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Colby S Thaxton

  • 7545 Citations
20032023
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Personal profile

Research Interests

Nanotechnology is the study of the fabrication, directed self-assembly, and characterization of materials that have size dimensions between 1 and 100 nanometers. In the context of biological nanostructures, this is the size regime of the molecular machinery that constitutes, for example, functional viruses, bacteria, and human cells. The challenge of bio-nanotechnology and the focus of our lab is to control the synthesis of structures that naturally interface with biological systems to develop exquisitely targeted, practical, safe, and effective nanoparticle therapeutics, imaging agents, and biosensors.

Education/Academic qualification

PhD, Northwestern University Feinberg School of Medicine

… → 2007

MD, Northwestern University Feinberg School of Medicine

… → 2004

Research interests

  • Atherosclerosis
  • Bioengineering
  • Cancer Biology
  • Nanotechnology
  • Radiology

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  • 19 Similar Profiles
Nanoparticles Medicine & Life Sciences
HDL Lipoproteins Medicine & Life Sciences
Lipoproteins Engineering & Materials Science
Gold Chemical Compounds
Prostatic Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Biomimetics Chemical Compounds
Cholesterol Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2006 2023

The role of A-to-I RNA editing in advanced prostate cancer

Thaxton, C. S. & Cao, Q.

U.S. Army Medical Research and Materiel Command

9/30/19 → 9/29/22

Project: Research project

RNA Editing
Prostatic Neoplasms
RNA
Proteins
immune RNA

The Role of MicroRNAs in Corneal Epithelial Homeostasis

Batlle, D., Lavker, R. M., Peng, H. & Thaxton, C. S.

Kennedy Institute - National Eye Clinic

7/1/19 → 7/31/23

Project: Research project

MicroRNAs
Homeostasis
Corneal Epithelium
HDL Lipoproteins
Nanoparticles

Highly Functional Organic Core Templated High-Density Lipoproteins to Reverse Vascular Disease

Dementieva, I. S., Thaxton, C. S. & Nguyen, S.

National Institute on Aging

4/1/19 → 12/31/20

Project: Research project

HDL Lipoproteins
Vascular Diseases
Cholesterol
Atherosclerotic Plaques
Inflammation

Lipoteichoic acid mediated immune modulation of chronic pain

Murphy, S. F., Schaeffer, A. J., Thaxton, C. S. & Thumbikat, P.

National Institute of Diabetes, Digestive and Kidney Diseases

8/1/16 → 7/31/20

Project: Research project

Pelvic Pain
Chronic Pain
Prostatitis
Prostate
Cell Degranulation

Thaxton - Synthetic, Bioprogrammable Lipid and Lipoprotein Particles for Phospolid and Cholesterol Metabolism

Schatz, G. C., Thaxton, C. S. & Thaxton, C. S.

Air Force Research Laboratory

6/8/15 → 6/7/20

Project: Research project

Metabolism
Lipoproteins
Cholesterol
Research laboratories
Lipids

Research Output 2003 2019

An update on synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Henrich, S. E. & Thaxton, C. S., Jun 3 2019, In : Expert review of anticancer therapy. 19, 6, p. 515-528 14 p.

Research output: Contribution to journal › Review article

HDL Lipoproteins
Nanoparticles
Neoplasms
Therapeutics
Biological Phenomena

Biomimetic Magnetic Nanostructures: A Theranostic Platform Targeting Lipid Metabolism and Immune Response in Lymphoma

Singh, A., Nandwana, V., Rink, J. S., Ryoo, S. R., Chen, T. H., Allen, S. D., Scott, E. A., Gordon, L. I., Thaxton, C. S. & Dravid, V. P., Sep 24 2019, In : ACS nano. 13, 9, p. 10301-10311 11 p.

Research output: Contribution to journal › Article

lipid metabolism
Scavenger Receptors
Cholesterol
biomimetics
Biomimetics
1 Citation (Scopus)

Supramolecular Assembly of High-Density Lipoprotein Mimetic Nanoparticles Using Lipid-Conjugated Core Scaffolds

Henrich, S. E., Hong, B. J., Rink, J. S., Nguyen, S. & Thaxton, C. S., Jun 26 2019, In : Journal of the American Chemical Society. 141, 25, p. 9753-9757 5 p.

Research output: Contribution to journal › Article

Lipoproteins
HDL Lipoproteins
Scaffolds (biology)
Scaffolds
Nanoparticles
9 Citations (Scopus)

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity

Seckler, H. D. S., Fornelli, L., Mutharasan, R. K., Thaxton, C. S., Fellers, R., Daviglus, M., Sniderman, A., Rader, D., Kelleher, N. L., Lloyd-Jones, D. M., Compton, P. D. & Wilkins, J. T., Jun 1 2018, In : Journal of Proteome Research. 17, 6, p. 2156-2164 9 p.

Research output: Contribution to journal › Article

Apolipoprotein A-I
Proteomics
HDL Cholesterol
Bearings (structural)
Lipoylation
8 Citations (Scopus)

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma

Bell, J. B., Rink, J. S., Eckerdt, F., Clymer, J., Goldman, S., Thaxton, C. S. & Platanias, L. C., Dec 1 2018, In : Scientific reports. 8, 1, 1211.

Research output: Contribution to journal › Article

Medulloblastoma
Nanoparticles
HDL Lipoproteins
Scavenger Receptors
Ewing's Sarcoma