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Darren M Brenner

  • 670 Citations
20002020
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Personal profile

Research Interests

My current research includes the following: 1. Evaluation of new treatments for Opioid Related Constipation 2. Therapeutic trials for the treatment of constipation in adults with cystic fibrosis 3. Prevalence and quality of life assessments in individuals with refractory constipation and fecal incontinence 4. Use of newer pharmaceuticals and endoscopic modalities for treating gastroparesis 5. Use of virtual reality for treating functional GI disorders 6. Phase II/III pharmaceutical trials for functional GI disorders--predominately IBS

Gastrointestinal motility disorders and pelvic floor disorders including but not limited to Constipation/Fecal Incontinence/Irritable Bowel Syndrome/Dyspepsia/Gastroparesis/Opioid related bowel dysfunction as well as complications of systemic motility disorders with an emphasis on Scleroderma.

Certifications and Licenses

Gastroenterology
Internal Medicine

Training Experience

2005Residency, University of Michigan Health System
2008Fellowship, University of Michigan Health System

Education/Academic qualification

MD, University of Chicago

… → 2002

Research interests

  • Pelvic Floor Disorders and Surgery

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  • 2 Similar Profiles
Irritable Bowel Syndrome Medicine & Life Sciences
Constipation Medicine & Life Sciences
Opioid Analgesics Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Placebos Medicine & Life Sciences
Cognitive Therapy Medicine & Life Sciences
Randomized Controlled Trials Medicine & Life Sciences
Systemic Scleroderma Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2008 2015

Antidepressent Therapy for Functional Dyspepsia

Brenner, D. M. & Yun, L. H.

Mayo Clinic, National Institute of Diabetes, Digestive and Kidney Diseases

8/1/10 → 7/31/11

Project: Research project

Self-administered CBT for IBS: A Multicenter Trial

Brenner, D. M.

State University of New York at Buffalo, National Institute of Diabetes, Digestive and Kidney Diseases

5/15/08 → 4/30/15

Project: Research project

Research Output 2000 2020

Current US Food and Drug Administration-Approved Pharmacologic Therapies for the Treatment of Irritable Bowel Syndrome with Diarrhea

Brenner, D. M. & Sayuk, G. S., Jan 1 2020, In : Advances in Therapy. 37, 1, p. 83-96 14 p.

Research output: Contribution to journal › Review article

Open Access
Irritable Bowel Syndrome
rifaximin
United States Food and Drug Administration
Diarrhea
Gastrointestinal Motility

A Randomized, Multicenter, Prospective, Crossover, Open-Label Study of Factors Associated with Patient Preferences for Naloxegol or PEG 3350 for Opioid-Induced Constipation

Brenner, D. M., Hu, Y., Datto, C., Creanga, D. & Camilleri, M., Jun 1 2019, In : American Journal of Gastroenterology. 114, 6, p. 954-963 10 p.

Research output: Contribution to journal › Article

Patient Preference
Constipation
Opioid Analgesics
Therapeutics
Laxatives
3 Citations (Scopus)

Durability and Decay of Treatment Benefit of Cognitive Behavioral Therapy for Irritable Bowel Syndrome: 12-Month Follow-Up

Lackner, J. M., Jaccard, J., Radziwon, C. D., Firth, R. S., Gudleski, G. D., Hamilton, F., Katz, L. A., Keefer, L., Krasner, S. S., Ma, C. X., Sitrin, M. D. & Brenner, D. M., Feb 1 2019, In : American Journal of Gastroenterology. 114, 2, p. 330-338 9 p.

Research output: Contribution to journal › Article

Irritable Bowel Syndrome
Cognitive Therapy
Therapeutics
Education
Maintenance
1 Citation (Scopus)

Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study

Brenner, D. M., Sayuk, G. S., Gutman, C. R., Jo, E., Elmes, S. J. R., Liu, L. W. C. & Cash, B. D., Sep 1 2019, In : American Journal of Gastroenterology. 114, 9, p. 1502-1511 10 p.

Research output: Contribution to journal › Article

Loperamide
Irritable Bowel Syndrome
Diarrhea
Safety
Abdominal Pain
7 Citations (Scopus)

Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: Systematic review and network meta-analysis

Luthra, P., Burr, N. E., Brenner, D. M. & Ford, A. C., Mar 1 2019, In : Gut. 68, 3, p. 434-444 11 p.

Research output: Contribution to journal › Article

Constipation
Opioid Analgesics
Pharmacology
Naloxone
Therapeutics