David Klumpp

  • 2148 Citations
1991 …2022
If you made any changes in Pure, your changes will be visible here soon.

Personal profile

Research Interests

I received a Ph.D. in Biochemistry, Molecular Biology and Cell Biology from Northwestern University in 1994, studying retinal neuron physiology. After postdoctoral studies in HPV pathogenesis and epithelial biology at Northwestern’s Feinberg School of Medicine, I joined the Department of Urology in 1998. I am an Associate Professor of Urology and Microbiology-Immunology in the Feinberg School of Medicine and the Anthony J. Schaeffer MD Professor of Urology.

Our team studies diverse aspects of neuro-immune and bacterial mechanisms of bladder inflammation and pelvic pain as well as the influence of microbiota on pain and cognition. Pain modulation by bacteria. Urinary tract infections due to colonization by uropathogenic E. coli are characterized by inflammatory and symptomatic responses. In contrast, asymptomatic bacteriuria associated with E. coli are asymptomatic by definition, pointing to distinct bacterial pain phenotypes in the bladder. We are exploring the mechanisms underlying bacterial pain phenotypes in the bladder using murine models that recapitulate key clinical findings. We find that E. coli exhibit distinct pain phenotypes independent of inflammation and that specific strains possess analgesic properties amenable for development as therapies for urologic disease. Genetic modulation of pain. We have recently identified the gene encoding acyloxyacyl hydrolase, Aoah, as a genetic modulator of pelvic pain. AOAH protein is expressed along the bladder-brain axis, and we are working to define the mechanisms by which Aoah modulates pain and urinary function. Pain and the microbiome. Our current clinical studies include characterizing changes in gut microbiota associated with interstitial cystitis/bladder pain syndrome. Supported by mechanistic studies in mice, we are working to define the influence of microbiota on pelvic pain and urologic and cognitive functions.

Education/Academic qualification

PhD, Northwestern University

… → 1994

Research interests

  • Bacterial Pathogenesis
  • Bladder and Urinary Tract
  • Cellular Microbiology
  • Immunology
  • Infectious Diseases: Bacteria
  • Inflammation
  • Microbiome
  • Mood Disorders
  • Neuroscience
  • Pain
  • Phospholipids
  • Urology

Fingerprint Dive into the research topics where David Klumpp is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 8 Similar Profiles
Pelvic Pain Medicine & Life Sciences
Uropathogenic Escherichia coli Medicine & Life Sciences
Interstitial Cystitis Medicine & Life Sciences
Urinary Bladder Medicine & Life Sciences
Urinary Tract Infections Medicine & Life Sciences
Chronic Pain Medicine & Life Sciences
Cystitis Medicine & Life Sciences
Pain Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2003 2022

Pelvic Pain
Depression
Chronic Pain
Neuroimaging
Comorbidity
Pelvic Pain
Microbiota
Chronic Pain
Probiotics
Gastrointestinal Tract
Urology
Urologic Diseases
Education
Research
Foster Home Care
Pelvic Pain
Chronic Pain
Neuroimaging
Depression
Comorbidity

Research Output 1991 2019

Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor

MAPP Research Network Study Group, Aug 1 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 317, 2, p. R289-R300

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Peroxisome Proliferator-Activated Receptors
Paraventricular Hypothalamic Nucleus
Corticotropin-Releasing Hormone
Arachidonic Acid
2 Citations (Scopus)

Acyloxyacyl hydrolase modulates pelvic pain severity

Yang, W., Yaggie, R. E., Jiang, M., Rudick, C. N., Done, J., Heckman, C., Rosen, J. M., Schaeffer, A. J. & Klumpp, D., Mar 1 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 3, p. R353-R365

Research output: Contribution to journalArticle

Pelvic Pain
Urinary Bladder
Suid Herpesvirus 1
Hyperalgesia
Chronic Pain
3 Citations (Scopus)
Interstitial Cystitis
Urothelium
Tumor Necrosis Factor-alpha
Urinary Bladder
Cystitis

Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP network study

MAPP Research Network & MAPP Research Network Study Group, Dec 1 2018, In : PloS one. 13, 12, e0206807.

Research output: Contribution to journalArticle

Open Access
Pelvic Pain
Anisotropy
Chronic Pain
pain
Brain
3 Citations (Scopus)

Evaluation of the Live Biotherapeutic Product, Asymptomatic Bacteriuria Escherichia coli 2-12, in Healthy Dogs and Dogs with Clinical Recurrent UTI

Segev, G., Sykes, J. E., Klumpp, D. J., Schaeffer, A. J., Antaki, E. M., Byrne, B. A., Yaggie, R. E. & Westropp, J. L., Jan 1 2018, In : Journal of Veterinary Internal Medicine. 32, 1, p. 267-273 7 p.

Research output: Contribution to journalArticle

Bacteriuria
Dogs
Escherichia coli
dogs
urine