Charles David James

  • 22031 Citations
1984 …2023
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Personal profile

Research Interests

My primary research interest and activity involves the use of human brain tumor xenograft models for identifying effective therapeutics to treat brain tumor patients, as based on specific molecular characteristics of each patient’s tumor.

Training Experience

1989Postdoctoral Fellowship, McGill University, Canada

Education/Academic qualification

PhD, Wright State University School of Medicine

… → 1986

Keywords

  • Brain Cancer / Nervous System Cancer
  • Molecular Biology
  • Neuro-Oncology

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  • 21 Similar Profiles
Glioblastoma Medicine & Life Sciences
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Epidermal Growth Factor Receptor Medicine & Life Sciences
Brain Neoplasms Medicine & Life Sciences
temozolomide Medicine & Life Sciences
Astrocytoma Medicine & Life Sciences

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Grants 2014 2023

Glioblastoma
Brain Neoplasms
Therapeutics
Neoplasms
Survival

DTC Shared Resource

James, C. D.

National Cancer Institute

8/10/187/31/23

Project: Research project

Neoplasms
Medicine
Research
Population

Research Output 1984 2019

Open Access
Post Translational Protein Processing
Glioma
Histones
Immunohistochemistry
Pediatrics

Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis

Krenzlin, H., Behera, P., Lorenz, V., Passaro, C., Zdioruk, M., Nowicki, M. O., Grauwet, K., Zhang, H., Skubal, M., Ito, H., Zane, R., Gutknecht, M., Griessl, M. B., Ricklefs, F., Ding, L., Peled, S., Rooj, A., James, C. D., Cobbs, C. S., Cook, C. H. & 2 othersChiocca, E. A. & Lawler, S. E., Mar 11 2019, In : The Journal of clinical investigation. 130

Research output: Contribution to journalArticle

Open Access
Muromegalovirus
Pericytes
Glioblastoma
Cytomegalovirus
Growth
1 Citation (Scopus)

Glioblastoma-derived IL6 induces immunosuppressive peripheral myeloid cell PD-L1 and promotes tumor growth

Lamano, J. B., Lamano, J. B., Li, Y. D., DiDomenico, J. D., Choy, W., Veliceasa, D., Oyon, D. E., Fakurnejad, S., Ampie, L., Kesavabhotla, K., Kaur, R., Kaur, G., Biyashev, D., Unruh, D. J., Horbinski, C. M., James, C. D., Parsa, A. T. & Bloch, O., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3643-3657 15 p.

Research output: Contribution to journalArticle

Myeloid Cells
Glioblastoma
Immunosuppressive Agents
Interleukin-6
Immunosuppression

Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas

Lewis, R., Li, Y. D., Hoffman, L., Hashizume, R., Gravohac, G., Rice, G., Wadhwani, N. R., Jie, C., Pundy, T., Mania-Farnell, B., Mayanil, C. S. K., Soares, M. B., Lei, T., James, C. D., Foreman, N. K., Tomita, T. & Xi, G., Jun 1 2019, In : Neoplasia (United States). 21, 6, p. 505-515 11 p.

Research output: Contribution to journalArticle

Open Access
Ependymoma
Pediatrics
Histone Code
Neoplasms
Post Translational Protein Processing

High density is a property of slow-cycling and treatment-resistant human glioblastoma cells

Sabelström, H., Quigley, D. A., Fenster, T., Foster, D. J., Fuchshuber, C. A. M., Saxena, S., Yuan, E., Li, N., Paterno, F., Phillips, J. J., James, C. D., Norling, B., Berger, M. S. & Persson, A. I., May 1 2019, In : Experimental Cell Research. 378, 1, p. 76-86 11 p.

Research output: Contribution to journalArticle

Open Access
Glioblastoma
Cell Count
temozolomide
Therapeutics
Ionizing Radiation