• 1420 Citations
20002023
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Personal profile

Research Interests

We're devoted to understanding the cellular events that influence the aggressiveness of breast tumors, and are currently focused on the following areas: (1) Mechanisms of tumor maintenance and progression medicated by proto-oncogenes (i.e., MYC transcription factor, PIM family of serine/threonine kinases, etc), their activators and effectors, and tumor microenvironment. (2) Biology and therapeutic targetability of novel molecular factors that determine patient clinical outcome.

Training Experience

2014Postdoctoral Fellowship, University of California, San Francisco

Education/Academic qualification

PhD, Indiana University

… → 2007

Keywords

  • Bioinformatics
  • Breast Cancer
  • Cancer Biology
  • Cancer Genetics
  • Drug Discovery
  • Immune Regulation
  • Oncology
  • Translational Research

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Grants 2015 2023

Chemotherapy
Tumors
Oncology
Contrast Media
Medicine
Triple Negative Breast Neoplasms
Neoplasms
Breast Neoplasms
Therapeutics
Mutation
Triple Negative Breast Neoplasms
Phosphotransferases
Neoplasms
Therapeutics
Breast Neoplasms
Triple Negative Breast Neoplasms
Neoplasms
Therapeutics
Breast Neoplasms
Research
Imaging techniques
Microscopic examination
Microscopes
Medicine
Robotic arms

Research Output 2000 2018

  • 1420 Citations
  • 14 Article
  • 1 Chapter

Antineoplastic effects of selective CDK9 inhibition with atuveciclib on cancer stem-like cells in triple-negative breast cancer

Brisard, D., Eckerdt, F. D., Marsh, L. A., Blyth, G. T., Jain, S., Cristofanilli, M., Horiuchi, D. & Platanias, L. C., Dec 1 2018, In : Oncotarget. 9, 99, p. 37305-37318 14 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 9
Triple Negative Breast Neoplasms
Neoplastic Stem Cells
Antineoplastic Agents
Recurrence

NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity

Kang, H. J., Song, H. Y., Ahmed, M. A., Guo, Y., Zhang, M., Chen, C., Cristofanilli, M., Horiuchi, D. & Vasilopoulos, A., Oct 1 2018, In : Free Radical Biology and Medicine. 126, p. 358-371 14 p.

Research output: Contribution to journalArticle

Mitosis
NAD
Proteins
Poisons
Cell death
40 Citations (Scopus)

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

Horiuchi, D., Camarda, R., Zhou, A. Y., Yau, C., Momcilovic, O., Balakrishnan, S., Corella, A. N., Eyob, H., Kessenbrock, K., Lawson, D. A., Marsh, L. A., Anderton, B. N., Rohrberg, J., Kunder, R., Bazarov, A. V., Yaswen, P., McManus, M. T., Rugo, H. S., Werb, Z. & Goga, A., Nov 1 2016, In : Nature Medicine. 22, 11, p. 1321-1329 9 p.

Research output: Contribution to journalArticle

Tumors
Phosphotransferases
Breast Neoplasms
Neoplasms
Therapeutics
25 Citations (Scopus)

Linking tumor mutations to drug responses via a quantitative chemical–genetic interaction map

Martins, M. M., Zhou, A. Y., Corella, A., Horiuchi, D., Yau, C., Rakshandehroo, T., Gordan, J. D., Levin, R. S., Johnson, J., Jascur, J., Shales, M., Sorrentino, A., Cheah, J., Clemons, P. A., Shamji, A. F., Schreiber, S. L., Krogan, N. J., Shokat, K. M., McCormick, F., Goga, A. & 1 othersBandyopadhyay, S., Jan 1 2015, In : Cancer Discovery. 5, 2, p. 154-167 14 p.

Research output: Contribution to journalArticle

Mutation
Pharmaceutical Preparations
Neoplasms
Genotype
Triple Negative Breast Neoplasms
170 Citations (Scopus)

Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets

Balko, J. M., Giltnane, J. M., Wang, K., Schwarz, L. J., Young, C. D., Cook, R. S., Owens, P., Sanders, M. E., Kuba, M. G., Sánchez, V., Kurupi, R., Moore, P. D., Pinto, J. A., Doimi, F. D., Gómez, H., Horiuchi, D., Goga, A., Lehmann, B. D., Bauer, J. A., Pietenpol, J. A. & 7 othersRoss, J. S., Palmer, G. A., Yelensky, R., Cronin, M., Miller, V. A., Stephens, P. J. & Arteaga, C. L., Feb 1 2014, In : Cancer Discovery. 4, 2, p. 232-245 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Drug Therapy
Neoplasm Micrometastasis
Therapeutics
Neoplasms