Christine Marie Hoeman

  • 825 Citations
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Personal profile

Research Interests


My work focuses on studying the effects of ALK2 mutations on Diffuse Intrinsic Pontine Glioma, a lethal pediatric brain tumor that affects approximately 200-300 children per year. Through the use of genetically engineered mouse models, we are currently investigating the mechanism underlying ALK2 mutations on tumor biology and determining whether such mutations can be used as therapeutic targets for treating the disease.

My academic focus is to continue to improve our mouse models of DIPG so that we can more effectively screen possible treatments for children.

Training Experience

2016Postdoctoral Fellowship, Duke University

Education/Academic qualification

PhD, University of Missouri

… → 2012


  • Cancer Biology
  • Cancer Genetics
  • Neuro-Oncology
  • Pediatric Oncology
  • Pediatrics

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Grants 2017 2020

Genetic Models

Research Output 2008 2019

  • 825 Citations
  • 18 Article
  • 3 Review article

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

1 Citation (Scopus)

CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma

Hoeman, C. M., Shen, C. & Becher, O. J., May 31 2018, In : Frontiers in Oncology. 8, MAY, 191.

Research output: Contribution to journalReview article

Gene Transfer Techniques
Standard of Care
Brain Neoplasms
24 Citations (Scopus)

A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In : PloS one. 10, 3, e0118926.

Research output: Contribution to journalArticle

animal models
27 Citations (Scopus)

Children are not just little adults: Recent advances in understanding of diffuse intrinsic pontine glioma biology

Schroeder, K. M., Hoeman, C. M. & Becher, O. J., Jan 1 2014, In : Pediatric Research. 75, 1-2, p. 205-209 5 p.

Research output: Contribution to journalReview article

Phosphatidylinositol 3-Kinase
Platelet-Derived Growth Factor Receptors
229 Citations (Scopus)

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Buczkowicz, P., Hoeman, C., Rakopoulos, P., Pajovic, S., Letourneau, L., Dzamba, M., Morrison, A., Lewis, P., Bouffet, E., Bartels, U., Zuccaro, J., Agnihotri, S., Ryall, S., Barszczyk, M., Chornenkyy, Y., Bourgey, M., Bourque, G., Montpetit, A., Cordero, F., Castelo-Branco, P. & 32 othersMangerel, J., Tabori, U., Ho, K. C., Huang, A., Taylor, K. R., Mackay, A., Bendel, A. E., Nazarian, J., Fangusaro, J. R., Karajannis, M. A., Zagzag, D., Foreman, N. K., Donson, A., Hegert, J. V., Smith, A., Chan, J., Lafay-Cousin, L., Dunn, S., Hukin, J., Dunham, C., Scheinemann, K., Michaud, J., Zelcer, S., Ramsay, D., Cain, J., Brennan, C., Souweidane, M. M., Jones, C., Allis, C. D., Brudno, M., Becher, O. & Hawkins, C., Jan 1 2014, In : Nature Genetics. 46, 5, p. 451-456 6 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Activin Receptors