Grants per year
Personal profile
Research Interests
My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.
Education/Academic qualification
Biology, PhD, Georgia Tech
… → 2008
Research interests
- Biophysics
- Epilepsy
- Neurobiology
- Pharmacology
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Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Cellular Pathophysiology of Neuronal Na/K-ATPase Dysfunction
George, A. L. & Thompson, C. H.
National Institute of Neurological Disorders and Stroke
6/15/22 → 4/30/27
Project: Research project
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Development and investigation of murine models of channelopathy-associated epilepsy
Hawkins, N. A., Thompson, C. H. & Kearney, J. A.
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
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High-throughput functional evaluation of ion channel variants in epilepsy
George, A. L., Thompson, C. H. & Vanoye, C. G.
National Institute of Neurological Disorders and Stroke
9/30/18 → 8/31/23
Project: Research project
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Effects of PRAX-562 on sodium current and excitability of neurons from a Scn2aQ54 gain-of-function mouse
George, A. L., Kearney, J. A. & Thompson, C. H.
Praxis Precision Medicines, Inc.
10/13/21 → 4/12/22
Project: Research project
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Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice
Echevarria-Cooper, D. M., Hawkins, N. A., Misra, S. N., Huffman, A. M., Thaxton, T., Thompson, C. H., Ben-Shalom, R., Nelson, A. D., Lipkin, A. M., George, A. L., Bender, K. J. & Kearney, J. A., Aug 25 2022, In: Human molecular genetics. 31, 17, p. 2964-2988 25 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria
DeKeyser, J. M., Thompson, C. H. & George, A. L., Jan 1 2021, In: Journal of Biological Chemistry. 296, 100298.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Enhanced slow inactivation contributes to dysfunction of a recurrent SCN2A mutation associated with developmental and epileptic encephalopathy
Ganguly, S., Thompson, C. H. & George, A. L., Sep 15 2021, In: Journal of Physiology. 599, 18, p. 4375-4388 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Functional evaluation of human ion channel variants using automated electrophysiology
Vanoye, C. G., Thompson, C. H., Desai, R. R., DeKeyser, J. M., Chen, L., Rasmussen-Torvik, L. J., Welty, L. J. & George, A. L., Jan 2021, Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function. Minor, D. L. & Colecraft, H. M. (eds.). Academic Press Inc, p. 383-405 23 p. (Methods in Enzymology; vol. 654).Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Scopus citations -
Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants
Thompson, C. H., Ben-Shalom, R., Bender, K. J. & George, A. L., Mar 2 2020, In: Journal of General Physiology. 152, 3, 201912442.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations