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Personal profile

Research Interests

The research in my lab is centered on autophagy, a lysosomal degradation pathway essential for nutrient recycling, cellular maintenance and physiological function. Autophagy is induced by various stress conditions, and allows cells to adapt to changing nutrient and energy demands through protein catabolism. Malfunction of autophagy is implicated in a variety of diseases such as cancer, neurodegeneration, infection and aging. Our interest focuses on the roles and mechanisms of autophagy in the metabolic regulation of mammals and in the pathogenesis of metabolic disorders in human, including obesity and type 2 diabetes. There are many open questions in this largely unexplored area; our research directions include studies of the functions of autophagy in exercise-induced metabolic benefits, and investigation of the molecular mechanism of autophagy and its relationship to other lysosomal degradation pathways in the prevention of metabolic dysregulation.

Training Experience

2013Fellowship, UT Southwestern Medical Center, Dallas, TX

Education/Academic qualification

PhD, University of Michigan

… → 2009

Research interests

  • Brain and Nervous System
  • Cell Biology
  • Diabetes
  • Endocrinology
  • Metabolism
  • Molecular Biology
  • Obesity

Fingerprint Dive into the research topics where Congcong He is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Autophagy Medicine & Life Sciences
Lysosomes Medicine & Life Sciences
Insulin Resistance Medicine & Life Sciences
Membranes Medicine & Life Sciences
Organelles Medicine & Life Sciences
Zebrafish Medicine & Life Sciences
Vacuoles Medicine & Life Sciences
MicroRNAs Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2014 2022

Alzheimer Disease
Amyloid
Autophagy
Brain
Poisons
Autophagy
Type 2 Diabetes Mellitus
Insulin
Insulin Resistance
Fasting
pilot project
dementia
interaction
resources
caregiver
pilot project
dementia
interaction
resources
caregiver
Cannabinoids
Autophagy
Alzheimer Disease
Cannabinoid Receptors
Class III Phosphatidylinositol 3-Kinases

Research Output 2006 2019

  • 10842 Citations
  • 24 Article
  • 7 Review article
  • 3 Comment/debate
2 Citations (Scopus)

Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance

Yang, S., Yan, J., Yang, L., Meng, Y., Wang, N., He, C., Fan, Y. & Zhou, Y., Apr 1 2019, In : International Journal of Biological Macromolecules. 126, p. 466-474 9 p.

Research output: Contribution to journalArticle

Mushroom Bodies
Insulin
Alkalies
Polysaccharides
Insulin Resistance
13 Citations (Scopus)

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

Yamamoto, S., Kuramoto, K., Wang, N., Situ, X., Priyadarshini, M., Zhang, W., Cordoba-Chacon, J., Layden, B. T. & He, C., Jun 12 2018, In : Cell reports. 23, 11, p. 3286-3299 14 p.

Research output: Contribution to journalArticle

Autophagy
Insulin Resistance
Insulin
High Fat Diet
Nutrition
79 Citations (Scopus)

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W. C., Marciano, D. K., Schiattarella, G. G., Bhagat, G., Moe, O. W., Hu, M. C. & Levine, B., Jun 7 2018, In : Nature. 558, 7708, p. 136-140 5 p.

Research output: Contribution to journalArticle

Autophagy
Premature Aging
Phenotype
Mutation
Infertility
4 Citations (Scopus)

Erratum to: Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice (Nature, (2018), 558, 7708, (136-140), 10.1038/s41586-018-0162-7)

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W. C., Marciano, D. K., Schiattarella, G. G., Bhagat, G., Moe, O. W., Hu, M. C. & Levine, B., Sep 20 2018, In : Nature. 561, 7723, p. E30

Research output: Contribution to journalComment/debate

Information Storage and Retrieval
Autophagy
Ointments
6 Citations (Scopus)

MicroRNAs-103/107 Regulate Autophagy in the Epidermis

Wang, S., Kobeissi, A., Dong, Y., Kaplan, N., Yang, W., He, C., Zeng, K. & Peng, H., Jul 2018, In : Journal of Investigative Dermatology. 138, 7, p. 1481-1490 10 p.

Research output: Contribution to journalArticle

Dynamins
Autophagy
MicroRNAs
Epidermis
Keratinocytes