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Personal profile
Research Interests
David Sullivan is currently a Research Assistant Professor at Northwestern University in the Pathology Department. Dr. Sullivan's research focuses on the mechanisms and signaling pathways involved in leukocyte-endothelial interactions during diapedesis, the process by which leukocytes leave the blood stream and gain access to tissue. To dissect these complex intercellular interactions, Dr. Sullivan has helped develop in vitro and in vivo imaging techniques. He has also pioneered methods to follow leukocytes, endothelial cells, and parasites (T. cruzi) in the brain, gut, and general vasculatures of live animals. Dr. Sullivan received his BS in Biochemistry from Indiana University. While there, he worked with John Richardson studying the bacterial transcription termination factor Rho. Dr. Sullivan then joined the Biochemistry Graduate Program at the University of Wisconsin - Madison in the lab of Anant Menon studying the mechanisms underlying the intracellular transport of sterols between different organelles in Saccharomyces cerevisiae. Partway through his thesis work, he moved with the lab to Weill Cornell Medical School in New York City. After graduating, he joined the lab of William Muller in Chicago as a postdoctoral research fellow and has been there ever since 2008. In addition to research, Dr. Sullivan is committed to mentoring and community outreach. He has been involved with several local outreach organizations including the Boy Scouts of America – STEM Scouts program, Northwestern’s Science in Society program, and CHIentist, an organization that seeks to bring together academicians, professionals, and community members to foster interactions and collaborations. Dr. Sullivan has been a member of American Society for Investigative Pathology since 2008 and has served on the program committee and as an organizer of the Vascular and Mucosal Pathobiology (VAMP) Scientific Interest Group. He has received the Young Scientist Leadership and the Experimental Pathologist In Training awards.
Education/Academic qualification
PhD, Biochemistry, Weill Medical College of Cornell University
… → 2008
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Collaborations and top research areas from the last five years
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Aging Exacerbates Neutrophil Persistence and Negatively Impacts Stroke Outcomes
Batra, A. (PD/PI), Sullivan, D. P. (PD/PI), Muller, W. A. (Co-Investigator) & Sumagin, R. (Co-Investigator)
5/15/24 → 4/30/26
Project: Research project
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Transendothelial Migration of Leukocytes: Developing New Paradigms in Health and Disease
Muller, W. A. (PD/PI), Muller, W. A. (PD/PI), Fu, T. (Co-Investigator), Fu, T. (Co-Investigator), Fu, T. (Co-Investigator), Gonzalez, A. M. (Co-Investigator), Gonzalez, A. M. (Co-Investigator), Sullivan, D. P. (Co-Investigator) & Sullivan, D. P. (Co-Investigator)
National Heart, Lung, and Blood Institute
3/15/21 → 2/29/28
Project: Research project
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Beyond PECAM: Mechanisms of Transendothelial Migration
Muller, W. A. (PD/PI), Gonzalez, A. M. (Co-PD/PI), Sullivan, D. P. (Co-PD/PI) & Thorp, E. B. (Co-PD/PI)
National Heart, Lung, and Blood Institute
12/15/16 → 2/28/21
Project: Research project
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The Roles of Endothelial PECAM and the LBRC in Leukocyte Transmigration
Muller, W. A. (PD/PI), Sullivan, D. P. (Co-PD/PI), Thorp, E. B. (Co-PD/PI), Gonzalez, A. M. (Co-Investigator) & Sullivan, D. P. (Other)
National Heart, Lung, and Blood Institute
6/1/16 → 2/28/21
Project: Research project
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A clinically relevant model and method to study necrosis as a driving force in glioma restructuring and progression
Li, J., Shih, L. K., Markwell, S. M., Olson, C. L., Sullivan, D. P., Arvanitis, C., Ross, J. L., Lam, N. G., Nuszen, H., Hambardzumyan, D., Becher, O. J. & Brat, D. J., Feb 19 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 7, e2416024122.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanical regulation of macrophage metabolism by allograft inflammatory factor 1 leads to adverse remodeling after cardiac injury
DeBerge, M., Glinton, K., Lantz, C., Ge, Z.-D., Sullivan, D. P., Patil, S., Lee, B. R., Thorp, M. I., Mullick, A., Yeh, S., Han, S., van der Laan, A. M., Niessen, H. W. M., Luo, X., Sibinga, N. E. S. & Thorp, E. B., Jan 2025, In: Nature Cardiovascular Research. 4, 1, p. 83-101 19 p., e001993.Research output: Contribution to journal › Article › peer-review
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Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice
Romay, M. C., Knutsen, R. H., Ma, F., Mompeón, A., Hernandez, G. E., Salvador, J., Mirkov, S., Batra, A., Sullivan, D. P., Procissi, D., Buchanan, S., Kronquist, E., Ferrante, E. A., Muller, W. A., Walshon, J., Steffens, A., McCortney, K., Horbinski, C., Tournier‑Lasserve, E. & Sonabend, A. M. & 5 others, , Jan 16 2024, In: Journal of Clinical Investigation. 134, 2, e166134.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Hypoxia-inducible factor-2α enhances neutrophil survival to promote cardiac injury following myocardial infarction
Piccolo, E. B., Ge, Z. D., Filipp, M. E., Sullivan, D. P., Thorp, E. B. & Sumagin, R., Nov 2024, In: American Journal of Physiology - Heart and Circulatory Physiology. 327, 5, p. H1230-H1243Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Neutrophil Infiltration and Function in the Pathogenesis of Inflammatory Airspace Disease
Haynes, M. E., Sullivan, D. P. & Muller, W. A., May 2024, In: American Journal of Pathology. 194, 5, p. 628-636 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations