Christine Marie Hoeman

  • 853 Citations
20082020
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Personal profile

Research Interests

My work focuses on studying the effects of ALK2 mutations on Diffuse Intrinsic Pontine Glioma, a lethal pediatric brain tumor that affects approximately 200-300 children per year. Through the use of genetically engineered mouse models, we are currently investigating the mechanism underlying ALK2 mutations on tumor biology and determining whether such mutations can be used as therapeutic targets for treating the disease.

My academic focus is to continue to improve our mouse models of DIPG so that we can more effectively screen possible treatments for children.

N/A

Training Experience

2016Postdoctoral Fellowship, Duke University

Education/Academic qualification

PhD, University of Missouri

… → 2012

Research interests

  • Cancer Biology
  • Cancer Genetics
  • Neuro-Oncology
  • Pediatric Oncology
  • Pediatrics

Fingerprint Dive into the research topics where Christine Marie Hoeman is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Grants 2017 2020

Glioma
Dissection
Neoplasms
Genes
Genetic Models

Research Output 2008 2019

  • 853 Citations
  • 19 Article
  • 3 Review article
3 Citations (Scopus)

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

pathogenesis
Glioma
Tumors
tumors
mutations

A new IRF-1–driven apoptotic pathway triggered by IL-4/IL-13 kills neonatal Th1 cells and weakens protection against viral infection

Miller, M. M., Barik, S., Cattin-Roy, A. N., Ukah, T. K., Hoeman, C. M. & Zaghouani, H., Jun 1 2019, In : Journal of Immunology. 202, 11, p. 3173-3186 14 p.

Research output: Contribution to journalArticle

Th1 Cells
Cytoprotection
Interleukin-13
Virus Diseases
Interleukin-4
1 Citation (Scopus)

CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma

Hoeman, C. M., Shen, C. & Becher, O. J., May 31 2018, In : Frontiers in Oncology. 8, MAY, 191.

Research output: Contribution to journalReview article

Glioma
Gene Transfer Techniques
Manuscripts
Standard of Care
Brain Neoplasms
27 Citations (Scopus)

A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In : PloS one. 10, 3, e0118926.

Research output: Contribution to journalArticle

Glioma
animal models
Throughput
drugs
therapeutics
27 Citations (Scopus)

Children are not just little adults: Recent advances in understanding of diffuse intrinsic pontine glioma biology

Schroeder, K. M., Hoeman, C. M. & Becher, O. J., Jan 1 2014, In : Pediatric Research. 75, 1-2, p. 205-209 5 p.

Research output: Contribution to journalReview article

Glioma
Phosphatidylinositol 3-Kinase
Platelet-Derived Growth Factor Receptors
Mutation
Pons