• 5648 Citations
1990 …2020

Research output per year

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Personal profile

Research Interests

Cell-cell adhesion in health and disease

We are interested in how cells stick to each other, what constitutes dynamic versus static adhesion at the molecular level, and how the state of cell-cell adhesion is interpreted by the nucleus to control gene expression and cellular differentiation. These processes are highly relevant to human health and disease because the proteins comprising the major macromolecular adhesion complex on cells (known as the cadherin/catenin complex) are associated with numerous diseases ranging from proliferative/invasive conditions like cancer and fibrosis to chronic conditions such as asthma. We collaborate with Drosophila geneticists, biochemists/ crystallographers, biophysicists and physician scientists with access to patient sample data sets for these investigations.

Education/Academic qualification

PhD, Yale University

… → 1994

Research interests

  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Cell Biology
  • Fibrosis
  • Gene Regulation
  • Lung Cancer / Chest Cancer
  • Respiratory Diseases
  • Signal Transduction

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Grants

Research Output

Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Kim, S., Cheresh, P., Jablonski, R. P., Rachek, L., Yeldandi, A., Piseaux-Aillon, R., Ciesielski, M. J., Ridge, K., Gottardi, C., Lam, A. P., Pardo, A., Selman, M., Natarajan, V. & Kamp, D. W., May 1 2020, In : American journal of physiology. Lung cellular and molecular physiology. 318, 5, p. L1084-L1096

Research output: Contribution to journalArticle

Open Access
  • Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

    Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

    Research output: Contribution to journalArticle

    Open Access
  • Macrophages as a Source and Recipient of Wnt Signals

    Malsin, E. S., Kim, S., Lam, A. P. & Gottardi, C. J., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

    Research output: Contribution to journalReview article

    Open Access
  • 3 Scopus citations

    Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

    Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

    Research output: Contribution to journalArticle

    Open Access
  • 75 Scopus citations