Grants per year
Personal profile
Research Interests
The elucidation of eukaryotic signal transduction pathways, the study of signal transduction pathway perturbation in disease or injury, and the utilization of this knowledgebase for rational drug discovery and development.
Training Experience
| 1977 | Postdoctoral Fellowship, Duke University |
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Emory University
… → 1975
Research interests
- Alzheimer's Drug
- Biochemistry: Proteins
- Brain Cancer / Nervous System Cancer
- Brain Injury
- Drug Discovery
- Neuroinflammation
- Pharmacology
- Signal Transduction
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CardioExcyte 96 System for Pharmacology Research at Northwestern University
George Jr., A. L., Abdulkadir, S. A., Ardehali, H., Arora, R. K., Burridge, P., Kearney, J. A., McNally, E. M., Schiltz, G. E., Silverman, R. B., Watterson, D. M. & Wilsbacher, L. D.
Office of the Director, National Institutes of Health
6/15/20 → 6/30/25
Project: Research project
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Preclinical development of a novel small molecule inhibitor of Alzheimer's disease-related cognitive impairment
Watterson, D. M. & Anderson, W. F.
5/15/20 → 4/30/24
Project: Research project
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First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers
Van Eldik, L. J., Sawaki, L., Bowen, K., Laskowitz, D. T., Noveck, R. J., Hauser, B., Jordan, L., Spears, T. G., Wu, H., Watt, K., Raja, S., Roy, S. M., Watterson, D. M. & Guptill, J. T., Feb 2021, In: Clinical Pharmacology in Drug Development. 10, 2, p. 131-143 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Phosphorylation-dependent subcellular redistribution of small myosin light chain kinase
Khapchaev, A. Y., Watterson, D. M. & Shirinsky, V. P., Oct 2021, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1868, 11, 119104.Research output: Contribution to journal › Article › peer-review
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Erratum: A selective and brain penetrant p38αMAPK inhibitor candidate for neurologic and neuropsychiatric disorders that attenuates neuroinflammation and cognitive dysfunction (J. Med. Chem. (2019) 62:11 (5298-5311) DOI: 10.1021/acs.jmedchem.9b00058)
Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Martin Watterson, D., Aug 13 2020, In: Journal of Medicinal Chemistry. 63, 15, p. 8649 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Involvement of p38 mapk in synaptic function and dysfunction
Falcicchia, C., Tozzi, F., Arancio, O., Watterson, D. M. & Origlia, N., Aug 2 2020, In: International journal of molecular sciences. 21, 16, p. 1-14 14 p., 5624.Research output: Contribution to journal › Review article › peer-review
Open Access20 Scopus citations -
A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction
Roy, S. M., Minasov, G., Arancio, O., Chico, L. W., Van Eldik, L. J., Anderson, W. F., Pelletier, J. C. & Watterson, D. M., Jun 13 2019, In: Journal of Medicinal Chemistry. 62, 11, p. 5298-5311 14 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations