David O Walterhouse

  • 2515 Citations
1984 …2020

Research output per year

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Personal profile

Research Interests

As a member of the soft tissue sarcoma committee of the Children's Oncology Group (COG), my primary clinical research interest lies in the area of clinical trials for pediatric patients with soft tissue sarcomas. I have served as study chair for a group-wide phase III COG clinical trial for rhabdomyosarcoma. I also serve as Institutional Principal Investigator for COG. My primary basic research interest lies in understanding the regulation and function of the GLI1 oncogene, as well as understanding the role of Hedgehog-GLI1 signal transduction in pediatric solid tumors.

Certifications and Licenses

Pediatric Hematology-Oncology

Training Experience

1986Residency, Children's Hospital of Philadelphia
1989Fellowship, Children's Hospital of Philadelphia

Education/Academic qualification

MD, University of Michigan

… → 1983

Research interests

  • Cancer Biology
  • Clinical Research
  • Developmental Biology
  • Oncology
  • Pediatrics
  • Signal Transduction

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Research Output

Survival of Patients With Non-Rhabdomyosarcoma Soft Tissue Sarcomas of the Head and Neck

Rastatter, J. C., Sinard, R. N., Dilger, A., Reichek, J. L., Walterhouse, D. O. & Patel, U., Jan 1 2020, (Accepted/In press) In : Laryngoscope.

Research output: Contribution to journalArticle

  • Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma

    Yoon, J. W., Lamm, M., Chandler, C., Iannaccone, P. M. & Walterhouse, D. O., Jun 3 2020, In : BMC cancer. 20, 1, 511.

    Research output: Contribution to journalArticle

    Open Access
  • Cardiac-Sparing Whole Lung IMRT in Patients With Pediatric Tumors and Lung Metastasis: Final Report of a Prospective Multicenter Clinical Trial

    Kalapurakal, J. A., Gopalakrishnan, M., Walterhouse, D. O., Rigsby, C. K., Rademaker, A. W., Helenowski, I., Kessel, S., Morano, K., Laurie, F., Ulin, K., Esiashvili, N., Katzenstein, H., Marcus, K., Followill, D. S., Wolden, S. L., Mahajan, A. & Fitzgerald, T. J., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics. 103, 1, p. 28-37 10 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Regulation of GLI1 by cis DNA elements and epigenetic marks

    Taylor, R., Long, J., Yoon, J. W., Childs, R., Sylvestersen, K. B., Nielsen, M. L., Leong, K. F., Iannaccone, S., Walterhouse, D. O., Robbins, D. J. & Iannaccone, P., Jul 2019, In : DNA Repair. 79, p. 10-21 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Risk-based treatment for patients with first relapse or progression of rhabdomyosarcoma: A report from the Children's Oncology Group

    Mascarenhas, L., Lyden, E. R., Breitfeld, P. P., Walterhouse, D. O., Donaldson, S. S., Rodeberg, D. A., Parham, D. M., Anderson, J. R., Meyer, W. H. & Hawkins, D. S., Aug 1 2019, In : Cancer. 125, 15, p. 2602-2609 8 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations