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Christopher Hal Thompson

  • 602 Citations
20052020

Research output per year

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Personal profile

Research Interests

My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.

Education/Academic qualification

PhD, Georgia Institute of Technology

… → 2008

Research interests

  • Biophysics
  • Epilepsy
  • Neurobiology
  • Pharmacology

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Grants

Tandem Genetically Encoded Voltage and Calcium Indicator Mice for Optical Physiology of Excitable Cells

Thompson, C. H.

Office of the Director, National Institutes of Health

2/1/19 → 1/31/21

Project: Research project

    • Development and investigation of murine models of channelopathy-associated epilepsy

    Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

    National Institute of Neurological Disorders and Stroke

    9/30/18 → 8/31/23

    Project: Research project

    • High-throughput functional evaluation of ion channel variants in epilepsy

    George Jr, A. L., Thompson, C. H. & Vanoye, C. G.

    National Institute of Neurological Disorders and Stroke

    9/30/18 → 8/31/23

    Project: Research project

    • Functional Annotation of a Comprehensive Set of SCN2A Variants

    George Jr, A. L. & Thompson, C. H.

    Broad Institute, Inc., National Institute of Neurological Disorders and Stroke

    9/15/18 → 8/31/20

    Project: Research project

    • Animal Models for SCN2A Neurodevelopmental Disorders

    Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

    Office of the Director, National Institutes of Health

    8/1/18 → 7/31/20

    Project: Research project

    • Research Output

    • 602 Citations
    • 18 Article
    • 1 Review article

    Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants

    Thompson, C. H., Ben-Shalom, R., Bender, K. J. & George, A. L., Mar 2 2020, In : Journal of General Physiology. 152, 3, 201912442.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Functional consequences of a KCNT1 variant associated with status dystonicus and early-onset infantile encephalopathy

    Gertler, T. S., Thompson, C. H., Vanoye, C. G., Millichap, J. J. & George, A. L., Sep 1 2019, In : Annals of clinical and translational neurology. 6, 9, p. 1606-1615 10 p.

    Research output: Contribution to journal › Article

    Open Access
    • 2 Scopus citations

    Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

    Simmons, C. Q., Thompson, C. H., Cawthon, B. E., Westlake, G., Swoboda, K. J., Kiskinis, E., Ess, K. C. & George, A. L., Jul 2018, In : Neurobiology of Disease. 115, p. 29-38 10 p.

    Research output: Contribution to journal › Article

    • 9 Scopus citations

    SCN1A variants associated with sudden infant death syndrome

    Brownstein, C. A., Goldstein, R. D., Thompson, C. H., Haynes, R. L., Giles, E., Sheidley, B., Bainbridge, M., Haas, E. A., Mena, O. J., Lucas, J., Schaber, B., Holm, I. A., George, A. L., Kinney, H. C. & Poduri, A. H., Apr 2018, In : Epilepsia. 59, 4, p. e56-e62

    Research output: Contribution to journal › Article

    • 9 Scopus citations

    The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

    Baker, E. M., Thompson, C. H., Hawkins, N. A., Wagnon, J. L., Wengert, E. R., Patel, M. K., George, A. L., Meisler, M. H. & Kearney, J. A., Jun 2018, In : Epilepsia. 59, 6, p. 1166-1176 11 p.

    Research output: Contribution to journal › Article

    • 17 Scopus citations