Grants per year
Personal profile
Research Interests
N/A
My work focuses on studying the effects of ALK2 mutations on Diffuse Intrinsic Pontine Glioma, a lethal pediatric brain tumor that affects approximately 200-300 children per year. Through the use of genetically engineered mouse models, we are currently investigating the mechanism underlying ALK2 mutations on tumor biology and determining whether such mutations can be used as therapeutic targets for treating the disease.
My academic focus is to continue to improve our mouse models of DIPG so that we can more effectively screen possible treatments for children.
Training Experience
| 2016 | Postdoctoral Fellowship, Duke University |
Education/Academic qualification
PhD, University of Missouri
… → 2012
Keywords
- Cancer Biology
- Cancer Genetics
- Neuro-Oncology
- Pediatric Oncology
- Pediatrics
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Network
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Grants 2017 2020
- 1 Active
Functional Dissection of EZH2 in Diffuse Intrinsic Pontine Glioma
1/1/17 → 12/31/20
Project: Research project
Glioma
Dissection
Neoplasms
Genes
Genetic Models
Research Output 2008 2019
ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.Research output: Contribution to journal › Article
pathogenesis
Glioma
Tumors
tumors
mutations
1
Citation
(Scopus)
CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma
Hoeman, C. M., Shen, C. & Becher, O. J., May 31 2018, In : Frontiers in Oncology. 8, MAY, 191.Research output: Contribution to journal › Review article
Glioma
Gene Transfer Techniques
Manuscripts
Standard of Care
Brain Neoplasms
24
Citations
(Scopus)
A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent
Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In : PloS one. 10, 3, e0118926.Research output: Contribution to journal › Article
Glioma
animal models
Throughput
drugs
therapeutics
27
Citations
(Scopus)
Children are not just little adults: Recent advances in understanding of diffuse intrinsic pontine glioma biology
Schroeder, K. M., Hoeman, C. M. & Becher, O. J., Jan 1 2014, In : Pediatric Research. 75, 1-2, p. 205-209 5 p.Research output: Contribution to journal › Review article
Glioma
Phosphatidylinositol 3-Kinase
Platelet-Derived Growth Factor Receptors
Mutation
Pons
229
Citations
(Scopus)
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
Buczkowicz, P., Hoeman, C., Rakopoulos, P., Pajovic, S., Letourneau, L., Dzamba, M., Morrison, A., Lewis, P., Bouffet, E., Bartels, U., Zuccaro, J., Agnihotri, S., Ryall, S., Barszczyk, M., Chornenkyy, Y., Bourgey, M., Bourque, G., Montpetit, A., Cordero, F., Castelo-Branco, P. & 32 others, Jan 1 2014, In : Nature Genetics. 46, 5, p. 451-456 6 p.Research output: Contribution to journal › Article
Glioma
Mutation
Brain Neoplasms
Histones
Activin Receptors