Grants per year
Personal profile
Research Interests
Epidemiological and genetic studies have shown that disruption of the circadian clock is a factor in multiple pathologies, including metabolic disease, myopathy, and cancer. Our laboratory aims to uncover the physiological impact of the circadian clock on nutrient-responsive regulatory pathways, including oxygen-sensing transcriptional networks. Indeed, we have recently identified a key connection between skeletal muscle clocks and the hypoxia-inducible factor (HIF) pathway, which drives circadian control of the hypoxic response and glucose metabolism. The goal of our laboratory is to understand the interplay between hypoxic and circadian transcriptional pathways both at the genomic and nutrient-signaling levels, and to apply these findings to understand the role of circadian clocks in metabolic diseases such as type-2 diabetes and cancer.
Training Experience
2015 | Postdoctoral Fellowship, Northwestern University Feinberg School of Medicine |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Biochemistry, Cellular and Molecular Biology, Johns Hopkins University
… → 2010
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Diabetes Research and Training Center
Bass, J. (PD/PI), Hong, H. (Co-Investigator) & Peek, C. (Co-Investigator)
The University of Chicago, National Institute of Diabetes and Digestive and Kidney Diseases
4/10/23 → 3/31/28
Project: Research project
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Clock Control of Muscle Glucose Metabolism and HIF Activity
Peek, C. (PD/PI) & Peek, C. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
8/12/20 → 5/31/25
Project: Research project
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Role of Clock-HIF signaling in adult muscle stem cell regenerative capacity during obesity
Peek, C. (PD/PI)
The University of Chicago, National Institute of Diabetes and Digestive and Kidney Diseases
4/1/21 → 3/31/23
Project: Research project
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Circadian Control of Nutrient-Sensing Pathways Through Clock-HIF Interactions in Skeletal Muscle
Peek, C. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
3/15/18 → 2/29/20
Project: Research project
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Alterations of Sleep and Circadian Timing in Aging
Zee, P. C. (PD/PI), Abbott, S. M. (Co-Investigator), Braun, R. I. (Co-Investigator), Grimaldi, D. (Co-Investigator), Hong, H. (Co-Investigator), Peek, C. (Co-Investigator), Reid, K. J. (Co-Investigator), Spring, B. (Co-Investigator), Vitaterna, M. H. (Co-Investigator), Allada, R. (Other), Bass, J. (Other), Jiang, P. (Other), Ramsey, K. M. (Other) & Turek, F. W. (Other)
9/15/17 → 5/31/23
Project: Research project
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Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury
Kahn, R. E., Zhu, P., Roy, I., Peek, C., Hawley, J. A. & Dayanidhi, S., Jan 31 2025, In: FASEB Journal. 39, 2, e70325.Research output: Contribution to journal › Article › peer-review
Open Access -
Circadian Dysfunction in the Skeletal Muscle Impairs Limb Perfusion and Muscle Regeneration in Peripheral Artery Disease
Zhu, P., Chao, C. L., Steffeck, A. W. T., Dang, C., Hamlish, N. X., Pfrender, E. M., Jiang, B. & Peek, C. B., Feb 1 2025, In: Arteriosclerosis, thrombosis, and vascular biology. 45, 2, p. e30-e47Research output: Contribution to journal › Article › peer-review
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Control of circadian muscle glucose metabolism through the BMAL1–HIF axis in obesity
Chaikin, C. A., Thakkar, A. V., Steffeck, A. W. T., Pfrender, E. M., Hung, K., Zhu, P., Waldeck, N. J., Nozawa, R., Song, W., Futtner, C. R., Quattrocelli, M., Bass, J., Ben-Sahra, I. & Peek, C. B., Apr 1 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 13, e2424046122.Research output: Contribution to journal › Article › peer-review
Open Access -
Immunomodulatory role of the stem cell circadian clock in muscle repair
Zhu, P., Pfrender, E. M., Steffeck, A. W. T., Reczek, C. R., Zhou, Y., Thakkar, A. V., Gupta, N. R., Kupai, A., Willbanks, A., Lieber, R. L., Roy, I., Chandel, N. S. & Peek, C. B., Mar 7 2025, In: Science Advances. 11, 10, eadq8538.Research output: Contribution to journal › Article › peer-review
Open Access -
Circadian timing of satellite cell function and muscle regeneration
Zhu, P. & Peek, C. B., Jan 2024, Muscle Stem Cells. Rudnicki, M. A. & Dilworth, F. J. (eds.). Academic Press Inc, p. 307-339 33 p. (Current Topics in Developmental Biology; vol. 158).Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations