Grants per year
Personal profile
Research Interests
My research is focused on the mechanisms underlying Parkinson's disease, Huntington's disease and chronic pain. This pursuit employs a combination of electrophysiological, optical, genetic and behavioral approaches.
Education/Academic qualification
PhD, Physiology-Psychology, University of Washington
… → 1983
MS, Mathematics, University of Oregon
… → 1976
Research interests keywords
- Molecular Biology
- Movement Disorders
- Neuroscience
- Parkinson’s Disease
- Physiology
- Schizophrenia
Fingerprint
Dive into the research topics where Dalton James Surmeier Jr is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dopaminergic and Muscarinic Signaling in the Striatum
Surmeier Jr, D. J. (PD/PI), Cui, Q. (Other), Shen, W. (Other) & Wokosin, D. L. (Other)
National Institute of Neurological Disorders and Stroke
7/1/24 → 6/30/27
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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Bifunctional intrabody targeting intracellular alpha-synuclein
Surmeier Jr, D. J. (PD/PI), Surmeier Jr, D. J. (PD/PI), Xie, Z. (Other) & Xie, Z. (Other)
Michael J. Fox Foundation for Parkinson's Research
2/1/22 → 2/1/25
Project: Research project
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Striatal determinants of Parkinson's disease progression
Surmeier Jr, D. J. (PD/PI), Surmeier Jr, D. J. (PD/PI), Zhai, S. (PD/PI), Zhai, S. (Co-Investigator) & Surmeier Jr, D. J. (Other)
William N. & Bernice E. Bumpus Foundation
1/1/22 → 12/31/24
Project: Research project
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Redefining PD pathophysiology mechanisms in the context of heterogeneous substantia nigra neuron subtypes
Awatramani, R. (PD/PI), Awatramani, R. (PD/PI), Bevan, M. D. (Co-Investigator), Bevan, M. D. (Co-Investigator), Dombeck, D. A. (Co-Investigator), Dombeck, D. A. (Co-Investigator), Parisiadou, L. (Co-Investigator), Parisiadou, L. (Co-Investigator), Surmeier Jr, D. J. (Co-Investigator) & Surmeier Jr, D. J. (Co-Investigator)
Michael J. Fox Foundation for Parkinson's Research
11/1/21 → 10/31/24
Project: Research project
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Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses
Zhai, S., Otsuka, S., Xu, J., Clarke, V. R. J., Tkatch, T., Wokosin, D., Xie, Z., Tanimura, A., Agarwal, H. K., Ellis-Davies, G. C. R., Contractor, A. & Surmeier, D. J., Aug 27 2024, In: Cell reports. 43, 8, 114540.Research output: Contribution to journal › Article › peer-review
Open Access -
Correction to: Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice (Molecular Psychiatry, (2024), 29, 8, (2372-2388), 10.1038/s41380-024-02493-w)
Wang, Y. Z., Perez-Rosello, T., Smukowski, S. N., Surmeier, D. J. & Savas, J. N., Sep 2024, In: Molecular Psychiatry. 29, 9, p. 2919 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Correction to: Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson’s disease (npj Parkinson's Disease, (2024), 10, 1, (54), 10.1038/s41531-024-00670-w)
Summa, K. C., Jiang, P., González-Rodríguez, P., Huang, X., Lin, X., Vitaterna, M. H., Dan, Y., Surmeier, D. J. & Turek, F. W., Dec 2024, In: npj Parkinson's Disease. 10, 1, 131.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson’s disease
Summa, K. C., Jiang, P., González-Rodríguez, P., Huang, X., Lin, X., Vitaterna, M. H., Dan, Y., Surmeier, D. J. & Turek, F. W., Dec 2024, In: npj Parkinson's Disease. 10, 1, 54.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
GABAergic regulation of striatal spiny projection neurons depends upon their activity state
Day, M., Belal, M., Surmeier, W. C., Melendez, A., Wokosin, D. L., Tkatch, T., Clarke, V. R. J. & Surmeier Jr, D. J., Jan 2024, In: PLoS biology. 22, 1Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations
Datasets
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Raw data for: "CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors"
Crittenden, J. R. (Contributor), Zhai, S. (Contributor), Sauvage, M. (Contributor), Kitsukawa, T. (Contributor), Burguière, E. (Contributor), Thomsen, M. (Contributor), Zhang, H. (Contributor), Costa, C. (Contributor), Martella, G. (Contributor), Ghiglieri, V. (Contributor), Picconi, B. (Contributor), Pescatore, K. A. (Contributor), Unterwald, E. M. (Contributor), Jackson, W. S. (Contributor), Housman, D. E. (Contributor), Caine, S. B. (Contributor), Sulzer, D. (Contributor), Calabresi, P. (Contributor), Smith, A. C. (Contributor), Surmeier, D. J. (Contributor) & Graybiel, A. M. (Contributor), ZENODO, Aug 8 2021
DOI: 10.5281/zenodo.6275973, https://zenodo.org/records/6275973
Dataset
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Source data for "Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons"
Zampese, E. (Contributor), Wokosin, D. L. (Contributor), Guzman, J. N. (Contributor), Tkatch, T. (Contributor), Kondapalli, J. (Contributor), Surmeier, W. C. (Contributor), D'Alessandro, K. B. (Contributor), De Stefani, D. (Contributor), Rizzuto, R. (Contributor), Iino, M. (Contributor), Molkentin, J. D. (Contributor), Chandel, N. S. (Contributor), Schumacker, P. T. (Contributor) & Surmeier, D. J. (Contributor), ZENODO, Aug 8 2022
DOI: 10.5281/zenodo.6949450, https://zenodo.org/records/6949450
Dataset
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Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses: NEURON + Python model of striatal projection neurons
Zhai, S. (Contributor), Surmeíer, D. J. (Contributor) & Clarke, V. R. J. (Contributor), ZENODO, Jun 21 2024
DOI: 10.5281/zenodo.12213217, https://zenodo.org/records/12213217
Dataset
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CCDC 899840: Experimental Crystal Structure Determination
Kang, S. (Creator), Cooper, G. (Creator), Dunne, S. F. (Creator), Dusel, B. (Creator), Luan, C.-H. (Creator), Surmeier, D. J. (Creator) & Silverman, R. B. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/ccz6c3m, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccz6c3m&sid=DataCite
Dataset