• 24079 Citations
1985 …2024
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Personal profile

Research Interests

My research is focused on the mechanisms underlying Parkinson's disease, Huntington's disease and chronic pain. This pursuit employs a combination of electrophysiological, optical, genetic and behavioral approaches.

Education/Academic qualification

PhD, University of Washington

… → 1983

MS, University of Oregon

… → 1976

Research interests

  • Molecular Biology
  • Movement Disorders
  • Neuroscience
  • Parkinson’s Disease
  • Physiology
  • Schizophrenia

Fingerprint Dive into the research topics where Dalton James Surmeier Jr is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 37 Similar Profiles
Neurons Medicine & Life Sciences
Corpus Striatum Medicine & Life Sciences
Parkinson Disease Medicine & Life Sciences
Dopaminergic Neurons Medicine & Life Sciences
Dopamine Medicine & Life Sciences
Cholinergic Agents Medicine & Life Sciences
Interneurons Medicine & Life Sciences
Calcium Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2000 2024

Nitric Oxide Synthase Type I
Nitric Oxide Synthase
Cerebral Palsy
Hydrogen Peroxide
Nitric Oxide Synthase Type I
Nitric Oxide Synthase
Cerebral Palsy
Hydrogen Peroxide
Parkinson Disease
Dopaminergic Neurons
Substantia Nigra
Autistic Disorder
Ion Channels
Chronic Pain
Substance-Related Disorders
Opioid Analgesics
Opiate Alkaloids

Research Output 1985 2020

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves, S. M., Xie, Z., Stout, K. A., Zampese, E., Burbulla, L. F., Shih, J. C., Kondapalli, J., Patriarchi, T., Tian, L., Brichta, L., Greengard, P., Krainc, D., Schumacker, P. T. & Surmeier, D. J., Jan 1 2020, In : Nature Neuroscience. 23, 1, p. 15-20 6 p.

Research output: Contribution to journalArticle

Monoamine Oxidase
Electron Transport
Mitochondrial Membranes
Hydrogen Peroxide
7 Citations (Scopus)

Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington’s disease

Zeitler, B., Froelich, S., Marlen, K., Shivak, D. A., Yu, Q., Li, D., Pearl, J. R., Miller, J. C., Zhang, L., Paschon, D. E., Hinkley, S. J., Ankoudinova, I., Lam, S., Guschin, D., Kopan, L., Cherone, J. M., Nguyen, H. O. B., Qiao, G., Ataei, Y., Mendel, M. C. & 31 others, Amora, R., Surosky, R., Laganiere, J., Vu, B. J., Narayanan, A., Sedaghat, Y., Tillack, K., Thiede, C., Gärtner, A., Kwak, S., Bard, J., Mrzljak, L., Park, L., Heikkinen, T., Lehtimäki, K. K., Svedberg, M. M., Häggkvist, J., Tari, L., Tóth, M., Varrone, A., Halldin, C., Kudwa, A. E., Ramboz, S., Day, M., Kondapalli, J., Surmeier, D. J., Urnov, F. D., Gregory, P. D., Rebar, E. J., Muñoz-Sanjuán, I. & Zhang, H. S., Jan 1 2019, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

Huntington Disease
Zinc Fingers
6 Citations (Scopus)

Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models

Tanimura, A., Du, Y., Kondapalli, J., Wokosin, D. L. & Surmeier Jr, D. J., Feb 6 2019, In : Neuron. 101, 3, p. 444-458.e6

Research output: Contribution to journalArticle

Intralaminar Thalamic Nuclei
Corpus Striatum
Cholinergic Agents
Parkinson Disease

Cholinergic modulation of striatal nitric oxide-producing interneurons

Melendez-Zaidi, A. E., Lakshminarasimhah, H. & Surmeier, D. J., Dec 1 2019, In : European Journal of Neuroscience. 50, 11, p. 3713-3731 19 p.

Research output: Contribution to journalArticle

Corpus Striatum
Cholinergic Agents
Nitric Oxide
3 Citations (Scopus)
Open Access
Parkinson Disease