D Martin Watterson

  • 7637 Citations
1976 …2020

Research output per year

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Personal profile

Research Interests

The elucidation of eukaryotic signal transduction pathways, the study of signal transduction pathway perturbation in disease or injury, and the utilization of this knowledgebase for rational drug discovery and development.

Training Experience

1977Postdoctoral Fellowship, Duke University

Education/Academic qualification

PhD, Emory University

… → 1975

Research interests

  • Alzheimer's Drug
  • Biochemistry: Proteins
  • Brain Cancer / Nervous System Cancer
  • Brain Injury
  • Drug Discovery
  • Neuroinflammation
  • Pharmacology
  • Signal Transduction

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Grants

  • Research Output

    First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers

    Van Eldik, L. J., Sawaki, L., Bowen, K., Laskowitz, D. T., Noveck, R. J., Hauser, B., Jordan, L., Spears, T. G., Wu, H., Watt, K., Raja, S., Roy, S. M., Watterson, D. M. & Guptill, J. T., 2020, (Accepted/In press) In : Clinical Pharmacology in Drug Development.

    Research output: Contribution to journalArticle

    Open Access
  • A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction

    Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., Van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Jun 13 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5298-5311 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia

    Braun, D. J., Bachstetter, A. D., Sudduth, T. L., Wilcock, D. M., Watterson, D. M. & Van Eldik, L. J., Oct 1 2019, In : GeroScience. 41, 5, p. 671-679 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene

    Al-Sadi, R., Youssef, M., Rawat, M., Guo, S., Dokladny, K., Haque, M., Watterson, M. D. & Ma, T. Y., Feb 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 2, p. G278-G290

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy

    Simon, C. M., Van Alstyne, M., Lotti, F., Bianchetti, E., Tisdale, S., Watterson, D. M., Mentis, G. Z. & Pellizzoni, L., Dec 17 2019, In : Cell reports. 29, 12, p. 3885-3901.e5

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations