• 9965 Citations
1988 …2020

Research output per year

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Research Output

2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism

Lin, X., Zhang, F., Bradbury, C. M., Kaushal, A., Li, L., Spitz, D. R., Aft, R. L. & Gius, D., Jun 15 2003, In : Cancer Research. 63, 12, p. 3413-3417 5 p.

Research output: Contribution to journalArticle

119 Scopus citations

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer

Nottingham, L. K., Yan, C. H., Yang, X., Si, H., Coupar, J., Bian, Y., Cheng, T. F., Allen, C., Arun, P., Gius, D., Dang, L., Van Waes, C. & Chen, Z., Feb 27 2014, In : Oncogene. 33, 9, p. 1135-1147 13 p.

Research output: Contribution to journalArticle

53 Scopus citations

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress

Ozden, O., Park, S. H., Kim, H. S., Jiang, H., Coleman, M. C., Spitz, D. R. & Gius, D., Feb 2011, In : Aging. 3, 2, p. 102-107 6 p.

Research output: Contribution to journalReview article

104 Scopus citations
Open Access
40 Scopus citations

An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth

Vidimar, V., Beilhartz, G. L., Park, M., Biancucci, M., Kieffer, M. B., Gius, D. R., Melnyk, R. A. & Satchell, K. J. F., Jul 21 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 29, p. 16938-16948 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)

Ohiro, Y., Garkavtsev, I., Kobayashi, S., Sreekumar, K. R., Nantz, R., Higashikubo, B. T., Duffy, S. L., Higashikubo, R., Usheva, A., Gius, D., Kley, N. & Horikoshi, N., Jul 31 2002, In : FEBS Letters. 524, 1-3, p. 163-171 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma

Zhu, Y., Paul, P., Lee, S., Craig, B. T., Rellinger, E. J., Qiao, J., Gius, D. R. & Chung, D. H., Sep 1 2015, In : Surgery (United States). 158, 3, p. 827-836 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

Zhang, H., Head, P. S. E., Daddacha, W., Park, S. H., Li, X., Pan, Y., Madden, M. Z., Duong, D. M., Xie, M., Yu, B., Warren, M. D., Liu, E. A., Dhere, V. R., Li, C., Pradilla, I., Torres, M. A., Wang, Y., Dynan, W. S., Doetsch, P. W., Deng, X. & 3 others, Seyfried, N. T., Gius, D. & Yu, D. S., Feb 16 2016, In : Cell reports. 14, 6, p. 1435-1447 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening

Rader, J. S., Malone, J. P., Gross, J., Gilmore, P., Brooks, R. A., Nguyen, L., Crimmins, D. L., Feng, S., Wright, J. D., Taylor, N., Zighelboim, I., Funk, M. C., Huettner, P. C., Ledenson, J. H., Gius, D. & Townsend, R. R., Dec 1 2008, In : Proteomics - Clinical Applications. 2, 12, p. 1658-1669 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer

Annunziata, C. M., Kleinberg, L., Davidson, B., Berner, A., Gius, D., Tchabo, N., Steinberg, S. M. & Kohn, E. C., Nov 15 2007, In : Clinical Cancer Research. 13, 22, p. 6585-6592 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression

Nguyen, P., Bar-Sela, G., Sun, L., Bisht, K. S., Cui, H., Kohn, E., Feinberg, A. P. & Gius, D., Nov 1 2008, In : Molecular and cellular biology. 28, 21, p. 6720-6729 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts

Liang, Q., Benavides, G. A., Vassilopoulos, A., Gius, D., Darley-Usmar, V. & Zhang, J., Sep 1 2013, In : Biochemical Journal. 454, 2, p. 249-257 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer

Horn, L., Eisenberg, R., Gius, D. R., Kimmelshue, K. N., Massion, P. P., Putnam, J. B., Robinson, C. G. & Carbone, D. P., Oct 22 2013, Abeloff's Clinical Oncology: Fifth Edition. Elsevier Inc, p. 1143-1192 50 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

CDK1-mediated SIRT3 activation enhances mitochondrial function and tumor radioresistance

Liu, R., Fan, M., Candas, D., Qin, L., Zhang, X., Eldridge, A., Zou, J. X., Zhang, T., Juma, S., Jin, C., Li, R. F., Perks, J., Sun, L. Q., Vaughan, A. T. M., Hai, C. X., Gius, D. R. & Li, J. J., Sep 1 2015, In : Molecular cancer therapeutics. 14, 9, p. 2090-2102 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Cell cycle-coupled variation in topoisomerase IIα mRNA is regulated by the 3′-untranslated region: Possible role of redox-sensitive protein binding in mRNA accumulation

Goswami, P. C., Sheren, J., Albee, L. D., Parsian, A., Sim, J. E., Ridnour, L. A., Higashikubo, R., Gius, D., Hunt, C. R. & Spitz, D. R., Dec 8 2000, In : Journal of Biological Chemistry. 275, 49, p. 38384-38392 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

Xu, Y., Gao, X. D., Lee, J. H., Huang, H., Tan, H., Ahn, J., Reinke, L. M., Peter, M. E., Feng, Y., Gius, D., Siziopikou, K. P., Peng, J., Xiao, X. & Cheng, C., Jun 1 2014, In : Genes and Development. 28, 11, p. 1191-1203 13 p.

Research output: Contribution to journalArticle

100 Scopus citations

Changes in gene expression in SIRT3 knockout liver cells

Tao, R., Leclerc, J., Yildiz, K., Park, S. H., Jung, B., Gius, D. & Özden, Ö., 2015, In : Turkish Journal of Biology. 39, 3, p. 380-387 8 p.

Research output: Contribution to journalArticle

Changes in sub-nuclear structures and functional perturbations: implications for radiotherapy.

Roti Roti, J. L., Gius, D., VanderWaal, R. P. & Xu, M., Jan 1 2000, In : Journal of cellular biochemistry. Supplement. Suppl 35, p. 142-150 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

Bao, J., Lu, Z., Joseph, J. J., Carabenciov, D., Dimond, C. C., Pang, L., Samsel, L., McCoy, J. P., Leclerc, J., Nguyen, P., Gius, D. & Sack, M. N., May 1 2010, In : Journal of Cellular Biochemistry. 110, 1, p. 238-247 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

Bien, C., Affinati, A. H., Ramsey, K. M., Kuo, H. Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., Levine, D. C., Bacsik, D. J., Gius, D. R., Newgard, C. B., Goetzman, E., Chandel, N., Denu, J. M., Mrksich, M. & Bass, J., 2013, In : Science. 342, 6158, 1243417.

Research output: Contribution to journalArticle

340 Scopus citations

Clinical Trials Referral Resource. Clinical trials in cervical cancer.

Trimble, E. L., Schoenfeldt, M., Streicher, H., Gius, D. & Cornelison, T. L., Jan 2003, In : Oncology (Williston Park, N.Y.). 17, 1, p. 84-89 6 p.

Research output: Contribution to journalArticle

Co-activation of ERK, NF-κβ, and GADD45β in response to ionizing radiation

Wang, T., Hui, Y. C., Dong, S., Fan, M., Tamae, D., Ozeki, M., Gao, Q., Gius, D. & Jian, J. L., Apr 1 2005, In : Journal of Biological Chemistry. 280, 13, p. 12593-12601 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region

Nguyen, P., Cui, H., Bisht, K. S., Sun, L., Patel, K., Lee, R. S., Kugoh, H., Oshimura, M., Feinberg, A. P. & Gius, D., Jul 15 2008, In : Cancer Research. 68, 14, p. 5546-5551 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer

Desouki, M. M., Doubinskaia, I., Gius, D. & Abdulkadir, S. A., Jan 1 2014, In : Human Pathology. 45, 5, p. 1071-1077 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Dietary restriction: Standing up for sirtuins

Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., De Cabo, R., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., Helfand, S. L., Imai, S. I., Itoh, H., Kadowaki, T., Koya, D., Leeuwenburgh, C., Mcburney, M., Nabeshima, Y. O. I., Neri, C., Oberdoerffer, P. & 13 others, Pestell, R. G., Rogina, B., Sadoshima, J., Sartorelli, V., Serrano, M., Sinclair, D. A., Steegborn, C., Tatar, M., Tissenbaum, H. A., Tong, Q., Tsubota, K., Vaquero, A. & Verdin, E., Aug 27 2010, In : Science. 329, 5995, p. 1012-1013 2 p.

Research output: Contribution to journalLetter

52 Scopus citations

Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression

Zhao, W., Chuang, E. Y., Mishra, M., Awwad, R., Bisht, K., Sun, L., Nguyen, P., Pennington, J. D., Wang, T. J. C., Bradbury, C. M., Huang, L., Chen, Z., Bar-Sela, G., Robbins, M. E. C. & Gius, D., Jun 15 2006, In : Clinical Cancer Research. 12, 12, p. 3823-3830 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach

Gius, D., Cui, H., Bradbury, C. M., Cook, J., Smart, D. D. K., Zhao, S., Young, L., Brandenburg, S. A., Hu, Y., Bisht, K. S., Ho, A. S., Mattson, D., Sun, L., Munson, P. J., Chuang, E. Y., Mitchell, J. B. & Feinberg, A. P., Oct 1 2004, In : Cancer Cell. 6, 4, p. 361-371 11 p.

Research output: Contribution to journalArticle

147 Scopus citations

DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16ink4A down-regulation

Guo, Z., Tsai, M. H., Shiao, Y. H., Chen, L. H., Wei, M. L., Lv, X., Gius, D., Little, J. B., Mitchell, J. B. & Chuang, E. Y., Mar 1 2008, In : Journal of Biomedical Science. 15, 2, p. 163-168 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

Sun, L., Huang, L., Nguyen, P., Bisht, K. S., Bar-Sela, G., Ho, A. S., Bradbury, C. M., Yu, W., Cui, H., Lee, S., Trepel, J. B., Feinberg, A. P. & Gius, D., Apr 15 2008, In : Cancer Research. 68, 8, p. 2726-2735 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells

Mishra, M. V., Bisht, K. S., Sun, L., Muldoon-Jacobs, K., Awwad, R., Kaushal, A., Nguyen, P., Huang, L., Pennington, J. D., Markovina, S., Bradbury, C. M. & Gius, D., Feb 1 2008, In : Molecular Cancer Research. 6, 2, p. 243-249 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
8 Scopus citations

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., Schumacker, P. T. & Thorp, E. B., Feb 5 2019, In : Cell Metabolism. 29, 2, p. 443-456.e5

Research output: Contribution to journalArticle

35 Scopus citations

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

Zhu, Y., Dean, A. E., Horikoshi, N., Heer, C., Spitz, D. R. & Gius, D., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3682-3691 10 p.

Research output: Contribution to journalReview article

23 Scopus citations

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

Yu, W., Gius, D., Onyango, P., Muldoon-Jacobs, K., Karp, J., Feinberg, A. P. & Cui, H., Jan 10 2008, In : Nature. 451, 7175, p. 202-206 5 p.

Research output: Contribution to journalArticle

671 Scopus citations

Erratum: Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of γ-glutamylcysteine synthetase (Free Radical Biology and Medicine (2002) 32 (650-662) PII: S089158490200755)

Sekhar, K. R., Spitz, D. R., Harris, S., Nguyen, T. T., Meredith, M. J., Holt, J. T., Gius, D., Marnett, L. J., Summar, M. L. & Freeman, M. L., Jul 1 2002, In : Free Radical Biology and Medicine. 33, 1, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death

Aft, R. L., Zhang, F. W. & Gius, D., Jan 1 2002, In : British Journal of Cancer. 87, 7, p. 805-812 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements

Rim, M., Qureshi, S. A., Gius, D., Nho, J., Sukhatme, V. P. & Foster, D. A., Oct 1 1992, In : Oncogene. 7, 10, p. 2069-2072 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

Kibria, G., Ramos, E. K., Wan, Y., Gius, D. R. & Liu, H., Sep 4 2018, In : Molecular Pharmaceutics. 15, 9, p. 3625-3633 9 p.

Research output: Contribution to journalReview article

26 Scopus citations

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity

Zhu, Y., Park, S. H., Ozden, O., Kim, H. S., Jiang, H., Vassilopoulos, A., Spitz, D. R. & Gius, D., Aug 15 2012, In : Free Radical Biology and Medicine. 53, 4, p. 828-833 6 p.

Research output: Contribution to journalReview article

38 Scopus citations

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., Sack, M. N., Jing, E., Kahn, C. R., Friedman, J. E. & Jonscher, K. R., Feb 1 2011, In : Biochemical Journal. 433, 3, p. 505-514 10 p.

Research output: Contribution to journalArticle

240 Scopus citations

Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin Potentiate the in Vitro and in Vivo Radiation Response of Cervical Tumor Cells via the Heat Shock Protein 90-Mediated Intracellular Signaling and Cytotoxicity

Bisht, K. S., Bradbury, C. M., Mattson, D., Kaushal, A., Sowers, A., Markovina, S., Ortiz, K. L., Sieck, L. K., Isaacs, J. S., Brechbiel, M. W., Mitchell, J. B., Neckers, L. M. & Gius, D., Dec 15 2003, In : Cancer Research. 63, 24, p. 8984-8995 12 p.

Research output: Contribution to journalArticle

158 Scopus citations

Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3 - Modulated adhesion and invasion

Kassis, J. N., Virador, V. M., Guancial, E. A., Kimm, D., Ho, A. S., Mishra, M., Chuang, E. Y., Cook, J., Gius, D. & Kohn, E. C., Aug 2009, In : Journal of Pathology. 218, 4, p. 495-504 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas

Shankavaram, U., Fliedner, S. M. J., Elkahloun, A. G., Barb, J. J., Munson, P. J., Huynh, T. T., Matro, J. C., Turkova, H., Marston Linehan, W., Timmers, H. J., Tischler, A. S., Powers, J. F., de Krijger, R., Baysal, B. E., Takacova, M., Pastorekova, S., Gius, D., Lehnert, H., Camphausen, K. & Pacak, K., Apr 2013, In : Neoplasia (United States). 15, 4, p. 435-447 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Glycogen phosphorylase: A novel biomarker in doxorubicin-induced cardiac injury

Zhu, Y. & Gius, D., Apr 1 2018, In : Clinical Cancer Research. 24, 7, p. 1516-1517 2 p.

Research output: Contribution to journalArticle

G protein-coupled bile acid receptor TGR5 activation inhibits kidney disease in obesity and diabetes

Wang, X. X., Edelstein, M. H., Gafter, U., Qiu, L., Luo, Y., Dobrinskikh, E., Lucia, S., Adorini, L., D'Agati, V. D., Levi, J., Rosenberg, A., Kopp, J. B., Gius, D. R., Saleem, M. A. & Levi, M., May 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1362-1378 17 p.

Research output: Contribution to journalArticle

46 Scopus citations

Heat shock and the activation of AP-1 and inhibition of NF-κB DNA-binding activity: Possible role of intracellular redox status

Mattson, D., Bradbury, C. M., Bisht, K. S., Curry, H. A., Spitz, D. R. & Gius, D., Mar 1 2004, In : International Journal of Hyperthermia. 20, 2, p. 224-233 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Heat shock inhibits radiation-induced activation of NF-κB via inhibition of I-κB kinase

Curry, H. A., Clemens, R. A., Shah, S., Bradbury, C. M., Botero, A., Goswami, P. & Gius, D., Aug 13 1999, In : Journal of Biological Chemistry. 274, 33, p. 23061-23067 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

High incidence of oral dysesthesias on a trial of gefitinib, paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers

Sharp, H., Morris, J. C., Van Waes, C., Gius, D., Cooley-Zgela, T. & Singh, A. K., Dec 2008, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 31, 6, p. 557-560 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Histone deacetylase inhibitor and demethylating agent chromatin compaction and the radiation response by cancer cells

Bar-Sela, G., Jacobs, K. M. & Gius, D., Jan 1 2007, In : Cancer Journal. 13, 1, p. 65-69 5 p.

Research output: Contribution to journalReview article

15 Scopus citations

Homeostatic roles of STING in cell proliferation and chromosomal instability

Gius, D. & Zhu, Y., Jan 1 2019, In : Cancer Research. 79, 7, p. 1295-1296 2 p.

Research output: Contribution to journalArticle