• 5791 Citations
1990 …2020

Research output per year

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Research Output

A basolateral sorting signal is encoded in the α-subunit of Na-K- ATPase

Muth, T. R., Gottardi, C. J., Roush, D. L. & Caplan, M. J., Mar 1998, In : American Journal of Physiology - Cell Physiology. 274, 3 43-3, p. C688-C696

Research output: Contribution to journalArticle

38 Scopus citations

Activity of the β-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

Maher, M. T., Flozak, A. S., Stocker, A. M., Chenn, A. & Gottardi, C. J., Jul 27 2009, In : Journal of Cell Biology. 186, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

93 Scopus citations

Adhesion signaling: How β-catenin interacts with its partners

Gottardi, C. J. & Gumbiner, B. M., Oct 2 2001, In : Current Biology. 11, 19, p. R792-R794

Research output: Contribution to journalReview article

182 Scopus citations

A Dileucine Motif Targets E-cadherin to the Basolateral Cell Surface in Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells

Miranda, K. C., Khromykh, T., Christy, P., Le, T. L., Gottardi, C. J., Yap, A. S., Stow, J. L. & Teasdale, R. D., Jun 22 2001, In : Journal of Biological Chemistry. 276, 25, p. 22565-22572 8 p.

Research output: Contribution to journalArticle

135 Scopus citations

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling

Reinke, L., Lam, A. P., Flozak, A. S., Varga, J. & Gottardi, C. J., Feb 12 2016, In : Biochemical and Biophysical Research Communications. 470, 3, p. 606-612 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

An ion-transporting ATPase encodes multiple apical localization signals

Gottardi, C. J. & Caplan, M. J., Apr 1993, In : Journal of Cell Biology. 121, 2, p. 283-293 11 p.

Research output: Contribution to journalArticle

115 Scopus citations

A simple method to assess abundance of the β-Catenin signaling pool in cells

Flozak, A. S., Lam, A. P. & Gottardi, C. J., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc, p. 49-60 12 p. (Methods in Molecular Biology; vol. 1481).

Research output: Chapter in Book/Report/Conference proceedingChapter

A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes

Lecuit, M., Dramsi, S., Gottardi, C., Fedor-Chaiken, M., Gumbiner, B. & Cossart, P., Jul 15 1999, In : EMBO Journal. 18, 14, p. 3956-3963 8 p.

Research output: Contribution to journalArticle

337 Scopus citations
23 Scopus citations

Beyond β-catenin: Prospects for a larger catenin network in the nucleus

McCrea, P. D. & Gottardi, C. J., Jan 1 2016, In : Nature Reviews Molecular Cell Biology. 17, 1, p. 55-64 10 p.

Research output: Contribution to journalReview article

72 Scopus citations

Biotinylation and assessment of membrane polarity: Caveats and methodological concerns

Gottardi, C. J., Dunbar, L. A. & Caplan, M. J., 1995, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 268, 2 37-2, p. F285-F295

Research output: Contribution to journalArticle

168 Scopus citations

Cadherins and cancer: How does cadherin dysfunction promote tumor progression?

Jeanes, A., Gottardi, C. J. & Yap, A. S., Nov 24 2008, In : Oncogene. 27, 55, p. 6920-6929 10 p.

Research output: Contribution to journalReview article

549 Scopus citations

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

Wei, J., Melichian, D., Komura, K., Hinchcliff, M. E., Lam, A. P., Lafyatis, R., Gottardi, C., MacDougald, O. A. & Varga, J., Jun 1 2011, In : Arthritis and rheumatism. 63, 6, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

139 Scopus citations

Cardiomyocytes of the heart and pulmonary veins: Novel contributors to asthma?

Folmsbee, S. S. & Gottardi, C. J., Nov 2017, In : American journal of respiratory cell and molecular biology. 57, 5, p. 512-518 7 p.

Research output: Contribution to journalReview article

3 Scopus citations

Cell surface biotinylation in the determination of epithelial membrane polarity

Gottardi, C. J. & Caplan, M. J., Dec 1 1992, In : Journal of Tissue Culture Methods. 14, 4, p. 173-180 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Considerations for targeting β-catenin signaling in fibrosis

Gottardi, C. & Königshoff, M., Mar 15 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 6, p. 566-568 3 p.

Research output: Contribution to journalEditorial

18 Scopus citations

Delivery of Na+,K(+)-ATPase in polarized epithelial cells.

Gottardi, C. J. & Caplan, M. J., Apr 23 1993, In : Science. 260, 5107, p. 552-554; author reply 554-556

Research output: Contribution to journalComment/debate

Open Access
66 Scopus citations

Delivery of Na+,K+-ATPase in polarized epithelial cells

Zurzolo, C., Rodriguez-Boulan, E., Gottardi, C. J., Caplan, M. J., Siemers, K. A., Wilson, R., Mays, R. W., Ryan, T. A., Wollner, D. A. & Nelson, W. J., 1993, In : Science. 260, 5107, p. 550-556 7 p.

Research output: Contribution to journalComment/debate

37 Scopus citations

Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes

Gottardi, C. J. & Gumbiner, B. M., Oct 25 2004, In : Journal of Cell Biology. 167, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

248 Scopus citations

E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion

McEwen, A. E., Maher, M. T., Mo, R. & Gottardi, C. J., 2014, In : Molecular biology of the cell. 25, 16, p. 2365-2374 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner

Gottardi, C. J., Wong, E. & Gumbiner, B. M., May 25 2001, In : Journal of Cell Biology. 153, 5, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

429 Scopus citations

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

Research output: Contribution to journalArticle

Open Access

Expression of a protein in rat kidney and distal colon that is related to the gastric H,K-ATPase

Okusa, M. D., Gottardi, C. J., Rajendran, V. M., Binder, H. J. & Caplan, M. J., Jan 1 1995, In : Cellular Physiology and Biochemistry. 5, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fat in fibrosis

Lam, A. P. & Gottardi, C. J., Nov 15 2013, In : American journal of respiratory and critical care medicine. 188, 10, p. 1268-1269 2 p.

Research output: Contribution to journalLetter

Fibrosis in systemic sclerosis: Common and unique pathobiology

Bhattacharyya, S., Wei, J., Tourtellotte, W. G., Hinchcliff, M., Gottardi, C. G. & Varga, J., Jun 6 2012, In : Fibrogenesis and Tissue Repair. 5, SUPPL.1, S18.

Research output: Contribution to journalArticle

27 Scopus citations

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C. J., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.

Research output: Contribution to journalArticle

14 Scopus citations

Functional properties of an H,K-ATPase/Na,K-ATPase chimera

Blostein, R., Zhang, R. P., Gottardi, C. J. & Caplan, M. J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 14, p. 10654-10658 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

Campos, M. L., Sánchez-Arévalo Lobo, V. J., Rodolosse, A., Gottardi, C. J., Mafficini, A., Beghelli, S., Scardoni, M., Bassi, C., Scarpa, A. & Real, F. X., May 1 2013, In : Biochemical Journal. 451, 3, p. 395-405 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours (Biochemical Journal (2013) 451, (395-405))

Campos, M. L., Sánchez-Arévalo Lobo, V. J., Rodolosse, A., Gottardi, C. J., Mafficini, A., Beghelli, S., Scardoni, M., Bassi, C., Scarpa, A. & Real, F. X., Jul 1 2013, In : Biochemical Journal. 453, 1, 1 p.

Research output: Contribution to journalComment/debate

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Gottardi, C. J. & Bulun, S. E., May 2014, In : Fertility and Sterility. 101, 5, p. 1441-1449.e1

Research output: Contribution to journalArticle

43 Scopus citations

Integrin regulation of β-catenin signaling in ovarian carcinoma

Burkhalter, R. J., Symowicz, J., Hudson, L. G., Gottardi, C. J. & Stack, M. S., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 23467-23475 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Issues associated with assessing nuclear localization of N-terminally unphosphorylated β-catenin with monoclonal antibody 8E7

Maher, M. T., Flozak, A. S., Hartsell, A. M., Russell, S., Beri, R., Peled, O. N. & Gottardi, C. J., Feb 2 2009, In : Biology Direct. 4, 5.

Research output: Contribution to journalArticle

18 Scopus citations
17 Scopus citations

Macrophages as a Source and Recipient of Wnt Signals

Malsin, E. S., Kim, S., Lam, A. P. & Gottardi, C. J., 2019, In : Frontiers in immunology. 10, 1 p., 1813.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Kim, S. J., Cheresh, P., Jablonski, R. P., Rachek, L., Yeldandi, A., Piseaux-Aillon, R., Ciesielski, M. J., Ridge, K., Gottardi, C., Lam, A. P., Pardo, A., Selman, M., Natarajan, V. & Kamp, D. W., May 1 2020, In : American journal of physiology. Lung cellular and molecular physiology. 318, 5, p. L1084-L1096

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M. & Chandel, N. S., Feb 5 2013, In : Science Signaling. 6, 261, ra8.

Research output: Contribution to journalArticle

166 Scopus citations

Molecular components of the adherens junction

Niessen, C. M. & Gottardi, C. J., Mar 1 2008, In : Biochimica et Biophysica Acta - Biomembranes. 1778, 3, p. 562-571 10 p.

Research output: Contribution to journalReview article

162 Scopus citations
106 Scopus citations

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

215 Scopus citations

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin

Mirkovic, I., Gault, W. J., Rahnama, M., Jenny, A., Gaengel, K., Bessette, D., Gottardi, C. J., Verheyen, E. M. & Mlodzik, M., Jun 2011, In : Nature Structural and Molecular Biology. 18, 6, p. 665-672 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Nesprin-2 interacts with α-catenin and regulates Wnt signaling at the nuclear envelope

Neumann, S., Schneider, M., Daugherty, R. L., Gottardi, C. J., Eming, S. A., Beijer, A., Noegel, A. A. & Karakesisoglou, I., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34932-34938 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Nuclear signaling from cadherin adhesion complexes

McCrea, P. D., Maher, M. T. & Gottardi, C. J., Jan 1 2015, Current Topics in Developmental Biology. Academic Press Inc, p. 129-196 68 p. (Current Topics in Developmental Biology; vol. 112).

Research output: Chapter in Book/Report/Conference proceedingChapter

45 Scopus citations

Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin

Serebryannyy, L. A., Yemelyanov, A., Gottardi, C. J. & de Lanerolle, P., May 15 2017, In : Journal of cell science. 130, 10, p. 1717-1729 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

Lam, A. P., Flozak, A. S., Russell, S. R., Wei, J., Jain, M., Mutlu, G. M., Budinger, GR. S., Feghali-Bostwick, C. A., Varga, J. & Gottardi, C., Nov 1 2011, In : American journal of respiratory cell and molecular biology. 45, 5, p. 915-922 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Serna, V. A., Qiang, W., Brooks, D. C., Malpani, S. S., Ma, J., Ercan, C. M., Mittal, N., Monsivais, D., Dyson, M. T., Yemelyanov, A., Maruyama, T., Chakravarti, D., Kim, J. J., Kurita, T. & 2 others, Gottardi, C. J. & Bulun, S. E., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17053-17058 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II

Serebryannyy, L. A., Parilla, M., Annibale, P., Cruz, C. M., Laster, K., Gratton, E., Kudryashov, D., Kosak, S. T., Gottardi, C. J. & de Lanerolle, P., 2016, In : Journal of cell science. 129, 18, p. 3412-3425 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Phospho-regulation of β-catenin adhesion and signaling functions

Daugherty, R. L. & Gottardi, C. J., Oct 2007, In : Physiology. 22, 5, p. 303-309 7 p.

Research output: Contribution to journalReview article

182 Scopus citations

Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

Lal, M., Song, X., Pluznick, J. L., Di Giovanni, V., Merrick, D. M., Rosenblum, N. D., Chauvet, V., Gottardi, C. J., Pei, Y. & Caplan, M. J., 2008, In : Human molecular genetics. 17, 20, p. 3105-3117 13 p.

Research output: Contribution to journalArticle

121 Scopus citations