• 5809 Citations
1990 …2020

Research output per year

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Research Output

Article

A basolateral sorting signal is encoded in the α-subunit of Na-K- ATPase

Muth, T. R., Gottardi, C. J., Roush, D. L. & Caplan, M. J., Mar 1998, In : American Journal of Physiology - Cell Physiology. 274, 3 43-3, p. C688-C696

Research output: Contribution to journalArticle

38 Scopus citations

Activity of the β-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

Maher, M. T., Flozak, A. S., Stocker, A. M., Chenn, A. & Gottardi, C. J., Jul 27 2009, In : Journal of Cell Biology. 186, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

93 Scopus citations

A Dileucine Motif Targets E-cadherin to the Basolateral Cell Surface in Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells

Miranda, K. C., Khromykh, T., Christy, P., Le, T. L., Gottardi, C. J., Yap, A. S., Stow, J. L. & Teasdale, R. D., Jun 22 2001, In : Journal of Biological Chemistry. 276, 25, p. 22565-22572 8 p.

Research output: Contribution to journalArticle

135 Scopus citations

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling

Reinke, L., Lam, A. P., Flozak, A. S., Varga, J. & Gottardi, C. J., Feb 12 2016, In : Biochemical and Biophysical Research Communications. 470, 3, p. 606-612 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

An ion-transporting ATPase encodes multiple apical localization signals

Gottardi, C. J. & Caplan, M. J., Apr 1993, In : Journal of Cell Biology. 121, 2, p. 283-293 11 p.

Research output: Contribution to journalArticle

115 Scopus citations

A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes

Lecuit, M., Dramsi, S., Gottardi, C., Fedor-Chaiken, M., Gumbiner, B. & Cossart, P., Jul 15 1999, In : EMBO Journal. 18, 14, p. 3956-3963 8 p.

Research output: Contribution to journalArticle

337 Scopus citations
24 Scopus citations

Biotinylation and assessment of membrane polarity: Caveats and methodological concerns

Gottardi, C. J., Dunbar, L. A. & Caplan, M. J., 1995, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 268, 2 37-2, p. F285-F295

Research output: Contribution to journalArticle

168 Scopus citations

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

Wei, J., Melichian, D., Komura, K., Hinchcliff, M. E., Lam, A. P., Lafyatis, R., Gottardi, C., MacDougald, O. A. & Varga, J., Jun 1 2011, In : Arthritis and rheumatism. 63, 6, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

140 Scopus citations

Cell surface biotinylation in the determination of epithelial membrane polarity

Gottardi, C. J. & Caplan, M. J., Dec 1 1992, In : Journal of Tissue Culture Methods. 14, 4, p. 173-180 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes

Gottardi, C. J. & Gumbiner, B. M., Oct 25 2004, In : Journal of Cell Biology. 167, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

248 Scopus citations

E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion

McEwen, A. E., Maher, M. T., Mo, R. & Gottardi, C. J., 2014, In : Molecular biology of the cell. 25, 16, p. 2365-2374 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner

Gottardi, C. J., Wong, E. & Gumbiner, B. M., May 25 2001, In : Journal of Cell Biology. 153, 5, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

429 Scopus citations

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

Research output: Contribution to journalArticle

Open Access

Expression of a protein in rat kidney and distal colon that is related to the gastric H,K-ATPase

Okusa, M. D., Gottardi, C. J., Rajendran, V. M., Binder, H. J. & Caplan, M. J., Jan 1 1995, In : Cellular Physiology and Biochemistry. 5, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fibrosis in systemic sclerosis: Common and unique pathobiology

Bhattacharyya, S., Wei, J., Tourtellotte, W. G., Hinchcliff, M., Gottardi, C. G. & Varga, J., Jun 6 2012, In : Fibrogenesis and Tissue Repair. 5, SUPPL.1, S18.

Research output: Contribution to journalArticle

27 Scopus citations

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C. J., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.

Research output: Contribution to journalArticle

14 Scopus citations

Functional properties of an H,K-ATPase/Na,K-ATPase chimera

Blostein, R., Zhang, R. P., Gottardi, C. J. & Caplan, M. J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 14, p. 10654-10658 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

Campos, M. L., Sánchez-Arévalo Lobo, V. J., Rodolosse, A., Gottardi, C. J., Mafficini, A., Beghelli, S., Scardoni, M., Bassi, C., Scarpa, A. & Real, F. X., May 1 2013, In : Biochemical Journal. 451, 3, p. 395-405 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Gottardi, C. J. & Bulun, S. E., May 2014, In : Fertility and Sterility. 101, 5, p. 1441-1449.e1

Research output: Contribution to journalArticle

43 Scopus citations

Integrin regulation of β-catenin signaling in ovarian carcinoma

Burkhalter, R. J., Symowicz, J., Hudson, L. G., Gottardi, C. J. & Stack, M. S., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 23467-23475 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Issues associated with assessing nuclear localization of N-terminally unphosphorylated β-catenin with monoclonal antibody 8E7

Maher, M. T., Flozak, A. S., Hartsell, A. M., Russell, S., Beri, R., Peled, O. N. & Gottardi, C. J., Feb 2 2009, In : Biology Direct. 4, 5.

Research output: Contribution to journalArticle

19 Scopus citations
17 Scopus citations

Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Kim, S. J., Cheresh, P., Jablonski, R. P., Rachek, L., Yeldandi, A., Piseaux-Aillon, R., Ciesielski, M. J., Ridge, K., Gottardi, C., Lam, A. P., Pardo, A., Selman, M., Natarajan, V. & Kamp, D. W., May 1 2020, In : American journal of physiology. Lung cellular and molecular physiology. 318, 5, p. L1084-L1096

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M. & Chandel, N. S., Feb 5 2013, In : Science Signaling. 6, 261, ra8.

Research output: Contribution to journalArticle

167 Scopus citations
106 Scopus citations

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

216 Scopus citations

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin

Mirkovic, I., Gault, W. J., Rahnama, M., Jenny, A., Gaengel, K., Bessette, D., Gottardi, C. J., Verheyen, E. M. & Mlodzik, M., Jun 2011, In : Nature Structural and Molecular Biology. 18, 6, p. 665-672 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Nesprin-2 interacts with α-catenin and regulates Wnt signaling at the nuclear envelope

Neumann, S., Schneider, M., Daugherty, R. L., Gottardi, C. J., Eming, S. A., Beijer, A., Noegel, A. A. & Karakesisoglou, I., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34932-34938 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin

Serebryannyy, L. A., Yemelyanov, A., Gottardi, C. J. & de Lanerolle, P., May 15 2017, In : Journal of cell science. 130, 10, p. 1717-1729 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

Lam, A. P., Flozak, A. S., Russell, S., Wei, J., Jain, M., Mutlu, G. M., Budinger, G. R. S., Feghali-Bostwick, C. A., Varga, J. & Gottardi, C. J., Nov 1 2011, In : American journal of respiratory cell and molecular biology. 45, 5, p. 915-922 8 p.

Research output: Contribution to journalArticle

100 Scopus citations

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Serna, V. A., Qiang, W., Brooks, D. C., Malpani, S. S., Ma, J., Ercan, C. M., Mittal, N., Monsivais, D., Dyson, M. T., Yemelyanov, A., Maruyama, T., Chakravarti, D., Kim, J. J., Kurita, T. & 2 others, Gottardi, C. J. & Bulun, S. E., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17053-17058 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II

Serebryannyy, L. A., Parilla, M., Annibale, P., Cruz, C. M., Laster, K., Gratton, E., Kudryashov, D., Kosak, S. T., Gottardi, C. J. & de Lanerolle, P., 2016, In : Journal of cell science. 129, 18, p. 3412-3425 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

Lal, M., Song, X., Pluznick, J. L., Di Giovanni, V., Merrick, D. M., Rosenblum, N. D., Chauvet, V., Gottardi, C. J., Pei, Y. & Caplan, M. J., 2008, In : Human molecular genetics. 17, 20, p. 3105-3117 13 p.

Research output: Contribution to journalArticle

121 Scopus citations

Role for ICAT in β-catenin-dependent nuclear signaling and cadherin functions

Gottardi, C. J. & Gumbiner, B. M., Apr 1 2004, In : American Journal of Physiology - Cell Physiology. 286, 4 55-4

Research output: Contribution to journalArticle

63 Scopus citations

Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis

Zhou, Q., Pardo, A., Königshoff, M., Eickelberg, O., Budinger, G. R. S., Thavarajah, K., Gottardi, C. J., Jones, J., Varga, J., Selman, M., Sznajder, J. I., Raj, J. U. & Zhou, G., Sep 1 2011, In : FASEB Journal. 25, 9, p. 3032-3044 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Signaling from the adherens junction

McEwen, A. E., Escobar, D. E. & Gottardi, C. J., Jan 1 2012, In : Sub-cellular biochemistry. 60, p. 171-196 26 p.

Research output: Contribution to journalArticle

27 Scopus citations

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
112 Scopus citations

Sorting of ion pumps in polarized epithelial cells

Dunbar, L. A., Roush, D. L., Courtois-Coutry, N., Muth, T. R., Gottardi, C. J., Rajendran, V., Geibel, J., Kashgarian, M. & Caplan, M. J., 1997, In : Annals of the New York Academy of Sciences. 834, p. 514-523 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sorting of ion transport proteins in polarized cells

Gottardi, C. J., Pietrini, G., Roush, D. L. & Caplan, M. J., 1993, In : Journal of cell science. 106, SUPPL. 17, p. 13-20 8 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Sorting of P-type ATPases in polarized epithelial cells

Dunbar, L. A., Courtois-Coutry, N., Roush, D. L., Muth, T. R., Gottardi, C. J., Rajendran, V., Geibel, J., Kashgarian, M. & Caplan, M. J., Jan 1 1998, In : Acta Physiologica Scandinavica, Supplement. 163, 643, p. 289-295 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Sorting of the Gastric H,K‐ATPase in Endocrine and Epithelial Cells

Roush, D. L., Gottardi, C. J. & Caplan, M. J., Sep 1994, In : Annals of the New York Academy of Sciences. 733, 1, p. 212-222 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structural determinants of the mechanical stability of α-Catenin

Li, J., Newhall, J., Ishiyama, N., Gottardi, C., Ikura, M., Leckband, D. E. & Tajkhorshid, E., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, p. 18890-18903 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Synthesis and Sorting of Ion Pumps in Polarized Cells

Gottardi, C. J., Pietrini, G., Shiel, M. J. & Caplan, M. J., Jan 1 1994, In : Current topics in membranes. 41, C, p. 143-168 26 p.

Research output: Contribution to journalArticle

3 Scopus citations

The cardiac protein αT-catenin contributes to chemical-induced asthma

Folmsbee, S. S., Morales-Nebreda, L., Van Henge, J., Tyberghein, K., Van Roy, F., Budinger, G. R. S., Bryce, P. J. & Gottardi, C. J., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 3, p. L253-L258

Research output: Contribution to journalArticle

10 Scopus citations

The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation

Folmsbee, S. S., Budinger, G. R. S., Bryce, P. J. & Gottardi, C. J., Jul 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 123-129.e2

Research output: Contribution to journalArticle

6 Scopus citations

The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype

Valenti, F., Ibetti, J., Komiya, Y., Baxter, M., Lucchese, A. M., Derstine, L., Covaciu, C., Rizzo, V., Vento, R., Russo, G., Macaluso, M., Cotelli, F., Castiglia, D., Gottardi, C. J., Habas, R., Giordano, A. & Bellipanni, G., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 418-430 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
274 Scopus citations

The Na,K-ATPase β2 subunit is expressed in rat brain and copurifies with Na,K-ATPase activity

Shyjan, A. W., Gottardi, C. & Levenson, R., 1990, In : Journal of Biological Chemistry. 265, 9, p. 5166-5169 4 p.

Research output: Contribution to journalArticle

62 Scopus citations

The sphingosine kinase 1 inhibitor, pf543, mitigates pulmonary fibrosis by reducing lung epithelial cell mtdna damage and recruitment of fibrogenic monocytes

Cheresh, P., Kim, S. J., Huang, L. S., Watanabe, S., Joshi, N., Williams, K. J. N., Chi, M., Lu, Z., Harijith, A., Yeldandi, A., Lam, A. P., Gottardi, C., Misharin, A. V., Budinger, G. R. S., Natarajan, V. & Kamp, D. W., 2020, In : International journal of molecular sciences. 21, 16, p. 1-17 17 p., 5595.

Research output: Contribution to journalArticle

Open Access