Grants per year
Personal profile
Research Interests
The goal of regenerative rehabilitation is to boost innate repair processes and/or to replace tissues in order to improve function. This is the focus of my career as a physiatrist-scientist with expertise in neuromuscular medicine, rehabilitation, gene therapy, and disease modeling with induced pluripotent stem cells (iPSCs). In the clinic, I see patients with nerve injuries, neuromuscular disease, as well as perform electromyography testing. In the laboratory, I use a combination of molecular, biochemical, and electrophysiological assays to study neurotrauma, axon regeneration and motor neuron disease with a priority on human pre-clinical models involving neurons generated from patient-specific iPSCs.
1. Axon regeneration 2. Peripheral nerve diseases 3. Motor neuron disease 4. Neurotrauma 5. Nerve repair biomarkers
1. Diagnostic electrophysiology including electromyography and nerve conduction studies 2. Peripheral nerve injuries, nerve repair and nerve transfers 3. Amyotrophic lateral sclerosis/motor neuron diseases 4. Peripheral neuropathy 5. Neuromuscular ultrasound
Certifications and Licenses
Physical Medicine & Rehabilitation | |
Neuromuscular Medicine |
Training Experience
2007 | Postdoctoral Fellowship, Emory University |
2012 | Postdoctoral Fellowship, University of Calgary Faculty of Medicine, Canada |
2013 | Internship, Northwestern University, McGaw Medical Center (Northwestern Memorial Hospital) |
2017 | Residency, Northwestern University, McGaw Medical Center (Rehabilitation Institute of Chicago) |
2018 | Fellowship, Northwestern University, McGaw Medical Center |
Education/Academic qualification
MD, Medicine, University of Calgary Faculty of Medicine
… → 2012
PhD, Anatomy, Dalhousie University
… → 2007
Research interests keywords
- ALS
- Clinical Research
- EMG
- Neuromuscular Disorders
- Peripheral Neuropathy
- Regenerative Medicine
- Rehabilitation/Therapy
- Stem Cells
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Grants
- 2 Finished
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Accelerating Nerve Regeneration with Therapeutic Electrical Stimulation and Botulinum Toxin
Franz, C. K. (PD/PI), Jordan, S. W. (Co-PD/PI) & Rogers, J. A. (Co-PD/PI)
Rehabilitation Institute of Chicago, National Institute of Child Health and Human Development
4/5/21 → 3/31/23
Project: Research project
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Exercise in a Dish: Studying the Effects of Activity Based Treatments for Neuromuscular Disorders with Human Induced Pluripotent Stem Cells and Optogenetics
Franz, C. K. (PD/PI), Heckman, C. (Co-Investigator) & Kiskinis, E. (Co-Investigator)
Rehabilitation Institute of Chicago, Craig H. Neilsen Foundation
6/1/16 → 3/31/18
Project: Research project
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Predictive Value of Diaphragm Muscle Ultrasound for Ventilator Weaning Outcomes After Cervical Spinal Cord Injury: A Retrospective Case Series
Bhatia, N. S., Kunzweiler, S., Conley, C., Kim, K. H., Adewuyi, A. A., Mondriguez-Gonzalez, A., Wolfe, L. F., Kwasny, M. & Franz, C. K., Jan 2025, In: Journal of Ultrasound in Medicine. 44, 1, p. 119-126 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Anomalous education: You can't bypass electrodiagnostic training in PM&R residency
Howard, I. M., Tan, F. C., Irwin, R. W., Laughlin, R. S., Chiodo, A., Grant, P. A., Adkins, S., Krzesniak-Swinarska, M., Malhotra, G., Franz, C. K. & Quan, D., 2024, (Accepted/In press) In: PM and R.Research output: Contribution to journal › Letter › peer-review
Open Access -
Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis
Liu, J., Liu, N., Xu, Y., Wu, M., Zhang, H., Wang, Y., Yan, Y., Hill, A., Song, R., Xu, Z., Park, M., Wu, Y., Ciatti, J. L., Gu, J., Luan, H., Zhang, Y., Yang, T., Ahn, H. Y., Li, S. & Ray, W. Z. & 6 others, , Mar 8 2024, In: Science. 383, 6687, p. 1096-1103 8 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Decellularized Biohybrid Nerve Promotes Motor Axon Projections
Mehta, A. S., Zhang, S. L., Xie, X., Khanna, S., Tropp, J., Ji, X., Daso, R. E., Franz, C. K., Jordan, S. W. & Rivnay, J., Dec 4 2024, In: Advanced Healthcare Materials. 13, 30, 2401875.Research output: Contribution to journal › Article › peer-review
Open Access -
Incorporation of decellularized-ECM in graphene-based scaffolds enhances axonal outgrowth and branching in neuro-muscular co-cultures
Serna, C., Sandepudi, K., Keate, R. L., Zhang, S. L., Cotton, K. Y., De La Isla, A., Murillo, M., Bouricha, Y., Domenighetti, A. A., Franz, C. K. & Jordan, S. W., Jul 1 2024, In: Science Progress. 107, 3Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models
Franz, C. K. (Creator), Puritz, A. (Creator), Jordan, L. A. (Creator), Chow, J. (Creator), Ortega, J. A. (Contributor), Kiskinis, E. (Creator) & Heckman, C. J. (Creator), figshare, 2018
DOI: 10.25384/sage.c.4178645, https://figshare.com/collections/Botulinum_Toxin_Conditioning_Enhances_Motor_Axon_Regeneration_in_Mouse_and_Human_Preclinical_Models/4178645
Dataset