Grants per year
Personal profile
Research Interests
My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.
Education/Academic qualification
Biology, PhD, Georgia Tech
… → 2008
Research interests keywords
- Biophysics
- Epilepsy
- Neurobiology
- Pharmacology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Project 2 - George
George, A. L. (PD/PI), Guemez Gamboa, A. D. (Co-Investigator), Guemez Gamboa, A. D. (Co-Investigator), Simmons, C. (Co-Investigator), Thompson, C. H. (Co-Investigator) & George, A. L. (Other)
National Institute of Mental Health
5/1/24 → 2/28/29
Project: Research project
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Cellular Pathophysiology of Neuronal Na/K-ATPase Dysfunction
George, A. L. (PD/PI), George, A. L. (PD/PI), Thompson, C. H. (Co-Investigator) & Thompson, C. H. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
6/15/22 → 4/30/27
Project: Research project
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Genetic Modifiers of Childhood Epilepsy
Kearney, J. A. (PD/PI), Kearney, J. A. (PD/PI), Kearney, J. A. (PD/PI), Hawkins, N. A. (Co-Investigator), Hawkins, N. A. (Co-Investigator), Hawkins, N. A. (Co-Investigator), Thompson, C. H. (Co-Investigator), Thompson, C. H. (Co-Investigator) & Thompson, C. H. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/1/20 → 12/31/25
Project: Research project
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Effects of XPC-5462, NBI921353, NBI921354, and NBI921355 on SCN2A (NaV1.2) gain-of-function (GOF) variants (hereinafter "Project")
George, A. L. (PD/PI) & Thompson, C. H. (Co-Investigator)
3/28/22 → 3/31/23
Project: Research project
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Effects of PRAX-562 on sodium current and excitability of neurons from a Scn2aQ54 gain-of-function mouse
George, A. L. (PD/PI), Kearney, J. A. (Co-Investigator) & Thompson, C. H. (Co-Investigator)
Praxis Precision Medicines, Inc.
10/13/21 → 9/30/22
Project: Research project
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Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
Kang, S. K., Hawkins, N. A., Thompson, C. H., Baker, E. M., Echevarria-Cooper, D. M., Barse, L., Thenstedt, T., Dixon, C. J., Speakes, N., George, A. L. & Kearney, J. A., May 2024, In: Neurobiology of Disease. 194, 106470.Research output: Contribution to journal › Article › peer-review
Open Access -
Exome sequencing of ATP1A3-negative cases of alternating hemiplegia of childhood reveals SCN2A as a novel causative gene
Panagiotakaki, E., Tiziano, F. D., Mikati, M. A., Vijfhuizen, L. S., Nicole, S., Lesca, G., Abiusi, E., Novelli, A., Di Pietro, L., Harder, A. V. E., Walley, N. M., De Grandis, E., Poulat, A. L., Portes, V. D., Lépine, A., Nassogne, M. C., Arzimanoglou, A., Vavassori, R., Koenderink, J. & Thompson, C. H. & 4 others, , Feb 2024, In: European Journal of Human Genetics. 32, 2, p. 224-231 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Molecular and cellular context influences SCN8A variant function
Vanoye, C. G., Abramova, T. V., DeKeyser, J. M., Ghabra, N. F., Oudin, M. J., Burge, C. B., Helbig, I., Thompson, C. H. & George, A. L., 2024, In: JCI Insight. 9, 12, e177530.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties
Thompson, C. H., Potet, F., Abramova, T. V., DeKeyser, J. M., Ghabra, N. F., Vanoye, C. G., Millichap, J. J. & George, A. L., Oct 2 2023, In: Journal of General Physiology. 155, 10, e202313375.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing
Pablo, J. L. B., Cornett, S. L., Wang, L. A., Jo, S., Brünger, T., Budnik, N., Hegde, M., DeKeyser, J. M., Thompson, C. H., Doench, J. G., Lal, D., George, A. L. & Pan, J. Q., Jun 27 2023, In: Cell reports. 42, 6, 112563.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations