D Martin Watterson

  • 7249 Citations
1976 …2019
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Personal profile

Research Interests

The elucidation of eukaryotic signal transduction pathways, the study of signal transduction pathway perturbation in disease or injury, and the utilization of this knowledgebase for rational drug discovery and development.

Training Experience

1977Postdoctoral Fellowship, Duke University

Education/Academic qualification

PhD, Emory University

… → 1975

Keywords

  • Alzheimer's Drug
  • Biochemistry: Proteins
  • Brain Cancer / Nervous System Cancer
  • Brain Injury
  • Drug Discovery
  • Neuroinflammation
  • Pharmacology
  • Signal Transduction

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Grants 2003 2019

Drug Delivery Systems
Neurodegenerative Diseases
Encephalitis
Neuroglia
Dementia
Protein Kinase Inhibitors
Contracts
Drug Storage
Drug Stability
Information Storage and Retrieval

Research Output 1976 2019

MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

Al-Sadi, R., Youssef, M., Rawat, M., Guo, S., Dokladny, K., Haque, M., Watterson, D. M. & Ma, T. Y., Feb 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 2, p. G278-G290

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
MAP Kinase Signaling System
Matrix Metalloproteinase 9
Permeability
Tight Junctions
1 Citation (Scopus)

An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease

Rutigliano, G., Stazi, M., Arancio, O., Watterson, D. M. & Origlia, N., Oct 1 2018, In : Neurobiology of Aging. 70, p. 86-91 6 p.

Research output: Contribution to journalArticle

Entorhinal Cortex
p38 Mitogen-Activated Protein Kinases
Protein Kinase Inhibitors
Long-Term Potentiation
Amyloid beta-Protein Precursor
1 Citation (Scopus)

P38a MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

Robson, M. J., Quinlan, M. A., Margolis, K. G., Gajewski-Kurdziel, P. A., Veenstra-Vander Weele, J., Gershon, M. D., Watterson, D. M. & Blakely, R. D., Oct 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. E10245-E10254

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Serotonin
Phenotype
Receptor, Serotonin, 5-HT2A
Brain
4 Citations (Scopus)

Inhibition of polo-like kinase 4 (PLK4): A new therapeutic option for rhabdoid tumors and pediatric medulloblastoma

Sredni, S. T., Bailey, A. W., Suri, A., Hashizume, R., He, X., Louis, N., Gokirmak, T., Piper, D. R., Watterson, D. M. & Tomita, T., Jan 1 2017, In : Oncotarget. 8, 67, p. 111190-111212 23 p.

Research output: Contribution to journalArticle

Rhabdoid Tumor
Medulloblastoma
Phosphotransferases
Pediatrics
Neoplasms
8 Citations (Scopus)
Myosin-Light-Chain Kinase
Toll-Like Receptor 4
Lipopolysaccharides
Permeability
Tight Junctions