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Personal profile

Research Interests

The research in my lab is centered on autophagy, a lysosomal degradation pathway essential for nutrient recycling, cellular maintenance and physiological function. Autophagy is induced by various stress conditions, and allows cells to adapt to changing nutrient and energy demands through protein catabolism. Malfunction of autophagy is implicated in a variety of diseases such as cancer, neurodegeneration, infection and aging. Our interest focuses on the roles and mechanisms of autophagy in the metabolic regulation of mammals and in the pathogenesis of metabolic disorders in human, including obesity and type 2 diabetes. There are many open questions in this largely unexplored area; our research directions include studies of the functions of autophagy in exercise-induced metabolic benefits, and investigation of the molecular mechanism of autophagy and its relationship to other lysosomal degradation pathways in the prevention of metabolic dysregulation.

Training Experience

2013Fellowship, UT Southwestern Medical Center, Dallas, TX

Education/Academic qualification

PhD, University of Michigan

… → 2009

Research interests

  • Brain and Nervous System
  • Cell Biology
  • Diabetes
  • Endocrinology
  • Metabolism
  • Molecular Biology
  • Obesity

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Grants

  • Research Output

    • 11635 Citations
    • 24 Article
    • 7 Review article
    • 3 Comment/debate

    Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance

    Yang, S., Yan, J., Yang, L., Meng, Y., Wang, N., He, C., Fan, Y. & Zhou, Y., Apr 1 2019, In : International Journal of Biological Macromolecules. 126, p. 466-474 9 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations

    Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

    Yamamoto, S., Kuramoto, K., Wang, N., Situ, X., Priyadarshini, M., Zhang, W., Cordoba-Chacon, J., Layden, B. T. & He, C., Jun 12 2018, In : Cell reports. 23, 11, p. 3286-3299 14 p.

    Research output: Contribution to journalArticle

  • 19 Scopus citations

    Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

    Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W. C., Marciano, D. K., Schiattarella, G. G., Bhagat, G., Moe, O. W., Hu, M. C. & Levine, B., Jun 7 2018, In : Nature. 558, 7708, p. 136-140 5 p.

    Research output: Contribution to journalArticle

  • 100 Scopus citations

    Erratum to: Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice (Nature, (2018), 558, 7708, (136-140), 10.1038/s41586-018-0162-7)

    Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W. C., Marciano, D. K., Schiattarella, G. G., Bhagat, G., Moe, O. W., Hu, M. C. & Levine, B., Sep 20 2018, In : Nature. 561, 7723, p. E30

    Research output: Contribution to journalComment/debate

  • 4 Scopus citations

    MicroRNAs-103/107 Regulate Autophagy in the Epidermis

    Wang, S., Kobeissi, A., Dong, Y., Kaplan, N., Yang, W., He, C., Zeng, K. & Peng, H., Jul 2018, In : Journal of Investigative Dermatology. 138, 7, p. 1481-1490 10 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations