Grants per year
Personal profile
Research Interests
My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biology, PhD, Georgia Tech
… → 2008
Research interests keywords
- Biophysics
- Epilepsy
- Neurobiology
- Pharmacology
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Project 2 - George
George, A. L. (PD/PI), Guemez Gamboa, A. D. (Co-Investigator), Guemez Gamboa, A. D. (Co-Investigator), Simmons, C. (Co-Investigator), Thompson, C. H. (Co-Investigator) & George, A. L. (Other)
National Institute of Mental Health
5/1/24 → 2/28/29
Project: Research project
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Cellular Pathophysiology of Neuronal Na/K-ATPase Dysfunction
George, A. L. (PD/PI), George, A. L. (PD/PI), Thompson, C. H. (Co-Investigator) & Thompson, C. H. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
6/15/22 → 4/30/27
Project: Research project
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Genetic Modifiers of Childhood Epilepsy
Kearney, J. A. (PD/PI), Kearney, J. A. (PD/PI), Kearney, J. A. (PD/PI), Hawkins, N. A. (Co-Investigator), Hawkins, N. A. (Co-Investigator), Hawkins, N. A. (Co-Investigator), Thompson, C. H. (Co-Investigator), Thompson, C. H. (Co-Investigator) & Thompson, C. H. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
4/1/20 → 12/31/25
Project: Research project
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Effects of XPC-5462, NBI921353, NBI921354, and NBI921355 on SCN2A (NaV1.2) gain-of-function (GOF) variants (hereinafter "Project")
George, A. L. (PD/PI) & Thompson, C. H. (Co-Investigator)
3/28/22 → 3/31/23
Project: Research project
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Effects of PRAX-562 on sodium current and excitability of neurons from a Scn2aQ54 gain-of-function mouse
George, A. L. (PD/PI), Kearney, J. A. (Co-Investigator) & Thompson, C. H. (Co-Investigator)
Praxis Precision Medicines, Inc.
10/13/21 → 9/30/22
Project: Research project
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Genotype-function-phenotype correlations for SCN1A variants identified by clinical genetic testing
Knox, A. T., Thompson, C. H., Scott, D., Abramova, T. V., Stieve, B., Freeman, A. & George, A. L., Mar 2025, In: Annals of clinical and translational neurology. 12, 3, p. 499-511 13 p.Research output: Contribution to journal › Article › peer-review
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Rare dysfunctional SCN2A variants are associated with malformation of cortical development
Clatot, J., Thompson, C. H., Sotardi, S., Jiang, J., Trivisano, M., Balestrini, S., Ward, D. I., Ginn, N., Guaragni, B., Malerba, L., Vakrinou, A., Sherer, M., Helbig, I., Somarowthu, A., Sisodiya, S. M., Ben-Shalom, R., Guerrini, R., Specchio, N., George, A. L. & Goldberg, E. M., Mar 2025, In: Epilepsia. 66, 3, p. 914-928 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Altered neurological and neurobehavioral phenotypes in a mouse model of the recurrent KCNB1-p.R306C voltage-sensor variant
Kang, S. K., Hawkins, N. A., Thompson, C. H., Baker, E. M., Echevarria-Cooper, D. M., Barse, L., Thenstedt, T., Dixon, C. J., Speakes, N., George, A. L. & Kearney, J. A., May 2024, In: Neurobiology of Disease. 194, 106470.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Erratum: Scanning mutagenesis of the voltage-gated sodium channel NaV1.2 using base editing (Cell Reports (2023) 42(6), (S2211124723005740), (10.1016/j.celrep.2023.112563))
Pablo, J. L. B., Cornett, S. L., Wang, L. A., Jo, S., Brünger, T., Budnik, N., Hegde, M., DeKeyser, J. M., Thompson, C. H., Doench, J. G., Lal, D., George, A. L. & Pan, J. Q., Jun 25 2024, In: Cell reports. 43, 6, 114327.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Exome sequencing of ATP1A3-negative cases of alternating hemiplegia of childhood reveals SCN2A as a novel causative gene
Panagiotakaki, E., Tiziano, F. D., Mikati, M. A., Vijfhuizen, L. S., Nicole, S., Lesca, G., Abiusi, E., Novelli, A., Di Pietro, L., Harder, A. V. E., Walley, N. M., De Grandis, E., Poulat, A. L., Portes, V. D., Lépine, A., Nassogne, M. C., Arzimanoglou, A., Vavassori, R., Koenderink, J. & Thompson, C. H. & 4 others, , Feb 2024, In: European Journal of Human Genetics. 32, 2, p. 224-231 8 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations