Grants per year
Personal profile
Research Interests
My research is focused on the mechanisms underlying Parkinson's disease, Huntington's disease and chronic pain. This pursuit employs a combination of electrophysiological, optical, genetic and behavioral approaches.
Education/Academic qualification
PhD, Physiology-Psychology, University of Washington
… → 1983
MS, Mathematics, University of Oregon
… → 1976
Research interests keywords
- Molecular Biology
- Movement Disorders
- Neuroscience
- Parkinson’s Disease
- Physiology
- Schizophrenia
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration Hub
Savas, J. N., Caraveo Piso, G., Contractor, A., Disterhoft, J. F., Duncan, F. E., Foltz, D. R., Goel, R., Kafader, J. O., Kalb, R. G., Kelleher, N. L., Kiskinis, E., Krainc, D., Mendillo, M. L., Menichella, D. M., Penzes, P., Smith, G. A., Surmeier Jr, D. J., Vassar, R. J., Walsh, D. & Zelano, C.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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SyncroPatch 384 Automated Patch Clamp Instrument
George, A. L., Burridge, P., DeCaen, P. G., Horvath, C. M., Kearney, J. A., Kiskinis, E., McNally, E. M., Miller, R. J., Prakriya, M., Smith, R. S., Surmeier Jr, D. J. & Vanoye, C. G.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Preclinical Pharmacokinetics and Efficacy of Intranasal Isradipine
3/1/23 → 2/29/24
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J., Vassar, R. J., Weintraub, S., Weintraub, S., Allada, R., Allada, R., Bevan, M. D., Bevan, M. D., Caraveo Piso, G., Caraveo Piso, G., Carvill, G. L., Carvill, G. L., Chan, S., Chan, S., Contractor, A., Contractor, A., Disterhoft, J. F., Disterhoft, J. F., Dombeck, D. A., Dombeck, D. A., Dong, H., Dong, H., Ferreira, A. B., Ferreira, A. B., Flanagan, M. E., Flanagan, M. E., Gefen, T. D., Gefen, T. D., Geula, C., Geula, C., Gratton, C., Gratton, C., He, C., He, C., Kahnt, T., Kahnt, T., Kalb, R. G., Kalb, R. G., Kennedy, A., Kennedy, A., Kessler, J., Kessler, J., Kiskinis, E., Kiskinis, E., Klein, W. L., Klein, W. L., Kozorovitskiy, Y., Kozorovitskiy, Y., Krainc, D., Krainc, D., Li, L., Li, L., Mazzulli, J., Mazzulli, J., Mesulam, M., Mesulam, M., Miller, R. J., Miller, R. J., Morimoto, R. I., Morimoto, R. I., Opal, P., Opal, P., Ozdinler, H., Ozdinler, H., Paller, K., Paller, K., Parisiadou, L., Parisiadou, L., Penzes, P., Penzes, P., Pinto, L., Pinto, L., Prakriya, M., Prakriya, M., Reber, P. J., Reber, P. J., Roberts, A. L., Roberts, A. L., Rogalski, E., Rogalski, E., Savas, J. N., Savas, J. N., Surmeier Jr, D. J., Surmeier Jr, D. J., Swanson, G. T., Swanson, G. T., Voss, J. L., Voss, J. L., Zee, P. C., Zee, P. C., Zelano, C. & Zelano, C.
5/1/22 → 4/30/27
Project: Research project
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Bifunctional intrabody targeting intracellular alpha-synuclein
Michael J. Fox Foundation for Parkinson's Research
2/1/22 → 2/1/24
Project: Research project
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Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington’s disease model mice
Pancani, T., Day, M., Tkatch, T., Wokosin, D. L., González-Rodríguez, P., Kondapalli, J., Xie, Z., Chen, Y., Beaumont, V. & Surmeier Jr, D. J., Dec 2023, In: Nature communications. 14, 1, 1398.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Disease mechanisms as Subtypes: Mitochondrial and bioenergetic dysfunction
Gonzalez-Rodriguez, P., Zampese, E. & Surmeier, D. J., Jan 2023, Handbook of Clinical Neurology. Elsevier B.V., p. 53-66 14 p. (Handbook of Clinical Neurology; vol. 193).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease
Zhai, S., Cui, Q., Simmons, D. N. V. & Surmeier, D. J., Dec 2023, In: Current opinion in neurobiology. 83, 102798.Research output: Contribution to journal › Review article › peer-review
Open Access -
Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons
Tubert, C., Zampese, E., Pancani, T., Tkatch, T. & Surmeier, D. J., Nov 2023, In: Neurobiology of Disease. 188, 106328.Research output: Contribution to journal › Article › peer-review
Open Access -
Parkinson's disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons
Song, P., Peng, W., Sauve, V., Fakih, R., Xie, Z., Ysselstein, D., Krainc, T., Wong, C. H. Y., Mencacci, N. E., Savas, J. N., Surmeier, D. J., Gehring, K. & Krainc, D., 2023, (Accepted/In press) In: Neuron.Research output: Contribution to journal › Article › peer-review
Datasets
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Raw data for: "CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors"
Crittenden, J. R. (Contributor), Zhai, S. (Contributor), Sauvage, M. (Contributor), Kitsukawa, T. (Contributor), Burguière, E. (Contributor), Thomsen, M. (Contributor), Zhang, H. (Contributor), Costa, C. (Contributor), Martella, G. (Contributor), Ghiglieri, V. (Contributor), Picconi, B. (Contributor), Pescatore, K. A. (Contributor), Unterwald, E. M. (Contributor), Jackson, W. S. (Contributor), Housman, D. E. (Contributor), Caine, S. B. (Contributor), Sulzer, D. (Contributor), Calabresi, P. (Contributor), Smith, A. C. (Contributor), Surmeier Jr, D. J. (Contributor), Graybiel, A. M. (Contributor), Eric, B. (Contributor) & Cinzia, C. (Contributor), ZENODO, Aug 8 2021
DOI: 10.5281/zenodo.6275973, https://zenodo.org/record/6275973
Dataset
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Source data for "Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons"
Zampese, E. (Contributor), Wokosin, D. L. (Contributor), Guzman-Lucero, J. N. (Contributor), Tkatch, T. (Contributor), Kondapalli, J. (Contributor), Surmeier, W. C. (Contributor), D'Alessandro, K. B. (Contributor), De Stefani, D. (Contributor), Rizzuto, R. (Contributor), Iino, M. (Contributor), Molkentin, J. D. (Contributor), Chandel, N. (Contributor), Schumacker, P. T. (Contributor) & Surmeier Jr, D. J. (Contributor), ZENODO, Aug 8 2022
DOI: 10.5281/zenodo.6949450, https://zenodo.org/record/6949450
Dataset
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CCDC 899840: Experimental Crystal Structure Determination
Kang, S. (Creator), Cooper, G. (Creator), Dunne, S. F. (Creator), Dusel, B. (Creator), Luan, C. (Creator), Surmeier Jr, D. J. (Creator) & Silverman, R. B. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/ccz6c3m, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccz6c3m&sid=DataCite
Dataset