Curt M Horvath

  • 12680 Citations
1990 …2020

Research output per year

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Research Output

2019

RNA Helicase LGP2 Negatively Regulates RIG-I Signaling by Preventing TRIM25-Mediated Caspase Activation and Recruitment Domain Ubiquitination

Quicke, K. M., Kim, K. Y., Horvath, C. M. & Suthar, M. S., Nov 2019, In : Journal of Interferon and Cytokine Research. 39, 11, p. 669-683 15 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Constitutively Active MDA5 Proteins Are Inhibited by Paramyxovirus v Proteins

Mandhana, R., Qian, L. K. & Horvath, C. M., Aug 1 2018, In : Journal of Interferon and Cytokine Research. 38, 8, p. 319-332 14 p.

Research output: Contribution to journalArticle

Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G

Pollpeter, D., Parsons, M., Sobala, A. E., Coxhead, S., Lang, R. D., Bruns, A. M., Papaioannou, S., McDonnell, J. M., Apolonia, L., Chowdhury, J. A., Horvath, C. M. & Malim, M. H., Feb 1 2018, In : Nature Microbiology. 3, 2, p. 220-233 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Histone H2A.Z Suppression of Interferon-Stimulated Transcription and Antiviral Immunity Is Modulated by GCN5 and BRD2

Au-Yeung, N. & Horvath, C. M., Aug 31 2018, In : iScience. 6, p. 68-82 15 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

IFN--inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5

Saleiro, D., Blyth, G. T., Kosciuczuk, E. M., Ozark, P. A., Majchrzak-Kita, B., Arslan, A. D., Fischietti, M., Reddy, N. K., Horvath, C. M., Davis, R. J., Fish, E. N. & Platanias, L. C., Nov 20 2018, In : Science Signaling. 11, 557, aap9921.

Research output: Contribution to journalArticle

1 Scopus citations

RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling

Parisien, J. P., Lenoir, J. J., Mandhana, R., Rodriguez, K. R., Qian, K., Bruns, A. M. & Horvath, C. M., Jun 2018, In : EMBO Reports. 19, 6, e45176.

Research output: Contribution to journalArticle

15 Scopus citations

Sendai Virus Infection Induces Expression of Novel RNAs in Human Cells

Mandhana, R. & Horvath, C. M., Dec 1 2018, In : Scientific reports. 8, 1, 16815.

Research output: Contribution to journalArticle

Transcriptional and chromatin regulation in interferon and innate antiviral gene expression

Au-Yeung, N. & Horvath, C. M., Dec 2018, In : Cytokine and Growth Factor Reviews. 44, p. 11-17 7 p.

Research output: Contribution to journalReview article

6 Scopus citations
2016

The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection

Komuro, A., Homma, Y., Negoro, T., Barber, G. N. & Horvath, C. M., Nov 11 2016, In : Biochemical and Biophysical Research Communications. 480, 2, p. 187-193 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

A serpin takes a bite out of the flu

Horvath, C. M., Mar 11 2015, In : Cell Host and Microbe. 17, 3, p. 283-284 2 p.

Research output: Contribution to journalShort survey

Editorial overview: Antiviral strategies

Gale, M. & Horvath, C. M., Jun 14 2015, In : Current Opinion in Virology. 12, p. v-vii

Research output: Contribution to journalEditorial

1 Scopus citations

LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling

Bruns, A. M. & Horvath, C. M., Dec 3 2015, In : Cytokine. 74, 2, p. 198-206 9 p.

Research output: Contribution to journalReview article

43 Scopus citations

Pan-cancer analysis of TCGA data reveals notable signaling pathways

Neapolitan, R. E., Horvath, C. M. & Jiang, X., Jul 14 2015, In : BMC cancer. 15, 1, 516.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Antiviral RNA recognition and assembly by RLR family innate immune sensors

Bruns, A. M. & Horvath, C. M., Oct 1 2014, In : Cytokine and Growth Factor Reviews. 25, 5, p. 507-512 6 p.

Research output: Contribution to journalArticle

38 Scopus citations
29 Scopus citations

High-density nucleosome occupancy map of human chromosome 9p21-22 reveals chromatin organization of the type I interferon gene cluster

Freaney, J. E., Zhang, Q., Yigit, E., Kim, R., Widom, J., Wang, J. & Horvath, C. M., Sep 1 2014, In : Journal of Interferon and Cytokine Research. 34, 9, p. 676-685 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

MDA5 and LGP2: Accomplices and antagonists of antiviral signal transduction

Rodriguez, K. R., Bruns, A. M. & Horvath, C. M., 2014, In : Journal of virology. 88, 15, p. 8194-8200 7 p.

Research output: Contribution to journalShort survey

50 Scopus citations
18 Scopus citations

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

Bruns, A. M., Leser, G. P., Lamb, R. A. & Horvath, C. M., Jan 1 2014, In : Molecular cell. 55, 5, p. 771-781 11 p.

Research output: Contribution to journalArticle

117 Scopus citations
2013

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory

Light, W. H., Freaney, J., Sood, V., Thompson, A., D'Urso, A., Horvath, C. M. & Brickner, J. H., Mar 2013, In : PLoS biology. 11, 3, e1001524.

Research output: Contribution to journalArticle

93 Scopus citations

Amino acid requirements for MDA5 and LGP2 recognition by paramyxovirus V proteins: A single arginine distinguishes MDA5 from RIG-I

Rodriguez, K. R. & Horvath, C. M., Mar 1 2013, In : Journal of virology. 87, 5, p. 2974-2978 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2)

Bruns, A. M., Pollpeter, D., Hadizadeh, N., Myong, S., Marko, J. F. & Horvath, C. M., Jan 11 2013, In : Journal of Biological Chemistry. 288, 2, p. 938-946 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Detection of activated STAT proteins.

Parisien, J. P. & Horvath, C. M., Jun 13 2013, In : Methods in molecular biology (Clifton, N.J.). 967, p. 135-145 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Extensive cooperation of immune master regulators IRF3 and NFκB in RNA Pol II recruitment and pause release in human innate antiviral transcription

Freaney, J. E., Kim, R., Mandhana, R. & Horvath, C. M., May 12 2013, In : Cell reports. 4, 5, p. 959-973 15 p.

Research output: Contribution to journalArticle

39 Scopus citations

MicroRNA profiling of sendai virus-infected A549 cells identifies miR-203 as an interferon-inducible regulator of IFIT1/ISG56

Buggele, W. A. & Horvath, C. M., Aug 1 2013, In : Journal of virology. 87, 16, p. 9260-9270 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Small RNA Profiling of Influenza A Virus-Infected Cells Identifies miR-449b as a Regulator of Histone Deacetylase 1 and Interferon Beta

Buggele, W. A., Krause, K. E. & Horvath, C. M., Sep 26 2013, In : PloS one. 8, 9, e76560.

Research output: Contribution to journalArticle

29 Scopus citations

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway

Au-Yeung, N., Mandhana, R. & Horvath, C. M., 2013, In : JAK-STAT. e23931 .

Research output: Contribution to journalArticle

2012

Activation and inhibition of JAK-STAT signal transduction by RNA viruses

Horvath, C. M., Nov 1 2012, Jak-Stat Signaling: From Basics to Disease. Springer-Verlag Wien, Vol. 9783709108918. p. 371-385 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Activation of RIG-I-like receptor signal transduction

Bruns, A. M. & Horvath, C. M., Mar 1 2012, In : Critical Reviews in Biochemistry and Molecular Biology. 47, 2, p. 194-206 13 p.

Research output: Contribution to journalReview article

54 Scopus citations

Influenza A virus infection of human respiratory cells induces primary microRNA expression

Buggele, W. A., Johnson, K. E. & Horvath, C. M., Sep 7 2012, In : Journal of Biological Chemistry. 287, 37, p. 31027-31040 14 p.

Research output: Contribution to journalArticle

80 Scopus citations
2011

Impaired cellular responses to cytosolic DNA or infection with listeria monocytogenes and vaccinia virus in the absence of the murine LGP2 protein

Pollpeter, D., Komuro, A., Barber, G. N. & Horvath, C. M., 2011, In : PloS one. 6, 4, e18842.

Research output: Contribution to journalArticle

27 Scopus citations
2010
48 Scopus citations
2009

A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting

Puri, M., Lemon, K., Duprex, W. P., Rima, B. K. & Horvath, C. M., Jul 1 2009, In : Journal of virology. 83, 13, p. 6347-6356 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

A shared interface mediates Paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2

Parisien, J. P., Bamming, D., Komuro, A., Ramachandran, A., Rodriguez, J. J., Barber, G., Wojahn, R. D. & Horvath, C. M., Jul 1 2009, In : Journal of virology. 83, 14, p. 7252-7260 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Paramyxovirus disruption of interferon signal transduction: STATus report

Ramachandran, A. & Horvath, C. M., Sep 1 2009, In : Journal of Interferon and Cytokine Research. 29, 9, p. 531-537 7 p.

Research output: Contribution to journalReview article

49 Scopus citations

Regulating immune response using polyvalent nucleic acid-gold nanoparticle conjugates

Massich, M. D., Giljohann, D. A., Seferos, D. S., Ludlow, L. E., Horvath, C. M. & Mirkin, C. A., Dec 7 2009, In : Molecular Pharmaceutics. 6, 6, p. 1934-1940 7 p.

Research output: Contribution to journalArticle

102 Scopus citations

Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2

Bamming, D. & Horvath, C. M., Apr 10 2009, In : Journal of Biological Chemistry. 284, 15, p. 9700-9712 13 p.

Research output: Contribution to journalArticle

113 Scopus citations
2008

Enabled interferon signaling evasion in an immune-competent transgenic mouse model of parainfluenza virus 5 infection

Kraus, T. A., Garza, L. & Horvath, C. M., Feb 5 2008, In : Virology. 371, 1, p. 196-205 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Henipavirus V protein association with polo-like kinase reveals functional overlap with STAT1 binding and interferon evasion

Ludlow, L. E., Lo, M. K., Rodriguez, J. J., Rota, P. A. & Horvath, C. M., Jul 1 2008, In : Journal of virology. 82, 13, p. 6259-6271 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Negative regulation of cytoplasmic RNA-mediated antiviral signaling

Komuro, A., Bamming, D. & Horvath, C. M., Sep 1 2008, In : Cytokine. 43, 3, p. 350-358 9 p.

Research output: Contribution to journalReview article

98 Scopus citations

Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of κB kinase ε (IKKe)/TBK1

Lu, L. L., Puri, M., Horvath, C. M. & Sen, G. C., May 23 2008, In : Journal of Biological Chemistry. 283, 21, p. 14269-14276 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition

Ramachandran, A., Parisien, J. P. & Horvath, C. M., Sep 1 2008, In : Journal of virology. 82, 17, p. 8330-8338 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

Friedman, C. S., O'Donnell, M. A., Legarda-Addison, D., Ng, A., Cárdenas, W. B., Yount, J. S., Moran, T. M., Basler, C. F., Komuro, A., Horvath, C. M., Xavier, R. & Ting, A. T., Jul 21 2008, In : EMBO Reports. 9, 9, p. 930-936 7 p.

Research output: Contribution to journalArticle

213 Scopus citations
2006

A novel role for viral-defective interfering particles in enhancing dendritic cell maturation

Yount, J. S., Kraus, T. A., Horvath, C. M., Moran, T. M. & López, C. B., Oct 1 2006, In : Journal of Immunology. 177, 7, p. 4503-4513 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases

Gu, W., Nusinzon, I., Smith, R. D., Horvath, C. M. & Silverman, R. B., May 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 10, p. 3320-3329 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Measles virus V protein inhibits p53 family member p73

Cruz, C. D., Palosaari, H., Parisien, J. P., Devaux, P., Cattaneo, R., Ouchi, T. & Horvath, C. M., Jun 1 2006, In : Journal of virology. 80, 11, p. 5644-5650 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation

Nusinzon, I. & Horvath, C. M., Apr 1 2006, In : Molecular and cellular biology. 26, 8, p. 3106-3113 8 p.

Research output: Contribution to journalArticle

102 Scopus citations

RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2

Komuro, A. & Horvath, C. M., Dec 2006, In : Journal of virology. 80, 24, p. 12332-12342 11 p.

Research output: Contribution to journalArticle

202 Scopus citations
2005

Composition and assembly of STAT-targeting ubiquitin ligase complexes: Paramyxovirus V protein carboxyl terminus is an oligomerization domain

Ulane, C. M., Kentsis, A., Cruz, C. D., Parisien, J. P., Schneider, K. L. & Horvath, C. M., Aug 1 2005, In : Journal of virology. 79, 16, p. 10180-10189 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation.

Nusinzon, I. & Horvath, C. M., Aug 9 2005, In : Science's STKE : signal transduction knowledge environment. 2005, 296, p. re11

Research output: Contribution to journalReview article

72 Scopus citations