• 1594 Citations

Research output per year

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Research Output

  • 1594 Citations
  • 14 Article
  • 1 Chapter

Antineoplastic effects of selective CDK9 inhibition with atuveciclib on cancer stem-like cells in triple-negative breast cancer

Brisard, D., Eckerdt, F., Marsh, L. A., Blyth, G. T., Jain, S., Cristofanilli, M., Horiuchi, D. & Platanias, L. C., Dec 1 2018, In : Oncotarget. 9, 99, p. 37305-37318 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity

Kang, H. J., Song, H. Y., Ahmed, M. A., Guo, Y., Zhang, M., Chen, C., Cristofanilli, M., Horiuchi, D. & Vassilopoulos, A., Oct 2018, In : Free Radical Biology and Medicine. 126, p. 358-371 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

Horiuchi, D., Camarda, R., Zhou, A. Y., Yau, C., Momcilovic, O., Balakrishnan, S., Corella, A. N., Eyob, H., Kessenbrock, K., Lawson, D. A., Marsh, L. A., Anderton, B. N., Rohrberg, J., Kunder, R., Bazarov, A. V., Yaswen, P., McManus, M. T., Rugo, H. S., Werb, Z. & Goga, A., Nov 1 2016, In : Nature Medicine. 22, 11, p. 1321-1329 9 p.

Research output: Contribution to journalArticle

65 Scopus citations

Linking tumor mutations to drug responses via a quantitative chemical–genetic interaction map

Martins, M. M., Zhou, A. Y., Corella, A., Horiuchi, D., Yau, C., Rakshandehroo, T., Gordan, J. D., Levin, R. S., Johnson, J., Jascur, J., Shales, M., Sorrentino, A., Cheah, J., Clemons, P. A., Shamji, A. F., Schreiber, S. L., Krogan, N. J., Shokat, K. M., McCormick, F., Goga, A. & 1 others, Bandyopadhyay, S., Jan 1 2015, In : Cancer discovery. 5, 2, p. 154-167 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets

Balko, J. M., Giltnane, J. M., Wang, K., Schwarz, L. J., Young, C. D., Cook, R. S., Owens, P., Sanders, M. E., Kuba, M. G., Sánchez, V., Kurupi, R., Moore, P. D., Pinto, J. A., Doimi, F. D., Gómez, H., Horiuchi, D., Goga, A., Lehmann, B. D., Bauer, J. A., Pietenpol, J. A. & 7 others, Ross, J. S., Palmer, G. A., Yelensky, R., Cronin, M., Miller, V. A., Stephens, P. J. & Arteaga, C. L., Feb 1 2014, In : Cancer discovery. 4, 2, p. 232-245 14 p.

Research output: Contribution to journalArticle

216 Scopus citations

Taking on challenging targets: Making MYC druggable

Oncology, A. A. O. C., Horiuchi, D., Anderton, B. & Goga, A., 2014, 2014 American Association of Clinical Oncology Educational Book. N/A: American Society of Clinical Oncology, p. 497-520

Research output: Chapter in Book/Report/Conference proceedingChapter

31 Scopus citations

Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways

Horiuchi, D., Huskey, N. E., Kusdra, L., Wohlbold, L., Merrick, K. A., Zhang, C., Creasman, K. J., Shokat, K. M., Fisher, R. P. & Goga, A., Apr 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. E1019-E1027

Research output: Contribution to journalArticle

35 Scopus citations

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition

Horiuchi, D., Kusdra, L., Huskey, N. E., Chandriani, S., Lenburg, M. E., Gonzalez-Angulo, A. M., Creasman, K. J., Bazarov, A. V., Smyth, J. W., Davis, S. E., Yaswen, P., Mills, G. B., Esserman, L. J. & Goga, A., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 679-696 18 p.

Research output: Contribution to journalArticle

188 Scopus citations

Switching Cdk2 On or Off with Small Molecules to Reveal Requirements in Human Cell Proliferation

Merrick, K. A., Wohlbold, L., Zhang, C., Allen, J. J., Horiuchi, D., Huskey, N. E., Goga, A., Shokat, K. M. & Fisher, R. P., Jun 10 2011, In : Molecular cell. 42, 5, p. 624-636 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion

Huang, T. H., Wu, F., Loeb, G. B., Hsu, R., Heidersbach, A., Brincat, A., Horiuchi, D., Lebbink, R. J., Mo, Y. Y., Goga, A. & McManus, M. T., Jul 3 2009, In : Journal of Biological Chemistry. 284, 27, p. 18515-18524 10 p.

Research output: Contribution to journalArticle

164 Scopus citations

Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides

Barkus, R. V., Klyachko, O., Horiuchi, D., Dickson, B. J. & Saxton, W. M., Jan 1 2008, In : Molecular biology of the cell. 19, 1, p. 274-283 10 p.

Research output: Contribution to journalArticle

131 Scopus citations

Control of a Kinesin-Cargo Linkage Mechanism by JNK Pathway Kinases

Horiuchi, D., Collins, C. A., Bhat, P., Barkus, R. V., DiAntonio, A. & Saxton, W. M., Aug 7 2007, In : Current Biology. 17, 15, p. 1313-1317 5 p.

Research output: Contribution to journalArticle

115 Scopus citations

Kinesin-1 and dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons

Pilling, A. D., Horiuchi, D., Lively, C. M. & Saxton, W. M., Apr 1 2006, In : Molecular biology of the cell. 17, 4, p. 2057-2068 12 p.

Research output: Contribution to journalArticle

404 Scopus citations

APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila

Horiuchi, D., Barkus, R. V., Pilling, A. D., Gassman, A. & Saxton, W. M., Dec 6 2005, In : Current Biology. 15, 23, p. 2137-2141 5 p.

Research output: Contribution to journalArticle

111 Scopus citations

Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells

Sato, K. I., Kimoto, M., Kakumoto, M., Horiuchi, D., Iwasaki, T., Tokmakov, A. A. & Fukami, Y., Oct 5 2000, In : Genes to Cells. 5, 9, p. 749-764 16 p.

Research output: Contribution to journalArticle

43 Scopus citations