• 3809 Citations
19982023
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Personal profile

Research Interests

Dr. Stehlik research focuses on the inflammatory response to infection and tissue damage. A particular focus is on the molecular mechanisms regulating these responses in macrophages, utilizing bacterial and viral infection models and models of autoinflammatory and autoimmune disease.

Education/Academic qualification

PhD, University of Vienna

… → 1999

Research interests

  • Inflammation

Fingerprint Dive into the research topics where Christian Stehlik is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 15 Similar Profiles
Inflammasomes Medicine & Life Sciences
Caspase 1 Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
Proteins Medicine & Life Sciences
Interleukin-1 Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Cytokines Medicine & Life Sciences
Chemical activation Chemical Compounds

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Grants 2007 2023

Lung Injury
Monocytes
Transplantation
Tissue Donors
Primary Graft Dysfunction
Intermediate Filaments
Acute Lung Injury
Lung Injury
Influenza A virus
Human Influenza
Pattern Recognition Receptors
Proteins
Inflammasomes
Innate Immunity
Transgenic Mice

Research Output 1998 2018

9 Citations (Scopus)

COPs and POPs Patrol Inflammasome Activation

Indramohan, M., Stehlik, C. & Dorfleutner, A., Jan 19 2018, In : Journal of Molecular Biology. 430, 2, p. 153-173 21 p.

Research output: Contribution to journalReview article

Inflammasomes
Proteins
Cytokines
Pattern Recognition Receptors
Interleukin-18
6 Citations (Scopus)

Lysosomal cholesterol hydrolysis couples efferocytosis to anti-inflammatory oxysterol production

Viaud, M., Ivanov, S., Vujic, N., Duta-Mare, M., Aira, L. E., Barouillet, T., Garcia, E., Orange, F., Dugail, I., Hainault, I., Stehlik, C., Marchetti, S., Boyer, L., Guinamard, R., Foufelle, F., Bochem, A., Hovingh, K. G., Thorp, E. B., Gautier, E. L., Kratky, D. & 2 others, Dasilva-Jardine, P. & Yvan-Charvet, L., May 1 2018, In : Circulation research. 122, 10, p. 1369-1384 16 p.

Research output: Contribution to journalArticle

Sterol Esterase
Hydrolysis
Anti-Inflammatory Agents
Cholesterol
Macrophages
21 Citations (Scopus)

The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages

Chu, L. H., Indramohan, M., Ratsimandresy, R. A., Gangopadhyay, A., Morris, E. P., Monack, D. M., Dorfleutner, A. & Stehlik, C., Dec 1 2018, In : Nature communications. 9, 1, 996.

Research output: Contribution to journalArticle

Inflammasomes
macrophages
Phosphorylcholine
Macrophages
Septic Shock
7 Citations (Scopus)

TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Bhattacharyya, S., Wang, W., Qin, W., Cheng, K., Coulup, S., Chavez, S., Jiang, S., Raparia, K., De Almeida, L. M. V., Stehlik, C., Tamaki, Z., Yin, H. & Varga, J., Jul 12 2018, In : JCI Insight. 3, 13

Research output: Contribution to journalArticle

Open Access
Systemic Scleroderma
Fibrosis
Fibroblasts
Lung
Skin
3 Citations (Scopus)

Bim suppresses the development of SLE by limiting myeloid inflammatory responses

Tsai, F. N., Homan, P. J., Agrawal, H., Misharin, A., Abdala-Valencia, H., Haines, G. K., Dominguez, S., Bloomfield, C. L., Saber, R., Chang, A., Mohan, C., Hutcheson, J., Davidson, A., Budinger, GR. S., Bouillet, P., Dorfleutner, A., Stehlik, C., Winter, D. R., Cuda, C. M. & Perlman, H. R., Dec 1 2017, In : Journal of Experimental Medicine. 214, 12, p. 3753-3773 21 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Macrophages
Glomerulonephritis
Kidney
Interferon Type I