Personal profile

Research Interests

My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.

Keywords

  • Epilepsy
  • Neurobiology
  • Pharmacology
  • Biophysics

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 7 Similar Profiles
Sodium Medicine & Life Sciences
Chloride Channels Medicine & Life Sciences
Mutation Medicine & Life Sciences
Epilepsy Medicine & Life Sciences
Myoclonic Epilepsy Medicine & Life Sciences
Peptides Medicine & Life Sciences
Neurons Medicine & Life Sciences
Anticonvulsants Medicine & Life Sciences

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Research Output 2005 2017

  • 373 Citations
  • 12 Article
  • 1 Review article
2 Citations
Calcium-Calmodulin-Dependent Protein Kinases
Protein Kinases
Sodium
Neurons
Epilepsy
3 Citations

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Anderson, L. L., Hawkins, N. A., Thompson, C. H., Kearney, J. A. & George, A. L. Dec 1 2017 In : Scientific Reports. 7, 1, 1682

Research output: Research - peer-reviewArticle

Myoclonic Epilepsy
Sodium Channels
6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)(1,2,4)triazolo(4,3-a)pyridine
Pyramidal Cells
Sodium

Watch out, no brakes! impaired inhibition results in hyperexcitable networks

Thompson, C. H. & Kearney, J. A. Jan 1 2015 In : Epilepsy Currents. 15, 6, p. 342-343 2 p.

Research output: Research - peer-reviewArticle

14 Citations

Antiepileptic activity of preferential inhibitors of persistent sodium current

Anderson, L. L., Thompson, C. H., Hawkins, N. A., Nath, R. D., Petersohn, A. A., Rajamani, S., Bush, W. S., Frankel, W. N., Vanoye, C. G., Kearney, J. A. & George, A. L. Jan 1 2014 In : Epilepsia. 55, 8, p. 1274-1283 10 p.

Research output: Research - peer-reviewArticle

Anticonvulsants
Sodium
6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)(1,2,4)triazolo(4,3-a)pyridine
Seizures
Pharmaceutical Preparations
31 Citations
Myoclonic Epilepsy
Epilepsy
Sodium
Neurons
Phenotype