• 26994 Citations
1992 …2020

Research output per year

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Personal profile

Research Interests

Dr. Brat received his MD and PhD from the Mayo Medical and Graduate Schools and then completed Residency in Anatomic Pathology and a Fellowship in Neuropathology at Johns Hopkins Hospital. He joined the Department of Pathology and Laboratory Medicine at Emory University in 1999, spending 17 years on faculty before accepting the position of Magerstadt Professor and Chair of Pathology at the Northwestern University Feinberg School of Medicine and Pathologist-in-Chief of Northwestern Memorial Hospital.

Dr. Brat directs a basic and translational research lab that investigates mechanisms of glioma progression, including the contributions of hypoxia, genetics, tumor microenvironment and stem cells. Glioma progression is characterized by tumor necrosis, severe hypoxia and angiogenesis. One project investigates mechanisms that cause hypoxia and has focused on vaso-occlusion and intravascular thrombosis that are thought to be initiated by tissue factor, a highly potent pro-coagulant. His lab is studying how the resulting altered micro-environment leads to accelerated tumor growth how the enrichment of glioma stem cells and influx of tumor associated macrophages may promote this. His lab also studies mechanisms that confer specialized biologic properties to glioma stem cells (GSC) in GBM, including their ability to divide asymmetrically and their ability to home to hypoxic micro-environments. The Drosophila brain tumor (brat) gene normally regulates asymmetric cellular division and neural progenitor differentiation in the CNS of flies and, when mutated, leads to a massive brain containing only neuroblastic cells with tumor-like properties. We study the human homolog of Drosophila brat, Trim3, for its role in regulating asymmetric cell division and stem-like properties in GSCs. We are currently investigating those gene products that antagonize the tumor promoting effects of Brat/Trim3 loss on brain tumor development and are focused on CDK5/p35. Dr. Brat has over 18 years of experience in brain tumor research and has written more than 200 peer-reviewed manuscripts and reviews. In the laboratory setting, he has trained over 50 students, residents and fellows and has received major awards for mentoring.

Dr. Brat is Board certified in Anatomic Pathology and Neuropathology. His clinical practice includes Surgical Neuropathology at Northwestern Memorial Hospital and his expertise is on the diffuse gliomas, including glioblastoma. He has co-authored two textbooks in Neuropathology: Practical Surgical Neuropathology: A Diagnostic Approach, and Biopsy Interpretation of Central Nervous System. He has been involved with the WHO Classification of Brain Tumors since 2000 and co-authored 9 chapters in the 2016 edition. He has overseen the clinical training of over a 100 residents and fellows in Surgical Neuropathology and has also participated in over 50 CME courses nationally and internationally. Dr. Brat has served in leadership positions that oversee clinical practice and investigation in Oncology and Pathology, including the TCGA Glioblastoma and Lower Grade Gliomas (Co-Chair) Working Groups; the College of American Pathologists Glioma Guidelines Committee; the Executive Council of the American Association of Neuropathologists; the Board of Directors for the Society of Neuro-oncology; the WHO Committee for Classification of Brain Tumors; and the AJCC Expert Panel. He is a member of the American Society for Clinical Investigation.

Training Experience

1997Residency, Johns Hopkins Hospital
1999Fellowship, Johns Hopkins Hospital

Education/Academic qualification

MD, Mayo Medical School

… → 1994

PhD, Mayo Medical School

… → 1994

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Grants

  • Research Output

    Bone Flap Resorption Associated with Indolent Propionibacterium acnes Infection After Cranioplasty: Case Report with Pathological Analysis

    Shlobin, N. A., Palmer, A. H., Kam, K. L., Brat, D. J. & Potts, M. B., Jun 2020, In : World neurosurgery. 138, p. 313-316 4 p.

    Research output: Contribution to journalArticle

  • cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas

    Brat, D. J., Aldape, K., Colman, H., Figrarella-Branger, D., Fuller, G. N., Giannini, C., Holland, E. C., Jenkins, R. B., Kleinschmidt-DeMasters, B., Komori, T., Kros, J. M., Louis, D. N., McLean, C., Perry, A., Reifenberger, G., Sarkar, C., Stupp, R., van den Bent, M. J., von Deimling, A. & Weller, M., Mar 1 2020, In : Acta Neuropathologica. 139, 3, p. 603-608 6 p.

    Research output: Contribution to journalArticle

    6 Scopus citations

    cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading

    Louis, D. N., Wesseling, P., Aldape, K., Brat, D. J., Capper, D., Cree, I. A., Eberhart, C., Figarella-Branger, D., Fouladi, M., Fuller, G. N., Giannini, C., Haberler, C., Hawkins, C., Komori, T., Kros, J. M., Ng, H. K., Orr, B. A., Park, S. H., Paulus, W., Perry, A. & 13 others, Pietsch, T., Reifenberger, G., Rosenblum, M., Rous, B., Sahm, F., Sarkar, C., Solomon, D. A., Tabori, U., van den Bent, M. J., von Deimling, A., Weller, M., White, V. A. & Ellison, D. W., Jul 1 2020, In : Brain Pathology. 30, 4, p. 844-856 13 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Data sets for the reporting of tumors of the central nervous system recommendations from the international collaboration on cancer reporting

    Louis, D. N., Wesseling, P., Brandner, S., Brat, D. J., Ellison, D. W., Giangaspero, F., Hattab, E. M., Hawkins, C., Judge, M. J., Kleinschmidt-DeMasters, B., Komori, T., McLean, C., Paulus, W., Perry, A., Reifenberger, G., Weller, M. & Rous, B., Jan 1 2020, In : Archives of Pathology and Laboratory Medicine. 144, 2, p. 196-206 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Methods for in vitro modeling of glioma invasion: Choosing tools to meet the need

    Dundar, B., Markwell, S. M., Sharma, N. V., Olson, C. L., Mukherjee, S. & Brat, D. J., Jan 1 2020, (Accepted/In press) In : Glia.

    Research output: Contribution to journalReview article