Grants per year
Personal profile
Research Interests
Epidemiological and genetic studies have shown that disruption of the circadian clock is a factor in multiple pathologies, including metabolic disease, myopathy, and cancer. Our laboratory aims to uncover the physiological impact of the circadian clock on nutrient-responsive regulatory pathways, including oxygen-sensing transcriptional networks. Indeed, we have recently identified a key connection between skeletal muscle clocks and the hypoxia-inducible factor (HIF) pathway, which drives circadian control of the hypoxic response and glucose metabolism. The goal of our laboratory is to understand the interplay between hypoxic and circadian transcriptional pathways both at the genomic and nutrient-signaling levels, and to apply these findings to understand the role of circadian clocks in metabolic diseases such as type-2 diabetes and cancer.
Training Experience
2015 | Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine |
Education/Academic qualification
PhD, Johns Hopkins University
… → 2010
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Network
Grants
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Clock Control of Muscle Glucose Metabolism and HIF Activity
National Institute of Diabetes and Digestive and Kidney Diseases
8/12/20 → 5/31/25
Project: Research project
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Alterations of Sleep and Circadian Timing in Aging
Abbott, S. M., Allada, R., Bass, J., Peek, C., Braun, R. I., Grimaldi, D., Hong, H., Jiang, P., Ramsey, K. M., Reid, K. J., Spring, B., Vitaterna, M. H., Turek, F. W. & Zee, P. C.
9/15/17 → 5/31/22
Project: Research project
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Circadian Control of Nutrient-Sensing Pathways Through Clock-HIF Interactions in Skeletal Muscle
National Institute of Diabetes and Digestive and Kidney Diseases
3/15/18 → 2/29/20
Project: Research project
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Circadian control of nutrient-sensing and fuel utilization in skeletal muscle
National Institute of Diabetes and Digestive and Kidney Diseases
4/1/15 → 5/31/18
Project: Research project
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Circadian Control of NAD+ as New Antineoplastic Target for Breast Cancer
Bass, J., Peek, C. & Ramsey, K. M.
Northwestern Memorial Hospital
9/1/14 → 8/31/16
Project: Research project
Research Output
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Associations of Poly (ADP-Ribose) Polymerase1 abundance in calf skeletal muscle with walking performance in peripheral artery disease
Saini, S. K., Li, L., Peek, C. B., Kosmac, K., Polonsky, T. S., Tian, L., Criqui, M. H., Ferrucci, L., Guralnik, J. M., Kibbe, M., Sufit, R. L., Leeuwenburgh, C. & McDermott, M. M., Oct 15 2020, In: Experimental Gerontology. 140, 111048.Research output: Contribution to journal › Article › peer-review
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Metabolic Implications of Circadian–HIF Crosstalk
Peek, C. B., Jun 2020, In: Trends in Endocrinology and Metabolism. 31, 6, p. 459-468 10 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging
Levine, D. C., Hong, H., Weidemann, B. J., Ramsey, K. M., Affinati, A. H., Schmidt, M. S., Cedernaes, J., Omura, C., Braun, R., Lee, C., Brenner, C., Peek, C. B. & Bass, J., Jun 4 2020, In: Molecular cell. 78, 5, p. 835-849.e7Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism
Rizzini, L., Levine, D. C., Perelis, M., Bass, J., Peek, C. B. & Pagano, M., Feb 10 2019, In: Unknown Journal.Research output: Contribution to journal › Article › peer-review
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Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism
Rizzini, L., Levine, D. C., Perelis, M., Bass, J., Peek, C. B. & Pagano, M., Jun 17 2019, In: Current Biology. 29, 12, p. 1954-1962.e4Research output: Contribution to journal › Article › peer-review
4 Scopus citations