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Dalton James Surmeier Jr

  • 24079 Citations
1985 …2024
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Personal profile

Research Interests

My research is focused on the mechanisms underlying Parkinson's disease, Huntington's disease and chronic pain. This pursuit employs a combination of electrophysiological, optical, genetic and behavioral approaches.

Education/Academic qualification

PhD, University of Washington

… → 1983

MS, University of Oregon

… → 1976

Research interests

  • Molecular Biology
  • Movement Disorders
  • Neuroscience
  • Parkinson’s Disease
  • Physiology
  • Schizophrenia

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  • 37 Similar Profiles
Neurons Medicine & Life Sciences
Corpus Striatum Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Dopamine Medicine & Life Sciences
Cholinergic Agents Medicine & Life Sciences
Interneurons Medicine & Life Sciences
Calcium Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2000 2024

Dr. Surmeier Subproject for SP0049303

Surmeier Jr, D. J.

National Institute of General Medical Sciences

5/1/19 → 4/30/24

Project: Research project

Nitric Oxide Synthase Type I
Melanoma
Nitric Oxide Synthase
Cerebral Palsy
Hydrogen Peroxide

Selective inhibition of nitric oxide synthase for multiple indications

Silverman, R. B. & Surmeier Jr, D. J.

National Institute of General Medical Sciences

5/1/19 → 4/30/24

Project: Research project

Nitric Oxide Synthase Type I
Nitric Oxide Synthase
Melanoma
Cerebral Palsy
Hydrogen Peroxide

Molecular and Cellular Mechanisms of Parkinson’s Disease

Guzman-Lucero, J. N., Kondapalli, J., Shen, W., Surmeier Jr, D. J. & Wokosin, D. L.

JPB Foundation

11/1/18 → 10/31/21

Project: Research project

Parkinson Disease
Levodopa
Dopaminergic Neurons
Dyskinesias
Substantia Nigra

Autism-Associated Mutations in L-Type Ca2+ Channels

Surmeier Jr, D. J.

U.S. Army Medical Research and Materiel Command

9/30/18 → 9/29/21

Project: Research project

Autistic Disorder
Mutation
Ion Channels
Brain
Neurons

Center for chronic pain and drug abuse

Apkarian, A., Awatramani, R., Drenan, R. M., Graves, S. M., Griffith, J. W., Huang, L., Jovasevic, V., Martina, M., Miller, R. J., Parrish, T. B., Procissi, D., Radulovic, J., Rodes, M. E., Schnitzer, T. J. & Surmeier Jr, D. J.

National Institute on Drug Abuse

9/1/18 → 6/30/23

Project: Research project

Chronic Pain
Substance-Related Disorders
Opioid Analgesics
Opiate Alkaloids
Brain

Research Output 1985 2020

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature Neuroscience. 23, 1, p. 15-20 6 p.

Research output: Contribution to journal › Article

Monoamine Oxidase
Electron Transport
Dopamine
Mitochondrial Membranes
Hydrogen Peroxide
7 Citations (Scopus)

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Zeitler, B., Froelich, S., Marlen, K., Shivak, D. A., Yu, Q., Li, D., Pearl, J. R., Miller, J. C., Zhang, L., Paschon, D. E., Hinkley, S. J., Ankoudinova, I., Lam, S., Guschin, D., Kopan, L., Cherone, J. M., Nguyen, H. O. B., Qiao, G., Ataei, Y., Mendel, M. C. & 31 others, Amora, R., Surosky, R., Laganiere, J., Vu, B. J., Narayanan, A., Sedaghat, Y., Tillack, K., Thiede, C., Gärtner, A., Kwak, S., Bard, J., Mrzljak, L., Park, L., Heikkinen, T., Lehtimäki, K. K., Svedberg, M. M., Häggkvist, J., Tari, L., Tóth, M., Varrone, A., Halldin, C., Kudwa, A. E., Ramboz, S., Day, M., Kondapalli, J., Surmeier, D. J., Urnov, F. D., Gregory, P. D., Rebar, E. J., Muñoz-Sanjuán, I. & Zhang, H. S., Jan 1 2019, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journal › Article

Huntington Disease
Zinc Fingers
Genes
Alleles
Zinc
6 Citations (Scopus)

Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models

Tanimura, A., Du, Y., Kondapalli, J., Wokosin, D. L. & Surmeier Jr, D. J., Feb 6 2019, In : Neuron. 101, 3, p. 444-458.e6

Research output: Contribution to journal › Article

Intralaminar Thalamic Nuclei
Corpus Striatum
Interneurons
Cholinergic Agents
Parkinson Disease

Cholinergic modulation of striatal nitric oxide-producing interneurons

Melendez-Zaidi, A. E., Lakshminarasimhah, H. & Surmeier, D. J., Dec 1 2019, In : European Journal of Neuroscience. 50, 11, p. 3713-3731 19 p.

Research output: Contribution to journal › Article

Corpus Striatum
Interneurons
Cholinergic Agents
Nitric Oxide
Optogenetics
3 Citations (Scopus)

Delayed spine pruning of direct pathway spiny projection neurons in a mouse model of parkinson’s disease

Graves, S. M. & Surmeier Jr, D. J., Jan 29 2019, In : Frontiers in Cellular Neuroscience. 13, 32.

Research output: Contribution to journal › Article

Open Access
Parkinson Disease
Spine
Neurons
Oxidopamine
Synapses