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Cara Gottardi

  • 5476 Citations
1990 …2023

Research output per year

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Personal profile

Research Interests

Cell-cell adhesion in health and disease

We are interested in how cells stick to each other, what constitutes dynamic versus static adhesion at the molecular level, and how the state of cell-cell adhesion is interpreted by the nucleus to control gene expression and cellular differentiation. These processes are highly relevant to human health and disease because the proteins comprising the major macromolecular adhesion complex on cells (known as the cadherin/catenin complex) are associated with numerous diseases ranging from proliferative/invasive conditions like cancer and fibrosis to chronic conditions such as asthma. We collaborate with Drosophila geneticists, biochemists/ crystallographers, biophysicists and physician scientists with access to patient sample data sets for these investigations.

Education/Academic qualification

PhD, Yale University

… → 1994

Research interests

  • Cancer Biology
  • Cell Adhesion Mechanisms
  • Cell Biology
  • Fibrosis
  • Gene Regulation
  • Lung Cancer / Chest Cancer
  • Respiratory Diseases
  • Signal Transduction

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Grants

Gottardi Subproject for Development of Photoreversible 4D Cell Culture Technologies

Gottardi, C.

National Institute of General Medical Sciences

9/27/19 → 8/31/23

Project: Research project

    • Pathogenic Wnt-beta catenin target genes in macrophages and fibrosis

    Misharin, A., Tetreault, M., Winter, D. R. & Gottardi, C.

    Yale University, National Institute of Arthritis and Musculoskeletal and Skin Diseases

    7/3/19 → 6/30/20

    Project: Research project

    Cadherin-catenin regulation in dividing epithelial cells

    Gottardi, C. & Yemelyanov, A.

    National Institute of General Medical Sciences

    9/20/18 → 6/30/22

    Project: Research project

    • Prot #IIS2017-10679: Identifying Unique Pathogenic Macrophages in Systemic Sclerosis-ILD using High Throughput Single-cell RNA-Seq

    Bhorade, S. M., Dematte D'Amico, J. E., Hinchcliff, M. E., Lam, A. P. & Gottardi, C.

    Boehringer Ingelheim Pharmaceuticals, Inc.

    12/28/17 → 12/28/20

    Project: Research project

    Wnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILD

    Berdnikovs, S., Budinger, G. S., Dematte D'Amico, J. E., Hinchcliff, M. E., Lam, A. P., Misharin, A., Gottardi, C., Dematte D'Amico, J. E. & Hinchcliff, M. E.

    National Heart, Lung, and Blood Institute

    12/22/17 → 11/30/21

    Project: Research project

    • Research Output

    Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

    Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

    Research output: Contribution to journal › Article

    Open Access

    • Idiopathic pulmonary fibrosis and lung cancer: Finding similarities within differences

    Reyfman, P. A. & Gottardi, C. J., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 6, p. 667-668 2 p.

    Research output: Contribution to journal › Editorial

    Open Access

    Macrophages as a Source and Recipient of Wnt Signals

    Malsin, E. S., Kim, S., Lam, A. P. & Gottardi, C. J., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

    Research output: Contribution to journal › Review article

    Open Access
    • 2 Scopus citations

    Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

    Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

    Research output: Contribution to journal › Article

    Open Access
    • 46 Scopus citations

    Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

    Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C. J., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.

    Research output: Contribution to journal › Article

    • 11 Scopus citations