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Chyung-Ru Wang

  • 7488 Citations
1987 …2023
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Personal profile

Research Interests

My research focuses on the immune function of major histocompatibility complex (MHC) class Ib molecules in normal and diseased states. My lab is interested in understanding how MHC class Ib-restricted T cells are selected and regulated during development and how they contribute to the control of autoimmunity, anti-tumor immunity and infectious diseases. My lab is also interested in identifying microbial antigens recognized by MHC class Ib-restricted T cells with the goal of developing new T cell-based vaccines for microbial infection.

Education/Academic qualification

PhD, University of Texas

… → 1987

Research interests

  • Autoimmunity
  • Cancer Biology
  • Immune Regulation
  • Immune System
  • Infectious Diseases
  • Inflammatory Bowel Disease
  • Vaccine-preventable Illnesses

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  • 3 Similar Profiles
Natural Killer T-Cells Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
T-cells Chemical Compounds
Major Histocompatibility Complex Medicine & Life Sciences
Natural Killer Cells Medicine & Life Sciences
Peptides Medicine & Life Sciences
CD1d Antigen Medicine & Life Sciences
Listeria monocytogenes Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2008 2023

Design and characterization of biomimetic nanobiomaterials to elicit CD1-restricted T cell responses during sub-unit vaccination

Wang, C.

National Institute of Allergy and Infectious Diseases

8/1/19 → 7/31/23

Project: Research project

Biomimetics
Vaccination
Subunit Vaccines
T-Lymphocytes
Lipids

The role of non-classical MHC class I molecules in immune responses to Mycobacterium tuberculosis infection

Wang, C. & Bartom, E. T.

National Institute of Allergy and Infectious Diseases

5/14/18 → 4/30/23

Project: Research project

Mycobacterium Infections
Mycobacterium tuberculosis
T-Lymphocytes
NK Cell Lectin-Like Receptor Subfamily C
Vaccination

HIV and Mycobacterial Disease in Mali

Achenbach, C. J., Maiga, M., Murphy, R. L. & Wang, C.

John E. Fogarty International Center for Advanced Study in the Health Sciences

4/9/16 → 2/28/21

Project: Research project

Mali
HIV
Research
National Institute of Allergy and Infectious Diseases (U.S.)
Mycobacterium

The Role of Group 1 CD1-restricted T Cells in Infectious Disease

Wang, C.

National Institute of Allergy and Infectious Diseases

2/1/16 → 1/31/21

Project: Research project

Communicable Diseases
T-Lymphocytes
Mycobacterium tuberculosis
Mycobacterium Infections
Lipids

Development of Lipid-based Nanoparticle Vaccines Against Mycobacterium tuberculosis

Scott, E. A. & Wang, C.

National Institute of Allergy and Infectious Diseases

1/25/17 → 12/31/19

Project: Research project

Mycolic Acids
Mycobacterium tuberculosis
Nanoparticles
Vaccines
Lipids

Research Output 1987 2019

  • 7488 Citations
  • 92 Article
  • 5 Review article
  • 1 Comment/debate
  • 1 Short survey

Invariant natural killer T-cells and total cd1d restricted cells differentially influence lipid metabolism and atherosclerosis in low density receptor deficient mice

VanderLaan, P. A., Reardon, C. A., Cabana, V. G., Wang, C. R. & Getz, G. S., Sep 2 2019, In : International journal of molecular sciences. 20, 18, 4566.

Research output: Contribution to journal › Article

Open Access
lipid metabolism
arteriosclerosis
Natural Killer T-Cells
T-cells
Lipid Metabolism
3 Citations (Scopus)

Induction of mycobacterium tuberculosislipid-specific t cell responses by pulmonary delivery of mycolic acid-loaded polymeric micellar nanocarriers

Shang, S., Kats, D., Cao, L., Morgun, E., Velluto, D., He, Y., Xu, Q., Wang, C. R. & Scott, E. A., Nov 27 2018, In : Frontiers in immunology. 9, NOV, 02709.

Research output: Contribution to journal › Article

Mycolic Acids
Mycobacterium
Lung
T-Lymphocytes
Mycobacterium tuberculosis
1 Citation (Scopus)

Linking CD1-restricted T cells with autoimmunity and dyslipidemia: Lipid levels matter

Bagchi, S., Genardi, S. & Wang, C. R., Jul 16 2018, In : Frontiers in immunology. 9, JUL, 1616.

Research output: Contribution to journal › Review article

Dyslipidemias
Autoimmunity
T-Lymphocytes
Lipids
Autoimmune Diseases
67 Citations (Scopus)

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

Linehan, J. L., Harrison, O. J., Han, S. J., Byrd, A. L., Vujkovic-Cvijin, I., Villarino, A. V., Sen, S. K., Shaik, J., Smelkinson, M., Tamoutounour, S., Collins, N., Bouladoux, N., Dzutsev, A., Rosshart, S. P., Arbuckle, J. H., Wang, C. R., Kristie, T. M., Rehermann, B., Trinchieri, G., Brenchley, J. M. & 2 others, O'Shea, J. J. & Belkaid, Y., Feb 8 2018, In : Cell. 172, 4, p. 784-796.e18

Research output: Contribution to journal › Article

Microbiota
Immunity
Skin
Repair
T-cells
21 Citations (Scopus)

CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice

Bagchi, S., He, Y., Zhang, H., Cao, L., Rhijn, I. V., Moody, D. B., Gudjonsson, J. E. & Wang, C. R., Jun 1 2017, In : Journal of Clinical Investigation. 127, 6, p. 2339-2352 14 p.

Research output: Contribution to journal › Article

Hyperlipidemias
Inflammation
T-Lymphocytes
Skin
Apolipoproteins E