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Christine Marie Hoeman

  • 919 Citations
20082019

Research output per year

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Personal profile

Research Interests

My work focuses on studying the effects of ALK2 mutations on Diffuse Intrinsic Pontine Glioma, a lethal pediatric brain tumor that affects approximately 200-300 children per year. Through the use of genetically engineered mouse models, we are currently investigating the mechanism underlying ALK2 mutations on tumor biology and determining whether such mutations can be used as therapeutic targets for treating the disease.

My academic focus is to continue to improve our mouse models of DIPG so that we can more effectively screen possible treatments for children.

N/A

Training Experience

2016Postdoctoral Fellowship, Duke University

Education/Academic qualification

PhD, University of Missouri

… → 2012

Research interests

  • Cancer Biology
  • Cancer Genetics
  • Neuro-Oncology
  • Pediatric Oncology
  • Pediatrics

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Grants

Functional Dissection of EZH2 in Diffuse Intrinsic Pontine Glioma

Becher, O. J. & Hoeman, C. M.

American Cancer Society

1/1/17 → 5/31/19

Project: Research project

    • Research Output

    • 919 Citations
    • 19 Article
    • 3 Review article

    ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

    Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In : Nature communications. 10, 1, 1023.

    Research output: Contribution to journal › Article

    • 11 Scopus citations

    A new IRF-1–driven apoptotic pathway triggered by IL-4/IL-13 kills neonatal Th1 cells and weakens protection against viral infection

    Miller, M. M., Barik, S., Cattin-Roy, A. N., Ukah, T. K., Hoeman, C. M. & Zaghouani, H., Jun 1 2019, In : Journal of Immunology. 202, 11, p. 3173-3186 14 p.

    Research output: Contribution to journal › Article

    • CDK4/6 and PDGFRA signaling as therapeutic targets in diffuse intrinsic pontine glioma

    Hoeman, C., Shen, C. & Becher, O. J., May 31 2018, In : Frontiers in Oncology. 8, MAY, 191.

    Research output: Contribution to journal › Review article

    • 4 Scopus citations

    A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

    Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In : PloS one. 10, 3, e0118926.

    Research output: Contribution to journal › Article

    • 29 Scopus citations

    Children are not just little adults: Recent advances in understanding of diffuse intrinsic pontine glioma biology

    Schroeder, K. M., Hoeman, C. M. & Becher, O. J., Jan 1 2014, In : Pediatric Research. 75, 1-2, p. 205-209 5 p.

    Research output: Contribution to journal › Review article

    • 30 Scopus citations