, In : Immunobiology. 222, 2, p. 343-349 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

BCL-2 protects human and mouse Th17 cells from glucocorticoid-induced apoptosis

Banuelos, J., Shin, S., Cao, Y., Bochner, B. S., Morales-Nebreda, L., Budinger, G. R. S., Zhou, L., Li, S., Xin, J., Lingen, M. W., Dong, C., Schleimer, R. P. & Lu, N. Z., May 1 2016, In : Allergy: European Journal of Allergy and Clinical Immunology. 71, 5, p. 640-650 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Control of lung defence by mucins and macrophages: Ancient defence mechanisms with modern functions

Janssen, W. J., Stefanski, A. L., Bochner, B. S. & Evans, C. M., Oct 1 2016, In : European Respiratory Journal. 48, 4, p. 1201-1214 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Gender is a determinative factor in the initial clinical presentation of eosinophilic esophagitis

Lynch, K. L., Dhalla, S., Chedid, V., Ravich, W. J., Stein, E. M., Montgomery, E. A., Bochner, B. S. & Clarke, J. O., Feb 1 2016, In : Diseases of the Esophagus. 29, 2, p. 174-178 5 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

Kiwamoto, T., Katoh, T., Evans, C. M., Janssen, W. J., Brummet, M. E., Hudson, S. A., Zhu, Z., Tiemeyer, M. & Bochner, B. S., May 2015, In : Journal of Allergy and Clinical Immunology. 135, 5, p. 1329-1340.e9

Research output: Contribution to journalArticle

44 Scopus citations

Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells

Jia, Y., Yu, H., Fernandes, S. M., Wei, Y., Gonzalez-Gil, A., Motari, M. G., Vajn, K., Stevens, W. W., Peters, A. T., Bochner, B. S., Kern, R. C., Schleimer, R. P. & Schnaar, R. L., Mar 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 3, p. 799-810.e7

Research output: Contribution to journalArticle

30 Scopus citations

The human IgG anti-carbohydrate repertoire exhibits a universal architecture and contains specificity for microbial attachment sites

Schneider, C., Smith, D. F., Cummings, R. D., Boligan, K. F., Hamilton, R. G., Bochner, B. S., Miescher, S., Simon, H. U., Pashov, A., Vassilev, T. & Von Gunten, S., Jan 1 2015, In : Science Translational Medicine. 7, 269, 269ra1.

Research output: Contribution to journalArticle

55 Scopus citations
2014

Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation

Kiwamoto, T., Brummet, M. E., Wu, F., Motari, M. G., Smith, D. F., Schnaar, R. L., Zhu, Z. & Bochner, B. S., Jan 2014, In : Journal of Allergy and Clinical Immunology. 133, 1, p. 240-247.e3

Research output: Contribution to journalArticle

37 Scopus citations
2013

Antiallergic effect of anti-Siglec-F through reduction of eosinophilic inflammation in murine allergic rhinitis

Kim, Y. H., Park, C. S., Lim, D. H., Son, B. K., Kim, J. H., Ahn, S. H., Bochner, B. S., Na, K. & Jang, T. Y., May 1 2013, In : American Journal of Rhinology and Allergy. 27, 3, p. 187-191 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

High-dose cyclophosphamide used to treat aplastic anemia in a patient with respiratory and food allergies has a prolonged effect on serum IgE levels

Cook, M. L., Brodsky, R. A., Hamilton, R., Wood, R. A. & Bochner, B. S., Jan 1 2013, In : Journal of Allergy and Clinical Immunology. 132, 1, p. 237-239 3 p.

Research output: Contribution to journalArticle

Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: Role for reactive oxygen species-enhanced MEK/ERK activation

Kano, G., Almanan, M., Bochner, B. S. & Zimmermann, N., Aug 1 2013, In : Journal of Allergy and Clinical Immunology. 132, 2, p. 437-445 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Mechanisms of Siglec-F-Induced Eosinophil Apoptosis: A Role for Caspases but Not for SHP-1, Src Kinases, NADPH Oxidase or Reactive Oxygen

Mao, H., Kano, G., Hudson, S. A., Brummet, M., Zimmermann, N., Zhu, Z. & Bochner, B. S., Jun 28 2013, In : PloS one. 8, 6, e68143.

Research output: Contribution to journalArticle

27 Scopus citations
2012

Advances in mechanisms of asthma, allergy, and immunology in 2011

Boyce, J. A., Bochner, B., Finkelman, F. D. & Rothenberg, M. E., Jan 1 2012, In : Journal of Allergy and Clinical Immunology. 129, 2, p. 335-341 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
22 Scopus citations

Controversies and open questions in the definitions and classification of the hypereosinophilic syndromes and eosinophilic leukemias

Valent, P., Horny, H. P., Bochner, B. S., Haferlach, T. & Reiter, A., Apr 1 2012, In : Seminars in Hematology. 49, 2, p. 171-181 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Glycomic analysis of human mast cells, eosinophils and basophils

North, S. J., Von Gunten, S., Antonopoulos, A., Trollope, A., MacGlashan, D. W., Jang-Lee, J., Dell, A., Metcalfe, D. D., Kirshenbaum, A. S., Bochner, B. S. & Haslam, S. M., Jan 1 2012, In : Glycobiology. 22, 1, p. 12-22 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

ICON: Eosinophil Disorders

Valent, P., Klion, A. D., Rosenwasser, L. J., Arock, M., Bochner, B. S., Butterfield, J. H., Gotlib, J., Haferlach, T., Hellmann, A., Horny, H. P., Leiferman, K. M., Metzgeroth, G., Matsumoto, K., Reiter, A., Roufosse, F., Rothenberg, M. E., Simon, H. U., Sotlar, K., Vandenberghe, P., Weller, P. F. & 1 others, Gleich, G. J., 2012, In : World Allergy Organization Journal. 5, 12, p. 174-181 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

ICON: Eosinophil disorders

Valent, P., Klion, A. D., Rosenwasser, L. J., Arock, M., Bochner, B. S., Butterfield, J. H., Gotlib, J., Haferlach, T., Hellmann, A., Horny, H. P., Leiferman, K. M., Metzgeroth, G., Matsumoto, K., Reiter, A., Roufosse, F., Rothenberg, M. E., Simon, H. U., Sotlar, K., Vandenberghe, P., Weller, P. F. & 1 others, Gleich, G. J., Dec 2012, In : World Allergy Organization Journal. 5, 12, p. 174-181 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils

Na, H. J., Hudson, S. A. & Bochner, B. S., Jan 2012, In : Cytokine. 57, 1, p. 169-174 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Workshop report from the national institutes of health taskforce on the research needs of eosinophil-associated diseases (TREAD)

Bochner, B. S., Book, W., Busse, W. W., Butterfield, J., Furuta, G. T., Gleich, G. J., Klion, A. D., Lee, J. J., Leiferman, K. M., Minnicozzi, M., Moqbel, R., Rothenberg, M. E., Schwartz, L. B., Simon, H. U., Wechsler, M. E. & Weller, P. F., Sep 1 2012, In : Journal of Allergy and Clinical Immunology. 130, 3, p. 587-596 10 p.

Research output: Contribution to journalArticle

36 Scopus citations
2011

Advances in mechanisms of asthma, allergy, and immunology in 2010

Broide, D. H., Finkelman, F., Bochner, B. S. & Rothenberg, M. E., Mar 1 2011, In : Journal of Allergy and Clinical Immunology. 127, 3, p. 689-695 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease

Grader-Beck, T., Boin, F., Von Gunten, S., Smith, D., Rosen, A. & Bochner, B. S., Dec 1 2011, In : Annals of the Rheumatic Diseases. 70, 12, p. 2218-2224 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cat allergen-induced blood basophil reactivity in vitro predicts acute human nasal allergen challenge responses in vivo

Paterniti, M., Kelly, D. C., Eckman, J. A., Sterba, P. M., Hamilton, R. G., Bochner, B. S., Macglashan, D. W. & Saini, S. S., Jul 1 2011, In : Clinical and Experimental Allergy. 41, 7, p. 963-969 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs

Guo, J. P., Brummet, M. E., Myers, A. C., Na, H. J., Rowland, E., Schnaar, R. L., Zheng, T., Zhu, Z. & Bochner, B. S., Feb 1 2011, In : American journal of respiratory cell and molecular biology. 44, 2, p. 238-243 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression

Hudson, S. A., Herrmann, H., Du, J., Cox, P., Haddad, E. B., Butler, B., Crocker, P. R., Ackerman, S. J., Valent, P. & Bochner, B. S., Dec 1 2011, In : Journal of Clinical Immunology. 31, 6, p. 1045-1053 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
2010

Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge

Eckman, J. A., Sterba, P. M., Kelly, D., Alexander, V., Liu, M. C., Bochner, B. S., MacGlashan, D. W. & Saini, S. S., Apr 2010, In : Journal of Allergy and Clinical Immunology. 125, 4, p. 889-895.e7

Research output: Contribution to journalArticle

90 Scopus citations