Charles David James

  • 24031 Citations
1984 …2020

Research output per year

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Personal profile

Research Interests

My primary research interest and activity involves the use of human brain tumor xenograft models for identifying effective therapeutics to treat brain tumor patients, as based on specific molecular characteristics of each patient’s tumor.

Training Experience

1989Postdoctoral Fellowship, McGill University, Canada

Education/Academic qualification

PhD, Wright State University School of Medicine

… → 1986

Research interests

  • Brain Cancer / Nervous System Cancer
  • Molecular Biology
  • Neuro-Oncology

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Research Output

Bone morphogenetic protein 4 targeting glioma stem-like cells for malignant glioma treatment: Latest advances and implications for clinical application

Nayak, S., Mahenthiran, A., Yang, Y., McClendon, M., Mania-Farnell, B., James, C. D., Kessler, J. A., Tomita, T., Cheng, S. Y., Stupp, S. I. & Xi, G., Feb 2020, In : Cancers. 12, 2, 516.

Research output: Contribution to journalReview article

Open Access
  • Activation of dopamine receptor 2 prompts transcriptomic and metabolic plasticity in glioblastoma

    Caragher, S. P., Shireman, J. M., Huang, M., Miska, J., Atashi, F., Baisiwala, S., Park, C. H., Saathoff, M. R., Warnke, L., Xiao, T., Lesniak, M. S., David James, C., Meltzer, H., Tryba, A. K. & Ahmed, A. U., Mar 13 2019, In : Journal of Neuroscience. 39, 11, p. 1982-1993 12 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations
    Open Access
  • Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis

    Krenzlin, H., Behera, P., Lorenz, V., Passaro, C., Zdioruk, M., Nowicki, M. O., Grauwet, K., Zhang, H., Skubal, M., Ito, H., Zane, R., Gutknecht, M., Griessl, M. B., Ricklefs, F., Ding, L., Peled, S., Rooj, A., David James, C., Cobbs, C. S., Cook, C. H. & 2 others, Antonio Chiocca, E. & Lawler, S. E., Apr 1 2019, In : Journal of Clinical Investigation. 129, 4, p. 1671-1683 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 10 Scopus citations

    Glioblastoma-derived IL6 induces immunosuppressive peripheral myeloid cell PD-L1 and promotes tumor growth

    Lamano, J. B., Lamano, J. B., Li, Y. D., DiDomenico, J. D., Choy, W., Veliceasa, D., Oyon, D. E., Fakurnejad, S., Ampie, L., Kesavabhotla, K., Kaur, R., Kaur, G., Biyashev, D., Unruh, D. J., Horbinski, C. M., James, C. D., Parsa, A. T. & Bloch, O., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3643-3657 15 p.

    Research output: Contribution to journalArticle

  • 14 Scopus citations