• 9673 Citations
1988 …2022

Research output per year

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Research Output

2019

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journalArticle

28 Scopus citations

Homeostatic roles of STING in cell proliferation and chromosomal instability

Gius, D. & Zhu, Y., Jan 1 2019, In : Cancer Research. 79, 7, p. 1295-1296 2 p.

Research output: Contribution to journalArticle

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

Zhu, Y., Zou, X., Dean, A. E., Brien, J. O., Gao, Y., Tran, E. L., Park, S. H., Liu, G., Kieffer, M. B., Jiang, H., Stauffer, M. E., Hart, R., Quan, S., Satchell, K. J. F., Horikoshi, N., Bonini, M. & Gius, D., Dec 1 2019, In : Nature communications. 10, 1, 2399.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses

Kosciuczuk, E. M., Mehrotra, S., Saleiro, D., Kroczynska, B., Majchrzak-Kita, B., Lisowski, P., Driehaus, C., Rogalska, A., Turner, A., Lienhoop, T., Gius, D., Fish, E. N., Vassilopoulos, A. & Platanias, L. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 3, p. 827-837 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer

He, C., Danes, J. M., Hart, P. C., Zhu, Y., Huang, Y., de Abreu, A. L., O’Brien, J., Mathison, A. J., Tang, B., Frasor, J. M., Wakefield, L. M., Ganini, D., Stauder, E., Zielonka, J., Gantner, B. N., Urrutia, R. A., Gius, D. & Bonini, M. G., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 47, p. 23534-23541 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

Zhu, Y., Dean, A. E., Horikoshi, N., Heer, C., Spitz, D. R. & Gius, D., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3682-3691 10 p.

Research output: Contribution to journalReview article

21 Scopus citations

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

Kibria, G., Ramos, E. K., Wan, Y., Gius, D. R. & Liu, H., Sep 4 2018, In : Molecular Pharmaceutics. 15, 9, p. 3625-3633 9 p.

Research output: Contribution to journalReview article

18 Scopus citations

Glycogen phosphorylase: A novel biomarker in doxorubicin-induced cardiac injury

Zhu, Y. & Gius, D. R., Apr 1 2018, In : Clinical Cancer Research. 24, 7, p. 1516-1517 2 p.

Research output: Contribution to journalArticle

Inhibition of sirtuin 6 induces neuroblastoma differentiation

Song, H. Y., Rellinger, E. J., Park, S. H., Paul, P., Qiao, J., Vasilopoulos, A., Ozden, O., Gius, D. & Chung, D. H., Feb 2018, In : Anticancer research. 38, 2, p. 647-654 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice

Quan, S., Principe, D. R., Dean, A. E., Park, S. H., Grippo, P. J., Gius, D. & Horikoshi, N., Dec 1 2018, In : Scientific reports. 8, 1, 16501.

Research output: Contribution to journalArticle

2 Scopus citations

SIRT2 knockout exacerbates insulin resistance in high fat-fed mice

Lantier, L., Williams, A. S., Hughey, C. C., Bracy, D. P., James, F. D., Ansari, M. A., Gius, D. & Wasserman, D. H., Dec 2018, In : PloS one. 13, 12, e0208634.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy

Liu, G., Park, S. H., Imbesi, M., Nathan, W. J., Zou, X., Zhu, Y., Jiang, H., Parisiadou, L. & Gius, D., May 20 2017, In : Antioxidants and Redox Signaling. 26, 15, p. 846-863 18 p.

Research output: Contribution to journalArticle

33 Scopus citations

Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung

Traver, G., Mont, S., Gius, D., Lawson, W. E., Ding, G. X., Sekhar, K. R. & Freeman, M. L., Nov 2017, In : Free Radical Biology and Medicine. 112, p. 578-586 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

Zou, X., Ratti, B. A., O’Brien, J. G., Lautenschlager, S. O., Gius, D. R., Bonini, M. G. & Zhu, Y., Aug 1 2017, In : Journal of Bioenergetics and Biomembranes. 49, 4, p. 325-333 9 p.

Research output: Contribution to journalReview article

34 Scopus citations

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

Traba, J., Geiger, S. S., Kwarteng-Siaw, M., Han, K., Ra, O. H., Siegel, R. M., Gius, D. & Sack, M. N., Jan 1 2017, In : Journal of Biological Chemistry. 292, 29, p. 12153-12164 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis

Jablonski, R. P., Kim, S. J., Cheresh, P., Williams, D. B., Morales-Nebreda, L., Cheng, Y., Yeldandi, A., Bhorade, S., Pardo, A., Selman, M., Ridge, K., Gius, D., Budinger, G. R. S. & Kamp, D. W., Jun 2017, In : FASEB Journal. 31, 6, p. 2520-2532 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

SIRT3-mediated dimerization of IDH2 directs cancer cell metabolism and tumor growth

Zou, X., Zhu, Y., Park, S. H., Liu, G., O'Brien, J., Jiang, H. & Gius, D., Aug 1 2017, In : Cancer Research. 77, 15, p. 3990-3999 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress

Shi, H., Deng, H. X., Gius, D., Schumacker, P. T., Surmeier, D. J. & Ma, Y. C., May 15 2017, In : Human molecular genetics. 26, 10, p. 1915-1926 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

Yang, X., Park, S. H., Chang, H. C., Shapiro, J. S., Vassilopoulos, A., Sawicki, K. T., Chen, C., Shang, M., Burridge, P. W., Epting, C. L., Wilsbacher, L. D., Jenkitkasemwong, S., Knutson, M., Gius, D. & Ardehali, H., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1505-1516 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
2016

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

Zhang, H., Head, P. S. E., Daddacha, W., Park, S. H., Li, X., Pan, Y., Madden, M. Z., Duong, D. M., Xie, M., Yu, B., Warren, M. D., Liu, E. A., Dhere, V. R., Li, C., Pradilla, I., Torres, M. A., Wang, Y., Dynan, W. S., Doetsch, P. W., Deng, X. & 3 others, Seyfried, N. T., Gius, D. & Yu, D. S., Feb 16 2016, In : Cell reports. 14, 6, p. 1435-1447 13 p.

Research output: Contribution to journalArticle

23 Scopus citations
7 Scopus citations

G protein-coupled bile acid receptor TGR5 activation inhibits kidney disease in obesity and diabetes

Wang, X. X., Edelstein, M. H., Gafter, U., Qiu, L., Luo, Y., Dobrinskikh, E., Lucia, S., Adorini, L., D'Agati, V. D., Levi, J., Rosenberg, A., Kopp, J. B., Gius, D. R., Saleem, M. A. & Levi, M., May 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1362-1378 17 p.

Research output: Contribution to journalArticle

43 Scopus citations

Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype

Zou, X., Santa-Maria, C. A., O'Brien, J., Gius, D. & Zhu, Y., Aug 20 2016, In : Antioxidants and Redox Signaling. 25, 6, p. 326-336 11 p.

Research output: Contribution to journalReview article

21 Scopus citations

SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status

Song, H. Y., Biancucci, M., Kang, H. J., O'Callaghan, C., Park, S. H., Principe, D. R., Jiang, H., Yan, Y., Satchell, K. F., Raparia, K., Gius, D. & Vassilopoulos, A., Jan 1 2016, In : Oncotarget. 7, 49, p. 80336-80349 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor growth

Park, S. H., Ozden, O., Liu, G., Song, H. Y., Zhu, Y., Yan, Y., Zou, X., Kang, H. J., Jiang, H., Principe, D. R., Cha, Y. I., Roh, M., Vassilopoulos, A. & Gius, D., Jul 1 2016, In : Cancer Research. 76, 13, p. 3802-3812 11 p.

Research output: Contribution to journalArticle

35 Scopus citations
2015

Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma

Zhu, Y., Paul, P., Lee, S., Craig, B. T., Rellinger, E. J., Qiao, J., Gius, D. R. & Chung, D. H., Sep 1 2015, In : Surgery (United States). 158, 3, p. 827-836 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

CDK1-mediated SIRT3 activation enhances mitochondrial function and tumor radioresistance

Liu, R., Fan, M., Candas, D., Qin, L., Zhang, X., Eldridge, A., Zou, J. X., Zhang, T., Juma, S., Jin, C., Li, R. F., Perks, J., Sun, L. Q., Vaughan, A. T. M., Hai, C. X., Gius, D. R. & Li, J. J., Sep 1 2015, In : Molecular cancer therapeutics. 14, 9, p. 2090-2102 13 p.

Research output: Contribution to journalArticle

38 Scopus citations

Changes in gene expression in SIRT3 knockout liver cells

Tao, R., Leclerc, J., Yildiz, K., Park, S. H., Jung, B., Gius, D. & Özden, Ö., Jan 1 2015, In : Turkish Journal of Biology. 39, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

Pillai, V. B., Samant, S., Sundaresan, N. R., Raghuraman, H., Kim, G., Bonner, M. Y., Arbiser, J. L., Walker, D. I., Jones, D. P., Gius, D. & Gupta, M. P., Apr 14 2015, In : Nature communications. 6, 6656.

Research output: Contribution to journalArticle

153 Scopus citations

SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin resistance in high-fat-fed mice

Lantier, L., Williams, A. S., Williams, I. M., Yang, K. K., Bracy, D. P., Goelzer, M., James, F. D., Gius, D. & Wasserman, D. H., Sep 2015, In : Diabetes. 64, 9, p. 3081-3092 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Site-specific processing of Ras and Rap1 Switch i by a MARTX toxin effector domain

Antic, I., Biancucci, M., Zhu, Y., Gius, D. R. & Satchell, K. J. F., Jun 8 2015, In : Nature communications. 6, 7396.

Research output: Contribution to journalArticle

26 Scopus citations

The Makes Caterpillars Floppy (MCF)-like domain of Vibrio vulnificus induces mitochondrion-mediated apoptosis

Agarwal, S., Zhu, Y., Gius, D. R. & Satchell, K. J. F., Jan 1 2015, In : Infection and immunity. 83, 11, p. 4392-4403 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis

Vassilopoulos, A., Tominaga, Y., Kim, H. S., Lahusen, T., Li, B., Yu, H., Gius, D. & Deng, C. X., Jun 4 2015, In : Oncogene. 34, 23, p. 3023-3035 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer

Nottingham, L. K., Yan, C. H., Yang, X., Si, H., Coupar, J., Bian, Y., Cheng, T. F., Allen, C., Arun, P., Gius, D., Dang, L., Van Waes, C. & Chen, Z., Feb 27 2014, In : Oncogene. 33, 9, p. 1135-1147 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

Xu, Y., Gao, X. D., Lee, J. H., Huang, H., Tan, H., Ahn, J., Reinke, L. M., Peter, M. E., Feng, Y., Gius, D., Siziopikou, K. P., Peng, J., Xiao, X. & Cheng, C., Jun 1 2014, In : Genes and Development. 28, 11, p. 1191-1203 13 p.

Research output: Contribution to journalArticle

95 Scopus citations

Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer

Desouki, M. M., Doubinskaia, I., Gius, D. & Abdulkadir, S. A., Jan 1 2014, In : Human Pathology. 45, 5, p. 1071-1077 7 p.

Research output: Contribution to journalArticle

38 Scopus citations
82 Scopus citations

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

Ozden, O., Park, S. H., Wagner, B. A., Song, H. Y., Zhu, Y., Vassilopoulos, A., Jung, B., Buettner, G. R. & Gius, D., Nov 2014, In : Free Radical Biology and Medicine. 76, p. 163-172 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient-and exercise-induced stress

Vassilopoulos, A., Pennington, J. D., Andresson, T., Rees, D. M., Bosley, A. D., Fearnley, I. M., Ham, A., Flynn, C. R., Hill, S., Rose, K. L., Kim, H. S., Deng, C. X., Walker, J. E. & Gius, D., Aug 1 2014, In : Antioxidants and Redox Signaling. 21, 4, p. 551-564 14 p.

Research output: Contribution to journalArticle

77 Scopus citations

Strategies of dose escalation in the treatment of locally advanced non-small cell lung cancer: Image guidance and beyond

Chi, A., Nguyen, N. P., Welsh, J. S., Tse, W., Monga, M., Oduntan, O., Almubarak, M., Rogers, J., Remick, S. C. & Gius, D. R., Jan 1 2014, In : Frontiers in Oncology. 4 JUN, 156.

Research output: Contribution to journalReview article

8 Scopus citations

Superoxide mediates acute liver injury in irradiated mice lacking Sirtuin 3

Coleman, M. C., Olivier, A. K., Jacobus, J. A., Mapuskar, K. A., Mao, G., Martin, S. M., Riley, D. P., Gius, D. & Spitz, D. R., Mar 20 2014, In : Antioxidants and Redox Signaling. 20, 9, p. 1423-1435 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts

Liang, Q., Benavides, G. A., Vassilopoulos, A., Gius, D., Darley-Usmar, V. & Zhang, J., Sep 1 2013, In : Biochemical Journal. 454, 2, p. 249-257 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer

Horn, L., Eisenberg, R., Gius, D. R., Kimmelshue, K. N., Massion, P. P., Putnam, J. B., Robinson, C. G. & Carbone, D. P., Oct 22 2013, Abeloff's Clinical Oncology: Fifth Edition. Elsevier Inc, p. 1143-1192 50 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

Bien, C., Affinati, A. H., Ramsey, K. M., Kuo, H. Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., Levine, D. C., Bacsik, D. J., Gius, D. R., Newgard, C. B., Goetzman, E., Chandel, N., Denu, J. M., Mrksich, M. & Bass, J., Jan 1 2013, In : Science. 342, 6158, 1243417.

Research output: Contribution to journalArticle

324 Scopus citations

Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas

Shankavaram, U., Fliedner, S. M. J., Elkahloun, A. G., Barb, J. J., Munson, P. J., Huynh, T. T., Matro, J. C., Turkova, H., Marston Linehan, W., Timmers, H. J., Tischler, A. S., Powers, J. F., de Krijger, R., Baysal, B. E., Takacova, M., Pastorekova, S., Gius, D., Lehnert, H., Camphausen, K. & Pacak, K., Apr 2013, In : Neoplasia (United States). 15, 4, p. 435-447 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Low-dose radiation-induced enhancement of thymic lymphomagenesis in lck-bax mice is dependent on LET and gender

Jacobus, J. A., Duda, C. G., Coleman, M. C., Martin, S. M., Mapuskar, K., Mao, G., Smith, B. J., Aykin-Burns, N., Guida, P., Gius, D., Domann, F. E., Knudson, C. M. & Spitz, D. R., Aug 1 2013, In : Radiation Research. 180, 2, p. 156-165 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Metabolic regulation of Sirtuins upon fasting and the implication for cancer

Zhu, Y., Yan, Y., Gius, D. R. & Vassilopoulos, A., Nov 1 2013, In : Current opinion in oncology. 25, 6, p. 630-636 7 p.

Research output: Contribution to journalReview article

13 Scopus citations

SIRT2 directs the replication stress response through CDK9 deacetylation

Zhang, H., Park, S. H., Pantazides, B. G., Karpiuk, O., Warren, M. D., Hardy, C. W., Duong, D. M., Park, S. J., Kim, H. S., Vasilopoulos, A., Seyfried, N. T., Johnsen, S. A., Gius, D. R. & Yu, D. S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13546-13551 6 p.

Research output: Contribution to journalArticle

44 Scopus citations
2012

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity

Zhu, Y., Park, S. H., Ozden, O., Kim, H. S., Jiang, H., Vassilopoulos, A., Spitz, D. R. & Gius, D., Aug 15 2012, In : Free Radical Biology and Medicine. 53, 4, p. 828-833 6 p.

Research output: Contribution to journalReview article

37 Scopus citations

Oxidative stress in cancer biology and therapy

Spitz, D. R., Dornfeld, K. J., Krishnan, K. & Gius, D., Jan 1 2012, Humana Press Inc. 460 p.

Research output: Book/ReportBook

4 Scopus citations