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Personal profile

Research Interests

Cell-cell adhesion in health and disease

We are interested in how cells stick to each other, what constitutes dynamic versus static adhesion at the molecular level, and how the state of cell-cell adhesion is interpreted by the nucleus to control gene expression and cellular differentiation. These processes are highly relevant to human health and disease because the proteins comprising the major macromolecular adhesion complex on cells (known as the cadherin/catenin complex) are associated with numerous diseases ranging from proliferative/invasive conditions like cancer and fibrosis to chronic conditions such as asthma. We collaborate with Drosophila geneticists, biochemists/ crystallographers, biophysicists and physician scientists with access to patient sample data sets for these investigations.

Education/Academic qualification

PhD, Yale University

… → 1994

Research interests

  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Cell Biology
  • Fibrosis
  • Gene Regulation
  • Lung Cancer / Chest Cancer
  • Respiratory Diseases
  • Signal Transduction

Fingerprint Dive into the research topics where Cara Gottardi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
Catenins Medicine & Life Sciences
Cadherins Medicine & Life Sciences
Fibrosis Medicine & Life Sciences
Epithelial Cells Medicine & Life Sciences
Proton-Translocating ATPases Medicine & Life Sciences
Pulmonary Fibrosis Medicine & Life Sciences
Lung Medicine & Life Sciences
Adenosine Triphosphatases Chemical Compounds

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Grants 2004 2022

Research Output 1990 2019

7 Citations (Scopus)

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 othersNicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B. D., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A. V., Jun 15 2019, In : American journal of respiratory and critical care medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.

Research output: Contribution to journalArticle

Adherens Junctions
Catenins
Actins
helices
Cadherins
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

Chiarella, S. E., Rabin, E. E., Ostilla, L. A., Flozak, A. S. & Gottardi, C., Apr 3 2018, In : Tissue Barriers. 6, 2, e1463896.

Research output: Contribution to journalArticle

Catenins
Microfilament Proteins
Protein Subunits
Cadherins
Actin Cytoskeleton
15 Citations (Scopus)
Epithelial-Mesenchymal Transition
Asthma
Transcriptome
Epithelial Cells
Insulin