Christine Marie Hoeman

  • 876 Citations
20082019
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Research Output 2008 2019

  • 876 Citations
  • 19 Article
  • 3 Review article
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Article
2019
6 Citations (Scopus)

ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis

Hoeman, C. M., Cordero, F. J., Hu, G., Misuraca, K., Romero, M. M., Cardona, H. J., Nazarian, J., Hashizume, R., McLendon, R., Yu, P., Procissi, D., Gadd, S. L. & Becher, O. J., Mar 4 2019, In : Nature communications. 10, 1, 1023.

Research output: Contribution to journalArticle

pathogenesis
Glioma
Tumors
tumors
mutations

A new IRF-1–driven apoptotic pathway triggered by IL-4/IL-13 kills neonatal Th1 cells and weakens protection against viral infection

Miller, M. M., Barik, S., Cattin-Roy, A. N., Ukah, T. K., Hoeman, C. M. & Zaghouani, H., Jun 1 2019, In : Journal of Immunology. 202, 11, p. 3173-3186 14 p.

Research output: Contribution to journalArticle

Th1 Cells
Cytoprotection
Interleukin-13
Virus Diseases
Interleukin-4
2015
27 Citations (Scopus)

A high-throughput in Vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

Halvorson, K. G., Barton, K. L., Schroeder, K., Misuraca, K. L., Hoeman, C., Chung, A., Crabtree, D. M., Cordero, F. J., Singh, R., Spasojevic, I., Berlow, N., Pal, R. & Becher, O. J., Mar 6 2015, In : PloS one. 10, 3, e0118926.

Research output: Contribution to journalArticle

Glioma
animal models
Throughput
drugs
therapeutics
2014
251 Citations (Scopus)

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Buczkowicz, P., Hoeman, C., Rakopoulos, P., Pajovic, S., Letourneau, L., Dzamba, M., Morrison, A., Lewis, P., Bouffet, E., Bartels, U., Zuccaro, J., Agnihotri, S., Ryall, S., Barszczyk, M., Chornenkyy, Y., Bourgey, M., Bourque, G., Montpetit, A., Cordero, F., Castelo-Branco, P. & 32 others, Mangerel, J., Tabori, U., Ho, K. C., Huang, A., Taylor, K. R., Mackay, A., Bendel, A. E., Nazarian, J., Fangusaro, J. R., Karajannis, M. A., Zagzag, D., Foreman, N. K., Donson, A., Hegert, J. V., Smith, A., Chan, J., Lafay-Cousin, L., Dunn, S., Hukin, J., Dunham, C., Scheinemann, K., Michaud, J., Zelcer, S., Ramsay, D., Cain, J., Brennan, C., Souweidane, M. M., Jones, C., Allis, C. D., Brudno, M., Becher, O. & Hawkins, C., Jan 1 2014, In : Nature Genetics. 46, 5, p. 451-456 6 p.

Research output: Contribution to journalArticle

Glioma
Mutation
Brain Neoplasms
Histones
Activin Receptors
21 Citations (Scopus)

IL-13Rα1 is a surface marker for M2 macrophages influencing their differentiation and function

Dhakal, M., Hardaway, J. C., Guloglu, F. B., Miller, M. M., Hoeman, C. M., Zaghouani, A. A., Wan, X., Rowland, L. M., Cascio, J. A., Sherman, M. P. & Zaghouani, H., Jan 1 2014, In : European Journal of Immunology. 44, 3, p. 842-855 14 p.

Research output: Contribution to journalArticle

Interleukin-13 Receptors
Macrophages
Cell Differentiation
Phenotype
Zymosan
2013
3 Citations (Scopus)

Antigen-free adjuvant assists late effector CD4 t cells to transit to memory in lymphopenic hosts

Guloglu, F. B., Ellis, J. S., Wan, X., Dhakal, M., Hoeman, C. M., Cascio, J. A. & Zaghouani, H., Aug 1 2013, In : Journal of Immunology. 191, 3, p. 1126-1135 10 p.

Research output: Contribution to journalArticle

Antigens
T-Lymphocytes
T-Lymphoid Precursor Cells
Cell Death
Vaccines
8 Citations (Scopus)

Developmental expression of IL-12Rβ2 on murine naive neonatal T cells counters the upregulation of IL-13Rα1 on primary Th1 cells and balances immunity in the newborn

Hoeman, C. M., Dhakal, M., Zaghouani, A. A., Cascio, J. A., Wan, X., Khairallah, M. T., Chen, W. & Zaghouani, H., Jun 15 2013, In : Journal of Immunology. 190, 12, p. 6155-6163 9 p.

Research output: Contribution to journalArticle

Th1 Cells
Immunity
Up-Regulation
Interleukin-12
T-Lymphocytes
10 Citations (Scopus)

Recovery from overt type 1 diabetes ensues when immune tolerance and β-Cell formation are coupled with regeneration of endothelial cells in the pancreatic islets

Wan, X., Guloglu, F. B., VanMorlan, A. M., Rowland, L. M., Zaghouani, S., Cascio, J. A., Dhakal, M., Hoeman, C. M. & Zaghouani, H., Aug 1 2013, In : Diabetes. 62, 8, p. 2879-2889 11 p.

Research output: Contribution to journalArticle

Immune Tolerance
Type 1 Diabetes Mellitus
Islets of Langerhans
Regeneration
Endothelial Cells
2012
11 Citations (Scopus)

Bone marrow-derived IL-13Ra1-positive thymic progenitors are restricted to the myeloid lineage

Haymaker, C. L., Guloglu, F. B., Cascio, J. A., Hardaway, J. C., Dhakal, M., Wan, X., Hoeman, C. M., Zaghouani, S., Rowland, L. M., Tartar, D. M., VanMorlan, A. M. & Zaghouani, H., Apr 1 2012, In : Journal of Immunology. 188, 7, p. 3208-3216 9 p.

Research output: Contribution to journalArticle

Myeloid Cells
Bone Marrow
T-Lymphocytes
Myeloid Progenitor Cells
Phagocytes
15 Citations (Scopus)

Mechanisms underlying antigen-specific tolerance of stable and convertible Th17 cells during suppression of autoimmune diabetes

Wan, X., Guloglu, F. B., VanMorlan, A. M., Rowland, L. M., Jain, R., Haymaker, C. L., Cascio, J. A., Dhakal, M., Hoeman, C. M., Tartar, D. M. & Zaghouani, H., Aug 1 2012, In : Diabetes. 61, 8, p. 2054-2065 12 p.

Research output: Contribution to journalArticle

Th17 Cells
Type 1 Diabetes Mellitus
Antigens
Th1 Cells
Plastics
2011
11 Citations (Scopus)

T cell dynamics during induction of tolerance and suppression of experimental allergic encephalomyelitis

Divekar, R. D., Haymaker, C. L., Cascio, J. A., Guloglu, B. F., Ellis, J. S., Tartar, D. M., Hoeman, C. M., Franklin, C. L., Zinselmeyer, B. H., Lynch, J. N., Miller, M. J. & Zaghouani, H., Oct 15 2011, In : Journal of Immunology. 187, 8, p. 3979-3986 8 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Myelin-Oligodendrocyte Glycoprotein
T-Lymphocytes
Dendritic Cells
Th2 Cells
2010
5 Citations (Scopus)

APCs expressing high levels of programmed death ligand 2 sustain the development of CD4 T cell memory

Ellis, J. S., Betul Guloglu, F., Tartar, D. M., Hoeman, C. M., Haymaker, C. L., Cascio, J. A., Wan, X., Dhakal, M., VanMorlan, A., Yahng, S. H. & Zaghouani, H., Sep 15 2010, In : Journal of Immunology. 185, 6, p. 3149-3157 9 p.

Research output: Contribution to journalArticle

Ligands
T-Lymphocytes
Death Domain Receptors
Dendritic Cells
Vaccination
58 Citations (Scopus)

FoxP3+RORγt+ T helper intermediates display suppressive function against autoimmune diabetes

Tartar, D. M., VanMorlan, A. M., Wan, X., Guloglu, F. B., Jain, R., Haymaker, C. L., Ellis, J. S., Hoeman, C. M., Cascio, J. A., Dhakal, M., Oukka, M. & Zaghouani, H., Apr 1 2010, In : Journal of Immunology. 184, 7, p. 3377-3385 9 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
T-Lymphocytes
Th17 Cells
Inflammation
Inbred NOD Mouse
4 Citations (Scopus)

Overcoming dendritic cell tardiness to triumph over IL-13 receptor: a strategy for the development of effective pediatric vaccines.

Hoeman, C., Dhakal, M. & Zaghouani, H., Jan 1 2010, In : Discovery medicine. 9, 49, p. 554-559 6 p.

Research output: Contribution to journalArticle

Interleukin-13 Receptors
Th1 Cells
Interleukin-13 Receptor alpha1 Subunit
Dendritic Cells
Th2 Cells
2008
96 Citations (Scopus)

Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity

Lee, H. H., Hoeman, C. M., Hardaway, J. C., Guloglu, F. B., Ellis, J. S., Jain, R., Divekar, R., Tartar, D. M., Haymaker, C. L. & Zaghouani, H., Sep 29 2008, In : Journal of Experimental Medicine. 205, 10, p. 2269-2280 12 p.

Research output: Contribution to journalArticle

Interleukin-13 Receptors
Th1 Cells
Interleukin-12
Dendritic Cells
Immunity
7 Citations (Scopus)

Early effector T cells producing significant IFN-γ develop into memory

Bell, J. J., Ellis, J. S., Guloglu, F. B., Tartar, D. M., Lee, H. H., Divekar, R. D., Jain, R., Yu, P., Hoeman, C. M. & Zaghouani, H., Jan 1 2008, In : Journal of Immunology. 180, 1, p. 179-187 9 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Lymphoid Tissue
Cytokines
14 Citations (Scopus)

Fetal exposure to high-avidity TCR ligand enhances expansion of peripheral T regulatory cells

Yu, P., Haymaker, C. L., Divekar, R. D., Ellis, J. S., Hardaway, J., Jain, R., Tartar, D. M., Hoeman, C. M., Cascio, J. A., Ostermeier, A. & Zaghouani, H., Jan 1 2008, In : Journal of Immunology. 181, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

Proteolipids
Regulatory T-Lymphocytes
Ligands
T-Lymphocytes
Epitopes
140 Citations (Scopus)

Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

Jain, R., Tartar, D. M., Gregg, R. K., Divekar, R. D., Bell, J. J., Lee, H. H., Yu, P., Ellis, J. S., Hoeman, C. M., Franklin, C. L. & Zaghouani, H., Jan 21 2008, In : Journal of Experimental Medicine. 205, 1, p. 207-218 12 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Interleukin-17
Type 1 Diabetes Mellitus
Interferons
Th17 Cells
3 Citations (Scopus)

In trans T cell tolerance diminishes autoantibody responses and exacerbates experimental allergic encephalomyelitis

Bell, J. J., Divekar, R. D., Ellis, J. S., Cascio, J. A., Haymaker, C. L., Jain, R., Tartar, D. M., Hoeman, C. M., Hardaway, J. C. & Zaghouani, H., Feb 1 2008, In : Journal of Immunology. 180, 3, p. 1508-1516 9 p.

Research output: Contribution to journalArticle

Myelin-Oligodendrocyte Glycoprotein
Autoimmune Experimental Encephalomyelitis
Autoantibodies
T-Lymphocytes
Proteolipids