Personal profile

Research Interests

My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.

Education / Academic qualification

PhD, Georgia Tech

… → 2008

Keywords

  • Epilepsy
  • Neurobiology
  • Pharmacology
  • Biophysics

Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Research Output 2005 2018

  • 403 Citations
  • 13 Article
  • 1 Review article

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

Simmons, C. Q., Thompson, C. H., Cawthon, B. E., Westlake, G., Swoboda, K. J., Kiskinis, E., Ess, K. C. & George, A. L. Jul 1 2018 In : Neurobiology of Disease. 115, p. 29-38 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Neurons
Membrane Potentials
Mutation
Evoked Potentials
5 Citations
Calcium-Calmodulin-Dependent Protein Kinases
Protein Kinases
Sodium
Epilepsy
Neurons
6 Citations

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Anderson, L. L., Hawkins, N. A., Thompson, C. H., Kearney, J. A. & George, A. L. Dec 1 2017 In : Scientific Reports. 7, 1, 1682

Research output: Contribution to journalArticle

Myoclonic Epilepsy
Sodium Channels
Pyramidal Cells
Sodium Channel Blockers
Sodium

Watch out, no brakes! impaired inhibition results in hyperexcitable networks

Thompson, C. H. & Kearney, J. A. Jan 1 2015 In : Epilepsy Currents. 15, 6, p. 342-343 2 p.

Research output: Contribution to journalArticle

15 Citations

Antiepileptic activity of preferential inhibitors of persistent sodium current

Anderson, L. L., Thompson, C. H., Hawkins, N. A., Nath, R. D., Petersohn, A. A., Rajamani, S., Bush, W. S., Frankel, W. N., Vanoye, C. G., Kearney, J. A. & George, A. L. Jan 1 2014 In : Epilepsia. 55, 8, p. 1274-1283 10 p.

Research output: Contribution to journalArticle

Anticonvulsants
Sodium
Seizures
Electroshock
Hippocampal Mossy Fibers