Grants per year
Personal profile
Research Interests
The main focus of our laboratory is developing a better understanding of how key mutations in gliomas alter their biological characteristics, and how best to exploit specific weaknesses that such mutations often impart. In particular, our laboratory focuses on mutant isocitrate dehydrogenase 1 (mutIDH1), which is present in the vast majority of WHO grade II and III gliomas. This mutation has profound effects on the epigenome and metabolome, yet produces tumors that are markedly less aggressive. Our work indicates that mutIDH1 also dramatically alters the glioma’s micro-environmental landscape by preventing the thrombosis-necrosis phenomenon that is characteristic of IDH1 wild-type gliomas. Furthermore, mutIDH1 increases the risk of seizures in patients. We are currently exploring the mechanisms by which these phenomena occur, as it will have major implications for understanding why mutIDH1 gliomas are less aggressive and how to better manage both wtIDH1 and mutIDH1 gliomas. On a clinical level, I specialize in the use of molecular testing in brain tumors to improve our diagnostic and prognostic accuracy. This is helping us achieve the goal of personalized medicine through cutting-edge next generation sequencing.
Training Experience
2004 | Postdoctoral Fellowship, University of Pittsburgh |
2007 | Residency, University of Pittsburgh |
2009 | Fellowship, University of Pittsburgh |
Education/Academic qualification
MD, State University of New York
… → 2003
PhD, State University of New York
… → 2003
Research interests
- Brain Cancer / Nervous System Cancer
- Cancer Biology
- Molecular Diagnostics
- Pathology
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Grants
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Targeting IDH mutations to improve seizure control in glioma patients
Horbinski, C. M., Templer, J. W. & Xi, G.
National Institute of Neurological Disorders and Stroke
8/1/20 → 4/30/25
Project: Research project
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Modeling the Glioblastoma Microenvironment to Uncover Progression Mechanisms and Therapeutic Targets
Brat, D. J., Horbinski, C. M., James, C. D. & Mukherjee, S.
5/1/20 → 4/30/25
Project: Research project
Research Output
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Activation of 4-1BBL+ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma
Lee-Chang, C., Miska, J., Hou, D., Rashidi, A., Zhang, P., Burga, R. A., Jusúe, I. T., Xiao, T., Arrieta, V. A., Zhang, D. Y., Lopez-Rosas, A., Han, Y., Sonabend, A. M., Horbinski, C. M., Stupp, R., Balyasnikova, I. V. & Lesniak, M. S., Jan 4 2021, In: Journal of Experimental Medicine. 218, 1Research output: Contribution to journal › Article › peer-review
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BET inhibition increases βIII-tubulin expression and sensitizes metastatic breast cancer in the brain to vinorelbine
Kanojia, D., Panek, W. K., Cordero, A., Fares, J., Xiao, A., Savchuk, S., Kumar, K., Xiao, T., Pituch, K. C., Miska, J., Zhang, P., Kam, K. L., Horbinski, C., Balyasnikova, I. V., Ahmed, A. U. & Lesniak, M. S., Aug 2020, In: Science translational medicine. 12, 558, eaax2879.Research output: Contribution to journal › Article › peer-review
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Beyond thrombosis: The impact of tissue factor signaling in cancer
Unruh, D. & Horbinski, C., Jul 14 2020, In: Journal of Hematology and Oncology. 13, 1, 93.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
CD8+ T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas
Kane, J. R., Zhao, J., Tsujiuchi, T., Laffleur, B., Arrieta, V. A., Mahajan, A., Rao, G., Mela, A., Dmello, C., Chen, L., Zhang, D. Y., Gonzalez-Buendia, E., Lee-Chang, C., Xiao, T., Rothschild, G., Basu, U., Horbinski, C., Lesniak, M. S., Heimberger, A. B., Rabadan, R. & 2 others, , Aug 15 2020, In: Clinical Cancer Research. 26, 16, p. 4390-4401 12 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Central nervous system cancers, version 3.2020
Nabors, L. B., Portnow, J., Ahluwalia, M., Baehring, J., Brem, H., Brem, S., Butowski, N., Campian, J. L., Clark, S. W., Fabiano, A. J., Forsyth, P., Hattangadi-Gluth, J., Holdhoff, M., Horbinski, C., Junck, L., Kaley, T., Kumthekar, P., Loeffler, J. S., Mrugala, M. M., Nagpal, S. & 15 others, , Nov 2020, In: JNCCN Journal of the National Comprehensive Cancer Network. 18, 11, p. 1537-1570 34 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations