Grants per year
Personal profile
Research Interests
My work focuses on studying the effects of ALK2 mutations on Diffuse Intrinsic Pontine Glioma, a lethal pediatric brain tumor that affects approximately 200-300 children per year. Through the use of genetically engineered mouse models, we are currently investigating the mechanism underlying ALK2 mutations on tumor biology and determining whether such mutations can be used as therapeutic targets for treating the disease.
My academic focus is to continue to improve our mouse models of DIPG so that we can more effectively screen possible treatments for children.
N/A
Training Experience
| 2016 | Postdoctoral Fellowship, Duke University |
Education/Academic qualification
PhD, University of Missouri
… → 2012
Research interests
- Cancer Biology
- Cancer Genetics
- Neuro-Oncology
- Pediatric Oncology
- Pediatrics
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Medicine & Life Sciences
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Interleukin-13 Receptors
Medicine & Life Sciences
Type 1 Diabetes Mellitus
Medicine & Life Sciences
Immunity
Medicine & Life Sciences
Dendritic Cells
Medicine & Life Sciences
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 2017 2020
- 1 Active
Functional Dissection of EZH2 in Diffuse Intrinsic Pontine Glioma
1/1/17 → 12/31/20
Project: Research project
Glioma
Dissection
Neoplasms
Genes
Genetic Models
Research Output 2008 2019
4
Citations
(Scopus)
ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Dec 1 2019, In : Nature communications. 10, 1, 1023.Research output: Contribution to journal › Article
pathogenesis
Glioma
Tumors
tumors
mutations
A new IRF-1–driven apoptotic pathway triggered by IL-4/IL-13 kills neonatal Th1 cells and weakens protection against viral infection
Miller, M. M., Barik, S., Cattin-Roy, A. N., Ukah, T. K., Hoeman, C. M. & Zaghouani, H., Jun 1 2019, In : Journal of Immunology. 202, 11, p. 3173-3186 14 p.Research output: Contribution to journal › Article
Th1 Cells
Cytoprotection
Interleukin-13
Virus Diseases
Interleukin-4
3
Citations
(Scopus)
CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma
Hoeman, C. M., Shen, C. & Becher, O. J., May 31 2018, In : Frontiers in Oncology. 8, MAY, 191.Research output: Contribution to journal › Review article
Glioma
Gene Transfer Techniques
Manuscripts
Standard of Care
Brain Neoplasms
27
Citations
(Scopus)
A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent
Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In : PloS one. 10, 3, e0118926.Research output: Contribution to journal › Article
Glioma
animal models
Throughput
drugs
therapeutics
27
Citations
(Scopus)
Children are not just little adults: Recent advances in understanding of diffuse intrinsic pontine glioma biology
Schroeder, K. M., Hoeman, C. M. & Becher, O. J., Jan 1 2014, In : Pediatric Research. 75, 1-2, p. 205-209 5 p.Research output: Contribution to journal › Review article
Glioma
Phosphatidylinositol 3-Kinase
Platelet-Derived Growth Factor Receptors
Mutation
Pons