Grants per year
Personal profile
Research Interests
As a member of the soft tissue sarcoma committee of the Children's Oncology Group (COG), my primary clinical research interest lies in the area of clinical trials for pediatric patients with soft tissue sarcomas. I have served as study chair for a group-wide phase III COG clinical trial for rhabdomyosarcoma. I also serve as Institutional Principal Investigator for COG. My primary basic research interest lies in understanding the regulation and function of the GLI1 oncogene, as well as understanding the role of Hedgehog-GLI1 signal transduction in pediatric solid tumors.
Certifications and Licenses
| Pediatric Hematology-Oncology | |
| Pediatrics |
Training Experience
| 1986 | Residency, Children's Hospital of Philadelphia |
| 1989 | Fellowship, Children's Hospital of Philadelphia |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MD, Medicine, University of Michigan
… → 1983
Research interests keywords
- Cancer Biology
- Clinical Research
- Developmental Biology
- Oncology
- Pediatrics
- Signal Transduction
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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GOG ADVL1722 - A Phase 2, multicenter, open-label study to assess safety and preliminary activity of eribulin mesylate in pediatric subjects with relapsed/refractory rhabdomyosarcoma (RMS), nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) and Ewing sarcoma
Walterhouse, D. O. (PD/PI)
Children’s Hospital of Philadelphia, Eisai Medical Research Inc
12/9/19 → 8/31/50
Project: Research project
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Per Case Reimbursement: COG NOCRP Research Base
Walterhouse, D. O. (PD/PI)
Children’s Hospital of Philadelphia, National Cancer Institute
9/2/19 → 7/31/25
Project: Research project
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SCIENTIFIC COUNCIL: NIH National Clinical Trials Network (NCTN) Grant (2U10CA180886)
Walterhouse, D. O. (PD/PI)
Children’s Hospital of Philadelphia, National Cancer Institute
3/1/19 → 2/28/25
Project: Research project
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COG APEC14B1, The Project: Every Child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study
Walterhouse, D. O. (PD/PI)
Children’s Hospital of Philadelphia, Children’s Oncology Group
10/26/15 → 10/25/25
Project: Research project
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COG NCTN Network Group Operation Center / WorkLoad Intensity
Walterhouse, D. O. (PD/PI)
Children’s Hospital of Philadelphia, National Cancer Institute
3/1/14 → 2/28/25
Project: Research project
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Severe labile hypertension in a patient with catecholamine-secreting neuroblastoma: a case report
Frisby-Zedan, J., Migotsky, M., Walterhouse, D. O. & Verghese, P. S., Jul 2024, In: Pediatric Nephrology. 39, 7, p. 2087-2090 4 p.Research output: Contribution to journal › Article › peer-review
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Differentiation-dependent chromosomal organization changes in normal myogenic cells are absent in rhabdomyosarcoma cells
Ibarra, J., Hershenhouse, T., Almassalha, L., Walterhouse, D., Backman, V. & MacQuarrie, K. L., 2023, In: Frontiers in Cell and Developmental Biology. 11, 1293891.Research output: Contribution to journal › Article › peer-review
Open Access -
Survival of patients with orbital and eyelid rhabdomyosarcoma treated on Children's Oncology Group studies from 1997 to 2013: A report from the Children's Oncology Group
Metts, J., Xue, W., Gao, Z., Ermoian, R., Bradley, J. A., Arnold, M. A., Dasgupta, R., Venkatramani, R. & Walterhouse, D., Jun 1 2023, In: cancer. 129, 11, p. 1735-1743 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The significance of margins in pediatric Non-Rhabdomyosarcoma soft tissue sarcomas: Consensus on surgical margin definition harmonization from the INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT)
Sparber-Sauer, M., Ferrari, A., Spunt, S. L., Vokuhl, C., Casey, D., Lautz, T. B., Meyer, W. H., Walterhouse, D. O., Pajtler, K. W., Alaggio, R., Schmidt, A., Safwat, A., Timmermann, B., Dall'Igna, P., Chen, S., Weiss, A. R. & Orbach, D., May 2023, In: Cancer medicine. 12, 10, p. 11719-11730 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access8 Scopus citations -
Clinical group and modified TNM stage for rhabdomyosarcoma: A review from the Children's Oncology Group
Crane, J. N., Xue, W., Qumseya, A., Gao, Z., Arndt, C. A. S., Donaldson, S. S., Harrison, D. J., Hawkins, D. S., Linardic, C. M., Mascarenhas, L., Meyer, W. H., Rodeberg, D. A., Rudzinski, E. R., Shulkin, B. L., Walterhouse, D. O., Venkatramani, R. & Weiss, A. R., Jun 2022, In: Pediatric Blood and Cancer. 69, 6, e29644.Research output: Contribution to journal › Review article › peer-review
Open Access19 Scopus citations
Datasets
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Additional file of Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma
Yoon, J. W. (Creator), Lamm, M. (Creator), Chandler, C. (Creator), Iannaccone, P. (Creator) & Walterhouse, D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12872234, https://springernature.figshare.com/articles/dataset/Additional_file_of_Up-regulation_of_GLI1_in_vincristine-resistant_rhabdomyosarcoma_and_Ewing_sarcoma/12872234
Dataset
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Additional file 2 of Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma
Yoon, J. W. (Creator), Lamm, M. (Creator), Chandler, C. (Creator), Iannaccone, P. (Creator) & Walterhouse, D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12872228, https://springernature.figshare.com/articles/figure/Additional_file_2_of_Up-regulation_of_GLI1_in_vincristine-resistant_rhabdomyosarcoma_and_Ewing_sarcoma/12872228
Dataset
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Transcription profiling of human Clear cell sarcoma of the kidney (CCSK) vs Wilms tumors (WT) and fetal kidney samples to address diagnostic challenges of CCSK
Cutcliffe, C. (Contributor), Kersey, D. (Contributor), Huang, C.-C. (Contributor), Zeng, Y. (Contributor), Walterhouse, D. (Contributor) & Perlman, E. J. (Contributor), ArrayExpress, 2007
https://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-2712
Dataset
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Additional file 1 of Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma
Yoon, J. W. (Creator), Lamm, M. (Creator), Chandler, C. (Creator), Iannaccone, P. (Creator) & Walterhouse, D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.12872225, https://springernature.figshare.com/articles/figure/Additional_file_1_of_Up-regulation_of_GLI1_in_vincristine-resistant_rhabdomyosarcoma_and_Ewing_sarcoma/12872225
Dataset
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Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma
Yoon, J. W. (Creator), Lamm, M. (Creator), Chandler, C. (Creator), Iannaccone, P. (Creator) & Walterhouse, D. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.5005973, https://springernature.figshare.com/collections/Up-regulation_of_GLI1_in_vincristine-resistant_rhabdomyosarcoma_and_Ewing_sarcoma/5005973
Dataset