David O Walterhouse

  • 2353 Citations
1984 …2025
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Personal profile

Research Interests

As a member of the soft tissue sarcoma committee of the Children's Oncology Group (COG), my primary clinical research interest lies in the area of clinical trials for pediatric patients with soft tissue sarcomas. I have served as study chair for a group-wide phase III COG clinical trial for rhabdomyosarcoma. I also serve as Institutional Principal Investigator for COG. My primary basic research interest lies in understanding the regulation and function of the GLI1 oncogene, as well as understanding the role of Hedgehog-GLI1 signal transduction in pediatric solid tumors.

Certifications and Licenses

Pediatric Hematology-Oncology
Pediatrics

Training Experience

1986Residency, Children's Hospital of Philadelphia
1989Fellowship, Children's Hospital of Philadelphia

Education/Academic qualification

MD, University of Michigan

… → 1983

Research interests

  • Cancer Biology
  • Clinical Research
  • Developmental Biology
  • Oncology
  • Pediatrics
  • Signal Transduction

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  • 5 Similar Profiles
Rhabdomyosarcoma Medicine & Life Sciences
Sarcoma Medicine & Life Sciences
Hedgehogs Medicine & Life Sciences
Vincristine Medicine & Life Sciences
Radiotherapy Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Drug Therapy Medicine & Life Sciences
Cyclophosphamide Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Grants 2011 2025

Research Output 1984 2019

1 Citation (Scopus)

Cardiac-Sparing Whole Lung IMRT in Patients With Pediatric Tumors and Lung Metastasis: Final Report of a Prospective Multicenter Clinical Trial

Kalapurakal, J. A., Gopalakrishnan, M., Walterhouse, D. O., Rigsby, C. K., Rademaker, A. W., Helenowski, I., Kessel, S., Morano, K., Laurie, F., Ulin, K., Esiashvili, N., Katzenstein, H., Marcus, K., Followill, D. S., Wolden, S. L., Mahajan, A. & Fitzgerald, T. J., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics. 103, 1, p. 28-37 10 p.

Research output: Contribution to journalArticle

metastasis
lungs
Multicenter Studies
radiation therapy
Radiotherapy

Regulation of GLI1 by cis DNA elements and epigenetic marks

Taylor, R., Long, J., Yoon, J. W., Childs, R., Sylvestersen, K. B., Nielsen, M. L., Leong, K. F., Iannaccone, S., Walterhouse, D. O., Robbins, D. J. & Iannaccone, P. M., Jul 1 2019, In : DNA Repair. 79, p. 10-21 12 p.

Research output: Contribution to journalArticle

Open Access
Epigenomics
Introns
DNA
Genes
Histones

Risk-based treatment for patients with first relapse or progression of rhabdomyosarcoma: A report from the Children's Oncology Group

Mascarenhas, L., Lyden, E. R., Breitfeld, P. P., Walterhouse, D. O., Donaldson, S. S., Rodeberg, D. A., Parham, D. M., Anderson, J. R., Meyer, W. H. & Hawkins, D. S., Aug 1 2019, In : Cancer. 125, 15, p. 2602-2609 8 p.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
Vincristine
Recurrence
tirapazamine
irinotecan
1 Citation (Scopus)

Treatment Approach and Outcomes in Infants With Localized Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group

Bradley, J. A., Kayton, M. L., Chi, Y. Y., Hawkins, D. S., Tian, J., Breneman, J., Wolden, S. L., Walterhouse, D. O., Rodeberg, D. A. & Donaldson, S. S., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics. 103, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
Sarcoma
therapy
cancer
Therapeutics

Demographic and treatment variables influencing outcome for localized paratesticular rhabdomyosarcoma: Results from a pooled analysis of North American and European cooperative groups

Walterhouse, D. O., Barkauskas, D. A., Hall, D., Ferrari, A., De Salvo, G. L., Koscielniak, E., Stevens, M. C. G., Martelli, H., Seitz, G., Rodeberg, D. A., Shnorhavorian, M., Dasgupta, R., Breneman, J. C., Anderson, J. R., Bergeron, C., Bisogno, G., Meyer, W. H., Hawkins, D. S. & Minard-Colin, V., Dec 10 2018, In : Journal of Clinical Oncology. 36, 35, p. 3466-3476 11 p.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
Disease-Free Survival
Demography
Neoplasms
Survival