Grants per year
Personal profile
Research Interests
Our research program is focused on the important basic question of how chromosomes are segregated during cell division to ensure the complete and accurate inheritance of the genome. Chromosome instability is a hallmark of cancer and can drive tumorigenesis. Therefore, how centromere specification is controlled is a basic biological question with great therapeutic potential. Centromeres are specified by the incorporation of a histone variant CENP-A, and stable inheritance of this locus is controlled by an epigenetic pathway. We are using a combination of cell biology, biochemical purification, and in vitro reconstitution of centromeric chromatin to discover the mechanism of epigenetic inheritance and CENP-A function across the cell cycle. The immediate goal is to determine the mechanism of epigenetic centromere inheritance, with a long-term goal of delineating the role of this process in tumorigenesis, and translate our basic understanding of the enzymes and proteins involved in this process into therapeutic approaches for targeting proliferative disease.
Training Experience
| 2008 | Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Cell Biology, Northwestern University
… → 2001
Research interests keywords
- Cancer Biology
- Cell Division
- Chromatin
- Chromosome Segregation
- Epigenetics
- Molecular Biology
- Nucleic Acid Structure/Function
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration Hub
Savas, J. N., Caraveo Piso, G., Contractor, A., Disterhoft, J. F., Duncan, F. E., Foltz, D. R., Goel, R., Kafader, J. O., Kalb, R. G., Kelleher, N. L., Kiskinis, E., Krainc, D., Mendillo, M. L., Menichella, D. M., Penzes, P., Smith, G. A., Surmeier Jr, D. J., Vassar, R. J., Walsh, D. & Zelano, C.
Office of the Director, National Institutes of Health
3/1/23 → 2/29/24
Project: Research project
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Histone chaperone networks for new and evicted histones
Foltz, D. R., Foltz, D. R., Ben-Sahra, I. & Ben-Sahra, I.
National Institute of General Medical Sciences
8/1/21 → 6/30/25
Project: Research project
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The role of nucleoli in human genome organization in normal and disease states
Foltz, D. R., Foltz, D. R., Huang, S., Huang, S., Mendillo, M. L., Mendillo, M. L. & Huang, S.
University of Massachusetts Medical School, National Cancer Institute
9/21/20 → 2/28/27
Project: Research project
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The subcellular distribution and uptake of PSMA-targeting ligands
8/1/22 → 7/31/23
Project: Research project
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Assembly and epigenetic inheritance of the human centromere
Foltz, D. R. & Zou, L.
National Institute of General Medical Sciences
8/1/19 → 7/31/23
Project: Research project
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Nucleoli and the nucleoli–centromere association are dynamic during normal development and in cancer
Rodrigues, A., MacQuarrie, K. L., Freeman, E., Lin, A., Willis, A. B., Xu, Z., Alvarez, A. A., Ma, Y., Perez White, B. E., Foltz, D. R. & Huang, S., Apr 2023, In: Molecular biology of the cell. 34, 4, br5.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability
Shrestha, R. L., Balachandra, V., Kim, J. H., Rossi, A., Vadlamani, P., Sethi, S. C., Ozbun, L., Lin, S., Cheng, K. C. C., Chari, R., Karpova, T. S., Pegoraro, G., Foltz, D. R., Caplen, N. J. & Basrai, M. A., May 15 2023, In: Journal of cell science. 136, 10Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways
Amici, D. R., Ansel, D. J., Metz, K. A., Smith, R. S., Phoumyvong, C. M., Gayatri, S., Chamera, T., Edwards, S. L., O’Hara, B. P., Srivastava, S., Brockway, S., Takagishi, S. R., Cho, B. K., Goo, Y. A., Kelleher, N. L., Ben-Sahra, I., Foltz, D. R., Li, J. & Mendillo, M. L., Jul 5 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 27, e2111262119.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
CENP-A overexpression promotes aneuploidy with karyotypic heterogeneity
Shrestha, R. L., Rossi, A., Wangsa, D., Hogan, A. K., Zaldana, K. S., Suva, E., Chung, Y. J., Sanders, C. L., Difilippantonio, S., Karpova, T. S., Karim, B., Foltz, D. R., Fachinetti, D., Aplan, P. D., Ried, T. & Basrai, M. A., Feb 2021, In: Journal of Cell Biology. 220, 4, e202007195.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia
Srivastava, S., Sahu, U., Zhou, Y., Hogan, A. K., Sathyan, K. M., Bodner, J., Huang, J., Wong, K. A., Khalatyan, N., Savas, J. N., Ntziachristos, P., Ben-Sahra, I. & Foltz, D. R., Jan 27 2021, In: Science Advances. 7, 5, abc9781.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations