If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

Epidemiological and genetic studies have shown that disruption of the circadian clock is a factor in multiple pathologies, including metabolic disease, myopathy, and cancer. Our laboratory aims to uncover the physiological impact of the circadian clock on nutrient-responsive regulatory pathways, including oxygen-sensing transcriptional networks. Indeed, we have recently identified a key connection between skeletal muscle clocks and the hypoxia-inducible factor (HIF) pathway, which drives circadian control of the hypoxic response and glucose metabolism. The goal of our laboratory is to understand the interplay between hypoxic and circadian transcriptional pathways both at the genomic and nutrient-signaling levels, and to apply these findings to understand the role of circadian clocks in metabolic diseases such as type-2 diabetes and cancer.

Training Experience

2015Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine

Education/Academic qualification

PhD, Johns Hopkins University

… → 2010

Fingerprint Dive into the research topics where Clara Bien is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 10 Similar Profiles
Circadian Clocks Medicine & Life Sciences
Cryptococcus neoformans Medicine & Life Sciences
Sterols Medicine & Life Sciences
Sterol Regulatory Element Binding Proteins Medicine & Life Sciences
Metabolism Chemical Compounds
NAD Medicine & Life Sciences
Oxygen Medicine & Life Sciences
Clocks Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2022

Circadian Clocks
Skeletal Muscle
Skeletal Muscle Fibers
skeletal muscle
circadian rhythm
stress response
Antineoplastic Agents
Breast Neoplasms
Circadian Clocks

Research Output 2007 2019

  • 1109 Citations
  • 13 Article
  • 3 Chapter
  • 2 Review article
1 Citation (Scopus)

Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism

Rizzini, L., Levine, D. C., Perelis, M., Bass, J., Bien, C. & Pagano, M., Jun 17 2019, In : Current Biology. 29, 12, p. 1954-1962.e4

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Plant Photoreceptors
7 Citations (Scopus)

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

Cedernaes, J., Huang, W., Ramsey, K. M., Waldeck, N., Cheng, L., Marcheva, B., Omura, C., Kobayashi, Y., Peek, C. B., Levine, D. C., Dhir, R., Awatramani, R., Bradfield, C. A., Wang, X. A., Takahashi, J. S., Mokadem, M., Ahima, R. S. & Bass, J., May 7 2019, In : Cell Metabolism. 29, 5, p. 1078-1091.e5

Research output: Contribution to journalArticle

Energy Metabolism
2 Citations (Scopus)

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

Wei, J., Yuan, Y., Chen, L., Xu, Y., Zhang, Y., Wang, Y., Yang, Y., Peek, C. B., Diebold, L., Yang, Y., Gao, B., Jin, C., Melo-Cardenas, J., Chandel, N. S., Zhang, D. D., Pan, H., Zhang, K., Wang, J., He, F. & Fang, D., Dec 1 2018, In : Nature communications. 9, 1, 3659.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl CoA Reductases
69 Citations (Scopus)

Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle

Peek, C. B., Levine, D. C., Cedernaes, J., Taguchi, A., Kobayashi, Y., Tsai, S. J., Bonar, N. A., McNulty, M. R., Ramsey, K. M. & Bass, J., Jan 10 2017, In : Cell Metabolism. 25, 1, p. 86-92 7 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Circadian Clocks
Skeletal Muscle

Circadian regulation of cellular physiology

Peek, C. B., Ramsey, K. M., Levine, D. C., Marcheva, B., Perelis, M. & Bass, J., 2015, Methods in Enzymology. Academic Press Inc, p. 165-184 20 p. (Methods in Enzymology; vol. 552).

Research output: Chapter in Book/Report/Conference proceedingChapter

Circadian Clocks
Physiological Phenomena