Grants per year
Personal profile
Research Interests
My research is focused on the mechanisms underlying Parkinson's disease, Huntington's disease and chronic pain. This pursuit employs a combination of electrophysiological, optical, genetic and behavioral approaches.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Physiology-Psychology, University of Washington
… → 1983
MS, Mathematics, University of Oregon
… → 1976
Research interests keywords
- Molecular Biology
- Movement Disorders
- Neuroscience
- Parkinson’s Disease
- Physiology
- Schizophrenia
Fingerprint
Dive into the research topics where Dalton James Surmeier Jr is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Surmeier Subproject
Surmeier Jr, D. J. (Co-PD/PI)
Michael J. Fox Foundation for Parkinson's Research
2/1/25 → 1/31/27
Project: Research project
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Development of a Cav1.3 calcium channel inhibitor to slow PD progression
Surmeier Jr, D. J. (PD/PI)
1/27/25 → 1/26/27
Project: Research project
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Distributed circuit dysfunction underlying motor and sleep deficits in a progressive mouse model of Parkinson’s disease (Renewal)
Surmeier Jr, D. J. (PD/PI), Clarke, V. (Other), Ilijic, E. (Other), Wokosin, D. L. (Other) & Zhai, S. (Other)
Michael J. Fox Foundation for Parkinson's Research
11/1/24 → 10/31/26
Project: Research project
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Surmeier Subproject
Surmeier Jr, D. J. (Other)
Michael J. Fox Foundation for Parkinson's Research
11/1/24 → 10/31/26
Project: Research project
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Molecular and Cellular Mechanisms of Parkinson's Disease
Surmeier Jr, D. J. (PD/PI), Guzman-Lucero, J. N. (Other), Ilijic, E. (Other), Shen, W. (Other), Tkatch, T. (Other), Wokosin, D. L. (Other) & Zampese, E. (Other)
10/1/24 → 9/30/27
Project: Research project
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Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use
Lashuel, H. A., Surmeier, D. J., Simuni, T., Merchant, K., Caughey, B., Soto, C., Fares, M. B., Heym, R. G. & Melki, R., Apr 4 2025, In: Science Advances. 11, 14, eadt7195.Research output: Contribution to journal › Article › peer-review
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Acetyl-DL-leucine in two individuals with REM sleep behavior disorder improves symptoms, reverses loss of striatal dopamine-transporter binding and stabilizes pathological metabolic brain pattern—case reports
Oertel, W. H., Janzen, A., Henrich, M. T., Geibl, F. F., Sittig, E., Meles, S. K., Carli, G., Leenders, K., Booij, J., Surmeier, D. J., Timmermann, L. & Strupp, M., Dec 2024, In: Nature communications. 15, 1, 7619.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses
Zhai, S., Otsuka, S., Xu, J., Clarke, V. R. J., Tkatch, T., Wokosin, D., Xie, Z., Tanimura, A., Agarwal, H. K., Ellis-Davies, G. C. R., Contractor, A. & Surmeier, D. J., Aug 27 2024, In: Cell reports. 43, 8, 114540.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Correction to: Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iSPNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice (Molecular Psychiatry, (2024), 29, 8, (2372-2388), 10.1038/s41380-024-02493-w)
Wang, Y. Z., Perez-Rosello, T., Smukowski, S. N., Surmeier, D. J. & Savas, J. N., Sep 2024, In: Molecular Psychiatry. 29, 9, p. 2919 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Correction to: Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson’s disease (npj Parkinson's Disease, (2024), 10, 1, (54), 10.1038/s41531-024-00670-w)
Summa, K. C., Jiang, P., González-Rodríguez, P., Huang, X., Lin, X., Vitaterna, M. H., Dan, Y., Surmeier, D. J. & Turek, F. W., Dec 2024, In: npj Parkinson's Disease. 10, 1, 131.Research output: Contribution to journal › Comment/debate › peer-review
Open Access
Datasets
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Raw data for: "CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors"
Crittenden, J. R. (Contributor), Zhai, S. (Contributor), Sauvage, M. (Contributor), Kitsukawa, T. (Contributor), Burguière, E. (Contributor), Thomsen, M. (Contributor), Zhang, H. (Contributor), Costa, C. (Contributor), Martella, G. (Contributor), Ghiglieri, V. (Contributor), Picconi, B. (Contributor), Pescatore, K. A. (Contributor), Unterwald, E. M. (Contributor), Jackson, W. S. (Contributor), Housman, D. E. (Contributor), Caine, S. B. (Contributor), Sulzer, D. (Contributor), Calabresi, P. (Contributor), Smith, A. C. (Contributor), Surmeier, D. J. (Contributor) & Graybiel, A. M. (Contributor), ZENODO, Aug 8 2021
DOI: 10.5281/zenodo.6275973, https://zenodo.org/records/6275973
Dataset
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Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses: NEURON + Python model of striatal projection neurons
Zhai, S. (Contributor), Surmeíer, D. J. (Contributor) & Clarke, V. R. J. (Contributor), ZENODO, Jun 21 2024
DOI: 10.5281/zenodo.12213217, https://zenodo.org/records/12213217
Dataset
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Source data for "Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons"
Zampese, E. (Contributor), Wokosin, D. L. (Contributor), Guzman, J. N. (Contributor), Tkatch, T. (Contributor), Kondapalli, J. (Contributor), Surmeier, W. C. (Contributor), D'Alessandro, K. B. (Contributor), De Stefani, D. (Contributor), Rizzuto, R. (Contributor), Iino, M. (Contributor), Molkentin, J. D. (Contributor), Chandel, N. S. (Contributor), Schumacker, P. T. (Contributor) & Surmeier, D. J. (Contributor), ZENODO, Aug 8 2022
DOI: 10.5281/zenodo.6949450, https://zenodo.org/records/6949450
Dataset
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CCDC 899840: Experimental Crystal Structure Determination
Kang, S. (Creator), Cooper, G. (Creator), Dunne, S. F. (Creator), Dusel, B. (Creator), Luan, C.-H. (Creator), Surmeier, D. J. (Creator) & Silverman, R. B. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/ccz6c3m, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccz6c3m&sid=DataCite
Dataset