• 1226 Citations
20072020

Research output per year

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Personal profile

Research Interests

Epidemiological and genetic studies have shown that disruption of the circadian clock is a factor in multiple pathologies, including metabolic disease, myopathy, and cancer. Our laboratory aims to uncover the physiological impact of the circadian clock on nutrient-responsive regulatory pathways, including oxygen-sensing transcriptional networks. Indeed, we have recently identified a key connection between skeletal muscle clocks and the hypoxia-inducible factor (HIF) pathway, which drives circadian control of the hypoxic response and glucose metabolism. The goal of our laboratory is to understand the interplay between hypoxic and circadian transcriptional pathways both at the genomic and nutrient-signaling levels, and to apply these findings to understand the role of circadian clocks in metabolic diseases such as type-2 diabetes and cancer.

Training Experience

2015Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Johns Hopkins University

… → 2010

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Grants

  • Research Output

    • 1226 Citations
    • 15 Article
    • 3 Chapter
    • 3 Review article

    Metabolic Implications of Circadian–HIF Crosstalk

    Peek, C. B., Jun 2020, In : Trends in Endocrinology and Metabolism. 31, 6, p. 459-468 10 p.

    Research output: Contribution to journalReview article

  • NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging

    Levine, D. C., Hong, H., Weidemann, B. J., Ramsey, K. M., Affinati, A. H., Schmidt, M. S., Cedernaes, J., Omura, C., Braun, R. I., Lee, C., Brenner, C., Bien, C. & Bass, J., Jun 4 2020, In : Molecular cell. 78, 5, p. 835-849.e7

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism

    Rizzini, L., Levine, D. C., Perelis, M., Bass, J., Peek, C. B. & Pagano, M., Jun 17 2019, In : Current Biology. 29, 12, p. 1954-1962.e4

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming

    Quattrocelli, M., Zelikovich, A. S., Jiang, Z., Peek, C. B., Demonbreun, A. R., Kuntz, N. L., Barish, G. D., Haldar, S. M., Bass, J. & McNally, E. M., Dec 19 2019, In : JCI Insight. 4, 24, e132402.

    Research output: Contribution to journalArticle

    Open Access
  • Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

    Cedernaes, J., Huang, W., Ramsey, K. M., Waldeck, N., Cheng, L., Marcheva, B., Omura, C., Kobayashi, Y., Peek, C. B., Levine, D. C., Dhir, R., Awatramani, R., Bradfield, C. A., Wang, X. A., Takahashi, J. S., Mokadem, M., Ahima, R. S. & Bass, J., May 7 2019, In : Cell Metabolism. 29, 5, p. 1078-1091.e5

    Research output: Contribution to journalArticle

  • 17 Scopus citations