Grants per year
Personal profile
Research Interests
Cell-cell adhesion in health and disease
We are interested in how cells stick to each other, what constitutes dynamic versus static adhesion at the molecular level, and how the state of cell-cell adhesion is interpreted by the nucleus to control gene expression and cellular differentiation. These processes are highly relevant to human health and disease because the proteins comprising the major macromolecular adhesion complex on cells (known as the cadherin/catenin complex) are associated with numerous diseases ranging from proliferative/invasive conditions like cancer and fibrosis to chronic conditions such as asthma. We collaborate with Drosophila geneticists, biochemists/ crystallographers, biophysicists and physician scientists with access to patient sample data sets for these investigations.
Education/Academic qualification
PhD, Yale University
… → 1994
Research interests
- Cancer Biology
- Cell Adhesion Mechanisms
- Cell Biology
- Fibrosis
- Gene Regulation
- Lung Cancer / Chest Cancer
- Respiratory Diseases
- Signal Transduction
Fingerprint Dive into the research topics where Cara Gottardi is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 3 Similar Profiles
Catenins
Medicine & Life Sciences
Cadherins
Medicine & Life Sciences
Fibrosis
Medicine & Life Sciences
Epithelial Cells
Medicine & Life Sciences
Proton-Translocating ATPases
Medicine & Life Sciences
Wnt Signaling Pathway
Medicine & Life Sciences
Pulmonary Fibrosis
Medicine & Life Sciences
Adenosine Triphosphatases
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2004 2023
Gottardi Subproject for Development of Photoreversible 4D Cell Culture Technologies
National Institute of General Medical Sciences
9/27/19 → 8/31/23
Project: Research project
Cell Culture Techniques
Technology
Extracellular Matrix
Mechanics
Research
Cadherin-catenin regulation in dividing epithelial cells
National Institute of General Medical Sciences
9/20/18 → 6/30/22
Project: Research project
Catenins
Cadherins
Epithelial Cells
Actins
Mitosis
Prot #IIS2017-10679: Identifying Unique Pathogenic Macrophages in Systemic Sclerosis-ILD using High Throughput Single-cell RNA-Seq
Bhorade, S. M., Dematte D'Amico, J. E., Hinchcliff, M. E., Lam, A. P. & Gottardi, C.
Boehringer Ingelheim Pharmaceuticals, Inc.
12/28/17 → 12/28/20
Project: Research project
Wnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILD
Berdnikovs, S., Budinger, G. S., Dematte D'Amico, J. E., Hinchcliff, M. E., Lam, A. P., Misharin, A., Gottardi, C., Dematte D'Amico, J. E. & Hinchcliff, M. E.
National Heart, Lung, and Blood Institute
12/22/17 → 11/30/21
Project: Research project
Alveolar Epithelial Cells
Systemic Scleroderma
Interstitial Lung Diseases
Alveolar Macrophages
beta Catenin
Research Output 1990 2019
Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans
Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, , Dec 1 2019, In : Scientific reports. 9, 1, 18251.Research output: Contribution to journal › Article
Open Access
Wnt Signaling Pathway
Hypercapnia
Caenorhabditis elegans
Drosophila melanogaster
Mammals
Idiopathic pulmonary fibrosis and lung cancer: Finding similarities within differences
Reyfman, P. A. & Gottardi, C. J., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 6, p. 667-668 2 p.Research output: Contribution to journal › Editorial
Open Access
Macrophages as a Source and Recipient of Wnt Signals
Malsin, E. S., Kim, S., Lam, A. P. & Gottardi, C. J., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.Research output: Contribution to journal › Review article
Open Access
Macrophages
Debridement
Lenses
Stem Cells
Phenotype
38
Citations
(Scopus)
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, , Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.Research output: Contribution to journal › Article
Open Access
Single-Cell Analysis
Pulmonary Fibrosis
Lung
RNA Sequence Analysis
Alveolar Macrophages
10
Citations
(Scopus)
Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions
Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C. J., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.Research output: Contribution to journal › Article
Adherens Junctions
Catenins
Actins
helices
Cadherins