• 3280 Citations
19992019

Research output per year

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Personal profile

Research Interests

Our research program is focused on the important basic question of how chromosomes are segregated during cell division to ensure the complete and accurate inheritance of the genome. Chromosome instability is a hallmark of cancer and can drive tumorigenesis. Therefore, how centromere specification is controlled is a basic biological question with great therapeutic potential. Centromeres are specified by the incorporation of a histone variant CENP-A, and stable inheritance of this locus is controlled by an epigenetic pathway. We are using a combination of cell biology, biochemical purification, and in vitro reconstitution of centromeric chromatin to discover the mechanism of epigenetic inheritance and CENP-A function across the cell cycle. The immediate goal is to determine the mechanism of epigenetic centromere inheritance, with a long-term goal of delineating the role of this process in tumorigenesis, and translate our basic understanding of the enzymes and proteins involved in this process into therapeutic approaches for targeting proliferative disease.

Training Experience

2008Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA

Education/Academic qualification

PhD, Northwestern University

… → 2001

Research interests

  • Cancer Biology
  • Cell Division
  • Chromatin
  • Chromosome Segregation
  • Epigenetics
  • Molecular Biology
  • Nucleic Acid Structure/Function

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Grants

  • Research Output

    • 3280 Citations
    • 27 Article
    • 5 Short survey
    • 4 Review article

    Cell Biology: Hacking Alpha Satellites out of the HAC

    Willis, A. B. & Foltz, D. R., Nov 18 2019, In : Current Biology. 29, 22, p. R1194-R1196

    Research output: Contribution to journalShort survey

  • Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP

    Zasadzińska, E., Huang, J., Bailey, A. O., Guo, L. Y., Lee, N. S., Srivastava, S., Wong, K. A., French, B. T., Black, B. E. & Foltz, D. R., Nov 5 2018, In : Developmental Cell. 47, 3, p. 348-362.e7

    Research output: Contribution to journalArticle

  • 19 Scopus citations

    Posttranslational mechanisms controlling centromere function and assembly

    Srivastava, S., Zasadzińska, E. & Foltz, D. R., Jun 2018, In : Current Opinion in Cell Biology. 52, p. 126-135 10 p.

    Research output: Contribution to journalReview article

  • 6 Scopus citations

    Posttranslational modifications of CENP-A: marks of distinction

    Srivastava, S. & Foltz, D. R., Sep 1 2018, In : Chromosoma. 127, 3, p. 279-290 12 p.

    Research output: Contribution to journalReview article

  • 13 Scopus citations

    HJURP interaction with the condensin II complex during G1 promotes CENP-A deposition

    Barnhart-Dailey, M. C., Trivedi, P., Stukenberg, P. T. & Foltz, D. R., Jan 1 2017, In : Molecular biology of the cell. 28, 1, p. 54-64 11 p.

    Research output: Contribution to journalArticle

  • 9 Scopus citations