Grants per year
Personal profile
Research Interests
The research in my lab is centered on autophagy, a lysosomal degradation pathway essential for nutrient recycling, cellular maintenance and physiological function. Autophagy is induced by various stress conditions, and allows cells to adapt to changing nutrient and energy demands through protein catabolism. Malfunction of autophagy is implicated in a variety of diseases such as cancer, neurodegeneration, infection and aging. Our interest focuses on the roles and mechanisms of autophagy in the metabolic regulation of mammals and in the pathogenesis of metabolic disorders in human, including obesity and type 2 diabetes. There are many open questions in this largely unexplored area; our research directions include studies of the functions of autophagy in exercise-induced metabolic benefits, and investigation of the molecular mechanism of autophagy and its relationship to other lysosomal degradation pathways in the prevention of metabolic dysregulation.
Training Experience
| 2013 | Fellowship, UT Southwestern Medical Center, Dallas, TX |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Michigan
… → 2009
Research interests keywords
- Brain and Nervous System
- Cell Biology
- Diabetes
- Endocrinology
- Metabolism
- Molecular Biology
- Obesity
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Ocular mustard keratopathy elicits induced autophagy, which is detrimental to the cornea
Peng, H. (PD/PI), He, C. (Co-Investigator), Lavker, R. M. (Co-Investigator) & Lu, K. (Co-Investigator)
9/1/24 → 8/31/25
Project: Research project
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The Roles of Autophagy in Limbal/Corneal Epithelia
Peng, H. (PD/PI), He, C. (Co-Investigator) & Lu, K. (Co-Investigator)
3/1/24 → 2/28/29
Project: Research project
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Mechanism of autophagy activation in exercise-induced anti-diabetic benefits
He, C. (PD/PI) & He, C. (PD/PI)
National Institute of Diabetes and Digestive and Kidney Diseases
9/13/22 → 7/31/26
Project: Research project
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Autophagic regulation of cocaine abuse
He, C. (PD/PI) & He, C. (PD/PI)
National Institute on Drug Abuse
8/15/22 → 5/31/27
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Women in Autophagy: an initiative to promote gender parity in science
McCabe, M., Boya, P., Chen, R. H., Chu, C. T., Colombo, M. I., Delgui, L., Eskelinen, E. L., Hamasaki, M., Hansen, M., He, C., Jäättelä, M., Kimchi, A., Kraft, C., Kundu, M., Melendez, A., Pattingre, S., Proikas-Cezanne, T., Sebti, S., Simon, A. K. & Simonsen, A. & 6 others, , Dec 2024, In: Nature Cell Biology. 26, 12, p. 2009-2012 4 p.Research output: Contribution to journal › Comment/debate › peer-review
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Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
Kuramoto, K., Liang, H., Hong, J. H. & He, C., Apr 4 2023, In: Cell Metabolism. 35, 4, p. 620-632.e5Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Genetically prolonged beige fat in male mice confers long-lasting metabolic health
Wu, R., Park, J., Qian, Y., Shi, Z., Hu, R., Yuan, Y., Xiong, S., Wang, Z., Yan, G., Ong, S. G., Song, Q., Song, Z., Mahmoud, A. M., Xu, P., He, C., Arpke, R. W., Kyba, M., Shu, G., Jiang, Q. & Jiang, Y., Dec 2023, In: Nature communications. 14, 1, 2731.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs
Qiu, X., Li, N., Yang, Q., Wu, S., Li, X., Pan, X., Yamamoto, S., Zhang, X., Zeng, J., Liao, J., He, C., Wang, R. & Zhao, Y., 2023, In: Autophagy. 19, 11, p. 2884-2898 15 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Autophagy Enhances Longevity of Induced Pluripotent Stem Cell-Derived Endothelium via mTOR-Independent ULK1 Kinase
Hekman, K. E., Koss, K. M., Ivancic, D. Z., He, C. & Wertheim, J. A., Nov 2022, In: Stem Cells Translational Medicine. 11, 11, p. 1151-1164 14 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Datasets
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Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs
Qiu, X. (Contributor), Li, N. (Contributor), Yang, Q. (Contributor), Wu, S. (Contributor), Li, X. (Contributor), Pan, X. (Contributor), Yamamoto, S. (Contributor), Zhang, X. (Contributor), Zeng, J. (Contributor), Liao, J. (Contributor), He, C. (Contributor), Wang, R. (Contributor) & Zhao, Y. (Contributor), Protein Data Bank (PDB), Jul 26 2023
DOI: 10.2210/pdb8GT9/pdb, https://www.wwpdb.org/pdb?id=pdb_00008gt9
Dataset
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Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs
Qiu, X. (Contributor), Li, N. (Contributor), Yang, Q. (Contributor), Wu, S. (Contributor), Li, X. (Contributor), Pan, X. (Contributor), Yamamoto, S. (Contributor), Zhang, X. (Contributor), Zeng, J. (Contributor), Liao, J. (Contributor), He, C. (Contributor), Wang, R. (Contributor) & Zhao, Y. (Contributor), Protein Data Bank (PDB), Jul 26 2023
DOI: 10.2210/pdb8GU7/pdb, https://www.wwpdb.org/pdb?id=pdb_00008gu7
Dataset
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Identification of natural products with neuronal and metabolic benefits through autophagy induction
Rocchi, A. (Creator), Fan, Y. (Contributor), Zhang, W. (Contributor), Vassar, R. (Creator), He, C. (Contributor), Wang, N. (Creator) & Zhou, Y. (Contributor), Taylor & Francis, 2016
DOI: 10.6084/m9.figshare.4123170.v1, https://tandf.figshare.com/articles/dataset/Identification_of_natural_products_with_neuronal_and_metabolic_benefits_through_autophagy_induction/4123170/1
Dataset
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Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids
Kuramoto, K. (Creator), Wang, N. (Creator), Fan, Y. (Contributor), Zhang, W. (Contributor), Schoenen, F. J. (Creator), Frankowski, K. J. (Creator), Marugan, J. (Creator), Zhou, Y. (Contributor), Huang, S. (Creator) & He, C. (Contributor), figshare, 2016
DOI: 10.6084/m9.figshare.3438647.v1, https://tandf.figshare.com/articles/dataset/Autophagy_activation_by_novel_inducers_prevents_BECN2-mediated_drug_tolerance_to_cannabinoids/3438647/1
Dataset