• 753 Citations

Research output per year

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Personal profile

Research Interests

My current research includes the following: 1. Evaluation of new treatments for Opioid Related Constipation 2. Therapeutic trials for the treatment of constipation in adults with cystic fibrosis 3. Prevalence and quality of life assessments in individuals with refractory constipation and fecal incontinence 4. Use of newer pharmaceuticals and endoscopic modalities for treating gastroparesis 5. Use of virtual reality for treating functional GI disorders 6. Phase II/III pharmaceutical trials for functional GI disorders--predominately IBS

Gastrointestinal motility disorders and pelvic floor disorders including but not limited to Constipation/Fecal Incontinence/Irritable Bowel Syndrome/Dyspepsia/Gastroparesis/Opioid related bowel dysfunction as well as complications of systemic motility disorders with an emphasis on Scleroderma.

Certifications and Licenses

Internal Medicine

Training Experience

2005Residency, University of Michigan Health System
2008Fellowship, University of Michigan Health System

Education/Academic qualification

MD, The University of Chicago

… → 2002

Research interests

  • Pelvic Floor Disorders and Surgery

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Research Output

Current US Food and Drug Administration-Approved Pharmacologic Therapies for the Treatment of Irritable Bowel Syndrome with Diarrhea

Brenner, D. M. & Sayuk, G. S., Jan 1 2020, In : Advances in Therapy. 37, 1, p. 83-96 14 p.

Research output: Contribution to journalReview article

Open Access
  • 3 Scopus citations

    Efficacy and safety of linaclotide for opioid-induced constipation in patients with chronic noncancer pain syndromes from a phase 2 randomized study

    Brenner, D. M., Argoff, C. E., Fox, S. M., Bochenek, W., DʼAstoli, P., Blakesley, R. E., Reasner, D. S., OʼDea, C. R. & Cash, B. D., May 1 2020, In : Pain. 161, 5, p. 1027-1036 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • How to Manage Opioid-Related Constipation in Individuals with Chronic Nonmalignant Pain Syndromes

    Brenner, D. M., Barrett-Englert, M. & Cash, B. D., Mar 1 2020, In : American Journal of Gastroenterology. 115, 3, p. 307-310 4 p.

    Research output: Contribution to journalArticle

    Open Access
  • Response to Black et al.

    Brenner, D. M., Sayuk, G. S., Gutman, C. R., Jo, E., Elmes, S. J. R., Liu, L. W. C. & Cash, B. D., Mar 1 2020, In : American Journal of Gastroenterology. 115, 3, p. 484-485 2 p.

    Research output: Contribution to journalLetter

  • 2 Scopus citations