Chi-Hao Luan

  • 1942 Citations
1984 …2021

Research output per year

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Research Output

2019

Antibacterial activity of 2-amino-4-hydroxypyrimidine-5-carboxylates and binding to Burkholderia pseudomallei 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase

Watkins, S. M., Ghose, D., Blain, J. M., Grote, D. L., Luan, C-H., Clare, M., Meganathan, R., Horn, J. R. & Hagen, T. J., Oct 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 20, 126660.

Research output: Contribution to journalArticle

Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System

Du, Z., Valtierra, S., Cardona, L. R., Dunne, S. F., Luan, C. H. & Li, L., Dec 19 2019, In : Cell Chemical Biology. 26, 12, p. 1664-1680.e4

Research output: Contribution to journalArticle

Unique structural features of a bacterial autotransporter adhesin suggest mechanisms for interaction with host macromolecules

Paxman, J. J., Lo, A. W., Sullivan, M. J., Panjikar, S., Kuiper, M., Whitten, A. E., Wang, G., Luan, C. H., Moriel, D. G., Tan, L., Peters, K. M., Phan, M. D., Gee, C. L., Ulett, G. C., Schembri, M. A. & Heras, B., Dec 1 2019, In : Nature communications. 10, 1, 1967.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory

Patel, D., Roy, A., Kundu, M., Jana, M., Luan, C. H., Gonzalez, F. J. & Pahan, K., Jul 31 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7408-E7417

Research output: Contribution to journalArticle

10 Scopus citations

Selective disruption of TLR2/MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology

Rangasamy, S. B., Jana, M., Roy, A., Corbett, G. T., Kundu, M., Chandra, S., Mondal, S., Dasarathi, S., Mufson, E. J., Mishra, R. K., Luan, C-H., Bennett, D. A. & Pahan, K., Jul 10 2018, In : The Journal of clinical investigation.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Retraction: Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus (Nature Communications (2016) 7 (11000) DOI: 10.1038/ncomms11000)

Ji, Q., Chen, P. J., Qin, G., Deng, X., Hao, Z., Wawrzak, Z., Yeo, W. S., Quang, J. W., Cho, H., Luo, G. Z., Weng, X., You, Q., Luan, C. H., Yang, X., Bae, T., Yu, K., Jiang, H. & He, C., Feb 6 2017, In : Nature communications. 8, 14331.

Research output: Contribution to journalComment/debate

2 Scopus citations

Tsg101 chaperone function revealed by HIV-1 assembly inhibitors

Strickland, M., Ehrlich, L. S., Watanabe, S., Khan, M., Strub, M. P., Luan, C. H., Powell, M. D., Leis, J., Tjandra, N. & Carter, C. A., Dec 1 2017, In : Nature Communications. 8, 1, 1391.

Research output: Contribution to journalArticle

7 Scopus citations
2016

A Genome-wide RNAi Screen for Microtubule Bundle Formation and Lysosome Motility Regulation in Drosophila S2 Cells

Jolly, A. L., Luan, C. H., Dusel, B. E., Dunne, S. F., Winding, M., Dixit, V. J., Robins, C., Saluk, J. L., Logan, D. J., Carpenter, A. E., Sharma, M., Dean, D., Cohen, A. R. & Gelfand, V. I., Jan 26 2016, In : Cell reports. 14, 3, p. 611-620 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance

Filippova, E. V., Kieser, K. J., Luan, C. H., Wawrzak, Z., Kiryukhina, O., Rubin, E. J. & Anderson, W. F., Jun 1 2016, In : FEBS Journal. p. 2206-2218 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2

Manjasetty, B. A., Halavaty, A. S., Luan, C. H., Osipiuk, J., Mulligan, R., Kwon, K., Anderson, W. F. & Joachimiak, A., Jun 1 2016, In : Data in Brief. 7, p. 537-539 3 p.

Research output: Contribution to journalArticle

Identification and characterization of PPARα ligands in the hippocampus

Roy, A., Kundu, M., Jana, M., Mishra, R. K., Yung, Y., Luan, C. H., Gonzalez, F. J. & Pahan, K., Dec 1 2016, In : Nature Chemical Biology. 12, 12, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Loop-to-helix transition in the structure of multidrug regulator AcrR at the entrance of the drug-binding cavity

Manjasetty, B. A., Halavaty, A. S., Luan, C-H., Osipiuk, J., Mulligan, R., Kwon, K., Anderson, W. F. & Joachimiak, A., 2016, In : Journal of Structural Biology. Available online

Research output: Contribution to journalArticle

5 Scopus citations

Method for identifying small molecule inhibitors of the protein-protein interaction between HCN1 and TRIP8b

Han, Y., Lyman, K. A., Clutter, M., Schiltz, G. E., Ismail, Q. A., Cheng, X., Luan, C. H. & Chetkovich, D. M., Nov 11 2016, In : Journal of Visualized Experiments. 2016, 117, e54540.

Research output: Contribution to journalArticle

3 Scopus citations

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Ji, Q., Chen, P. J., Qin, G., Deng, X., Hao, Z., Wawrzak, Z., Yeo, W. S., Quang, J. W., Cho, H., Luo, G. Z., Weng, X., You, Q., Luan, C. H., Yang, X., Bae, T., Yu, K., Jiang, H. & He, C., Mar 18 2016, In : Nature Communications. 7, 11000.

Research output: Contribution to journalArticle

13 Scopus citations

The role of Fas-associated phosphatase 1 in leukemia stem cell persistence during tyrosine kinase inhibitor treatment of chronic myeloid leukemia

Huang, W., Luan, C. H., Hjort, E. E., Bei, L., Mishra, R., Sakamoto, K. M., Platanias, L. C. & Eklund, E. A., Jul 1 2016, In : Leukemia. 30, 7, p. 1502-1509 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

Roy, A., Jana, M., Kundu, M., Corbett, G. T., Rangaswamy, S. B., Mishra, R. K., Luan, C-H., Gonzalez, F. J. & Pahan, K., Aug 4 2015, In : Cell Metabolism. 22, 2, p. 253-265 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Identification of small-molecule inhibitors of hyperpolarization-activated cyclic nucleotide-gated channels

Han, Y., Lyman, K., Clutter, M., Schiltz, G. E., Ismail, Q. A., Prados, D. B., Luan, C. H. & Chetkovich, D. M., Oct 22 2015, In : Journal of Biomolecular Screening. 20, 9, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Wang, J., Luo, C., Shan, C., You, Q., Lu, J., Elf, S., Zhou, Y., Wen, Y., Vinkenborg, J. L., Fan, J., Kang, H., Lin, R., Han, D., Xie, Y., Karpus, J., Chen, S., Ouyang, S., Luan, C., Zhang, N., Ding, H. & 5 others, Merkx, M., Liu, H., Chen, J., Jiang, H. & He, C., Dec 1 2015, In : Nature chemistry. 7, 12, p. 968-979 12 p.

Research output: Contribution to journalArticle

74 Scopus citations

Nanoscale synaptic membrane mimetic allows unbiased high throughput screen that targets binding sites for Alzheimer's-associated Aβ oligomers

Wilcox, K. C., Marunde, M. R., Das, A., Velasco, P. T., Kuhns, B. D., Marty, M. T., Jiang, H., Luan, C. H., Sligar, S. G. & Klein, W. L., Apr 1 2015, In : PLoS One. 10, 4, e0125263.

Research output: Contribution to journalArticle

19 Scopus citations

Novel high content screen detects compounds that promote neurite regeneration from cochlear spiral ganglion neurons

Whitlon, D. S., Grover, M., Dunne, S. F., Richter, S., Luan, C. H. & Richter, C. P., Nov 2 2015, In : Scientific reports. 5, 15960.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Ligand screening using fluorescence thermal shift analysis (FTS)

Luan, C. H., Light, S. H., Dunne, S. F. & Anderson, W. F., Jan 1 2014, In : Methods in Molecular Biology. 1140, p. 263-289 27 p.

Research output: Contribution to journalArticle

7 Scopus citations
2 Scopus citations
2013

A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4

Krishna, S. N., Luan, C. H., Mishra, R. K., Xu, L., Scheidt, K. A., Anderson, W. F. & Bergan, R. C., Dec 5 2013, In : PloS one. 8, 12, e81504.

Research output: Contribution to journalArticle

22 Scopus citations

Antagonism of L-type Ca2+ channels CaV1.3 and Ca V1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics

Kang, S., Cooper, G., Dunne, S. F., Luan, C-H., Surmeier Jr, D. J. & Silverman, R. B., Jul 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 14, p. 4365-4373 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
16 Scopus citations

Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential

Jiao, L., Ouyang, S., Liang, M., Niu, F., Shaw, N., Wu, W., Ding, W., Jin, C., Peng, Y., Zhu, Y., Zhang, F., Wang, T., Li, C., Zuo, X., Luan, C. H., Li, D. & Liu, Z. J., Jun 1 2013, In : Journal of virology. 87, 12, p. 6829-6839 11 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease

Kang, S., Cooper, G., Dunne, S. F., Dusel, B., Luan, C. H., Surmeier, D. J. & Silverman, R. B., Nov 26 2012, In : Nature communications. 3, 1146.

Research output: Contribution to journalArticle

87 Scopus citations

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H. B., Seo, J. H., Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T. L., Jin, P., Alečković, M., LeRoy, G., Kang, Y., Sudderth, J. A., DeBerardinis, R. J., Luan, C. H., Chen, G. Z., Muller, S. & 12 others, Shin, D. M., Owonikoko, T. K., Lonial, S., Arellano, M. L., Khoury, H. J., Khuri, F. R., Lee, B. H., Ye, K., Boggon, T. J., Kang, S., He, C. & Chen, J., Nov 13 2012, In : Cancer Cell. 22, 5, p. 585-600 16 p.

Research output: Contribution to journalArticle

174 Scopus citations
2011

High-throughput screen for identifying small molecules that target fungal zinc homeostasis

Simm, C., Luan, C. H., Weiss, E. & O'Halloran, T., Sep 29 2011, In : PloS one. 6, 9, e25136.

Research output: Contribution to journalArticle

20 Scopus citations

Targeting MgrA-mediated virulence regulation in Staphylococcus aureus

Sun, F., Zhou, L., Zhao, B. C., Deng, X., Cho, H., Yi, C., Jian, X., Song, C. X., Luan, C-H., Bae, T., Li, Z. & He, C., Aug 26 2011, In : Chemistry and Biology. 18, 8, p. 1032-1041 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels CaV1.3 and CaV1.2

Chang, C. C., Cao, S., Kang, S., Kai, L., Tian, X., Pandey, P., Dunne, S. F., Luan, C. H., Surmeier, D. J. & Silverman, R. B., May 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 9, p. 3147-3158 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2009

Elastic, Plastic, and Hydrogel-forming Protein-based Polymers

Urry, D. W. & Luan, C-H., 2009, Polymer Data Handbook, 2nd ed. Oxford University Press

Research output: Chapter in Book/Report/Conference proceedingChapter

2008

A high throughput platform for eukaryotic genes.

Chen, Y., Qiu, S., Luan, C. H. & Luo, M., Jan 1 2008, In : Methods in molecular biology (Clifton, N.J.). 426, p. 209-220 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2007

Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: Amide- and ether-linked tethered dimers with α-amino acid end groups

Velu, S. E., Mou, L., Luan, C. H., Yang, Z. W., DeLucas, L. J., Brouillette, C. G. & Brouillette, W. J., May 31 2007, In : Journal of Medicinal Chemistry. 50, 11, p. 2612-2621 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins

Chen, Y., Qiu, S., Luan, C. H. & Luo, M., Jul 30 2007, In : BMC Biotechnology. 7, 45.

Research output: Contribution to journalArticle

6 Scopus citations
2005

Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases

Ganesh, V. K., Muller, N., Judge, K., Luan, C. H., Padmanabhan, R. & Murthy, K. H. M., Jan 3 2005, In : Bioorganic and Medicinal Chemistry. 13, 1, p. 257-264 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Improving solubility of Shewanella oneidensis MR-1 and Clostridium thermocellum JW-20 proteins expressed into Esherichia coli

Kataeva, I., Chang, J., Xu, H., Luan, C. H., Zhou, J., Uversky, V. N., Lin, D., Horanyi, P., Liu, Z. J., Ljungdahl, L. G., Rose, J., Luo, M. & Wang, B. C., Nov 1 2005, In : Journal of Proteome Research. 4, 6, p. 1942-1951 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Protein production and crystallization at SECSG - An overview

Wang, B. C., Adams, M. W. W., Dailey, H., DeLucas, L., Luo, M., Rose, J., Bunzel, R., Dailey, T., Habel, J., Horanyi, P., Jenney, F. E., Kataeva, I., Lee, H. S., Li, S., Li, T., Lin, D., Liu, Z. J., Luan, C. H., Mayer, M., Nagy, L. & 7 others, Newton, M. G., Ng, J., Poole, F. L., Shah, A., Shah, C., Sugar, F. J. & Xu, H., Sep 1 2005, In : Journal of Structural and Functional Genomics. 6, 2-3, p. 233-243 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Tethered dimer inhibitors of NAD synthetase: Parallel synthesis of an aryl-substituted SAR library

Velu, S. E., Luan, C. H., DeLucas, L. J., Brouillette, C. G. & Brouillette, W. J., Nov 1 2005, In : Journal of Combinatorial Chemistry. 7, 6, p. 898-904 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2004

High-throughput expression of C. elegans proteins

Luan, C. H., Qiu, S., Finley, J. B., Carson, M., Gray, R. J., Huang, W., Johnson, D., Tsao, J., Reboul, J., Vaglio, P., Hill, D. E., Vidal, M., DeLucas, L. L. & Luo, M., Oct 2004, In : Genome research. 14, 10 B, p. 2102-2110 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

Structural genomics for Caenorhabditis elegans: High throughput protein expression analysis

Finley, J. B., Qiu, S. H., Luan, C. H. & Luo, M., Jan 1 2004, In : Protein Expression and Purification. 34, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Structural genomics of Caenorhabditis elegans: Structure of the BAG domain

Symersky, J., Zhang, Y., Schormann, N., Li, S., Bunzel, R., Pruett, P., Luan, C. H. & Luo, M., Sep 1 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 9, p. 1606-1610 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2003

Structural Genomics of Caenorhabditis elegans: Structure of Dihydropteridine Reductase

Symersky, J., Li, S., Carson, M., Luo, D., Luan, C. H. & Luo, M., Dec 1 2003, In : Proteins: Structure, Function and Genetics. 53, 4, p. 944-946 3 p.

Research output: Contribution to journalArticle

3 Scopus citations

Tethered dimers as NAD synthetase inhibitors with antibacterial activity

Velu, S. E., Cristofoli, W. A., Garcia, G. J., Brouillette, C. G., Pierson, M. C., Luan, C. H., DeLucas, L. J. & Brouillette, W. J., Jul 17 2003, In : Journal of Medicinal Chemistry. 46, 15, p. 3371-3381 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2002

Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain

Li, S., Finley, J., Liu, Z. J., Qiu, S. H., Chen, H., Luan, C. H., Carson, M., Tsao, J., Johnson, D., Lin, G., Zhao, J., Thomas, W., Nagy, L. A., Sha, B., DeLucas, L. J., Wang, B. C. & Luo, M., Dec 13 2002, In : Journal of Biological Chemistry. 277, 50, p. 48596-48601 6 p.

Research output: Contribution to journalArticle

80 Scopus citations
2 Scopus citations

Identification of the N-terminal functional domains of Cdk5 by molecular truncation and computer modeling

Zhang, J., Luan, C. H., Chou, K. C. & Johnson, G. V. W., Aug 15 2002, In : Proteins: Structure, Function and Genetics. 48, 3, p. 447-453 7 p.

Research output: Contribution to journalArticle

83 Scopus citations
1999

Elastic, Plastic, and Hydrogel Protein-based Polymers

Luan, C-H. & Urry, D. W., 1999, Polymer Data Handbook. Mark, J. E. (ed.). Oxford University Press, p. 78-89

Research output: Chapter in Book/Report/Conference proceedingChapter

1997

Protein-based Materials with a Profound Range of Properties and Applications: The Elastin ΔTt Hydrophobic Paradigm

Urry, D. W., Luan, C-H., Harris, C. M. & Parker, T. M., 1997, Protein-Based Materials. McGrath, K. & Kaplan, D. (eds.). Birkhäuser, Boston, p. 133-178

Research output: Chapter in Book/Report/Conference proceedingChapter