Carlos Guillermo Vanoye

  • 2893 Citations
1990 …2020

Research output per year

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Personal profile

Research Interests

My research projects include the interaction between the voltage-gated potassium (KV) channel KCNQ1 and the accessory KCNE proteins that modify biophysical properties, surface expression (location and density) and pharmacology. In addition, I study the function and regulation of the KV potassium channels KCNQ1 and HERG that implicated in cardiac disease and how disease-associated mutations modify channel function. My studies also address mutations in the neuronal NaV channel a subunit genes SCN1A, SCN2A and SCN3A (encoding NaV1.1, NaV1.2 and NaV1.3, respectively) linked to a variety of inherited epileptic disorders with the goal to understand the mechanism by which NaV mutations trigger or modify epilepsy. I am also studying the properties of NaV1.9 which has been implicated in nociception including neuronal pain signaling triggered by inflammation. Another project involves PMP22 and its potential role in cell membrane conductance and Schwann cell function. My expertise is in the areas of ion channels and their regulation and role in membrane transport. I also have considerable experience in electrophysiology, molecular biology and biochemical techniques including immunocytochemistry in both mammalian cells and Xenopus oocytes

Education/Academic qualification

PhD, University of Texas

… → 1997

Research interests

  • Cardiovascular Diseases
  • Epilepsy
  • Ion Channels
  • Neurobiology
  • Pain
  • Proteins / Macromolecules

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Grants

  • Research Output

    • 2893 Citations
    • 72 Article
    • 4 Review article
    • 1 Editorial
    • 1 Letter

    Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

    Kramer, J., Himmel, H. M., Lindqvist, A., Stoelzle-Feix, S., Chaudhary, K. W., Li, D., Bohme, G. A., Bridgland-Taylor, M., Hebeisen, S., Fan, J., Renganathan, M., Imredy, J., Humphries, E. S. A., Brinkwirth, N., Strassmaier, T., Ohtsuki, A., Danker, T., Vanoye, C., Polonchuk, L., Fermini, B. & 2 others, Pierson, J. B. & Gintant, G., Dec 1 2020, In : Scientific reports. 10, 1, 5627.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations

    Decoding KCNH2 variants of unknown significance

    Vanoye, C. G. & George, A. L., Mar 2020, In : Heart rhythm. 17, 3, p. 501-502 2 p.

    Research output: Contribution to journalEditorial

    1 Scopus citations

    Long QT Syndrome Type 1 in an Australian Indigenous Patient

    Ganesan, A. N., Vanoye, C. G., Alam, F., Waddell-Smith, K. E., McGavigan, A. D., Correnti, G., Haan, E., Brown, A., Vandenberg, J. & George, A. L., Jan 1 2020, (Accepted/In press) In : Circulation: Genomic and Precision Medicine. p. 93-94 2 p.

    Research output: Contribution to journalLetter

    Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine

    Shen, W., Ren, W., Zhai, S., Yang, B., Vanoye, C. G., Mitra, A., George, A. L. & James Surmeier, D., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2593-2601 9 p.

    Research output: Contribution to journalArticle

  • Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome

    Brewer, K. R., Kuenze, G., Vanoye, C. G., George, A. L., Meiler, J. & Sanders, C. R., May 4 2020, In : Frontiers in Pharmacology. 11, 550.

    Research output: Contribution to journalReview article

    Open Access