Grants per year
Personal profile
Research Interests
Our research program is focused on the important basic question of how chromosomes are segregated during cell division to ensure the complete and accurate inheritance of the genome. Chromosome instability is a hallmark of cancer and can drive tumorigenesis. Therefore, how centromere specification is controlled is a basic biological question with great therapeutic potential. Centromeres are specified by the incorporation of a histone variant CENP-A, and stable inheritance of this locus is controlled by an epigenetic pathway. We are using a combination of cell biology, biochemical purification, and in vitro reconstitution of centromeric chromatin to discover the mechanism of epigenetic inheritance and CENP-A function across the cell cycle. The immediate goal is to determine the mechanism of epigenetic centromere inheritance, with a long-term goal of delineating the role of this process in tumorigenesis, and translate our basic understanding of the enzymes and proteins involved in this process into therapeutic approaches for targeting proliferative disease.
Training Experience
| 2008 | Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA |
Education/Academic qualification
PhD, Northwestern University
… → 2001
Research interests
- Cancer Biology
- Cell Division
- Chromatin
- Chromosome Segregation
- Epigenetics
- Molecular Biology
- Nucleic Acid Structure/Function
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Grants
Assembly and epigenetic inheritance of the human centromere
National Institute of General Medical Sciences
8/1/19 → 7/31/23
Project: Research project
UBR7 is a novel chromatin directed E3 ubiquitin ligase
National Institute of Child Health and Human Development
9/1/15 → 8/31/17
Project: Research project
Assembly and epigenetic inheritance of the human centromere
National Institute of General Medical Sciences
8/1/15 → 7/31/19
Project: Research project
Research Output
Cell Biology: Hacking Alpha Satellites out of the HAC
Willis, A. B. & Foltz, D. R., Nov 18 2019, In : Current Biology. 29, 22, p. R1194-R1196Research output: Contribution to journal › Short survey
Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP
Zasadzińska, E., Huang, J., Bailey, A. O., Guo, L. Y., Lee, N. S., Srivastava, S., Wong, K. A., French, B. T., Black, B. E. & Foltz, D. R., Nov 5 2018, In : Developmental Cell. 47, 3, p. 348-362.e7Research output: Contribution to journal › Article
19
Scopus
citations
Posttranslational mechanisms controlling centromere function and assembly
Srivastava, S., Zasadzińska, E. & Foltz, D. R., Jun 2018, In : Current Opinion in Cell Biology. 52, p. 126-135 10 p.Research output: Contribution to journal › Review article
6
Scopus
citations
Posttranslational modifications of CENP-A: marks of distinction
Srivastava, S. & Foltz, D. R., Sep 1 2018, In : Chromosoma. 127, 3, p. 279-290 12 p.Research output: Contribution to journal › Review article
13
Scopus
citations
HJURP interaction with the condensin II complex during G1 promotes CENP-A deposition
Barnhart-Dailey, M. C., Trivedi, P., Stukenberg, P. T. & Foltz, D. R., Jan 1 2017, In : Molecular biology of the cell. 28, 1, p. 54-64 11 p.Research output: Contribution to journal › Article
9
Scopus
citations