Grants per year
Personal profile
Research Interests
Cell-cell adhesion in health and disease
We are interested in how cells stick to each other, what constitutes dynamic versus static adhesion at the molecular level, and how the state of cell-cell adhesion is interpreted by the nucleus to control gene expression and cellular differentiation. These processes are highly relevant to human health and disease because the proteins comprising the major macromolecular adhesion complex on cells (known as the cadherin/catenin complex) are associated with numerous diseases ranging from proliferative/invasive conditions like cancer and fibrosis to chronic conditions such as asthma. We collaborate with Drosophila geneticists, biochemists/ crystallographers, biophysicists and physician scientists with access to patient sample data sets for these investigations.
Education/Academic qualification
PhD, Yale University
… → 1994
Research interests
- Cancer Biology
- Cell Adhesion Mechanisms
- Cell Biology
- Fibrosis
- Gene Regulation
- Lung Cancer / Chest Cancer
- Respiratory Diseases
- Signal Transduction
Fingerprint Dive into the research topics where Cara Gottardi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 3 Similar Profiles
Catenins
Medicine & Life Sciences
Cadherins
Medicine & Life Sciences
Fibrosis
Medicine & Life Sciences
Epithelial Cells
Medicine & Life Sciences
Proton-Translocating ATPases
Medicine & Life Sciences
Pulmonary Fibrosis
Medicine & Life Sciences
Adenosine Triphosphatases
Chemical Compounds
Lung
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2004 2023
Gottardi Subproject for Development of Photoreversible 4D Cell Culture Technologies
National Institute of General Medical Sciences
9/27/19 → 8/31/23
Project: Research project
Cell Culture Techniques
Technology
Extracellular Matrix
Mechanics
Research
Pathogenic Wnt-beta catenin target genes in macrophages and fibrosis
Lam, A. P., Misharin, A., Tetreault, M., Winter, D. R. & Gottardi, C.
Yale University, National Institute of Arthritis and Musculoskeletal and Skin Diseases
7/3/19 → 6/30/20
Project: Research project
Cadherin-catenin regulation in dividing epithelial cells
National Institute of General Medical Sciences
9/20/18 → 6/30/22
Project: Research project
Catenins
Cadherins
Epithelial Cells
Actins
Mitosis
Wnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILD
Berdnikovs, S., Budinger, G. S., Dematte D'Amico, J. E., Hinchcliff, M. E., Lam, A. P., Misharin, A. & Gottardi, C.
National Heart, Lung, and Blood Institute
12/22/17 → 11/30/21
Project: Research project
Alveolar Epithelial Cells
Systemic Scleroderma
Interstitial Lung Diseases
Alveolar Macrophages
beta Catenin
Carcinogenesis Training Program
Chandel, N., Chisholm, R. L., Crispino, J. D., Green, K. J., Holmgren, R. A., LaBonne, C., McGee, R., O'Halloran, T. V., Woloschak, G. E., Woodruff, T. K. & Gottardi, C.
7/1/16 → 6/30/17
Project: Research project
Research Output 1990 2019
Macrophages as a Source and Recipient of Wnt Signals
Malsin, E. S., Kim, S., Lam, A. P. & Gottardi, C., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.Research output: Contribution to journal › Review article
Open Access
Macrophages
Debridement
Lenses
Stem Cells
Phenotype
19
Citations
(Scopus)
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, , Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.Research output: Contribution to journal › Article
Open Access
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages
7
Citations
(Scopus)
Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions
Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.Research output: Contribution to journal › Article
Adherens Junctions
Catenins
Actins
helices
Cadherins
2
Citations
(Scopus)
αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
Chiarella, S. E., Rabin, E. E., Ostilla, L. A., Flozak, A. S. & Gottardi, C., Apr 3 2018, In : Tissue Barriers. 6, 2, e1463896.Research output: Contribution to journal › Article
Catenins
Microfilament Proteins
Protein Subunits
Cadherins
Actin Cytoskeleton
18
Citations
(Scopus)
Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma
Loffredo, L. F., Abdala-Valencia, H., Anekalla, K. R., Cuervo-Pardo, L., Gottardi, C. & Berdnikovs, S., Dec 1 2017, In : Allergy: European Journal of Allergy and Clinical Immunology. 72, 12, p. 1988-2004 17 p.Research output: Contribution to journal › Article
Epithelial-Mesenchymal Transition
Asthma
Transcriptome
Epithelial Cells
Insulin