Grants per year
Personal profile
Research Interests
Research Interests: Our laboratory concentrates its efforts into the investigation of the mechanistic connection between aging, cellular and/or mitochondrial metabolism, and carcinogenesis focusing on the Sirtuin gene family. To address this idea, over the past five years, we have constructed mice that have the three primary (Sirt1-3) sirtuins genetically deleted. The mice that lack Sirt1 (Wang et al., 2009, Cancer Cell), Sirt2 (Kim et al., 2011, Cancer Cell), and Sirt3 (Kim et al., 2010, Cancer Cell) each develop breast cancer, as well as other types of malignancies to varying degrees, and the levels of SIRT1-3 are also decreased in human cancer samples, as compared to normal tissues. In addition, the mechanism connecting the tumor permissive phenotype and the aberrant regulation of mitochondrial ROS, at least in part, in the Sirt3 knockout mouse has recently been published (Tao et al., 2010, Molecular Cell). Thus, based on these results it seems clear that the primary sirtuin deacetylase proteins are tumor suppressor in several breast cancers as well as to a lesser extent in several other human malignancies. These results seemed logical, since human sirtuins are the human homologs for the yeast and C. elegans longevity genes, and breast cancers have one of the strongest correlations to age. Thus, it is proposed that the primary sirtuin family knockout mice may present a novel group of models to establish, validate, and investigate the well established connection between aging, metabolism, and cancer. These murine models are also used to pursue the laboratories interest and the identification and validation of chemopreventative agents and we currently have a DOD and R01 grants to pursue this for luminal B breast malignancies. Finally, the laboratory has a series of murine in vivo and in vitro models to mechanistically connect Sirt2 and Sirt3 to cancers of the breast, pancreas, liver, and lung that are currently be used.
Certifications and Licenses
Radiation Oncology |
Training Experience
1993 | Internship, Weiss Memorial Hospital |
1994 | Residency, University of Michigan Hospital |
1997 | Fellowship, Washington University Medical Center |
Education/Academic qualification
MD, Loyola University/Stritch School of Medicine
… → 1992
PhD, The University of Chicago
… → 1989
Research interests
- Aging
- Breast Cancer
- Lung Injury
- Radiation Oncology
- Digestive Cancer (esophagus, stomach, colon, rectum)
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Network
Grants
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Reactive Oxygen Species in the Initiation, Survival and Racial Disparity of Uterine Leiomyoma
8/6/20 → 5/31/25
Project: Research project
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Dual inhibition of DNA damage repair in DIPG
Hashizume, R., Gius, D. R. & Zou, L.
7/1/20 → 6/30/21
Project: Research project
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Mechanistic insights into the deleterious effects of SIRT2 in the heart under stress conditions
Ardehali, H., Gius, D. R. & Gius, D. R.
National Heart, Lung, and Blood Institute
12/1/17 → 11/30/21
Project: Research project
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Supplement for Elizabeth Tsui - Dys-regulation of the MnSOD-Ac-ROS-HIF2a axis promotes IR / Cisplatin resistance phenotype
4/1/17 → 3/31/22
Project: Research project
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Dys-regulation of the MnSOD-Ac-ROS-HIF2a axis promotes IR / Cisplatin resistance phenotype
Abdulkadir, S. A. & Gius, D. R.
4/1/17 → 3/31/22
Project: Research project
Research Output
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An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth
Vidimar, V., Beilhartz, G. L., Park, M., Biancucci, M., Kieffer, M. B., Gius, D. R., Melnyk, R. A. & Satchell, K. J. F., Jul 21 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 29, p. 16938-16948 11 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance
Zhou, Z., Song, X., Chi, J. J., Gius, D. R., Huang, Y., Cristofanilli, M. & Wan, Y., Jun 2020, In: Cellular Signalling. 70, 109574.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair
Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In: Cell Metabolism. 29, 2, p. 443-456.e5Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
Homeostatic roles of STING in cell proliferation and chromosomal instability
Gius, D. & Zhu, Y., Jan 1 2019, In: Cancer Research. 79, 7, p. 1295-1296 2 p.Research output: Contribution to journal › Article › peer-review
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Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter
Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S. H., Liu, G., Kieffer, M. B., Jiang, H., Stauffer, M. E., Hart, R., Quan, S., Satchell, K. J. F., Horikoshi, N., Bonini, M. & Gius, D., Dec 1 2019, In: Nature communications. 10, 1, 2399.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations