D Martin Watterson

  • 7422 Citations
1976 …2021
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

The elucidation of eukaryotic signal transduction pathways, the study of signal transduction pathway perturbation in disease or injury, and the utilization of this knowledgebase for rational drug discovery and development.

Training Experience

1977Postdoctoral Fellowship, Duke University

Education/Academic qualification

PhD, Emory University

… → 1975

Research interests

  • Alzheimer's Drug
  • Biochemistry: Proteins
  • Brain Cancer / Nervous System Cancer
  • Brain Injury
  • Drug Discovery
  • Neuroinflammation
  • Pharmacology
  • Signal Transduction

Fingerprint Dive into the research topics where D Martin Watterson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Calmodulin Medicine & Life Sciences
Myosin-Light-Chain Kinase Medicine & Life Sciences
Protein Kinases Medicine & Life Sciences
Neuroglia Medicine & Life Sciences
Calcium Medicine & Life Sciences
Death-Associated Protein Kinases Medicine & Life Sciences
Proteins Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2003 2021

Protein Kinase Inhibitors
Contracts
Drug Storage
Drug Stability
Information Storage and Retrieval
Alzheimer Disease
Research Personnel
Drug Stability
Information Storage and Retrieval
Toxicology
Protein Kinase Inhibitors
Contracts
Drug Storage
Drug Stability
Information Storage and Retrieval
Drug Delivery Systems
Neurodegenerative Diseases
Encephalitis
Neuroglia
Dementia

Research Output 1976 2019

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., Van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5298-5311 14 p.

Research output: Contribution to journalArticle

Open Access
Nervous System Diseases
Pharmacology
Crystallography
Protein-Serine-Threonine Kinases
Brain

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia

Braun, D. J., Bachstetter, A. D., Sudduth, T. L., Wilcock, D. M., Watterson, D. M. & Van Eldik, L. J., Jan 1 2019, (Accepted/In press) In : GeroScience.

Research output: Contribution to journalArticle

Open Access
Myosin-Light-Chain Kinase
Blood-Brain Barrier
Blood Vessels
Dementia
Hyperhomocysteinemia
1 Citation (Scopus)

MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

Al-Sadi, R., Youssef, M., Rawat, M., Guo, S., Dokladny, K., Haque, M., Watterson, D. M. & Ma, T. Y., Feb 1 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 2, p. G278-G290

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
MAP Kinase Signaling System
Matrix Metalloproteinase 9
Permeability
Tight Junctions
3 Citations (Scopus)

An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease

Rutigliano, G., Stazi, M., Arancio, O., Watterson, D. M. & Origlia, N., Oct 1 2018, In : Neurobiology of Aging. 70, p. 86-91 6 p.

Research output: Contribution to journalArticle

Entorhinal Cortex
p38 Mitogen-Activated Protein Kinases
Protein Kinase Inhibitors
Long-Term Potentiation
Amyloid beta-Protein Precursor
3 Citations (Scopus)

P38a MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse

Robson, M. J., Quinlan, M. A., Margolis, K. G., Gajewski-Kurdziel, P. A., Veenstra-Vander Weele, J., Gershon, M. D., Watterson, D. M. & Blakely, R. D., Oct 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 43, p. E10245-E10254

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Serotonin
Phenotype
Receptor, Serotonin, 5-HT2A
Brain