My research projects include the interaction between the voltage-gated potassium (KV) channel KCNQ1 and the accessory KCNE proteins that modify biophysical properties, surface expression (location and density) and pharmacology. In addition, I study the function and regulation of the KV potassium channels KCNQ1 and HERG that implicated in cardiac disease and how disease-associated mutations modify channel function. My studies also address mutations in the neuronal NaV channel a subunit genes SCN1A, SCN2A and SCN3A (encoding NaV1.1, NaV1.2 and NaV1.3, respectively) linked to a variety of inherited epileptic disorders with the goal to understand the mechanism by which NaV mutations trigger or modify epilepsy. I am also studying the properties of NaV1.9 which has been implicated in nociception including neuronal pain signaling triggered by inflammation. Another project involves PMP22 and its potential role in cell membrane conductance and Schwann cell function. My expertise is in the areas of ion channels and their regulation and role in membrane transport. I also have considerable experience in electrophysiology, molecular biology and biochemical techniques including immunocytochemistry in both mammalian cells and Xenopus oocytes