Charles David James

  • 22424 Citations
1984 …2024
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Personal profile

Research Interests

My primary research interest and activity involves the use of human brain tumor xenograft models for identifying effective therapeutics to treat brain tumor patients, as based on specific molecular characteristics of each patient’s tumor.

Training Experience

1989Postdoctoral Fellowship, McGill University, Canada

Education/Academic qualification

PhD, Wright State University School of Medicine

… → 1986

Research interests

  • Brain Cancer / Nervous System Cancer
  • Molecular Biology
  • Neuro-Oncology

Fingerprint Dive into the research topics where Charles David James is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 14 Similar Profiles
Glioblastoma Medicine & Life Sciences
Glioma Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Heterografts Medicine & Life Sciences
Epidermal Growth Factor Receptor Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
temozolomide Medicine & Life Sciences
Astrocytoma Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2024

Research Output 1984 2019

Activation of dopamine receptor 2 prompts transcriptomic and metabolic plasticity in glioblastoma

Caragher, S. P., Shireman, J. M., Huang, M., Miska, J. M., Atashi, F., Baisiwala, S., Park, C. H., Saathoff, M. R., Warnke, L., Xiao, T., Lesniak, M. S., James, C. D., Meltzer, H. Y., Tryba, A. K. & Ahmed, A. U., Mar 13 2019, In : Journal of Neuroscience. 39, 11, p. 1982-1993 12 p.

Research output: Contribution to journalArticle

Dopamine Receptors
Glioblastoma
Dopamine
Neurotransmitter Agents
Tumor Microenvironment
Open Access
Post Translational Protein Processing
Glioma
Histones
Immunohistochemistry
Pediatrics
3 Citations (Scopus)

Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis

Krenzlin, H., Behera, P., Lorenz, V., Passaro, C., Zdioruk, M., Nowicki, M. O., Grauwet, K., Zhang, H., Skubal, M., Ito, H., Zane, R., Gutknecht, M., Griessl, M. B., Ricklefs, F., Ding, L., Peled, S., Rooj, A., James, C. D., Cobbs, C. S., Cook, C. H. & 2 others, Antonio Chiocca, E. & Lawler, S. E., Apr 1 2019, In : Journal of Clinical Investigation. 129, 4, p. 1671-1683 13 p.

Research output: Contribution to journalArticle

Open Access
Muromegalovirus
Pericytes
Glioblastoma
Cytomegalovirus
Growth
1 Citation (Scopus)

Glioblastoma-derived IL6 induces immunosuppressive peripheral myeloid cell PD-L1 and promotes tumor growth

Lamano, J. B., Lamano, J. B., Li, Y. D., DiDomenico, J. D., Choy, W., Veliceasa, D., Oyon, D. E., Fakurnejad, S., Ampie, L., Kesavabhotla, K., Kaur, R., Kaur, G., Biyashev, D., Unruh, D. J., Horbinski, C. M., James, C. D., Parsa, A. T. & Bloch, O., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3643-3657 15 p.

Research output: Contribution to journalArticle

Myeloid Cells
Glioblastoma
Immunosuppressive Agents
Interleukin-6
Immunosuppression

Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S. K., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 1 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.

Research output: Contribution to journalArticle

Open Access
Ependymoma
Pediatrics
Histone Code
Neoplasms
Post Translational Protein Processing