Grants per year
Personal profile
Research Interests
Cell-cell adhesion in health and disease
We are interested in how cells stick to each other, what constitutes dynamic versus static adhesion at the molecular level, and how the state of cell-cell adhesion is interpreted by the nucleus to control gene expression and cellular differentiation. These processes are highly relevant to human health and disease because the proteins comprising the major macromolecular adhesion complex on cells (known as the cadherin/catenin complex) are associated with numerous diseases ranging from proliferative/invasive conditions like cancer and fibrosis to chronic conditions such as asthma. We collaborate with Drosophila geneticists, biochemists/ crystallographers, biophysicists and physician scientists with access to patient sample data sets for these investigations.
Education/Academic qualification
PhD, Yale University
… → 1994
Research interests
- Cancer Biology
- Cell Adhesion Mechanisms
- Cell Biology
- Fibrosis
- Gene Regulation
- Lung Cancer / Chest Cancer
- Respiratory Diseases
- Signal Transduction
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Network
Grants
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Gottardi Subproject for Development of Photoreversible 4D Cell Culture Technologies
National Institute of General Medical Sciences
9/27/19 → 8/31/23
Project: Research project
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Cadherin-catenin regulation in dividing epithelial cells
Gottardi, C. & Yemelyanov, A.
National Institute of General Medical Sciences
9/20/18 → 6/30/22
Project: Research project
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Prot #IIS2017-10679: Identifying Unique Pathogenic Macrophages in Systemic Sclerosis-ILD using High Throughput Single-cell RNA-Seq
Bhorade, S. M., Dematte D'Amico, J. E., Hinchcliff, M. E., Lam, A. P. & Gottardi, C.
Boehringer Ingelheim Pharmaceuticals, Inc.
12/28/17 → 12/28/23
Project: Research project
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Wnt-beta-catenin cross interactions in alveolar macrophages and epithelial cells in persistence of SSc-ILD
Berdnikovs, S., Budinger, G. S., Dematte D'Amico, J. E., Dematte D'Amico, J. E., Hinchcliff, M. E., Hinchcliff, M. E., Lam, A. P., Misharin, A. & Gottardi, C.
National Heart, Lung, and Blood Institute
12/22/17 → 11/30/21
Project: Research project
Research Output
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Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis
Kim, S. J., Cheresh, P., Jablonski, R. P., Rachek, L., Yeldandi, A., Piseaux-Aillon, R., Ciesielski, M. J., Ridge, K., Gottardi, C., Lam, A. P., Pardo, A., Selman, M., Natarajan, V. & Kamp, D. W., May 1 2020, In: American journal of physiology. Lung cellular and molecular physiology. 318, 5, p. L1084-L1096Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Nesprin-2G tension fine-tunes Wnt/β-catenin signaling
Gottardi, C. J. & Luxton, G. W. G., 2020, In: Journal of Cell Biology. 219, 10, e202009042.Research output: Contribution to journal › Article › peer-review
Open Access -
The sphingosine kinase 1 inhibitor, pf543, mitigates pulmonary fibrosis by reducing lung epithelial cell mtdna damage and recruitment of fibrogenic monocytes
Cheresh, P., Kim, S. J., Huang, L. S., Watanabe, S., Joshi, N., Williams, K. J. N., Chi, M., Lu, Z., Harijith, A., Yeldandi, A., Lam, A. P., Gottardi, C., Misharin, A. V., Budinger, G. R. S., Natarajan, V. & Kamp, D. W., 2020, In: International journal of molecular sciences. 21, 16, p. 1-17 17 p., 5595.Research output: Contribution to journal › Article › peer-review
Open Access -
Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans
Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, , Dec 1 2019, In: Scientific reports. 9, 1, 18251.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Idiopathic pulmonary fibrosis and lung cancer: Finding similarities within differences
Reyfman, P. A. & Gottardi, C. J., 2019, In: American journal of respiratory cell and molecular biology. 61, 6, p. 667-668 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access1 Scopus citations