Carlos Guillermo Vanoye

  • 2664 Citations
1990 …2023
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

My research projects include the interaction between the voltage-gated potassium (KV) channel KCNQ1 and the accessory KCNE proteins that modify biophysical properties, surface expression (location and density) and pharmacology. In addition, I study the function and regulation of the KV potassium channels KCNQ1 and HERG that implicated in cardiac disease and how disease-associated mutations modify channel function. My studies also address mutations in the neuronal NaV channel a subunit genes SCN1A, SCN2A and SCN3A (encoding NaV1.1, NaV1.2 and NaV1.3, respectively) linked to a variety of inherited epileptic disorders with the goal to understand the mechanism by which NaV mutations trigger or modify epilepsy. I am also studying the properties of NaV1.9 which has been implicated in nociception including neuronal pain signaling triggered by inflammation. Another project involves PMP22 and its potential role in cell membrane conductance and Schwann cell function. My expertise is in the areas of ion channels and their regulation and role in membrane transport. I also have considerable experience in electrophysiology, molecular biology and biochemical techniques including immunocytochemistry in both mammalian cells and Xenopus oocytes

Education/Academic qualification

PhD, University of Texas

… → 1997

Research interests

  • Cardiovascular Diseases
  • Epilepsy
  • Ion Channels
  • Neurobiology
  • Pain
  • Proteins / Macromolecules

Fingerprint Dive into the research topics where Carlos Guillermo Vanoye is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Mutation Medicine & Life Sciences
P-Glycoprotein Medicine & Life Sciences
Voltage-Gated Potassium Channels Medicine & Life Sciences
KCNQ1 Potassium Channel Medicine & Life Sciences
Epilepsy Medicine & Life Sciences
Sodium Channels Medicine & Life Sciences
Long QT Syndrome Medicine & Life Sciences
Chloride Channels Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2023

Mutagenesis
Channelopathies
Epilepsy
Ion Channels
Neurons
Kidney
Kidney Diseases
Research Personnel
Therapeutics
Nanomedicine
Channelopathies
Sudden Death
Cardiomyopathies
Human Genome
Genetic Predisposition to Disease

Research Output 1990 2019

  • 2664 Citations
  • 68 Article
  • 3 Review article

Peripheral myelin protein 22 modulates store-operated calcium channel activity, providing insights into Charcot-Marie-Tooth disease etiology

Vanoye, C. G., Sakakura, M., Follis, R. M., Trevisan, A. J., Narayan, M., Li, J., Sanders, C. R. & Carter, B. D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 32, p. 12054-12065 12 p.

Research output: Contribution to journalArticle

Open Access
Myelin Proteins
Charcot-Marie-Tooth Disease
Calcium Channels
Endoplasmic Reticulum
Schwann Cells
3 Citations (Scopus)

High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance

Vanoye, C. G., Desai, R. R., Fabre, K. L., Gallagher, S. L., Potet, F., DeKeyser, J. M., Macaya, D., Meiler, J., Sanders, C. R. & George Jr, A. L., Nov 1 2018, In : Circulation. Genomic and precision medicine. 11, 11, p. e002345

Research output: Contribution to journalArticle

Ion Channels
Inborn Genetic Diseases
Cardiac Arrhythmias
Precision Medicine
Drug Discovery

Long QT syndrome KCNH2 mutation with sequential fetal and maternal sudden death

Tuveng, J. M., Berling, B. M., Bunford, G., Vanoye, C. G., Welch, R. C., Leren, T. P., George, A. L. & Rognum, T. O., Sep 1 2018, In : Forensic Science, Medicine, and Pathology. 14, 3, p. 367-371 5 p.

Research output: Contribution to journalArticle

Long QT Syndrome
Maternal Death
Sudden Death
Fetal Death
Mothers
12 Citations (Scopus)

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations

Huang, H., Kuenze, G., Smith, J. A., Taylor, K. C., Duran, A. M., Hadziselimovic, A., Meiler, J., Vanoye, C. G., George Jr, A. L. & Sanders, C. R., Mar 7 2018, In : Science Advances. 4, 3, eaar2631.

Research output: Contribution to journalArticle

Long QT Syndrome
Mutation
Proteasome Endopeptidase Complex
Membrane Proteins
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
2 Citations (Scopus)

Allelic complexity in long QT syndrome: A family-case study

Zullo, A., Frisso, G., Detta, N., Sarubbi, B., Romeo, E., Cordella, A., Vanoye, C. G., Calabrò, R., George Jr, A. L. & Salvatore, F., Aug 1 2017, In : International journal of molecular sciences. 18, 8, 1633.

Research output: Contribution to journalArticle

Long QT Syndrome
mutations
Clamping devices
Mutation
Genes