Grants per year
Personal profile
Research Interests
My primary research interest and activity involves the use of human brain tumor xenograft models for identifying effective therapeutics to treat brain tumor patients, as based on specific molecular characteristics of each patient’s tumor.
Training Experience
| 1989 | Postdoctoral Fellowship, McGill University, Canada |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biomedical Sciences, Wright State University School of Medicine
… → 1986
Research interests keywords
- Brain Cancer / Nervous System Cancer
- Molecular Biology
- Neuro-Oncology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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SPORE for Translational Approaches to Brain Cancer
Lesniak, M. S. (PD/PI), Heimberger, A. B. (Co-Investigator) & James, C. D. (Co-Investigator)
8/1/23 → 7/31/28
Project: Research project
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Cellular Plasticity and equilibrium in GBM Progression
Ahmed, A. U. (PD/PI), Ahmed, A. U. (PD/PI), Ben-Sahra, I. (Co-Investigator), Ben-Sahra, I. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator), Miska, J. M. (Co-Investigator), Miska, J. M. (Co-Investigator), Zhang, H. (Other) & Zhang, H. (Other)
National Institute of Neurological Disorders and Stroke
7/15/22 → 5/31/27
Project: Research project
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Cysteine Depletion-induced Ferroptosis as a Therapeutic Vulnerability in Glioblastoma Temozolomide Resistance
Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Cheng, S.-Y. (PD/PI), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), Hu, B. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator) & James, C. D. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
6/15/22 → 4/30/25
Project: Research project
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Understanding the Behavior of Novel IL13Ralpha2-directed T cell Engager for GBM
Balyasnikova, I. V. (PD/PI), Balyasnikova, I. V. (PD/PI), Horbinski, C. M. (Co-Investigator), Horbinski, C. M. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator), Stupp, R. (Co-Investigator), Stupp, R. (Co-Investigator), Zhang, B. (Co-Investigator), Zhang, H. (Co-Investigator), Zhang, B. (Co-Investigator) & Zhang, H. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/1/21 → 3/31/26
Project: Research project
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Development of B-cell-based vaccine for Glioblastoma
Lee Chang, C. (PD/PI), Lee Chang, C. (PD/PI), Balyasnikova, I. V. (Co-Investigator), Balyasnikova, I. V. (Co-Investigator), James, C. D. (Co-Investigator), James, C. D. (Co-Investigator), Miska, J. M. (Co-Investigator) & Miska, J. M. (Co-Investigator)
3/15/21 → 2/28/26
Project: Research project
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Corrigendum: miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma
Kouri, F. M., Hurley, L. A., Daniel, W. L., Day, E. S., Hua, Y., Hao, L., Peng, C. Y., Merkel, T. J., Queisser, M. A., Ritner, C., Zhang, H., James, C. D., Sznajder, J. I., Chin, L., Giljohann, D. A., Kessler, J. A., Peter, M. E., Mirkin, C. A. & Stegh, A. H., Apr 1 2024, In: Genes & development. 38, 7-8, p. 355 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases
Fares, J., Petrosyan, E., Kanojia, D., Dmello, C., Cordero, A., Duffy, J. T., Yeeravalli, R., Sahani, M. H., Zhang, P., Rashidi, A., Arrieta, V. A., Ulasov, I., Ahmed, A. U., Miska, J., Balyasnikova, I. V., James, C. D., Sonabend, A. M., Heimberger, A. B. & Lesniak, M. S., Dec 1 2023, In: Journal of Clinical Investigation. 133, 24, e161142.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production
Perrault, E. N., Shireman, J. M., Ali, E. S., Lin, P., Preddy, I., Park, C., Budhiraja, S., Baisiwala, S., Dixit, K., James, C. D., Heiland, D. H., Ben-Sahra, I., Pott, S., Basu, A., Miska, J. & Ahmed, A. U., 2023, In: Science Advances. 9, 20, eade7236.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
WDR82-Mediated H3K4me3 Is Associated with Tumor Proliferation and Therapeutic Efficacy in Pediatric High-Grade Gliomas
Wadhwani, N., Nayak, S., Wang, Y., Hashizume, R., Jie, C., Mania-Farnell, B., James, C. D., Xi, G. & Tomita, T., Jul 2023, In: Cancers. 15, 13, 3429.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system
Wei, J., Song, R., Sabbagh, A., Marisetty, A., Shukla, N., Fang, D., Najem, H., Ott, M., Long, J., Zhai, L., Lesniak, M. S., James, C. D., Platanias, L., Curran, M. & Heimberger, A. B., 2022, In: OncoImmunology. 11, 1, 2062827.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations
Datasets
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Additional file 1: of Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease
Qi, J. (Contributor), Esfahani, D. R. (Contributor), Huang, T. (Contributor), Ozark, P. (Contributor), Bartom, E. (Contributor), Hashizume, R. (Contributor), Bonner, E. R. (Contributor), An, S. (Contributor), Horbinski, C. M. (Contributor), James, C. D. (Contributor) & Saratsis, A. M. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.8135906, https://springernature.figshare.com/articles/Additional_file_1_of_Tenascin-C_expression_contributes_to_pediatric_brainstem_glioma_tumor_phenotype_and_represents_a_novel_biomarker_of_disease/8135906
Dataset
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Additional file 2: Figure S1. of Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy
Xi, G. (Contributor), Li, Y. D. (Contributor), Grahovac, G. (Creator), Rajaram, V. (Creator), Wadhwani, N. (Contributor), Pundy, T. (Creator), Mania-Farnell, B. (Creator), James, C. D. (Creator) & Tomita, T. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3696475_d3, https://springernature.figshare.com/articles/figure/Additional_file_2_Figure_S1_of_Targeting_CD133_improves_chemotherapeutic_efficacy_of_recurrent_pediatric_pilocytic_astrocytoma_following_prolonged_chemotherapy/4670890
Dataset
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Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in GBM and GSCs
Huang, T. (Contributor), Alvarez, A. A. (Contributor), Pangeni, R. P. (Contributor), Shi, T. (Contributor), Sastry, N. (Contributor), Lu, S. (Contributor), Kessler, J. A. (Contributor), Nakano, I. (Contributor), Lu, X. (Contributor), James, C. D. (Contributor), Hu, B. (Contributor) & Cheng, S.-Y. (Contributor), Gene Expression Omnibus, Nov 25 2016
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90498
Dataset
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Additional file 3: Figure S2. of Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy
Xi, G. (Contributor), Li, Y. D. (Contributor), Grahovac, G. (Creator), Rajaram, V. (Creator), Wadhwani, N. (Contributor), Pundy, T. (Creator), Mania-Farnell, B. (Creator), James, C. D. (Creator) & Tomita, T. (Creator), figshare, 2017
DOI: 10.6084/m9.figshare.c.3696475_d2.v1, https://springernature.figshare.com/articles/figure/Additional_file_3_Figure_S2_of_Targeting_CD133_improves_chemotherapeutic_efficacy_of_recurrent_pediatric_pilocytic_astrocytoma_following_prolonged_chemotherapy/4670875/1
Dataset
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Tenascin-C expression contributes to pediatric brainstem glioma tumor phenotype and represents a novel biomarker of disease
Qi, J. (Contributor), Esfahani, D. R. (Contributor), Huang, T. (Contributor), Ozark, P. (Contributor), Bartom, E. (Contributor), Hashizume, R. (Contributor), Bonner, E. R. (Contributor), An, S. (Contributor), Horbinski, C. M. (Contributor), James, C. D. (Contributor) & Saratsis, A. M. (Contributor), figshare, 2019
DOI: 10.6084/m9.figshare.c.4506875, https://springernature.figshare.com/collections/Tenascin-C_expression_contributes_to_pediatric_brainstem_glioma_tumor_phenotype_and_represents_a_novel_biomarker_of_disease/4506875
Dataset