Carlos Guillermo Vanoye

  • 2804 Citations
1990 …2023

Research output per year

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Personal profile

Research Interests

My research projects include the interaction between the voltage-gated potassium (KV) channel KCNQ1 and the accessory KCNE proteins that modify biophysical properties, surface expression (location and density) and pharmacology. In addition, I study the function and regulation of the KV potassium channels KCNQ1 and HERG that implicated in cardiac disease and how disease-associated mutations modify channel function. My studies also address mutations in the neuronal NaV channel a subunit genes SCN1A, SCN2A and SCN3A (encoding NaV1.1, NaV1.2 and NaV1.3, respectively) linked to a variety of inherited epileptic disorders with the goal to understand the mechanism by which NaV mutations trigger or modify epilepsy. I am also studying the properties of NaV1.9 which has been implicated in nociception including neuronal pain signaling triggered by inflammation. Another project involves PMP22 and its potential role in cell membrane conductance and Schwann cell function. My expertise is in the areas of ion channels and their regulation and role in membrane transport. I also have considerable experience in electrophysiology, molecular biology and biochemical techniques including immunocytochemistry in both mammalian cells and Xenopus oocytes

Education/Academic qualification

PhD, University of Texas

… → 1997

Research interests

  • Cardiovascular Diseases
  • Epilepsy
  • Ion Channels
  • Neurobiology
  • Pain
  • Proteins / Macromolecules

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Grants

  • Research Output

    • 2804 Citations
    • 70 Article
    • 3 Review article
    • 1 Editorial

    Decoding KCNH2 variants of unknown significance

    Vanoye, C. G. & George, A. L., Mar 2020, In : Heart rhythm. 17, 3, p. 501-502 2 p.

    Research output: Contribution to journalEditorial

    Open Access
  • Peripheral myelin protein 22 modulates store-operated calcium channel activity, providing insights into Charcot-Marie-Tooth disease etiology

    Vanoye, C. G., Sakakura, M., Follis, R. M., Trevisan, A. J., Narayan, M., Li, J., Sanders, C. R. & Carter, B. D., Jan 1 2019, In : Journal of Biological Chemistry. 294, 32, p. 12054-12065 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Spectrum of KV2.1 Dysfunction in KCNB1-Associated Neurodevelopmental Disorders

    Kang, S. K., Vanoye, C. G., Misra, S. N., Echevarria, D. M., Calhoun, J. D., O'Connor, J. B., Fabre, K. L., McKnight, D., Demmer, L., Goldenberg, P., Grote, L. E., Thiffault, I., Saunders, C., Strauss, K. A., Torkamani, A., van der Smagt, J., van Gassen, K., Carson, R. P., Diaz, J., Leon, E. & 12 others, Jacher, J. E., Hannibal, M. C., Litwin, J., Friedman, N. R., Schreiber, A., Lynch, B., Poduri, A., Marsh, E. D., Goldberg, E. M., Millichap, J. J., George, A. L. & Kearney, J. A., Dec 1 2019, In : Annals of neurology. 86, 6, p. 899-912 14 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Upgraded molecular models of the human KCNQ1 potassium channel

    Kuenze, G., Duran, A. M., Woods, H., Brewer, K. R., McDonald, E. F., Vanoye, C. G., George, A. L., Sanders, C. R. & Meiler, J., Jan 1 2019, In : PloS one. 14, 9, e0220415.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations