• 5578 Citations
1990 …2023

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2019

Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans

Shigemura, M., Lecuona, E., Angulo, M., Dada, L. A., Edwards, M. B., Welch, L. C., Casalino-Matsuda, S. M., Sporn, P. H. S., Vadász, I., Helenius, I. T., Nader, G. A., Gruenbaum, Y., Sharabi, K., Cummins, E., Taylor, C., Bharat, A., Gottardi, C. J., Beitel, G. J., Kaminski, N., Budinger, G. R. S. & 2 others, Berdnikovs, S. & Sznajder, J. I., Dec 1 2019, In : Scientific reports. 9, 1, 18251.

Research output: Contribution to journalArticle

Open Access

Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis

Reyfman, P. A., Walter, J. M., Joshi, N., Anekalla, K. R., McQuattie-Pimentel, A. C., Chiu, S., Fernandez, R., Akbarpour, M., Chen, C. I., Ren, Z., Verma, R., Abdala-Valencia, H., Nam, K., Chi, M., Han, S. H., Gonzalez-Gonzalez, F. J., Soberanes, S., Watanabe, S., Williams, K. J. N., Flozak, A. S. & 29 others, Nicholson, T. T., Morgan, V. K., Winter, D. R., Hinchcliff, M., Hrusch, C. L., Guzy, R. D., Bonham, C. A., Sperling, A. I., Bag, R., Hamanaka, R. B., Mutlu, G. M., Yeldandi, A. V., Marshall, S. A., Shilatifard, A., Amaral, L. A. N., Perlman, H. R., Sznajder, J. I., Christine Argento, A., Gillespie, C. T., Dematte, J., Jain, M., Singer, B., Ridge, K. M., Lam, A. P., Bharat, A., Bhorade, S. M., Gottardi, C., Budinger, GR. S. & Misharin, A., Jun 15 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 12, p. 1517-1536 20 p.

Research output: Contribution to journalArticle

Open Access
65 Scopus citations
2018

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

Ishiyama, N., Sarpal, R., Wood, M. N., Barrick, S. K., Nishikawa, T., Hayashi, H., Kobb, A. B., Flozak, A. S., Yemelyanov, A., Fernandez-Gonzalez, R., Yonemura, S., Leckband, D. E., Gottardi, C. J., Tepass, U. & Ikura, M., Dec 1 2018, In : Nature communications. 9, 1, 5121.

Research output: Contribution to journalArticle

11 Scopus citations

αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

Chiarella, S. E., Rabin, E. E., Ostilla, L. A., Flozak, A. S. & Gottardi, C. J., Apr 3 2018, In : Tissue Barriers. 6, 2, e1463896.

Research output: Contribution to journalArticle

2 Scopus citations
2017
21 Scopus citations
17 Scopus citations

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C. I., Anekalla, K. R., Joshi, N., Williams, K. J. N., Abdala-Valencia, H., Yacoub, T. J., Chi, M., Chiu, S., Gonzalez-Gonzalez, F. J., Gates, K., Lam, A. P., Nicholson, T. T., Homan, P. J., Soberanes, S. & 23 others, Dominguez, S., Morgan, V. K., Saber, R., Shaffer, A., Hinchcliff, M., Marshall, S. A., Bharat, A., Berdnikovs, S., Bhorade, S. M., Bartom, E. T., Morimoto, R. I., Balch, W. E., Sznajder, J. I., Chandel, N. S., Mutlu, G. M., Jain, M., Gottardi, C. J., Singer, B. D., Ridge, K. M., Bagheri, N., Shilatifard, A., Budinger, G. R. S. & Perlman, H., Aug 1 2017, In : Journal of Experimental Medicine. 214, 8, p. 2387-2404 18 p.

Research output: Contribution to journalArticle

171 Scopus citations

Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin

Serebryannyy, L. A., Yemelyanov, A., Gottardi, C. J. & de Lanerolle, P., May 15 2017, In : Journal of cell science. 130, 10, p. 1717-1729 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion

Wood, M. N., Ishiyama, N., Singaram, I., Chung, C. M., Flozak, A. S., Yemelyanov, A., Ikura, M., Cho, W. & Gottardi, C., Nov 1 2017, In : Journal of Cell Biology. 216, 11, p. 3767-3783 17 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling

Reinke, L., Lam, A. P., Flozak, A. S., Varga, J. & Gottardi, C. J., Feb 12 2016, In : Biochemical and Biophysical Research Communications. 470, 3, p. 606-612 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II

Serebryannyy, L. A., Parilla, M., Annibale, P., Cruz, C. M., Laster, K., Gratton, E., Kudryashov, D., Kosak, S. T., Gottardi, C. J. & de Lanerolle, P., Jan 1 2016, In : Journal of cell science. 129, 18, p. 3412-3425 14 p.

Research output: Contribution to journalArticle

26 Scopus citations

The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation

Folmsbee, S. S., Budinger, G. R. S., Bryce, P. J. & Gottardi, C. J., Jul 1 2016, In : Journal of Allergy and Clinical Immunology. 138, 1, p. 123-129.e2

Research output: Contribution to journalArticle

6 Scopus citations

Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation

Chen, Y., Li, Y., Xue, J., Gong, A., Yu, G., Zhou, A., Lin, K., Zhang, S., Zhang, N., Gottardi, C. & Huang, S., Mar 15 2016, In : EMBO Journal. 35, 6, p. 668-684 17 p.

Research output: Contribution to journalArticle

39 Scopus citations

αT-catenin in restricted brain cell types and its potential connection to autism

Folmsbee, S. S., Wilcox, D. R., Tyberghein, K., De Bleser, P., Tourtellotte, W. G., Hengel, J. V., van Roy, F. & Gottardi, C. J., Jan 1 2016, In : Journal of Molecular Psychiatry. 4, 1, 2.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Structural determinants of the mechanical stability of α-Catenin

Li, J., Newhall, J., Ishiyama, N., Gottardi, C., Ikura, M., Leckband, D. E. & Tajkhorshid, E., Jul 31 2015, In : Journal of Biological Chemistry. 290, 31, p. 18890-18903 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

The cardiac protein αT-catenin contributes to chemical-induced asthma

Folmsbee, S. S., Morales-Nebreda, L., Van Henge, J., Tyberghein, K., Van Roy, F., Budinger, G. R. S., Bryce, P. J. & Gottardi, C. J., Jan 1 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 3, p. L253-L258

Research output: Contribution to journalArticle

10 Scopus citations

The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype

Valenti, F., Ibetti, J., Komiya, Y., Baxter, M., Lucchese, A. M., Derstine, L., Covaciu, C., Rizzo, V., Vento, R., Russo, G., Macaluso, M., Cotelli, F., Castiglia, D., Gottardi, C. J., Habas, R., Giordano, A. & Bellipanni, G., Mar 1 2015, In : Journal of Cellular Biochemistry. 116, 3, p. 418-430 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism

Escobar, D. J., Desai, R., Ishiyama, N., Folmsbee, S. S., Novak, M. N., Flozak, A. S., Daugherty, R. L., Mo, R., Nanavati, D., Sarpal, R., Leckband, D., Ikura, M., Tepass, U. & Gottardi, C. J., Jan 1 2015, In : Journal of cell science. 128, 6, p. 1150-1165 16 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion

McEwen, A. E., Maher, M. T., Mo, R. & Gottardi, C. J., Jan 1 2014, In : Molecular biology of the cell. 25, 16, p. 2365-2374 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Gottardi, C. J. & Bulun, S. E., May 2014, In : Fertility and Sterility. 101, 5, p. 1441-1449.e1

Research output: Contribution to journalArticle

42 Scopus citations

Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis

Lam, A. P., Herazo-Maya, J. D., Sennello, J. A., Flozak, A. S., Russell, S., Mutlu, G. M., Budinger, G. R. S., DasGupta, R., Varga, J., Kaminski, N. & Gottardi, C. J., Jul 15 2014, In : American journal of respiratory and critical care medicine. 190, 2, p. 185-195 11 p.

Research output: Contribution to journalArticle

64 Scopus citations

α-Catenin cytomechanics - role in cadherin-dependent adhesion and mechanotransduction

Barry, A. K., Tabdili, H., Muhamed, I., Wu, J., Shashikanth, N., Gomez, G. A., Yap, A. S., Gottardi, C. J., De Rooij, J., Wang, N. & Leckband, D. E., 2014, In : Journal of cell science. 127, 8, p. 1779-1791 13 p.

Research output: Contribution to journalArticle

67 Scopus citations

α-Catenin is an inhibitor of transcription

Daugherty, R. L., Serebryannyy, L., Yemelyanov, A., Flozak, A. S., Yu, H. J., Kosak, S. T., De Lanerolle, P. & Gottardi, C., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 14, p. 5260-5265 6 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

Campos, M. L., Sánchez-Arévalo Lobo, V. J., Rodolosse, A., Gottardi, C., Mafficini, A., Beghelli, S., Scardoni, M., Bassi, C., Scarpa, A. & Real, F. X., May 1 2013, In : Biochemical Journal. 451, 3, p. 395-405 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M. & Chandel, N. S., Feb 5 2013, In : Science Signaling. 6, 261, ra8.

Research output: Contribution to journalArticle

156 Scopus citations

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth

Ono, M., Yin, P., Navarro, A., Moravek, M. B., Coon V, J. S., Druschitz, S. A., Serna, V. A., Qiang, W., Brooks, D. C., Malpani, S. S., Ma, J., Ercan, C. M., Mittal, N., Monsivais, D., Dyson, M. T., Yemelyanov, A., Maruyama, T., Chakravarti, D., Kim, J. J., Kurita, T. & 2 others, Gottardi, C. J. & Bulun, S. E., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17053-17058 6 p.

Research output: Contribution to journalArticle

77 Scopus citations
2012

Fibrosis in systemic sclerosis: Common and unique pathobiology

Bhattacharyya, S., Wei, J., Tourtellotte, W. G., Hinchcliff, M., Gottardi, C. G. & Varga, J., Jun 6 2012, In : Fibrogenesis and Tissue Repair. 5, SUPPL.1, S18.

Research output: Contribution to journalArticle

26 Scopus citations

Signaling from the adherens junction

McEwen, A. E., Escobar, D. E. & Gottardi, C. J., Jan 1 2012, In : Sub-cellular biochemistry. 60, p. 171-196 26 p.

Research output: Contribution to journalArticle

27 Scopus citations

UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes

Smith, K. A., Tong, X., Abu-Yousif, A. O., Mikulec, C. C., Gottardi, C., Fischer, S. M. & Pelling, J. C., Sep 1 2012, In : Molecular Carcinogenesis. 51, 9, p. 734-745 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

Wei, J., Fang, F., Lam, A. P., Sargent, J. L., Hamburg, E., Hinchcliff, M. E., Gottardi, C. J., Atit, R., Whitfield, M. L. & Varga, J., Aug 1 2012, In : Arthritis and rheumatism. 64, 8, p. 2734-2745 12 p.

Research output: Contribution to journalArticle

119 Scopus citations
2011

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

Wei, J., Melichian, D., Komura, K., Hinchcliff, M. E., Lam, A. P., Lafyatis, R., Gottardi, C., MacDougald, O. A. & Varga, J., Jun 1 2011, In : Arthritis and rheumatism. 63, 6, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

136 Scopus citations

Integrin regulation of β-catenin signaling in ovarian carcinoma

Burkhalter, R. J., Symowicz, J., Hudson, L. G., Gottardi, C. J. & Stack, M. S., Jul 1 2011, In : Journal of Biological Chemistry. 286, 26, p. 23467-23475 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin

Mirkovic, I., Gault, W. J., Rahnama, M., Jenny, A., Gaengel, K., Bessette, D., Gottardi, C., Verheyen, E. M. & Mlodzik, M., Jun 1 2011, In : Nature Structural and Molecular Biology. 18, 6, p. 665-672 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

Lam, A. P., Flozak, A. S., Russell, S. R., Wei, J., Jain, M., Mutlu, G. M., Budinger, GR. S., Feghali-Bostwick, C. A., Varga, J. & Gottardi, C., Nov 1 2011, In : American journal of respiratory cell and molecular biology. 45, 5, p. 915-922 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis

Zhou, Q., Pardo, A., Königshoff, M., Eickelberg, O., Budinger, G. R. S., Thavarajah, K., Gottardi, C. J., Jones, J., Varga, J., Selman, M., Sznajder, J. I., Raj, J. U. & Zhou, G., Sep 1 2011, In : FASEB Journal. 25, 9, p. 3032-3044 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2010

Nesprin-2 interacts with α-catenin and regulates Wnt signaling at the nuclear envelope

Neumann, S., Schneider, M., Daugherty, R. L., Gottardi, C. J., Eming, S. A., Beijer, A., Noegel, A. A. & Karakesisoglou, I., Nov 5 2010, In : Journal of Biological Chemistry. 285, 45, p. 34932-34938 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

β-Catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells

Flozak, A. S., Lam, A. P., Russell, S. R., Jain, M., Peled, O. N., Sheppard, K. A., Beri, R., Mutlu, G. M., Budinger, GR. S. & Gottardi, C., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3157-3167 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

β-catenin phosphorylated at serine 45 is spatially uncoupled from β-catenin phosphorylated in the GSK3 domain: Implications for signaling

Maher, M. T., Mo, R., Flozak, A. S., Peled, O. N. & Gottardi, C. J., Sep 10 2010, In : PloS one. 5, 4, e10184.

Research output: Contribution to journalArticle

63 Scopus citations
2009

Activity of the β-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion

Maher, M. T., Flozak, A. S., Stocker, A. M., Chenn, A. & Gottardi, C. J., Jul 27 2009, In : Journal of Cell Biology. 186, 2, p. 219-228 10 p.

Research output: Contribution to journalArticle

90 Scopus citations

Issues associated with assessing nuclear localization of N-terminally unphosphorylated β-catenin with monoclonal antibody 8E7

Maher, M. T., Flozak, A. S., Hartsell, A. M., Russell, S., Beri, R., Peled, O. N. & Gottardi, C. J., Feb 2 2009, In : Biology Direct. 4, 5.

Research output: Contribution to journalArticle

18 Scopus citations

The terminal region of β-catenin promotes stability by shielding the armadillo repeats from the axin-scaffold destruction complex

Mo, R., Chew, T. L., Maher, M. T., Bellipanni, G., Weinberg, E. S. & Gottardi, C. J., Oct 9 2009, In : Journal of Biological Chemistry. 284, 41, p. 28222-28231 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2008

Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling

Lal, M., Song, X., Pluznick, J. L., Di Giovanni, V., Merrick, D. M., Rosenblum, N. D., Chauvet, V., Gottardi, C. J., Pei, Y. & Caplan, M. J., Oct 13 2008, In : Human molecular genetics. 17, 20, p. 3105-3117 13 p.

Research output: Contribution to journalArticle

119 Scopus citations

VE-cadherin and β-catenin binding dynamics during histamine-induced endothelial hyperpermeability

Guo, M., Breslin, J. W., Wu, M. H., Gottardi, C. J. & Yuan, S. Y., Apr 1 2008, In : American Journal of Physiology - Cell Physiology. 294, 4, p. C977-C984

Research output: Contribution to journalArticle

43 Scopus citations
2005

When domestiques rebel: Kinesins, cadherins and neuronal proliferation

Gottardi, C., den Elzen, N. R. & Yap, A. S., May 1 2005, In : Nature Cell Biology. 7, 5, p. 445-447 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
2004

Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes

Gottardi, C. J. & Gumbiner, B. M., Oct 25 2004, In : Journal of Cell Biology. 167, 2, p. 339-349 11 p.

Research output: Contribution to journalArticle

245 Scopus citations

Role for ICAT in β-catenin-dependent nuclear signaling and cadherin functions

Gottardi, C. J. & Gumbiner, B. M., Apr 1 2004, In : American Journal of Physiology - Cell Physiology. 286, 4 55-4

Research output: Contribution to journalArticle

62 Scopus citations
2001

A Dileucine Motif Targets E-cadherin to the Basolateral Cell Surface in Madin-Darby Canine Kidney and LLC-PK1 Epithelial Cells

Miranda, K. C., Khromykh, T., Christy, P., Le, T. L., Gottardi, C. J., Yap, A. S., Stow, J. L. & Teasdale, R. D., Jun 22 2001, In : Journal of Biological Chemistry. 276, 25, p. 22565-22572 8 p.

Research output: Contribution to journalArticle

132 Scopus citations

E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner

Gottardi, C. J., Wong, E. & Gumbiner, B. M., May 25 2001, In : Journal of Cell Biology. 153, 5, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

424 Scopus citations
1999

A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes

Lecuit, M., Dramsi, S., Gottardi, C., Fedor-Chaiken, M., Gumbiner, B. & Cossart, P., Jul 15 1999, In : EMBO Journal. 18, 14, p. 3956-3963 8 p.

Research output: Contribution to journalArticle

335 Scopus citations
1998

A basolateral sorting signal is encoded in the α-subunit of Na-K- ATPase

Muth, T. R., Gottardi, C. J., Roush, D. L. & Caplan, M. J., Mar 1998, In : American Journal of Physiology - Cell Physiology. 274, 3 43-3, p. C688-C696

Research output: Contribution to journalArticle

38 Scopus citations