Grants per year
Personal profile
Research Interests
My research focuses on the immune function of major histocompatibility complex (MHC) class Ib molecules in normal and diseased states. My lab is interested in understanding how MHC class Ib-restricted T cells are selected and regulated during development and how they contribute to the control of autoimmunity, anti-tumor immunity and infectious diseases. My lab is also interested in identifying microbial antigens recognized by MHC class Ib-restricted T cells with the goal of developing new T cell-based vaccines for microbial infection.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Texas
… → 1987
Research interests
- Autoimmunity
- Cancer Biology
- Immune Regulation
- Immune System
- Infectious Diseases
- Inflammatory Bowel Disease
- Vaccine-preventable Illnesses
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The Role of Lipid-specific T cells in Mediating Protection Against M. tuberculosis
University of Washington, National Institute of Allergy and Infectious Diseases
6/1/20 → 5/31/25
Project: Research project
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The Role of Group 1 CD1-restricted T Cells in Infectious Disease
National Institute of Allergy and Infectious Diseases
2/1/16 → 1/31/22
Project: Research project
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Development of Lipid-based Nanoparticle Vaccines Against Mycobacterium tuberculosis
National Institute of Allergy and Infectious Diseases
1/25/17 → 12/31/19
Project: Research project
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CD1-Restricted T Cells in Inflammatory Skin Diseases
Genardi, S., Morgun, E. & Wang, C. R., 2021, (Accepted/In press) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Review article › peer-review
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Mitochondrial metabolism is essential for invariant natural killer T cell development and function
Weng, X., Kumar, A., Cao, L., He, Y., Morgun, E., Visvabharathy, L., Zhao, J., Sena, L. A., Weinberg, S. E., Chandel, N. S. & Wang, C. R., Mar 30 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 13, e2021385118.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Group 1 CD1-restricted T cells contribute to control of systemic Staphylococcus aureus infection
Visvabharathy, L., Genardi, S., Cao, L., He, Y., Alonzo, F., Berdyshev, E. & Wang, C. R., Apr 2020, In: PLoS pathogens. 16, 4, e1008443.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection
Genardi, S., Visvabharathy, L., Cao, L., Morgun, E., Cui, Y., Qi, C., Chen, Y. H., Gapin, L., Berdyshev, E. & Wang, C. R., Nov 18 2020, In: Frontiers in immunology. 11, 610010.Research output: Contribution to journal › Article › peer-review
Open Access -
USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination
Zhang, Y., Wang, Y., Gao, B., Sun, Y., Cao, L., Genardi, S. M., Wang, C. R., Li, H. B., Sun, Z., Yang, Y. & Fang, D., May 4 2020, In: Journal of Experimental Medicine. 217, 5, e20182218.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations