Grants per year
Personal profile
Research Interests
Cell-cell adhesion in health and disease
We are interested in how cells stick to each other, what constitutes dynamic versus static adhesion at the molecular level, and how the state of cell-cell adhesion is interpreted by the nucleus to control gene expression and cellular differentiation. These processes are highly relevant to human health and disease because the proteins comprising the major macromolecular adhesion complex on cells (known as the cadherin/catenin complex) are associated with numerous diseases ranging from proliferative/invasive conditions like cancer and fibrosis to chronic conditions such as asthma. We collaborate with Drosophila geneticists, biochemists/ crystallographers, biophysicists and physician scientists with access to patient sample data sets for these investigations.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Yale University
… → 1994
Research interests keywords
- Cancer Biology
- Cell Adhesion Mechanisms
- Cell Biology
- Fibrosis
- Gene Regulation
- Lung Cancer / Chest Cancer
- Respiratory Diseases
- Signal Transduction
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Collaborations and top research areas from the last five years
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Alveolar epithelial stress-induced polyploidization in lung injury and repair
Gottardi, C., Gottardi, C., Dada, L., Dada, L., Misharin, A. & Misharin, A.
National Heart, Lung, and Blood Institute
5/15/22 → 4/30/26
Project: Research project
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Prot #IIS2017-10679: Identifying Unique Pathogenic Macrophages in Systemic Sclerosis-ILD using High Throughput Single-cell RNA-Seq
Gottardi, C., Bhorade, S. M., Dematte D'Amico, J. E., Hinchcliff, M. E. & Lam, A. P.
Boehringer Ingelheim Pharmaceuticals, Inc.
12/28/17 → 12/28/23
Project: Research project
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Cadherin-catenin regulation in dividing epithelial cells
Gottardi, C. & Yemelyanov, A.
National Institute of General Medical Sciences
9/20/18 → 6/30/23
Project: Research project
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Wnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILD
Dematte D'Amico, J. E., Gottardi, C., Hinchcliff, M. E., Lam, A. P., Berdnikovs, S., Budinger, G. S., Dematte D'Amico, J. E., Hinchcliff, M. E. & Misharin, A.
National Heart, Lung, and Blood Institute
12/22/17 → 11/30/23
Project: Research project
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Alveolar epithelial regeneration in the aging lung
Han, S. H., Budinger, G. R. S. & Gottardi, C. J., Oct 16 2023, In: The Journal of clinical investigation. 133, 20Research output: Contribution to journal › Review article › peer-review
Open Access -
A Novel MIP-1-Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers
Reyfman, P. A., Malsin, E. S., Khuder, B., Joshi, N., Gadhvi, G., Flozak, A. S., Carns, M. A., Aren, K., Goldberg, I. A., Kim, S., Alexander, M. J., Sporn, P. H. S., Misharin, A. V., Budinger, G. R. S., Lam, A. P., Hinchcliff, M. E., Gottardi, C. J. & Winter, D. R., Feb 1 2023, In: American journal of respiratory cell and molecular biology. 68, 2, p. 176-185 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Endoplasmic reticulum tethering by desmosomes
Harmon, R. M. & Gottardi, C. J., Jun 2023, In: Nature Cell Biology. 25, 6, p. 796-797 2 p.Research output: Contribution to journal › Comment/debate › peer-review
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Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells
Dada, L. A., Welch, L. C., Magnani, N. D., Ren, Z., Han, H., Brazee, P. L., Celli, D., Flozak, A. S., Weng, A., Herrerias, M. M., Kryvenko, V., Vadász, I., Runyan, C. E., Abdala-Valencia, H., Shigemura, M., Casalino-Matsuda, S. M., Misharin, A. V., Budinger, G. R. S., Gottardi, C. J. & Sznajder, J. I., Feb 22 2023, In: JCI Insight. 8, 4, e159331.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mitochondrial integrated stress response controls lung epithelial cell fate
Han, S. H., Lee, M., Shin, Y., Giovanni, R., Chakrabarty, R. P., Herrerias, M. M., Dada, L. A., Flozak, A. S., Reyfman, P. A., Khuder, B., Reczek, C. R., Gao, L., Lopéz-Barneo, J., Gottardi, C. J., Budinger, G. R. S. & Chandel, N. S., Aug 24 2023, In: Nature. 620, 7975, p. 890-897 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations