Christopher Hal Thompson

Personal profile

Research Interests

My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.

Education/Academic qualification

PhD, Georgia Institute of Technology

… → 2008

Research interests

Biophysics
Epilepsy
Neurobiology
Pharmacology

Fingerprint Dive into the research topics where Christopher Hal Thompson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

7 Similar Profiles

Sodium Medicine & Life Sciences

Myoclonic Epilepsy Medicine & Life Sciences

Chloride Channels Medicine & Life Sciences

Epilepsy Medicine & Life Sciences

Brain Diseases Medicine & Life Sciences

Sodium Channels Medicine & Life Sciences

Neurons Medicine & Life Sciences

Cystic Fibrosis Transmembrane Conductance Regulator Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2023

5 Finished
7 Active

Tandem Genetically Encoded Voltage and Calcium Indicator Mice for Optical Physiology of Excitable Cells

Thompson, C. H.

Office of the Director, National Institutes of Health

2/1/19 → 1/31/21

Project: Research project

Cell Physiological Phenomena

Calcium

Epilepsy

Biophysics

Benchmarking

Development and investigation of murine models of channelopathy-associated epilepsy

Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

National Institute of Neurological Disorders and Stroke

9/30/18 → 8/31/23

Project: Research project

Channelopathies

Epilepsy

Ion Channels

Neurons

Genes

High-throughput functional evaluation of ion channel variants in epilepsy

George Jr, A. L., Thompson, C. H. & Vanoye, C. G.

National Institute of Neurological Disorders and Stroke

9/30/18 → 8/31/23

Project: Research project

Ion Channels

Channelopathies

Epilepsy

Neurons

Genes

Functional Annotation of a Comprehensive Set of SCN2A Variants

George Jr, A. L. & Thompson, C. H.

Broad Institute, Inc., National Institute of Neurological Disorders and Stroke

9/15/18 → 8/31/20

Project: Research project

Amino Acid Substitution

Mutagenesis

Alleles

Genotype

Genome

Animal Models for SCN2A Neurodevelopmental Disorders

Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

Office of the Director, National Institutes of Health

8/1/18 → 7/31/20

Project: Research project

Animal Models

Epilepsy

Phenotype

Intellectual Disability

Brain Diseases

Research Output 2005 2020

563 Citations
18 Article
1 Review article

Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

Thompson, C. H., Ben-Shalom, R., Bender, K. J. & George, A. L., Mar 2 2020, In : The Journal of general physiology. 152, 3

Research output: Contribution to journal › Article

Open Access

Alternative Splicing

Brain Diseases

Protein Isoforms

NAV1.2 Voltage-Gated Sodium Channel

Epilepsy

Functional consequences of a KCNT1 variant associated with status dystonicus and early-onset infantile encephalopathy

Gertler, T. S., Thompson, C. H., Vanoye, C. G., Millichap, J. J. & George, A. L., Sep 1 2019, In : Annals of clinical and translational neurology. 6, 9, p. 1606-1615 10 p.

Research output: Contribution to journal › Article

Open Access

Dystonia

Brain Diseases

Electrophysiology

Movement Disorders

Cricetulus

5 Citations (Scopus)

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

Simmons, C. Q., Thompson, C. H., Cawthon, B. E., Westlake, G., Swoboda, K. J., Kiskinis, E., Ess, K. C. & George, A. L., Jul 2018, In : Neurobiology of Disease. 115, p. 29-38 10 p.

Research output: Contribution to journal › Article

Neurons

Induced Pluripotent Stem Cells

Membrane Potentials

Mutation

Evoked Potentials

7 Citations (Scopus)

SCN1A variants associated with sudden infant death syndrome

Brownstein, C. A., Goldstein, R. D., Thompson, C. H., Haynes, R. L., Giles, E., Sheidley, B., Bainbridge, M., Haas, E. A., Mena, O. J., Lucas, J., Schaber, B., Holm, I. A., George, A. L., Kinney, H. C. & Poduri, A. H., Apr 2018, In : Epilepsia. 59, 4, p. e56-e62

Research output: Contribution to journal › Article

Sudden Infant Death

Epilepsy

Exome

Seizures

Genes

15 Citations (Scopus)

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

Baker, E. M., Thompson, C. H., Hawkins, N. A., Wagnon, J. L., Wengert, E. R., Patel, M. K., George, A. L., Meisler, M. H. & Kearney, J. A., Jun 2018, In : Epilepsia. 59, 6, p. 1166-1176 11 p.

Research output: Contribution to journal › Article

Sodium Channels

Brain Diseases

Sodium

Seizures

Phenytoin