Grants per year
Personal profile
Research Interests
My research focuses on the immune function of major histocompatibility complex (MHC) class Ib molecules in normal and diseased states. My lab is interested in understanding how MHC class Ib-restricted T cells are selected and regulated during development and how they contribute to the control of autoimmunity, anti-tumor immunity and infectious diseases. My lab is also interested in identifying microbial antigens recognized by MHC class Ib-restricted T cells with the goal of developing new T cell-based vaccines for microbial infection.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biology, University of Texas
… → 1987
Research interests keywords
- Autoimmunity
- Cancer Biology
- Immune Regulation
- Immune System
- Infectious Diseases
- Inflammatory Bowel Disease
- Vaccine-preventable Illnesses
Fingerprint
Dive into the research topics where Chyung-Ru Wang is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
The regulation and functions of Group 1 CD1-restricted T cells
Wang, C.-R. (PD/PI) & Scott, E. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
9/20/23 → 7/31/28
Project: Research project
-
A new mouse model to study the function of CD1b-restricted germline encoded, mycolyl lipid-reactive (GEM) T cells
Wang, C.-R. (PD/PI), Wang, C.-R. (PD/PI) & Wang, C.-R. (PD/PI)
National Institute of Allergy and Infectious Diseases
6/14/23 → 5/31/26
Project: Research project
-
The Role of Lipid-specific T cells in Mediating Protection Against M. tuberculosis
Wang, C.-R. (PD/PI) & Wang, C.-R. (PD/PI)
University of Washington, National Institute of Allergy and Infectious Diseases
6/1/20 → 5/31/25
Project: Research project
-
The role of non-classical MHC class I molecules in immune responses to Mycobacterium tuberculosis infection
Wang, C.-R. (PD/PI), Wang, C.-R. (PD/PI) & Bartom, E. T. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
5/14/18 → 4/30/25
Project: Research project
-
Development of Lipid-based Nanoparticle Vaccines Against Mycobacterium tuberculosis
Wang, C.-R. (PD/PI) & Scott, E. A. (Co-Investigator)
National Institute of Allergy and Infectious Diseases
1/25/17 → 12/31/19
Project: Research project
-
Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells
Morgun, E., Zhu, J., Almunif, S., Bobbala, S., Aguilar, M. S., Wang, J., Conner, K., Cui, Y., Cao, L., Seshadri, C., Scott, E. A. & Wang, C. R., Oct 25 2023, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
CD1-Restricted T Cells in Inflammatory Skin Diseases
Genardi, S., Morgun, E. & Wang, C. R., Mar 2022, In: Journal of Investigative Dermatology. 142, 3, p. 768-773 6 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
METTL14-dependent m6A modification controls iNKT cell development and function
Cao, L., Morgun, E., Genardi, S., Visvabharathy, L., Cui, Y., Huang, H. & Wang, C. R., Aug 2 2022, In: Cell reports. 40, 5, 111156.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides
Strand, A., Shen, S. T., Tomchick, D. R., Wang, J., Wang, C. R. & Deisenhofer, J., 2022, In: Journal of Biomolecular Structure and Dynamics. 40, 20, p. 10300-10312 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Mitochondrial metabolism is essential for invariant natural killer T cell development and function
Weng, X., Kumar, A., Cao, L., He, Y., Morgun, E., Visvabharathy, L., Zhao, J., Sena, L. A., Weinberg, S. E., Chandel, N. S. & Wang, C. R., Mar 30 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 13, e2021385118.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations
Datasets
-
MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, VAL MUTANT, TRICLINIC CELL, REFINED AT 1.60 ANGSTROMS RESOLUTION
Wang, C.-R. (Contributor), Loveland, B. E. (Contributor), Fischer Lindahl, K. (Contributor), Strand, A. (Contributor), Shen, S.-T. (Contributor), Tomchick, D. R. (Contributor), Wang, J. (Contributor), Deisenhofer, J. (Contributor), Castaño, A. R. (Contributor), Peterson, P. A. (Contributor) & Slaughter, C. (Contributor), Protein Data Bank (PDB), Jul 14 2021
DOI: 10.2210/pdb7LFM/pdb, https://www.wwpdb.org/pdb?id=pdb_00007lfm
Dataset
-
Structure and dynamics of major histocompatibility class Ib molecule H2-M3 complexed with mitochondrial-derived peptides
Strand, A. (Creator), Shen, S.-T. (Creator), Tomchick, D. R. (Creator), Wang, J. (Creator), Wang, C.-R. (Creator) & Deisenhofer, J. (Creator), Taylor & Francis, 2022
DOI: 10.6084/m9.figshare.14865087.v2, https://tandf.figshare.com/articles/dataset/Structure_and_dynamics_of_major_histocompatibility_class_Ib_molecule_H2-M3_complexed_with_mitochondrial-derived_peptides/14865087/2
Dataset
-
MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, THR MUTANT, REFINED AT 1.60 ANGSTROMS RESOLUTION
Strand, A. (Contributor), Shen, S.-T. (Contributor), Tomchick, D. R. (Contributor), Wang, J. (Contributor), Wang, C.-R. (Contributor), Deisenhofer, J. (Contributor), Castaño, A. R. (Contributor), Peterson, P. A. (Contributor), Slaughter, C. (Contributor) & Fischer Lindahl, K. (Contributor), Protein Data Bank (PDB), Jul 14 2021
DOI: 10.2210/pdb7LFK/pdb, https://www.wwpdb.org/pdb?id=pdb_00007lfk
Dataset
-
MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE REFINED AT 1.70 ANGSTROMS RESOLUTION
Wang, C.-R. (Contributor), Loveland, B. E. (Contributor), Fischer Lindahl, K. (Contributor), Strand, A. (Contributor), Shen, S.-T. (Contributor), Tomchick, D. R. (Contributor), Wang, J. (Contributor), Deisenhofer, J. (Contributor), Castaño, A. R. (Contributor), Peterson, P. A. (Contributor) & Slaughter, C. (Contributor), Protein Data Bank (PDB), Jul 14 2021
DOI: 10.2210/pdb7LFI/pdb, https://www.wwpdb.org/pdb?id=pdb_00007lfi
Dataset
-
MODEL OF MHC CLASS Ib H2-M3 WITH MOUSE ND1 N-TERMINAL HEPTAPEPTIDE, VAL MUTANT, MONOCLINIC CELL, REFINED AT 1.60 ANGSTROMS RESOLUTION
Wang, C.-R. (Contributor), Loveland, B. E. (Contributor), Fischer Lindahl, K. (Contributor), Strand, A. (Contributor), Shen, S.-T. (Contributor), Tomchick, D. R. (Contributor), Wang, J. (Contributor), Deisenhofer, J. (Contributor), Castaño, A. R. (Contributor), Peterson, P. A. (Contributor) & Slaughter, C. (Contributor), Protein Data Bank (PDB), Jul 14 2021
DOI: 10.2210/pdb7LFL/pdb, https://www.wwpdb.org/pdb?id=pdb_00007lfl
Dataset