Grants per year
Personal profile
Research Interests
My current research includes the following: 1. Evaluation of new treatments for Opioid Related Constipation 2. Therapeutic trials for the treatment of constipation in adults with cystic fibrosis 3. Prevalence and quality of life assessments in individuals with refractory constipation and fecal incontinence 4. Use of newer pharmaceuticals and endoscopic modalities for treating gastroparesis 5. Use of virtual reality for treating functional GI disorders 6. Phase II/III pharmaceutical trials for functional GI disorders--predominately IBS
Gastrointestinal motility disorders and pelvic floor disorders including but not limited to Constipation/Fecal Incontinence/Irritable Bowel Syndrome/Dyspepsia/Gastroparesis/Opioid related bowel dysfunction as well as complications of systemic motility disorders with an emphasis on Scleroderma.
Certifications and Licenses
Gastroenterology | |
Internal Medicine |
Training Experience
2005 | Residency, University of Michigan Health System |
2008 | Fellowship, University of Michigan Health System |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Chicago
… → 2002
Research interests keywords
- Pelvic Floor Disorders and Surgery
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Collaborations and top research areas from the last five years
Grants
- 4 Finished
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Open-Label Assessment of the Efficacy of Atrantil in the Treatment of Methane-Predominate Intestinal Bacterial Overgrowth.
Brenner, D. M. (PD/PI) & Cai, J. X. (Co-PD/PI)
Northwestern Memorial Hospital, Digestive Health Foundation
6/1/20 → 6/30/22
Project: Research project
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Prot# APD371-202: A Phase 2, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study to Evaluate the Safety, Tolerability, and Efficacy of Olorinab in Subjects with Irritable Bowel Syndrome Experiencing Abdominal Pain
Brenner, D. M. (PD/PI)
DrugDev Inc., Arena Pharmaceuticals, Inc.
5/8/20 → 5/8/23
Project: Research project
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Antidepressent Therapy for Functional Dyspepsia
Brenner, D. M. (Co-PD/PI) & Yun, L. H. (Co-PD/PI)
Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases
8/1/10 → 7/31/11
Project: Research project
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Self-administered CBT for IBS: A Multicenter Trial
Brenner, D. M. (Co-Investigator)
State University of New York at Buffalo, National Institute of Diabetes and Digestive and Kidney Diseases
5/15/08 → 4/30/15
Project: Research project
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Tenapanor Improves Abdominal Symptoms Irrespective of Changes in Complete Spontaneous Bowel Movement Frequency in Adults with Irritable Bowel Syndrome with Constipation
Brenner, D. M., Sayuk, G. S., Cash, B. D., Harris, L. A., Ahuja, N. K., Deutsch, J. K., Yang, Y., Zhao, S., Rosenbaum, D. P. & Lembo, A. J., Apr 1 2025, In: Digestive Diseases. 43, 2, p. 146-157 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The Vibrating Capsule: Safety and Tolerability in Patients With Chronic Idiopathic Constipation
Curtin, B. F., Quigley, E. M. M., Chey, W. D., Lembo, A. J., Brenner, D. M., Spiegel, B. M. R. & Rao, S. S. C., May 2025, In: Neurogastroenterology and Motility. 37, 5, e15004.Research output: Contribution to journal › Article › peer-review
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Abdominal Symptom Improvement during Clinical Trials of Tenapanor in Patients with Irritable Bowel Syndrome with Constipation: A Post Hoc Analysis
Lembo, A. J., Chey, W. D., Harris, L. A., Frazier, R., Brenner, D. M., Chang, L., Lacy, B. E., Edelstein, S., Yang, Y., Zhao, S. & Rosenbaum, D. P., May 1 2024, In: American Journal of Gastroenterology. 119, 5, p. 937-945 9 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Development and Current State of Digital Therapeutics for Irritable Bowel Syndrome
Brenner, D. M., Ladewski, A. M. & Kinsinger, S. W., Feb 2024, In: Clinical Gastroenterology and Hepatology. 22, 2, p. 222-234 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access16 Scopus citations -
Optimizing the Management Algorithm for Adults With Functional Constipation Failing a Fiber/Laxative Trial in General Gastroenterology: Cost-Effectiveness and Cost-Minimization Analysis
Shah, E. D., Ahuja, N. K., Brenner, D. M., Chan, W. W., Curley, M. A., Nee, J., Iturrino-Moreda, J., Staller, K., Saini, S. D. & Chey, W. D., Feb 1 2024, In: American Journal of Gastroenterology. 119, 2, p. 342-352 11 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations
Datasets
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Current US Food and Drug Administration–Approved Pharmacologic Therapies for the Treatment of Irritable Bowel Syndrome With Diarrhea
Brenner, D. M. (Creator) & Sayuk, G. S. (Creator), Adis Journals, 2019
DOI: 10.6084/m9.figshare.9944903.v1, https://adisjournals.figshare.com/articles/Current_US_Food_and_Drug_Administration_Approved_Pharmacologic_Therapies_for_the_Treatment_of_Irritable_Bowel_Syndrome_With_Diarrhea/9944903/1
Dataset
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Mast cell activation in the systemic sclerosis esophagus
Tom, K. (Creator), Mehta, B. K. (Contributor), Hoffmann, A. (Creator), Aren, K. (Creator), Carns, M. (Creator), Lee, J. (Contributor), Martyanov, V. (Creator), Popovich, D. (Creator), Kosarek, N. (Creator), Wood, T. A. (Contributor), Brenner, D. (Creator), Carlson, D. A. (Creator), Ostilla, L. (Creator), Willcocks, E. (Creator), Bryce, P. (Creator), Wechsler, J. B. (Creator), Whitfield, M. L. (Creator) & Hinchcliff, M. (Creator), SAGE Journals, 2020
DOI: 10.25384/sage.c.5075239, https://sage.figshare.com/collections/Mast_cell_activation_in_the_systemic_sclerosis_esophagus/5075239
Dataset