Grants per year
Personal profile
Research Interests
The neuronal activity underlying mammalian spatial navigation represents one of the most striking examples of behavioral correlation in the brain. Professor Dombeck is interested in the cellular and circuit mechanisms responsible for the neuronal activity that allows mammals to navigate and find their way to specific destinations. To accomplish this, his research team develops and applies novel optical and genetic techniques to perform cellular and subcellular resolution imaging and manipulation of neuronal population activity in mice navigating in virtual reality environments. By understanding the navigation circuitry, they hope to extract general principles about neuronal population dynamics in behaving mammals.
Education/Academic qualification
Biophysics, PhD, Cornell University
… → 2005
Physics, MS, Cornell University
… → 2003
Physics, BS, University of Illinois at Urbana-Champaign
… → 2000
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Collaborations and top research areas from the last five years
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Dombeck Subproject
Dombeck, D. A. (Co-Investigator)
Michael J. Fox Foundation for Parkinson's Research
11/1/24 → 10/31/26
Project: Research project
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Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony
Kozorovitskiy, Y. (PD/PI), Rogers, J. A. (PD/PI), Rogers, J. A. (PD/PI), Dombeck, D. A. (Co-Investigator), Kennedy, A. (Co-Investigator) & Kennedy, A. (Co-Investigator)
National Institute of Neurological Disorders and Stroke
9/1/23 → 8/31/26
Project: Research project
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Training Program in Neurobiology of Information Storage
Dombeck, D. A. (PD/PI)
National Institute of Mental Health
7/1/23 → 6/30/28
Project: Research project
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Multiplex Imaging of Brain Activity and Plasticity with Optimized FRET/FLIM-based Sensors
Dombeck, D. A. (PD/PI) & Dombeck, D. A. (PD/PI)
National Institute of Neurological Disorders and Stroke
1/1/23 → 12/31/26
Project: Research project
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Predoctoral and Postdoctoral Training Program in Aging and Dementia
Vassar, R. J. (PD/PI), Vassar, R. J. (PD/PI), Weintraub, S. (PD/PI), Weintraub, S. (PD/PI), Allada, R. (Other), Allada, R. (Other), Bevan, M. D. (Other), Bevan, M. D. (Other), Caraveo Piso, G. (Other), Caraveo Piso, G. (Other), Carvill, G. L. (Other), Carvill, G. L. (Other), Chan, S. (Other), Chan, S. (Other), Contractor, A. (Other), Contractor, A. (Other), Disterhoft, J. F. (Other), Disterhoft, J. F. (Other), Dombeck, D. A. (Other), Dombeck, D. A. (Other), Dong, H. (Other), Dong, H. (Other), Ferreira, A. B. (Other), Ferreira, A. B. (Other), Flanagan, M. E. (Other), Flanagan, M. E. (Other), Gefen, T. D. (Other), Gefen, T. D. (Other), Geula, C. (Other), Geula, C. (Other), Gratton, C. (Other), Gratton, C. (Other), He, C. (Other), He, C. (Other), Kahnt, T. (Other), Kahnt, T. (Other), Kalb, R. G. (Other), Kalb, R. G. (Other), Kennedy, A. (Other), Kennedy, A. (Other), Kessler, J. (Other), Kessler, J. (Other), Kiskinis, E. (Other), Kiskinis, E. (Other), Klein, W. L. (Other), Klein, W. L. (Other), Kozorovitskiy, Y. (Other), Kozorovitskiy, Y. (Other), Krainc, D. (Other), Krainc, D. (Other), Li, L. (Other), Li, L. (Other), Mazzulli, J. (Other), Mazzulli, J. (Other), Mesulam, M.-M. (Other), Mesulam, M.-M. (Other), Miller, R. J. (Other), Miller, R. J. (Other), Morimoto, R. I. (Other), Morimoto, R. I. (Other), Opal, P. (Other), Opal, P. (Other), Ozdinler, H. (Other), Ozdinler, H. (Other), Paller, K. (Other), Paller, K. (Other), Parisiadou, L. (Other), Parisiadou, L. (Other), Penzes, P. (Other), Penzes, P. (Other), Pinto, L. (Other), Pinto, L. (Other), Prakriya, M. (Other), Prakriya, M. (Other), Reber, P. J. (Other), Reber, P. J. (Other), Roberts, A. L. (Other), Roberts, A. L. (Other), Rogalski, E. (Other), Rogalski, E. (Other), Savas, J. N. (Other), Savas, J. N. (Other), Surmeier Jr, D. J. (Other), Surmeier Jr, D. J. (Other), Swanson, G. T. (Other), Swanson, G. T. (Other), Voss, J. L. (Other), Voss, J. L. (Other), Zee, P. C. (Other), Zee, P. C. (Other), Zelano, C. (Other) & Zelano, C. (Other)
5/1/22 → 4/30/27
Project: Research project
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A robot-rodent interaction arena with adjustable spatial complexity for ethologically relevant behavioral studies
Lai, A. T., Espinosa, G., Wink, G. E., Angeloni, C. F., Dombeck, D. A. & MacIver, M. A., Feb 27 2024, In: Cell reports. 43, 2, 113671.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Lateral entorhinal cortex subpopulations represent experiential epochs surrounding reward
Issa, J. B., Radvansky, B. A., Xuan, F. & Dombeck, D. A., Mar 2024, In: Nature neuroscience. 27, 3, p. 536-546 11 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Full field-of-view virtual reality goggles for mice
Pinke, D., Issa, J. B., Dara, G. A., Dobos, G. & Dombeck, D. A., Dec 20 2023, In: Neuron. 111, 24, p. 3941-3952.e6Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Unique functional responses differentially map onto genetic subtypes of dopamine neurons
Azcorra, M., Gaertner, Z., Davidson, C., He, Q., Kim, H., Nagappan, S., Hayes, C. K., Ramakrishnan, C., Fenno, L., Kim, Y. S., Deisseroth, K., Longnecker, R., Awatramani, R. & Dombeck, D. A., Oct 2023, In: Nature neuroscience. 26, 10, p. 1762-1774 13 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Molecular heterogeneity in the substantia nigra: A roadmap for understanding PD motor pathophysiology
Gaertner, Z., Azcorra, M., Dombeck, D. A. & Awatramani, R., Dec 2022, In: Neurobiology of Disease. 175, 105925.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations
Datasets
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Data from: Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement
Howe, M. (Creator), Ridouh, I. (Creator), Larios, A. (Creator), Azcorra, M. (Contributor) & Dombeck, D. A. (Creator), Dryad, Mar 29 2019
DOI: 10.5061/dryad.244nt37, https://datadryad.org/stash/dataset/doi:10.5061/dryad.244nt37
Dataset
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Data from: Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement
Howe, M. (Contributor), Ridouh, I. (Contributor), Larios, A. (Contributor), Azcorra, M. (Contributor) & Dombeck, D. A. (Contributor), ZENODO, Mar 29 2019
DOI: 10.5061/dryad.244nt37, https://zenodo.org/records/4982080
Dataset