• 2956 Citations
19992019
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

Our research program is focused on the important basic question of how chromosomes are segregated during cell division to ensure the complete and accurate inheritance of the genome. Chromosome instability is a hallmark of cancer and can drive tumorigenesis. Therefore, how centromere specification is controlled is a basic biological question with great therapeutic potential. Centromeres are specified by the incorporation of a histone variant CENP-A, and stable inheritance of this locus is controlled by an epigenetic pathway. We are using a combination of cell biology, biochemical purification, and in vitro reconstitution of centromeric chromatin to discover the mechanism of epigenetic inheritance and CENP-A function across the cell cycle. The immediate goal is to determine the mechanism of epigenetic centromere inheritance, with a long-term goal of delineating the role of this process in tumorigenesis, and translate our basic understanding of the enzymes and proteins involved in this process into therapeutic approaches for targeting proliferative disease.

Training Experience

2008Postdoctoral Fellowship, Ludwig Institute for Cancer Research, San Diego, CA

Education/Academic qualification

PhD, Northwestern University

… → 2001

Keywords

  • Cancer Biology
  • Cell Division
  • Chromatin
  • Chromosome Segregation
  • Epigenetics
  • Molecular Biology
  • Nucleic Acid Structure/Function

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 18 Similar Profiles
Centromere Medicine & Life Sciences
Nucleosomes Medicine & Life Sciences
Histones Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Kinetochores Medicine & Life Sciences
Epigenomics Medicine & Life Sciences
Chromosomes Medicine & Life Sciences
Chromatin Assembly and Disassembly Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2015 2019

Centromere
Epigenomics
Nucleosomes
Chromatin
Post Translational Protein Processing
Ubiquitin-Protein Ligases
Autistic Disorder
Chromatin
Histones
Genes

Research Output 1999 2018

  • 2956 Citations
  • 28 Article
  • 4 Review article
  • 3 Short survey
5 Citations (Scopus)

Inheritance of CENP-A Nucleosomes during DNA Replication Requires HJURP

Zasadzińska, E., Huang, J., Bailey, A. O., Guo, L. Y., Lee, N. S., Srivastava, S., Wong, K. A., French, B. T., Black, B. E. & Foltz, D. R., Nov 5 2018, In : Developmental Cell. 47, 3, p. 348-362.e7

Research output: Contribution to journalArticle

Nucleosomes
DNA Replication
DNA
S Phase
Centromere
3 Citations (Scopus)

Posttranslational mechanisms controlling centromere function and assembly

Srivastava, S., Zasadzińska, E. & Foltz, D. R., Jun 1 2018, In : Current Opinion in Cell Biology. 52, p. 126-135 10 p.

Research output: Contribution to journalReview article

Centromere
Nucleosomes
Histone Code
Kinetochores
Chromosome Segregation
3 Citations (Scopus)

Posttranslational modifications of CENP-A: marks of distinction

Srivastava, S. & Foltz, D. R., Sep 1 2018, In : Chromosoma. 127, 3, p. 279-290 12 p.

Research output: Contribution to journalReview article

Centromere
Staphylococcal Protein A
Post Translational Protein Processing
Histones
Nucleosomes
4 Citations (Scopus)

HJURP interaction with the condensin II complex during G1 promotes CENP-A deposition

Barnhart-Dailey, M. C., Trivedi, P., Stukenberg, P. T. & Foltz, D. R., Jan 1 2017, In : Molecular Biology of the Cell. 28, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

Centromere
Chromatin
Nucleosomes
condensin complexes
centromere protein A
15 Citations (Scopus)

Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells

Shrestha, R. L., Ahn, G. S., Staples, M. I., Sathyan, K. M., Karpova, T. S., Foltz, D. R. & Basrai, M. A., Jan 1 2017, In : Oncotarget. 8, 29, p. 46781-46800 20 p.

Research output: Contribution to journalArticle

Chromosomal Instability
Histones
Kinetochores
Centromere
Chromosomes