Christopher Hal Thompson

Personal profile

Research Interests

My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.

Education/Academic qualification

PhD, Georgia Tech

… → 2008

Research interests

Biophysics
Epilepsy
Neurobiology
Pharmacology

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2023

5 Active
7 Finished

Tandem Genetically Encoded Voltage and Calcium Indicator Mice for Optical Physiology of Excitable Cells

Thompson, C. H.

Office of the Director, National Institutes of Health

2/1/19 → 1/31/21

Project: Research project

Cell Physiological Phenomena

Calcium

Epilepsy

Biophysics

Benchmarking

High-throughput functional evaluation of ion channel variants in epilepsy

George Jr, A. L., Thompson, C. H. & Vanoye, C. G.

National Institute of Neurological Disorders and Stroke

9/30/18 → 8/31/23

Project: Research project

Ion Channels

Channelopathies

Epilepsy

Neurons

Genes

Development and investigation of murine models of channelopathy-associated epilepsy

Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

National Institute of Neurological Disorders and Stroke

9/30/18 → 8/31/23

Project: Research project

Channelopathies

Epilepsy

Ion Channels

Neurons

Genes

Animal Models for SCN2A Neurodevelopmental Disorders

Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

Office of the Director, National Institutes of Health

8/1/18 → 7/31/20

Project: Research project

Animal Models

Epilepsy

Phenotype

Intellectual Disability

Brain Diseases

Genetic Modifiers of Childhood Epilepsy

George Jr, A. L., Kearney, J. A. & Thompson, C. H.

National Institute of Neurological Disorders and Stroke

9/1/14 → 6/30/20

Project: Research project

Epilepsy

Modifier Genes

Phenotype

Myoclonic Epilepsy

Voltage-Gated Sodium Channels

Research Output 2005 2018

508 Citations
15 Article
1 Review article

4 Citations (Scopus)

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

Simmons, C. Q., Thompson, C. H., Cawthon, B. E., Westlake, G., Swoboda, K. J., Kiskinis, E., Ess, K. C. & George Jr, A. L., Jul 1 2018, In : Neurobiology of Disease. 115, p. 29-38 10 p.

Research output: Contribution to journal › Article

Neurons

Induced Pluripotent Stem Cells

Membrane Potentials

Mutation

Evoked Potentials

3 Citations (Scopus)

SCN1A variants associated with sudden infant death syndrome

Brownstein, C. A., Goldstein, R. D., Thompson, C. H., Haynes, R. L., Giles, E., Sheidley, B., Bainbridge, M., Haas, E. A., Mena, O. J., Lucas, J., Schaber, B., Holm, I. A., George Jr, A. L., Kinney, H. C. & Poduri, A. H., Apr 1 2018, In : Epilepsia. 59, 4, p. e56-e62

Research output: Contribution to journal › Article

Sudden Infant Death

Epilepsy

Exome

Seizures

Genes

7 Citations (Scopus)

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

Baker, E. M., Thompson, C. H., Hawkins, N. A., Wagnon, J. L., Wengert, E. R., Patel, M. K., George Jr, A. L., Meisler, M. H. & Kearney, J. A., Jun 1 2018, In : Epilepsia. 59, 6, p. 1166-1176 11 p.

Research output: Contribution to journal › Article

Sodium Channels

Brain Diseases

Sodium

Seizures

Phenytoin

9 Citations (Scopus)