Grants per year
Personal profile
Research Interests
My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.
Education/Academic qualification
Biology, PhD, Georgia Tech
… → 2008
Research interests keywords
- Biophysics
- Epilepsy
- Neurobiology
- Pharmacology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Cellular Pathophysiology of Neuronal Na/K-ATPase Dysfunction
George, A. L., George, A. L., Thompson, C. H. & Thompson, C. H.
National Institute of Neurological Disorders and Stroke
6/15/22 → 4/30/27
Project: Research project
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Genetic Modifiers of Childhood Epilepsy
Kearney, J. A., Kearney, J. A., Hawkins, N. A., Hawkins, N. A., Thompson, C. H. & Thompson, C. H.
National Institute of Neurological Disorders and Stroke
4/1/20 → 12/31/24
Project: Research project
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Effects of PRAX-562 on sodium current and excitability of neurons from a Scn2aQ54 gain-of-function mouse
George, A. L., Kearney, J. A. & Thompson, C. H.
Praxis Precision Medicines, Inc.
10/13/21 → 9/30/22
Project: Research project
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Rescuing Neuronal Function by Gene Therapy in Alternating Hemiplegia of Childhood
George, A. L., Thompson, C. H. & Simmons, C.
3/1/21 → 6/30/22
Project: Research project
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Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties
Thompson, C. H., Potet, F., Abramova, T. V., DeKeyser, J. M., Ghabra, N. F., Vanoye, C. G., Millichap, J. J. & George, A. L., Oct 2 2023, In: Journal of General Physiology. 155, 10, e202313375.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing
Pablo, J. L. B., Cornett, S. L., Wang, L. A., Jo, S., Brünger, T., Budnik, N., Hegde, M., DeKeyser, J. M., Thompson, C. H., Doench, J. G., Lal, D., George, A. L. & Pan, J. Q., Jun 27 2023, In: Cell reports. 42, 6, 112563.Research output: Contribution to journal › Article › peer-review
Open Access -
Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422Emice
Echevarria-Cooper, D. M., Hawkins, N. A., Misra, S. N., Huffman, A. M., Thaxton, T., Thompson, C. H., Ben-Shalom, R., Nelson, A. D., Lipkin, A. M., George, A. L., Bender, K. J. & Kearney, J. A., Sep 1 2022, In: Human molecular genetics. 31, 17, p. 2964-2988 25 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria
DeKeyser, J. M., Thompson, C. H. & George, A. L., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100298.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Enhanced slow inactivation contributes to dysfunction of a recurrent SCN2A mutation associated with developmental and epileptic encephalopathy
Ganguly, S., Thompson, C. H. & George, A. L., Sep 15 2021, In: Journal of physiology. 599, 18, p. 4375-4388 14 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations