David O Walterhouse

  • 2296 Citations
1984 …2025
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Personal profile

Research Interests

As a member of the soft tissue sarcoma committee of the Children's Oncology Group (COG), my primary clinical research interest lies in the area of clinical trials for pediatric patients with soft tissue sarcomas. I have served as study chair for a group-wide phase III COG clinical trial for rhabdomyosarcoma. I also serve as Institutional Principal Investigator for COG. My primary basic research interest lies in understanding the regulation and function of the GLI1 oncogene, as well as understanding the role of Hedgehog-GLI1 signal transduction in pediatric solid tumors.

Certifications and Licenses

Pediatric Hematology-Oncology

Training Experience

1986Residency, Children's Hospital of Philadelphia
1989Fellowship, Children's Hospital of Philadelphia

Education/Academic qualification

MD, University of Michigan

… → 1983


  • Cancer Biology
  • Clinical Research
  • Developmental Biology
  • Oncology
  • Pediatrics
  • Signal Transduction

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Grants 2011 2025

Research Output 1984 2019

1 Citations (Scopus)

Cardiac-Sparing Whole Lung IMRT in Patients With Pediatric Tumors and Lung Metastasis: Final Report of a Prospective Multicenter Clinical Trial

Kalapurakal, J. A., Gopalakrishnan, M., Walterhouse, D. O., Rigsby, C. K., Rademaker, A. W., Helenowski, I., Kessel, S., Morano, K., Laurie, F., Ulin, K., Esiashvili, N., Katzenstein, H., Marcus, K., Followill, D. S., Wolden, S. L., Mahajan, A. & Fitzgerald, T. J., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics. 103, 1, p. 28-37 10 p.

Research output: Contribution to journalArticle

Multicenter Studies
radiation therapy

Treatment Approach and Outcomes in Infants With Localized Rhabdomyosarcoma: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group

Bradley, J. A., Kayton, M. L., Chi, Y. Y., Hawkins, D. S., Tian, J., Breneman, J., Wolden, S. L., Walterhouse, D. O., Rodeberg, D. A. & Donaldson, S. S., Jan 1 2019, In : International Journal of Radiation Oncology Biology Physics. 103, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle


Demographic and treatment variables influencing outcome for localized paratesticular rhabdomyosarcoma: Results from a pooled analysis of North American and European cooperative groups

Walterhouse, D. O., Barkauskas, D. A., Hall, D., Ferrari, A., De Salvo, G. L., Koscielniak, E., Stevens, M. C. G., Martelli, H., Seitz, G., Rodeberg, D. A., Shnorhavorian, M., Dasgupta, R., Breneman, J. C., Anderson, J. R., Bergeron, C., Bisogno, G., Meyer, W. H., Hawkins, D. S. & Minard-Colin, V., Dec 10 2018, In : Journal of Clinical Oncology. 36, 35, p. 3466-3476 11 p.

Research output: Contribution to journalArticle

Disease-Free Survival
1 Citations (Scopus)

Localized vaginal/uterine rhabdomyosarcoma—results of a pooled analysis from four international cooperative groups

International Society of Pediatric Oncology Sarcoma Committee, the Children's Oncology Group, the Italian Cooperative Soft Tissue Sarcoma Group, and the European pediatric Soft tissue sarcoma Study Group, Sep 1 2018, In : Pediatric Blood and Cancer. 65, 9, e27096.

Research output: Contribution to journalArticle


Prolonged response to sorafenib in a patient with refractory metastatic osteosarcoma and a somatic PDGFRA D846V mutation

Armstrong, A. E., Walterhouse, D. O., Leavey, P. J., Reichek, J. & Walz, A. L., Jan 1 2018, (Accepted/In press) In : Pediatric Blood and Cancer. 66, 1, e27493.

Research output: Contribution to journalArticle