Research Output per year
Personal profile
Research Interests
My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.
Education / Academic qualification
PhD, Georgia Tech
… → 2008
Keywords
- Epilepsy
- Neurobiology
- Pharmacology
- Biophysics
Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2005 2018
Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood
Simmons, C. Q., Thompson, C. H., Cawthon, B. E., Westlake, G., Swoboda, K. J., Kiskinis, E., Ess, K. C. & George, A. L. Jul 1 2018 In : Neurobiology of Disease. 115, p. 29-38 10 p.Research output: Contribution to journal › Article
Induced Pluripotent Stem Cells
Neurons
Membrane Potentials
Mutation
Evoked Potentials
5
Citations
CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice
Thompson, C. H., Hawkins, N. A., Kearney, J. A. & George, A. L. Feb 14 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1696-1701 6 p.Research output: Contribution to journal › Article
Calcium-Calmodulin-Dependent Protein Kinases
Protein Kinases
Sodium
Epilepsy
Neurons
6
Citations
Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome
Anderson, L. L., Hawkins, N. A., Thompson, C. H., Kearney, J. A. & George, A. L. Dec 1 2017 In : Scientific Reports. 7, 1, 1682Research output: Contribution to journal › Article
Myoclonic Epilepsy
Sodium Channels
Pyramidal Cells
Sodium Channel Blockers
Sodium
Watch out, no brakes! impaired inhibition results in hyperexcitable networks
Thompson, C. H. & Kearney, J. A. Jan 1 2015 In : Epilepsy Currents. 15, 6, p. 342-343 2 p.Research output: Contribution to journal › Article
15
Citations
Antiepileptic activity of preferential inhibitors of persistent sodium current
Anderson, L. L., Thompson, C. H., Hawkins, N. A., Nath, R. D., Petersohn, A. A., Rajamani, S., Bush, W. S., Frankel, W. N., Vanoye, C. G., Kearney, J. A. & George, A. L. Jan 1 2014 In : Epilepsia. 55, 8, p. 1274-1283 10 p.Research output: Contribution to journal › Article
Anticonvulsants
Sodium
Seizures
Electroshock
Hippocampal Mossy Fibers