• 5729 Citations
1990 …2020

Research output per year

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Research Output

2020

Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Kim, S. J., Cheresh, P., Jablonski, R. P., Rachek, L., Yeldandi, A., Piseaux-Aillon, R., Ciesielski, M. J., Ridge, K., Gottardi, C., Lam, A. P., Pardo, A., Selman, M., Natarajan, V. & Kamp, D. W., May 1 2020, In : American journal of physiology. Lung cellular and molecular physiology. 318, 5, p. L1084-L1096

Research output: Contribution to journalArticle

Open Access
2019

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

Research output: Contribution to journalArticle

Open Access

Macrophages as a Source and Recipient of Wnt Signals

Malsin, E. S., Kim, S., Lam, A. P. & Gottardi, C. J., 2019, In : Frontiers in immunology. 10, 1 p., 1813.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations
2018

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C. J., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.

Research output: Contribution to journalArticle

14 Scopus citations

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

Chiarella, S. E., Rabin, E. E., Ostilla, L. A., Flozak, A. S. & Gottardi, C. J., Apr 3 2018, In : Tissue Barriers. 6, 2, e1463896.

Research output: Contribution to journalArticle

2 Scopus citations
2017
23 Scopus citations

Cardiomyocytes of the heart and pulmonary veins: Novel contributors to asthma?

Folmsbee, S. S. & Gottardi, C. J., Nov 2017, In : American journal of respiratory cell and molecular biology. 57, 5, p. 512-518 7 p.

Research output: Contribution to journalReview article

3 Scopus citations
17 Scopus citations

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

203 Scopus citations

Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin

Serebryannyy, L. A., Yemelyanov, A., Gottardi, C. J. & de Lanerolle, P., May 15 2017, In : Journal of cell science. 130, 10, p. 1717-1729 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion

Wood, M. N., Ishiyama, N., Singaram, I., Chung, C. M., Flozak, A. S., Yemelyanov, A., Ikura, M., Cho, W. & Gottardi, C., Nov 1 2017, In : Journal of Cell Biology. 216, 11, p. 3767-3783 17 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling

Reinke, L., Lam, A. P., Flozak, A. S., Varga, J. & Gottardi, C. J., Feb 12 2016, In : Biochemical and Biophysical Research Communications. 470, 3, p. 606-612 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

A simple method to assess abundance of the β-Catenin signaling pool in cells

Flozak, A. S., Lam, A. P. & Gottardi, C. J., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc, p. 49-60 12 p. (Methods in Molecular Biology; vol. 1481).

Research output: Chapter in Book/Report/Conference proceedingChapter

Beyond β-catenin: Prospects for a larger catenin network in the nucleus

McCrea, P. D. & Gottardi, C. J., Jan 1 2016, In : Nature Reviews Molecular Cell Biology. 17, 1, p. 55-64 10 p.

Research output: Contribution to journalReview article

72 Scopus citations

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II

Serebryannyy, L. A., Parilla, M., Annibale, P., Cruz, C. M., Laster, K., Gratton, E., Kudryashov, D., Kosak, S. T., Gottardi, C. J. & de Lanerolle, P., 2016, In : Journal of cell science. 129, 18, p. 3412-3425 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation

Folmsbee, S. S., Budinger, G. R. S., Bryce, P. J. & Gottardi, C. J., Jul 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 123-129.e2

Research output: Contribution to journalArticle

6 Scopus citations

Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation

Chen, Y., Li, Y., Xue, J., Gong, A., Yu, G., Zhou, A., Lin, K., Zhang, S., Zhang, N., Gottardi, C. & Huang, S., Mar 15 2016, In : EMBO Journal. 35, 6, p. 668-684 17 p.

Research output: Contribution to journalArticle

45 Scopus citations

αT-catenin in restricted brain cell types and its potential connection to autism

Folmsbee, S. S., Wilcox, D. R., Tyberghein, K., De Bleser, P., Tourtellotte, W. G., Hengel, J. V., van Roy, F. & Gottardi, C. J., 2016, In : Journal of Molecular Psychiatry. 4, 1, 2.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Nuclear signaling from cadherin adhesion complexes

McCrea, P. D., Maher, M. T. & Gottardi, C. J., Jan 1 2015, Current Topics in Developmental Biology. Academic Press Inc, p. 129-196 68 p. (Current Topics in Developmental Biology; vol. 112).

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Scopus citations

Structural determinants of the mechanical stability of α-Catenin

Li, J., Newhall, J., Ishiyama, N., Gottardi, C., Ikura, M., Leckband, D. E. & Tajkhorshid, E., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, p. 18890-18903 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

The cardiac protein αT-catenin contributes to chemical-induced asthma

Folmsbee, S. S., Morales-Nebreda, L., Van Henge, J., Tyberghein, K., Van Roy, F., Budinger, G. R. S., Bryce, P. J. & Gottardi, C. J., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 3, p. L253-L258

Research output: Contribution to journalArticle

10 Scopus citations

The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype

Valenti, F., Ibetti, J., Komiya, Y., Baxter, M., Lucchese, A. M., Derstine, L., Covaciu, C., Rizzo, V., Vento, R., Russo, G., Macaluso, M., Cotelli, F., Castiglia, D., Gottardi, C. J., Habas, R., Giordano, A. & Bellipanni, G., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 418-430 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism

Escobar, D. J., Desai, R., Ishiyama, N., Folmsbee, S. S., Novak, M. N., Flozak, A. S., Daugherty, R. L., Mo, R., Nanavati, D., Sarpal, R., Leckband, D., Ikura, M., Tepass, U. & Gottardi, C. J., Jan 1 2015, In : Journal of cell science. 128, 6, p. 1150-1165 16 p.

Research output: Contribution to journalArticle

29 Scopus citations
2014

E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion

McEwen, A. E., Maher, M. T., Mo, R. & Gottardi, C. J., Jan 1 2014, In : Molecular biology of the cell. 25, 16, p. 2365-2374 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Gottardi, C. J. & Bulun, S. E., May 2014, In : Fertility and Sterility. 101, 5, p. 1441-1449.e1

Research output: Contribution to journalArticle

43 Scopus citations

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis

Lam, A. P., Herazo-Maya, J. D., Sennello, J. A., Flozak, A. S., Russell, S., Mutlu, G. M., Budinger, G. R. S., DasGupta, R., Varga, J., Kaminski, N. & Gottardi, C. J., Jul 15 2014, In : American journal of respiratory and critical care medicine. 190, 2, p. 185-195 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

α-Catenin cytomechanics - role in cadherin-dependent adhesion and mechanotransduction

Barry, A. K., Tabdili, H., Muhamed, I., Wu, J., Shashikanth, N., Gomez, G. A., Yap, A. S., Gottardi, C. J., De Rooij, J., Wang, N. & Leckband, D. E., 2014, In : Journal of cell science. 127, 8, p. 1779-1791 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

α-Catenin is an inhibitor of transcription

Daugherty, R. L., Serebryannyy, L., Yemelyanov, A., Flozak, A. S., Yu, H. J., Kosak, S. T., De Lanerolle, P. & Gottardi, C. J., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 14, p. 5260-5265 6 p.

Research output: Contribution to journalArticle

26 Scopus citations
2013

Considerations for targeting β-catenin signaling in fibrosis

Gottardi, C. & Königshoff, M., Mar 15 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 6, p. 566-568 3 p.

Research output: Contribution to journalEditorial

18 Scopus citations

Fat in fibrosis

Lam, A. P. & Gottardi, C. J., Nov 15 2013, In : American journal of respiratory and critical care medicine. 188, 10, p. 1268-1269 2 p.

Research output: Contribution to journalLetter

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

Campos, M. L., Sánchez-Arévalo Lobo, V. J., Rodolosse, A., Gottardi, C., Mafficini, A., Beghelli, S., Scardoni, M., Bassi, C., Scarpa, A. & Real, F. X., May 1 2013, In : Biochemical Journal. 451, 3, p. 395-405 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours (Biochemical Journal (2013) 451, (395-405))

Campos, M. L., Sánchez-Arévalo Lobo, V. J., Rodolosse, A., Gottardi, C. J., Mafficini, A., Beghelli, S., Scardoni, M., Bassi, C., Scarpa, A. & Real, F. X., Jul 1 2013, In : Biochemical Journal. 453, 1, 1 p.

Research output: Contribution to journalComment/debate

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M. & Chandel, N. S., Feb 5 2013, In : Science Signaling. 6, 261, ra8.

Research output: Contribution to journalArticle

164 Scopus citations

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Serna, V. A., Qiang, W., Brooks, D. C., Malpani, S. S., Ma, J., Ercan, C. M., Mittal, N., Monsivais, D., Dyson, M. T., Yemelyanov, A., Maruyama, T., Chakravarti, D., Kim, J. J., Kurita, T. & 2 others, Gottardi, C. J. & Bulun, S. E., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17053-17058 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
2012

Fibrosis in systemic sclerosis: Common and unique pathobiology

Bhattacharyya, S., Wei, J., Tourtellotte, W. G., Hinchcliff, M., Gottardi, C. G. & Varga, J., Jun 6 2012, In : Fibrogenesis and Tissue Repair. 5, SUPPL.1, S18.

Research output: Contribution to journalArticle

27 Scopus citations

Signaling from adherens junctions

McEwen, A. E., Escobar, D. J. & Gottardi, C. J., 2012, The Adherens Junction. Harris, T. (ed.). New York: Elsevier

Research output: Chapter in Book/Report/Conference proceedingChapter

Signaling from the adherens junction

McEwen, A. E., Escobar, D. E. & Gottardi, C. J., Jan 1 2012, In : Sub-cellular biochemistry. 60, p. 171-196 26 p.

Research output: Contribution to journalArticle

27 Scopus citations

UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes

Smith, K. A., Tong, X., Abu-Yousif, A. O., Mikulec, C. C., Gottardi, C. J., Fischer, S. M. & Pelling, J. C., Sep 1 2012, In : Molecular Carcinogenesis. 51, 9, p. 734-745 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

Wei, J., Fang, F., Lam, A. P., Sargent, J. L., Hamburg, E., Hinchcliff, M. E., Gottardi, C. J., Atit, R., Whitfield, M. L. & Varga, J., Aug 1 2012, In : Arthritis and rheumatism. 64, 8, p. 2734-2745 12 p.

Research output: Contribution to journalArticle

125 Scopus citations
2011

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

Wei, J., Melichian, D., Komura, K., Hinchcliff, M. E., Lam, A. P., Lafyatis, R., Gottardi, C., MacDougald, O. A. & Varga, J., Jun 1 2011, In : Arthritis and rheumatism. 63, 6, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

138 Scopus citations

Integrin regulation of β-catenin signaling in ovarian carcinoma

Burkhalter, R. J., Symowicz, J., Hudson, L. G., Gottardi, C. J. & Stack, M. S., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 23467-23475 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin

Mirkovic, I., Gault, W. J., Rahnama, M., Jenny, A., Gaengel, K., Bessette, D., Gottardi, C., Verheyen, E. M. & Mlodzik, M., Jun 1 2011, In : Nature Structural and Molecular Biology. 18, 6, p. 665-672 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

Lam, A. P., Flozak, A. S., Russell, S. R., Wei, J., Jain, M., Mutlu, G. M., Budinger, GR. S., Feghali-Bostwick, C. A., Varga, J. & Gottardi, C., Nov 1 2011, In : American journal of respiratory cell and molecular biology. 45, 5, p. 915-922 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Regenerative pathways and emphysema: A new paradigm?

Lam, A. P., Gottardi, C. & Tuder, R., Mar 15 2011, In : American Journal of Respiratory and Critical Care Medicine. 183, 6, p. 688-690 3 p.

Research output: Contribution to journalEditorial

7 Scopus citations

Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis

Zhou, Q., Pardo, A., Königshoff, M., Eickelberg, O., Budinger, G. R. S., Thavarajah, K., Gottardi, C. J., Jones, J., Varga, J., Selman, M., Sznajder, J. I., Raj, J. U. & Zhou, G., Sep 1 2011, In : FASEB Journal. 25, 9, p. 3032-3044 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

β-catenin signaling: A novel mediator of fibrosis and potential therapeutic target

Lam, A. P. & Gottardi, C., Nov 1 2011, In : Current opinion in rheumatology. 23, 6, p. 562-567 6 p.

Research output: Contribution to journalReview article

109 Scopus citations
2010

Nesprin-2 interacts with α-catenin and regulates Wnt signaling at the nuclear envelope

Neumann, S., Schneider, M., Daugherty, R. L., Gottardi, C. J., Eming, S. A., Beijer, A., Noegel, A. A. & Karakesisoglou, I., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34932-34938 7 p.

Research output: Contribution to journalArticle

44 Scopus citations