• 588 Citations
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Personal profile

Research Interests

Gastrointestinal motility disorders and pelvic floor disorders including but not limited to Constipation/Fecal Incontinence/Irritable Bowel Syndrome/Dyspepsia/Gastroparesis/Opioid related bowel dysfunction as well as complications of systemic motility disorders with an emphasis on Scleroderma.

My current research includes the following: 1. Evaluation of new treatments for Opioid Related Constipation 2. Therapeutic trials for the treatment of constipation in adults with cystic fibrosis 3. Prevalence and quality of life assessments in individuals with refractory constipation and fecal incontinence 4. Use of newer pharmaceuticals and endoscopic modalities for treating gastroparesis 5. Use of virtual reality for treating functional GI disorders 6. Phase II/III pharmaceutical trials for functional GI disorders--predominately IBS

Certifications and Licenses

Internal Medicine

Training Experience

2005Residency, University of Michigan Health System
2008Fellowship, University of Michigan Health System

Education/Academic qualification

MD, University of Chicago

… → 2002


  • Pelvic Floor Disorders and Surgery

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 2 Similar Profiles
Irritable Bowel Syndrome Medicine & Life Sciences
Constipation Medicine & Life Sciences
Opioid Analgesics Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Randomized Controlled Trials Medicine & Life Sciences
Placebos Medicine & Life Sciences
Systemic Scleroderma Medicine & Life Sciences
Chronic Pain Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2008 2015

Research Output 2000 2019

2 Citations (Scopus)

Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: Systematic review and network meta-analysis

Luthra, P., Burr, N. E., Brenner, D. M. & Ford, A. C., Mar 1 2019, In : Gut. 68, 3, p. 434-444 11 p.

Research output: Contribution to journalArticle

Opioid Analgesics
1 Citation (Scopus)

(Can't Get No) Patient Satisfaction the Predictive Power of Demographic, GI, and Psychological Factors in IBS Patients

Quigley, B. M., Sova, C. C., Brenner, D. M., Keefer, L. A., Sitrin, M. D., Radziwon, C. D., Krasner, S. S. & Lackner, J. M., Aug 1 2018, In : Journal of Clinical Gastroenterology. 52, 7, p. 614-621 8 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Patient Satisfaction
Routine Diagnostic Tests
1 Citation (Scopus)

Abnormal esophageal acid exposure on high-dose proton pump inhibitor therapy is common in systemic sclerosis patients

Stern, E. K., Carlson, D. A., Falmagne, S., Hoffmann, A. D., Carns, M., Pandolfino, J. E., Hinchcliff, M. E. & Brenner, D. M., Feb 1 2018, In : Neurogastroenterology and Motility. 30, 2, e13247.

Research output: Contribution to journalArticle

Systemic Scleroderma
Proton Pump Inhibitors
Electric Impedance
1 Citation (Scopus)

Durability and Decay of Treatment Benefit of Cognitive Behavioral Therapy for Irritable Bowel Syndrome: 12-Month Follow-Up

Lackner, J. M., Jaccard, J., Radziwon, C. D., Firth, R. S., Gudleski, G. D., Hamilton, F., Katz, L. A., Keefer, L., Krasner, S. S., Ma, C. X., Sitrin, M. D. & Brenner, D. M., Jan 1 2018, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Cognitive Therapy
13 Citations (Scopus)

Efficacy, safety, and tolerability of plecanatide in patients with irritable bowel syndrome with constipation: Results of two phase 3 randomized clinical trials

Brenner, D. M., Fogel, R., Dorn, S. D., Krause, R., Eng, P., Kirshoff, R., Nguyen, A., Crozier, R. A., Magnus, L. & Griffin, P. H., May 1 2018, In : American Journal of Gastroenterology. 113, 5, p. 735-745 11 p.

Research output: Contribution to journalArticle

Phase III Clinical Trials
Irritable Bowel Syndrome
Randomized Controlled Trials