Grants per year
Personal profile
Research Interests
My work focuses on studying the effects of ALK2 mutations on Diffuse Intrinsic Pontine Glioma, a lethal pediatric brain tumor that affects approximately 200-300 children per year. Through the use of genetically engineered mouse models, we are currently investigating the mechanism underlying ALK2 mutations on tumor biology and determining whether such mutations can be used as therapeutic targets for treating the disease.
My academic focus is to continue to improve our mouse models of DIPG so that we can more effectively screen possible treatments for children.
N/A
Training Experience
| 2016 | Postdoctoral Fellowship, Duke University |
Education/Academic qualification
PhD, University of Missouri
… → 2012
Research interests
- Cancer Biology
- Cancer Genetics
- Neuro-Oncology
- Pediatric Oncology
- Pediatrics
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Grants
- 1 Finished
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Functional Dissection of EZH2 in Diffuse Intrinsic Pontine Glioma
1/1/17 → 5/31/19
Project: Research project
Research Output
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ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In: Nature communications. 10, 1, 1023.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
A new IRF-1–driven apoptotic pathway triggered by IL-4/IL-13 kills neonatal Th1 cells and weakens protection against viral infection
Miller, M. M., Barik, S., Cattin-Roy, A. N., Ukah, T. K., Hoeman, C. M. & Zaghouani, H., Jun 1 2019, In: Journal of Immunology. 202, 11, p. 3173-3186 14 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma
Hoeman, C., Shen, C. & Becher, O. J., May 31 2018, In: Frontiers in Oncology. 8, MAY, 191.Research output: Contribution to journal › Review article › peer-review
6 Scopus citations -
A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent
Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In: PloS one. 10, 3, e0118926.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Children are not just little adults: Recent advances in understanding of diffuse intrinsic pontine glioma biology
Schroeder, K. M., Hoeman, C. M. & Becher, O. J., Jan 1 2014, In: Pediatric Research. 75, 1-2, p. 205-209 5 p.Research output: Contribution to journal › Review article › peer-review
38 Scopus citations