Grants per year
Personal profile
Research Interests
My current research includes the following: 1. Evaluation of new treatments for Opioid Related Constipation 2. Therapeutic trials for the treatment of constipation in adults with cystic fibrosis 3. Prevalence and quality of life assessments in individuals with refractory constipation and fecal incontinence 4. Use of newer pharmaceuticals and endoscopic modalities for treating gastroparesis 5. Use of virtual reality for treating functional GI disorders 6. Phase II/III pharmaceutical trials for functional GI disorders--predominately IBS
Gastrointestinal motility disorders and pelvic floor disorders including but not limited to Constipation/Fecal Incontinence/Irritable Bowel Syndrome/Dyspepsia/Gastroparesis/Opioid related bowel dysfunction as well as complications of systemic motility disorders with an emphasis on Scleroderma.
Certifications and Licenses
| Gastroenterology | |
| Internal Medicine |
Training Experience
| 2005 | Residency, University of Michigan Health System |
| 2008 | Fellowship, University of Michigan Health System |
Education/Academic qualification
Medicine, MD, University of Chicago
… → 2002
Research interests keywords
- Pelvic Floor Disorders and Surgery
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Grants
- 4 Finished
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Open-Label Assessment of the Efficacy of Atrantil in the Treatment of Methane-Predominate Intestinal Bacterial Overgrowth.
Brenner, D. M. (PD/PI) & Cai, J. X. (Co-PD/PI)
Northwestern Memorial Hospital, Digestive Health Foundation
6/1/20 → 6/30/22
Project: Research project
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Prot# APD371-202: A Phase 2, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study to Evaluate the Safety, Tolerability, and Efficacy of Olorinab in Subjects with Irritable Bowel Syndrome Experiencing Abdominal Pain
Brenner, D. M. (PD/PI)
DrugDev Inc., Arena Pharmaceuticals, Inc.
5/8/20 → 5/8/23
Project: Research project
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Antidepressent Therapy for Functional Dyspepsia
Brenner, D. M. (Co-PD/PI) & Yun, L. H. (Co-PD/PI)
Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases
8/1/10 → 7/31/11
Project: Research project
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Self-administered CBT for IBS: A Multicenter Trial
Brenner, D. M. (Co-Investigator)
State University of New York at Buffalo, National Institute of Diabetes and Digestive and Kidney Diseases
5/15/08 → 4/30/15
Project: Research project
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Abdominal Symptom Improvement during Clinical Trials of Tenapanor in Patients with Irritable Bowel Syndrome with Constipation: A Post Hoc Analysis
Lembo, A. J., Chey, W. D., Harris, L. A., Frazier, R., Brenner, D. M., Chang, L., Lacy, B. E., Edelstein, S., Yang, Y., Zhao, S. & Rosenbaum, D. P., May 1 2024, In: American Journal of Gastroenterology. 119, 5, p. 937-945 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Development and Current State of Digital Therapeutics for Irritable Bowel Syndrome
Brenner, D. M., Ladewski, A. M. & Kinsinger, S. W., Feb 2024, In: Clinical Gastroenterology and Hepatology. 22, 2, p. 222-234 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Optimizing the Management Algorithm for Adults With Functional Constipation Failing a Fiber/Laxative Trial in General Gastroenterology: Cost-Effectiveness and Cost-Minimization Analysis
Shah, E. D., Ahuja, N. K., Brenner, D. M., Chan, W. W., Curley, M. A., Nee, J., Iturrino-Moreda, J., Staller, K., Saini, S. D. & Chey, W. D., Feb 1 2024, In: American Journal of Gastroenterology. 119, 2, p. 342-352 11 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Perceptions, Definitions, and Therapeutic Interventions for Occasional Constipation: A Rome Working Group Consensus Document
Brenner, D. M., Corsetti, M., Drossman, D., Tack, J. & Wald, A., Feb 2024, In: Clinical Gastroenterology and Hepatology. 22, 2, p. 397-412 16 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Plecanatide Improves Abdominal Bloating and Bowel Symptoms of Irritable Bowel Syndrome with Constipation
Brenner, D. M., Sharma, A., Rao, S. S. C., Laitman, A. P., Heimanson, Z., Allen, C. & Sayuk, G. S., May 2024, In: Digestive diseases and sciences. 69, 5, p. 1731-1738 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations
Datasets
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Mast cell activation in the systemic sclerosis esophagus
Tom, K. (Creator), Mehta, B. K. (Contributor), Hoffmann, A. (Creator), Aren, K. (Creator), Carns, M. (Creator), Lee, J. (Contributor), Martyanov, V. (Creator), Popovich, D. (Creator), Kosarek, N. (Creator), Wood, T. A. (Contributor), Brenner, D. (Creator), Carlson, D. A. (Creator), Ostilla, L. (Creator), Willcocks, E. (Creator), Bryce, P. (Creator), Wechsler, J. B. (Creator), Whitfield, M. L. (Creator) & Hinchcliff, M. (Creator), SAGE Journals, 2020
DOI: 10.25384/sage.c.5075239, https://sage.figshare.com/collections/Mast_cell_activation_in_the_systemic_sclerosis_esophagus/5075239
Dataset
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Current US Food and Drug Administration–Approved Pharmacologic Therapies for the Treatment of Irritable Bowel Syndrome With Diarrhea
Brenner, D. M. (Creator) & Sayuk, G. S. (Creator), Adis Journals, 2019
DOI: 10.6084/m9.figshare.9944903.v1, https://adisjournals.figshare.com/articles/Current_US_Food_and_Drug_Administration_Approved_Pharmacologic_Therapies_for_the_Treatment_of_Irritable_Bowel_Syndrome_With_Diarrhea/9944903/1
Dataset