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Craig Michael Horbinski

  • 4714 Citations
20002025

Research output per year

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Personal profile

Research Interests

The main focus of our laboratory is developing a better understanding of how key mutations in gliomas alter their biological characteristics, and how best to exploit specific weaknesses that such mutations often impart. In particular, our laboratory focuses on mutant isocitrate dehydrogenase 1 (mutIDH1), which is present in the vast majority of WHO grade II and III gliomas. This mutation has profound effects on the epigenome and metabolome, yet produces tumors that are markedly less aggressive. Our work indicates that mutIDH1 also dramatically alters the glioma’s micro-environmental landscape by preventing the thrombosis-necrosis phenomenon that is characteristic of IDH1 wild-type gliomas. Furthermore, mutIDH1 increases the risk of seizures in patients. We are currently exploring the mechanisms by which these phenomena occur, as it will have major implications for understanding why mutIDH1 gliomas are less aggressive and how to better manage both wtIDH1 and mutIDH1 gliomas. On a clinical level, I specialize in the use of molecular testing in brain tumors to improve our diagnostic and prognostic accuracy. This is helping us achieve the goal of personalized medicine through cutting-edge next generation sequencing.

Training Experience

2004Postdoctoral Fellowship, University of Pittsburgh
2007Residency, University of Pittsburgh
2009Fellowship, University of Pittsburgh

Education/Academic qualification

MD, State University of New York

… → 2003

PhD, State University of New York

… → 2003

Research interests

  • Brain Cancer / Nervous System Cancer
  • Cancer Biology
  • Molecular Diagnostics
  • Pathology

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Grants

Development of Novel MNK Inhibitors for Treating Glioblastoma

Clutter, M., Eckerdt, F. D., Horbinski, C. M., James, C. D., Mishra, R. K., Platanias, L. C. & Schiltz, G. E.

National Institute of Neurological Disorders and Stroke

9/1/19 → 6/30/24

Project: Research project

    • Tissue factor as a regulator of receptor tyrosine kinases in glioblastoma

    Horbinski, C. M.

    American Brain Tumor Association

    8/15/19 → 8/14/21

    Project: Research project

    • Neural Stem Cell Carriers for Glioblastoma Immunotherapy

    Balyasnikova, I. V., Horbinski, C. M. & James, C. D.

    National Institute of Neurological Disorders and Stroke

    6/1/19 → 5/31/21

    Project: Research project

    Genetic Approaches to Optimize CAR T cells for Glioblastoma Therapy

    Balyasnikova, I. V., Horbinski, C. M. & Lesniak, M. S.

    National Institute of Neurological Disorders and Stroke

    9/30/18 → 8/31/23

    Project: Research project

    • Biospecimen Core Subproject for Institution # SP0045923

    Horbinski, C. M.

    National Cancer Institute

    8/17/18 → 7/31/23

    Project: Research project

    • Research Output

    Advances in multidisciplinary therapy for meningiomas

    International Consortium on Meningiomas, Jan 14 2019, In : Neuro-oncology. 21, p. I18-I31

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    Author Correction: Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma (Nature Medicine, (2019), 25, 3, (462-469), 10.1038/s41591-019-0349-y)

    Zhao, J., Chen, A. X., Gartrell, R. D., Silverman, A. M., Aparicio, L., Chu, T., Bordbar, D., Shan, D., Samanamud, J., Mahajan, A., Filip, I., Orenbuch, R., Goetz, M., Yamaguchi, J. T., Cloney, M., Horbinski, C., Lukas, R. V., Raizer, J., Rae, A. I., Yuan, J. & 7 others, Canoll, P., Bruce, J. N., Saenger, Y. M., Sims, P., Iwamoto, F. M., Sonabend, A. M. & Rabadan, R., Jun 1 2019, In : Nature Medicine. 25, 6, 1 p.

    Research output: Contribution to journal › Comment/debate

    Open Access
    • 2 Scopus citations

    Characterization of squamous cell lung cancers from Appalachian Kentucky

    Liu, J., Murali, T., Yu, T., Liu, C., Sivakumaran, T. A., Moseley, H. N. B., Zhulin, I. B., Weiss, H. L., Durbin, E. B., Ellingson, S. R., Liu, J., Huang, B., Hallahan, B. J., Horbinski, C. M., Hodges, K., Napier, D. L., Bocklage, T., Mueller, J., Vanderford, N. L., Fardo, D. W. & 2 others, Wang, C. & Arnold, S. M., Feb 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 2, p. 348-356 9 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    Clinical Utility of GlioSeq Next-Generation Sequencing Test in Pediatric and Young Adult Patients with Brain Tumors

    Roy, S., Agnihotri, S., El Hallani, S., Ernst, W. L., Wald, A. I., Santana Dos Santos, L., Hamilton, R. L., Horbinski, C. M., Wadhwani, N. R., Born, D. E., Pollack, I. F., Nikiforov, Y. E. & Nikiforova, M. N., Jan 1 2019, In : Journal of neuropathology and experimental neurology. 78, 8, p. 694-702 9 p.

    Research output: Contribution to journal › Article

    • Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017)

    Zhai, L., Ladomersky, E., Lauing, K. L., Wu, M., Scholtens, D. M., Savoor, R., Zhang, B., Wu, J. D., Horbinski, C., Lukas, R. V., Binder, D. C. & Wainwright, D. A., Mar 4 2019, In : OncoImmunology. 8, 3, 1548242.

    Research output: Contribution to journal › Comment/debate