• 994 Citations
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

Epidemiological and genetic studies have shown that disruption of the circadian clock is a factor in multiple pathologies, including metabolic disease, myopathy, and cancer. Our laboratory aims to uncover the physiological impact of the circadian clock on nutrient-responsive regulatory pathways, including oxygen-sensing transcriptional networks. Indeed, we have recently identified a key connection between skeletal muscle clocks and the hypoxia-inducible factor (HIF) pathway, which drives circadian control of the hypoxic response and glucose metabolism. The goal of our laboratory is to understand the interplay between hypoxic and circadian transcriptional pathways both at the genomic and nutrient-signaling levels, and to apply these findings to understand the role of circadian clocks in metabolic diseases such as type-2 diabetes and cancer.

Training Experience

2015Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Johns Hopkins University

… → 2010

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 11 Similar Profiles
Circadian Clocks Medicine & Life Sciences
Cryptococcus neoformans Medicine & Life Sciences
Sterols Medicine & Life Sciences
Sterol Regulatory Element Binding Proteins Medicine & Life Sciences
Metabolism Chemical Compounds
NAD Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Clocks Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2022

Circadian Clocks
Skeletal Muscle
Skeletal Muscle Fibers
skeletal muscle
circadian rhythm
stress response
Antineoplastic Agents
Breast Neoplasms
Circadian Clocks

Research Output 2007 2019

  • 994 Citations
  • 13 Article
  • 2 Chapter
  • 2 Review article
2 Citations (Scopus)

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

Cedernaes, J., Huang, W., Ramsey, K. M., Waldeck, N., Cheng, L., Marcheva, B., Omura, C., Kobayashi, Y., Bien, C., Levine, D. C., Dhir, R., Awatramani, R., Bradfield, C. A., Wang, X. A., Takahashi, J. S., Mokadem, M., Ahima, R. S. & Bass, J., May 7 2019, In : Cell Metabolism. 29, 5, p. 1078-1091.e5

Research output: Contribution to journalArticle

Energy Metabolism

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

Wei, J., Yuan, Y., Chen, L., Xu, Y., Zhang, Y., Wang, Y., Yang, Y., Bien, C., Diebold, L., Yang, Y., Gao, B., Jin, C., Melo-Cardenas, J., Chandel, N., Zhang, D. D., Pan, H., Zhang, K., Wang, J., He, F. & Fang, D., Dec 1 2018, In : Nature communications. 9, 1, 3659.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl CoA Reductases
51 Citations (Scopus)

Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle

Bien, C., Levine, D. C., Cedernaes, J., Taguchi, A., Kobayashi, Y., Tsai, S. J., Bonar, N. A., McNulty, M. R., Ramsey, K. M. & Bass, J., Jan 10 2017, In : Cell Metabolism. 25, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Circadian Clocks
Skeletal Muscle
21 Citations (Scopus)

Circadian regulation of cellular physiology

Bien, C., Ramsey, K. M., Levine, D. C., Marcheva, B., Perelis, M. & Bass, J., Jan 1 2015, In : Methods in Enzymology. 552, p. 165-184 20 p.

Research output: Contribution to journalArticle

Circadian Clocks
Physiological Phenomena
102 Citations (Scopus)

Pancreatic b cell enhancers regulate rhythmic transcription of genes controlling insulin secretion

Perelis, M., Marcheva, B., Ramsey, K. M., Schipma, M. J., Hutchison, A. L., Taguchi, A., Bien, C., Hong, H., Huang, W., Omura, C., Allred, A. L., Bradfield, C. A., Dinner, A. R., Barish, G. D. & Bass, J., Nov 6 2015, In : Science. 350, 6261

Research output: Contribution to journalArticle

Transcription Factors
Glucose Intolerance
Gene Regulatory Networks