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Christopher Hal Thompson

  • 520 Citations
20052023
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Personal profile

Research Interests

My research interests focus on the neurobiological mechanism of epilepsy, examining the functional consequences of mutations in genes encoding voltage gated sodium channels. Additionally, mouse models are employed to examine underlying neurophysiological consequences epilepsy.

Education/Academic qualification

PhD, Georgia Tech

… → 2008

Research interests

  • Biophysics
  • Epilepsy
  • Neurobiology
  • Pharmacology

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Grants 2014 2023

Tandem Genetically Encoded Voltage and Calcium Indicator Mice for Optical Physiology of Excitable Cells

Thompson, C. H.

Office of the Director, National Institutes of Health

2/1/19 → 1/31/21

Project: Research project

Cell Physiological Phenomena
Calcium
Epilepsy
Biophysics
Benchmarking

High-throughput functional evaluation of ion channel variants in epilepsy

George Jr, A. L., Thompson, C. H. & Vanoye, C. G.

National Institute of Neurological Disorders and Stroke

9/30/18 → 8/31/23

Project: Research project

Ion Channels
Channelopathies
Epilepsy
Neurons
Genes

Development and investigation of murine models of channelopathy-associated epilepsy

Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

National Institute of Neurological Disorders and Stroke

9/30/18 → 8/31/23

Project: Research project

Channelopathies
Epilepsy
Ion Channels
Neurons
Genes

Functional Annotation of a Comprehensive Set of SCN2A Variants

George Jr, A. L. & Thompson, C. H.

Broad Institute, Inc., National Institute of Neurological Disorders and Stroke

9/15/18 → 8/31/20

Project: Research project

Amino Acid Substitution
Mutagenesis
Alleles
Genotype
Genome

Animal Models for SCN2A Neurodevelopmental Disorders

Hawkins, N. A., Kearney, J. A. & Thompson, C. H.

Office of the Director, National Institutes of Health

8/1/18 → 7/31/20

Project: Research project

Animal Models
Epilepsy
Phenotype
Intellectual Disability
Brain Diseases

Research Output 2005 2019

  • 520 Citations
  • 17 Article
  • 1 Review article

Functional consequences of a KCNT1 variant associated with status dystonicus and early-onset infantile encephalopathy

Gertler, T. S., Thompson, C. H., Vanoye, C. G., Millichap, J. J. & George, A. L., Sep 1 2019, In : Annals of clinical and translational neurology. 6, 9, p. 1606-1615 10 p.

Research output: Contribution to journal › Article

Open Access
Dystonia
Brain Diseases
Electrophysiology
Movement Disorders
Cricetulus
4 Citations (Scopus)

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood

Simmons, C. Q., Thompson, C. H., Cawthon, B. E., Westlake, G., Swoboda, K. J., Kiskinis, E., Ess, K. C. & George Jr, A. L., Jul 1 2018, In : Neurobiology of Disease. 115, p. 29-38 10 p.

Research output: Contribution to journal › Article

Neurons
Induced Pluripotent Stem Cells
Membrane Potentials
Mutation
Evoked Potentials
5 Citations (Scopus)

SCN1A variants associated with sudden infant death syndrome

Brownstein, C. A., Goldstein, R. D., Thompson, C. H., Haynes, R. L., Giles, E., Sheidley, B., Bainbridge, M., Haas, E. A., Mena, O. J., Lucas, J., Schaber, B., Holm, I. A., George Jr, A. L., Kinney, H. C. & Poduri, A. H., Apr 1 2018, In : Epilepsia. 59, 4, p. e56-e62

Research output: Contribution to journal › Article

Sudden Infant Death
Epilepsy
Exome
Seizures
Genes
8 Citations (Scopus)

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

Baker, E. M., Thompson, C. H., Hawkins, N. A., Wagnon, J. L., Wengert, E. R., Patel, M. K., George Jr, A. L., Meisler, M. H. & Kearney, J. A., Jun 1 2018, In : Epilepsia. 59, 6, p. 1166-1176 11 p.

Research output: Contribution to journal › Article

Sodium Channels
Brain Diseases
Sodium
Seizures
Phenytoin
9 Citations (Scopus)

CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice

Thompson, C. H., Hawkins, N. A., Kearney, J. A. & George Jr, A. L., Feb 14 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1696-1701 6 p.

Research output: Contribution to journal › Article

Calcium-Calmodulin-Dependent Protein Kinases
Protein Kinases
Sodium
Epilepsy
Neurons