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Personal profile

Research Interests

Epidemiological and genetic studies have shown that disruption of the circadian clock is a factor in multiple pathologies, including metabolic disease, myopathy, and cancer. Our laboratory aims to uncover the physiological impact of the circadian clock on nutrient-responsive regulatory pathways, including oxygen-sensing transcriptional networks. Indeed, we have recently identified a key connection between skeletal muscle clocks and the hypoxia-inducible factor (HIF) pathway, which drives circadian control of the hypoxic response and glucose metabolism. The goal of our laboratory is to understand the interplay between hypoxic and circadian transcriptional pathways both at the genomic and nutrient-signaling levels, and to apply these findings to understand the role of circadian clocks in metabolic diseases such as type-2 diabetes and cancer.

Training Experience

2015Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Johns Hopkins University

… → 2010

Fingerprint Dive into the research topics where Clara Bien is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Circadian Clocks Medicine & Life Sciences
Cryptococcus neoformans Medicine & Life Sciences
Sterols Medicine & Life Sciences
Sterol Regulatory Element Binding Proteins Medicine & Life Sciences
Metabolism Chemical Compounds
NAD Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Clocks Chemical Compounds

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Grants 2014 2022

Circadian Clocks
Skeletal Muscle
Food
Skeletal Muscle Fibers
Muscles
skeletal muscle
circadian rhythm
nutrients
fasting
stress response
Antineoplastic Agents
NAD
Breast Neoplasms
Circadian Clocks
Mitochondria

Research Output 2007 2019

  • 1055 Citations
  • 14 Article
  • 2 Chapter
  • 2 Review article

Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism

Rizzini, L., Levine, D. C., Perelis, M., Bass, J., Bien, C. & Pagano, M., Jun 17 2019, In : Current Biology. 29, 12, p. 1954-1962.e4

Research output: Contribution to journalArticle

Cryptochromes
Mammals
Glucocorticoid Receptors
mammals
Plant Photoreceptors
3 Citations (Scopus)

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

Cedernaes, J., Huang, W., Ramsey, K. M., Waldeck, N., Cheng, L., Marcheva, B., Omura, C., Kobayashi, Y., Bien, C., Levine, D. C., Dhir, R., Awatramani, R., Bradfield, C. A., Wang, X., Takahashi, J. S., Mokadem, M., Ahima, R. S. & Bass, J., May 7 2019, In : Cell Metabolism. 29, 5, p. 1078-1091.e5

Research output: Contribution to journalArticle

Hunger
Sleep
Neurons
Leptin
Energy Metabolism
2 Citations (Scopus)

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

Wei, J., Yuan, Y., Chen, L., Xu, Y., Zhang, Y., Wang, Y., Yang, Y., Bien, C., Diebold, L., Yang, Y., Gao, B., Jin, C., Melo-Cardenas, J., Chandel, N., Zhang, D. D., Pan, H., Zhang, K., Wang, J., He, F. & Fang, D., Dec 1 2018, In : Nature communications. 9, 1, 3659.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl CoA Reductases
metabolism
Ligases
Ubiquitin
liver
60 Citations (Scopus)

Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle

Bien, C., Levine, D. C., Cedernaes, J., Taguchi, A., Kobayashi, Y., Tsai, S. J., Bonar, N. A., McNulty, M. R., Ramsey, K. M. & Bass, J., Jan 10 2017, In : Cell Metabolism. 25, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Anaerobiosis
Hypoxia-Inducible Factor 1
Circadian Clocks
Glycolysis
Skeletal Muscle
21 Citations (Scopus)

Circadian regulation of cellular physiology

Bien, C., Ramsey, K. M., Levine, D. C., Marcheva, B., Perelis, M. & Bass, J., Jan 1 2015, In : Methods in Enzymology. 552, p. 165-184 20 p.

Research output: Contribution to journalArticle

Physiology
NAD
Clocks
Circadian Clocks
Physiological Phenomena