Grants per year
Personal profile
Research Interests
I received a Ph.D. in Biochemistry, Molecular Biology and Cell Biology from Northwestern University in 1994, studying retinal neuron physiology. After postdoctoral studies in HPV pathogenesis and epithelial biology at Northwestern’s Feinberg School of Medicine, I joined the Department of Urology in 1998. I am an Associate Professor of Urology and Microbiology-Immunology in the Feinberg School of Medicine and the Anthony J. Schaeffer MD Professor of Urology.
Our team studies diverse aspects of neuro-immune and bacterial mechanisms of bladder inflammation and pelvic pain as well as the influence of microbiota on pain and cognition. Pain modulation by bacteria. Urinary tract infections due to colonization by uropathogenic E. coli are characterized by inflammatory and symptomatic responses. In contrast, asymptomatic bacteriuria associated with E. coli are asymptomatic by definition, pointing to distinct bacterial pain phenotypes in the bladder. We are exploring the mechanisms underlying bacterial pain phenotypes in the bladder using murine models that recapitulate key clinical findings. We find that E. coli exhibit distinct pain phenotypes independent of inflammation and that specific strains possess analgesic properties amenable for development as therapies for urologic disease. Genetic modulation of pain. We have recently identified the gene encoding acyloxyacyl hydrolase, Aoah, as a genetic modulator of pelvic pain. AOAH protein is expressed along the bladder-brain axis, and we are working to define the mechanisms by which Aoah modulates pain and urinary function. Pain and the microbiome. Our current clinical studies include characterizing changes in gut microbiota associated with interstitial cystitis/bladder pain syndrome. Supported by mechanistic studies in mice, we are working to define the influence of microbiota on pelvic pain and urologic and cognitive functions.
Education/Academic qualification
PhD, Northwestern University
… → 1994
Research interests
- Bacterial Pathogenesis
- Bladder and Urinary Tract
- Cellular Microbiology
- Immunology
- Infectious Diseases: Bacteria
- Inflammation
- Microbiome
- Mood Disorders
- Neuroscience
- Pain
- Phospholipids
- Urology
Fingerprint
- 5 Similar Profiles
Network
Grants
-
Pelvic Pain and Depression
Flury, S. C., Griffith, J. W., Klumpp, D., Miller, R. J., Parrish, T. B. & Schaeffer, A. J.
National Institute of Diabetes and Digestive and Kidney Diseases
7/1/19 → 8/13/22
Project: Research project
-
Altered Microbiome of Chronic Pelvic Pain
Andersen, E. C., Griffith, J. W., Klumpp, D., Radulovic, J. & Schaeffer, A. J.
National Institute of Diabetes and Digestive and Kidney Diseases
5/18/16 → 2/28/21
Project: Research project
-
Basic Science Training Grant in Urology
National Institute of Diabetes and Digestive and Kidney Diseases
5/1/16 → 4/30/21
Project: Research project
-
Project 4
National Institute of Diabetes and Digestive and Kidney Diseases
9/15/14 → 6/30/19
Project: Research project
-
Pelvic Pain and Depression
Apkarian, A., Bass, M., Farmer, M. A., Flury, S. C., Griffith, J. W., Klumpp, D., Lloyd Jr, R. B., Miller, R. J., Parrish, T. B. & Schaeffer, A. J.
National Institute of Diabetes and Digestive and Kidney Diseases
9/15/14 → 6/30/19
Project: Research project
Research Output
-
Acyloxyacyl hydrolase regulates voiding activity
Aguiniga, L. M., Searl, T. J., Rahman-Enyart, A., Yaggie, R. E., Yang, W., Schaeffer, A. J. & Klumpp, D. J., Apr 2020, In: American Journal of Physiology - Renal Physiology. 318, 4, p. F1006-F1016Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
AOAH remodels arachidonic acid-containing phospholipid pools in a model of interstitial cystitis pain: A MAPP Network study
Yang, W., Yaggie, R. E., Schaeffer, A. J. & Klumpp, D. J., Sep 2020, In: PloS one. 15, 9 September, e0235384.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Natural bladder filling alters resting brain function at multiple spatial scales: a proof-of-concept MAPP Network Neuroimaging Study
Mawla, I., Schrepf, A., Ichesco, E., Harte, S. E., Klumpp, D. J., Griffith, J. W., Strachan, E., Yang, C. C., Lai, H., Andriole, G., Magnotta, V. A., Kreder, K., Clauw, D. J., Harris, R. E., Clemens, J. Q., Landis, J. R., Mullins, C., Rodriguez, L. V., Mayer, E. A. & Kutch, J. J., Dec 2020, In: Scientific reports. 10, 1, 19901.Research output: Contribution to journal › Article › peer-review
Open Access -
The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS)
Clemens, J. Q., Kutch, J. J., Mayer, E. A., Naliboff, B. D., Rodriguez, L. V., Klumpp, D. J., Schaeffer, A. J., Kreder, K. J., Clauw, D. J., Harte, S. E., Schrepf, A. D., Williams, D. A., Andriole, G. L., Lai, H. H., Buchwald, D., Lucia, M. S., van Bokhoven, A., Mackey, S., Moldwin, R. M., Pontari, M. A. & 3 others, , Aug 1 2020, In: Neurourology and Urodynamics. 39, 6, p. 1803-1814 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor
MAPP Research Network Study Group, Aug 2019, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 317, 2, p. R289-R300Research output: Contribution to journal › Article › peer-review
4 Scopus citations