Charles Lewis Goolsby

  • 2059 Citations
1988 …2020

Research output per year

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Personal profile

Research Interests

Clinical: Analytical flow cytometry. I am the Medical Director of Flow Cytometry Laboratory at Northwestern Memorial Hospital.

Research: The major research focus is on investigation of signal transduction abnormalities in hematopoietic malignancies at the individual cellular level with an emphasis on acute myeloid leukemia and myelodysplastic syndrome including both constitutive signal protein abnormalities and abnormal responses to myeloid growth factors and cytokines. These studies are centered on utilization, and development, of complex multi-parameter flow cytometry assays with the goal of developing cell based assays with diagnostic, prognostic or therapeutic monitoring application. These assays will provide potentially more sensitive and specific detection of minimal, or residual, disease post-therapy than current standard of practice. In addition, investigation of changing signal transduction responses to myeloid growth factors/cytokines during myeloid maturation, both granulocytic and monocytic, form a core aspect of these investigations and have revealed novel findings particular relevant to early monocytic maturation.

I am Director, Flow Cytometry Core Facility at the Robert Lurie Cancer Center of Feinberg School of Medicine.

Education/Academic qualification

PhD, Pennsylvania State University

… → 1985

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Signal Transduction

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Grants

Research Output

  • 2 Scopus citations
  • 9 Scopus citations

    Flow cytometric detection of altered signaling in myelodysplastic syndrome and cytopenia

    Gao, J., Swaminathan, S., Pai, N., Johnson, Z., Chen, Y-H., Peterson, L. C. & Goolsby, C. L., Jan 31 2015, In : Leukemia Research. 39, 12, p. 1396-1404 9 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Characterization of tissue findings in bone marrow biopsy specimens with small monoclonal B-cell populations

    Nelson, B. P., Abdul-Nabi, A., Goolsby, C., Winter, J. & Peterson, L. A., May 1 2014, In : American journal of clinical pathology. 141, 5, p. 687-696 10 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Clonality assessment of cutaneous B-Cell lymphoid proliferations: A comparison of flow cytometry immunophenotyping, molecular studies, and immunohistochemistry/in situ hybridization and review of the literature

    Schafernak, K. T., Variakojis, D., Goolsby, C. L., Tucker, R. M., Martínez-Escala, M. E., Smith, F. A., Dittman, D., Chenn, A. & Guitart, J., Jan 1 2014, In : American Journal of Dermatopathology. 36, 10, p. 781-795 15 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations