Charles Lewis Goolsby

  • 2033 Citations
1988 …2020
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Personal profile

Research Interests

Clinical: Analytical flow cytometry. I am the Medical Director of Flow Cytometry Laboratory at Northwestern Memorial Hospital.

Research: The major research focus is on investigation of signal transduction abnormalities in hematopoietic malignancies at the individual cellular level with an emphasis on acute myeloid leukemia and myelodysplastic syndrome including both constitutive signal protein abnormalities and abnormal responses to myeloid growth factors and cytokines. These studies are centered on utilization, and development, of complex multi-parameter flow cytometry assays with the goal of developing cell based assays with diagnostic, prognostic or therapeutic monitoring application. These assays will provide potentially more sensitive and specific detection of minimal, or residual, disease post-therapy than current standard of practice. In addition, investigation of changing signal transduction responses to myeloid growth factors/cytokines during myeloid maturation, both granulocytic and monocytic, form a core aspect of these investigations and have revealed novel findings particular relevant to early monocytic maturation.

I am Director, Flow Cytometry Core Facility at the Robert Lurie Cancer Center of Feinberg School of Medicine.

Education/Academic qualification

PhD, Pennsylvania State University

… → 1985

Research interests

  • Blood Cancer (leukemia and lymphomas)
  • Signal Transduction

Fingerprint Dive into the research topics where Charles Lewis Goolsby is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 16 Similar Profiles
Flow Cytometry Medicine & Life Sciences
B-Cell Chronic Lymphocytic Leukemia Medicine & Life Sciences
Immunophenotyping Medicine & Life Sciences
B-Lymphocytes Medicine & Life Sciences
Bone Marrow Medicine & Life Sciences
DNA Medicine & Life Sciences
Lymphoma Medicine & Life Sciences
Granulocyte-Macrophage Colony-Stimulating Factor Medicine & Life Sciences

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Grants 2001 2020

Research Output 1988 2017

2 Citations (Scopus)
Workload
Flow Cytometry
Surveys and Questionnaires
Costs and Cost Analysis
Health
9 Citations (Scopus)
Lymphoid Enhancer-Binding Factor 1
B-Cell Chronic Lymphocytic Leukemia
B-Cell Lymphoma
Fluorescence
Staining and Labeling
2 Citations (Scopus)

Flow cytometric detection of altered signaling in myelodysplastic syndrome and cytopenia

Gao, J., Swaminathan, S., Pai, N., Johnson, Z., Chen, Y-H., Peterson, L. C. & Goolsby, C. L., Jan 31 2015, In : Leukemia Research. 39, 12, p. 1396-1404 9 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Intercellular Signaling Peptides and Proteins
Stem Cell Factor
Phosphoproteins
Population
7 Citations (Scopus)

Characterization of tissue findings in bone marrow biopsy specimens with small monoclonal B-cell populations

Nelson, B. P., Abdul-Nabi, A., Goolsby, C. L., Winter, J. N. & Peterson, L. C., Jan 1 2014, In : American Journal of Clinical Pathology. 141, 5, p. 687-696 10 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Bone Marrow
Biopsy
Population
Lymphoma
11 Citations (Scopus)

Clonality assessment of cutaneous B-Cell lymphoid proliferations: A comparison of flow cytometry immunophenotyping, molecular studies, and immunohistochemistry/in situ hybridization and review of the literature

Schafernak, K. T., Variakojis, D., Goolsby, C. L., Tucker, R. M., Martínez-Escala, M. E., Smith, F. A., Dittman, D., Chenn, A. & Guitart, J., Jan 1 2014, In : American Journal of Dermatopathology. 36, 10, p. 781-795 15 p.

Research output: Contribution to journalArticle

Immunophenotyping
In Situ Hybridization
Flow Cytometry
B-Lymphocytes
Immunohistochemistry