• 9965 Citations
1988 …2020

Research output per year

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Research Output

2013

SIRT2 directs the replication stress response through CDK9 deacetylation

Zhang, H., Park, S. H., Pantazides, B. G., Karpiuk, O., Warren, M. D., Hardy, C. W., Duong, D. M., Park, S. J., Kim, H. S., Vassilopoulos, A., Seyfried, N. T., Johnsen, S. A., Gius, D. & Yu, D. S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13546-13551 6 p.

Research output: Contribution to journalArticle

49 Scopus citations
2012

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity

Zhu, Y., Park, S. H., Ozden, O., Kim, H. S., Jiang, H., Vassilopoulos, A., Spitz, D. R. & Gius, D., Aug 15 2012, In : Free Radical Biology and Medicine. 53, 4, p. 828-833 6 p.

Research output: Contribution to journalReview article

38 Scopus citations

Oxidative stress in cancer biology and therapy

Spitz, D. R., Dornfeld, K. J., Krishnan, K. & Gius, D., Jan 1 2012, Humana Press Inc. 460 p.

Research output: Book/ReportBook

4 Scopus citations

Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells

Wang, J., Anderson, P. D., Luo, W., Gius, D., Roh, M. & Abdulkadir, S. A., Apr 5 2012, In : Oncogene. 31, 14, p. 1794-1803 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress

Scarbrough, P. M., Mapuskar, K. A., Mattson, D. M., Gius, D., Watson, W. H. & Spitz, D. R., Jan 15 2012, In : Free Radical Biology and Medicine. 52, 2, p. 436-443 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Park, S. H., Zhu, Y., Ozden, O., Kim, H. S., Jiang, H., Deng, C. X., Gius, D. & Vassilopoulos, A., Jun 1 2012, In : Translational Cancer Research. 1, 1, p. 15-21 7 p.

Research output: Contribution to journalReview article

66 Scopus citations

SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis

Haigis, M. C., Deng, C. X., Finley, L. W. S., Kim, H. S. & Gius, D., May 15 2012, In : Cancer Research. 72, 10, p. 2468-2472 5 p.

Research output: Contribution to journalReview article

109 Scopus citations
2011

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress

Ozden, O., Park, S. H., Kim, H. S., Jiang, H., Coleman, M. C., Spitz, D. R. & Gius, D., Feb 2011, In : Aging. 3, 2, p. 102-107 6 p.

Research output: Contribution to journalReview article

104 Scopus citations

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., Sack, M. N., Jing, E., Kahn, C. R., Friedman, J. E. & Jonscher, K. R., Feb 1 2011, In : Biochemical Journal. 433, 3, p. 505-514 10 p.

Research output: Contribution to journalArticle

240 Scopus citations

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

Kim, H. S., Vassilopoulos, A., Wang, R. H., Lahusen, T., Xiao, Z., Xu, X., Li, C., Veenstra, T. D., Li, B., Yu, H., Ji, J., Wang, X. W., Park, S. H., Cha, Y. I., Gius, D. & Deng, C. X., Oct 18 2011, In : Cancer Cell. 20, 4, p. 487-499 13 p.

Research output: Contribution to journalArticle

320 Scopus citations

Sirt3, mitochondrial ROS, ageing, and carcinogenesis

Park, S. H., Ozden, O., Jiang, H., Cha, Y. I., Pennington, J. D., Aykin-Burns, N., Spitz, D. R., Gius, D. & Kim, H. S., Sep 2011, In : International journal of molecular sciences. 12, 9, p. 6226-6239 14 p.

Research output: Contribution to journalReview article

62 Scopus citations

The human sirtuin family: Evolutionary divergences and functions

Vassilopoulos, A., Fritz, K. S., Petersen, D. R. & Gius, D., Jul 2011, In : Human genomics. 5, 5, p. 485-496 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

Will targeting insulin growth factor help us or hurt us? An oncologist's perspective

Kamrava, M., Gius, D., Casagrande, G. & Kohn, E., Jan 2011, In : Ageing Research Reviews. 10, 1, p. 62-70 9 p.

Research output: Contribution to journalReview article

5 Scopus citations
2010

Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochondrial enrichment and deacetylase activity of long and short SIRT3 isoforms

Bao, J., Lu, Z., Joseph, J. J., Carabenciov, D., Dimond, C. C., Pang, L., Samsel, L., McCoy, J. P., Leclerc, J., Nguyen, P., Gius, D. & Sack, M. N., May 1 2010, In : Journal of Cellular Biochemistry. 110, 1, p. 238-247 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Dietary restriction: Standing up for sirtuins

Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., De Cabo, R., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., Helfand, S. L., Imai, S. I., Itoh, H., Kadowaki, T., Koya, D., Leeuwenburgh, C., Mcburney, M., Nabeshima, Y. O. I., Neri, C., Oberdoerffer, P. & 13 others, Pestell, R. G., Rogina, B., Sadoshima, J., Sartorelli, V., Serrano, M., Sinclair, D. A., Steegborn, C., Tatar, M., Tissenbaum, H. A., Tong, Q., Tsubota, K., Vaquero, A. & Verdin, E., Aug 27 2010, In : Science. 329, 5995, p. 1012-1013 2 p.

Research output: Contribution to journalLetter

52 Scopus citations

Molecular and Clinical Responses in a Pilot Study of Gefitinib With Paclitaxel and Radiation in Locally Advanced Head-and-Neck Cancer

Van Waes, C., Allen, C. T., Citrin, D., Gius, D., Colevas, A. D., Harold, N. A., Rudy, S., Nottingham, L., Muir, C., Chen, Z., Singh, A. K., Dancey, J. & Morris, J. C., Jun 1 2010, In : International Journal of Radiation Oncology Biology Physics. 77, 2, p. 447-454 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

Kim, H. S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., Vassilopoulos, A., Ozden, O., Park, S. H., Singh, K. K., Abdulkadir, S. A., Spitz, D. R., Deng, C. X. & Gius, D., Jan 19 2010, In : Cancer Cell. 17, 1, p. 41-52 12 p.

Research output: Contribution to journalArticle

523 Scopus citations

SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity

Bao, J., Scott, I., Lu, Z., Pang, L., Dimond, C. C., Gius, D. & Sack, M. N., Oct 1 2010, In : Free Radical Biology and Medicine. 49, 7, p. 1230-1237 8 p.

Research output: Contribution to journalArticle

112 Scopus citations

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S. H., Jiang, H., Kim, H. S., Flynn, C. R., Hill, S., McDonald, W. H., Olivier, A. K., Spitz, D. R. & Gius, D., Dec 22 2010, In : Molecular cell. 40, 6, p. 893-904 12 p.

Research output: Contribution to journalArticle

549 Scopus citations

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice

Xiao, C., Kim, H. S., Lahusen, T., Wang, R. H., Xu, X., Gavrilova, O., Jou, W., Gius, D. & Deng, C. X., Nov 19 2010, In : Journal of Biological Chemistry. 285, 47, p. 36776-36784 9 p.

Research output: Contribution to journalArticle

135 Scopus citations
2009

Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3 - Modulated adhesion and invasion

Kassis, J. N., Virador, V. M., Guancial, E. A., Kimm, D., Ho, A. S., Mishra, M., Chuang, E. Y., Cook, J., Gius, D. & Kohn, E. C., Aug 2009, In : Journal of Pathology. 218, 4, p. 495-504 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Ionizing radiation-induced oxidative stress alters miRNA expression

Simone, N. L., Soule, B. P., Ly, D., Saleh, A. D., Savage, J. E., DeGraff, W., Cook, J., Harris, C. C., Gius, D. & Mitchell, J. B., Jul 27 2009, In : PloS one. 4, 7, e6377.

Research output: Contribution to journalArticle

243 Scopus citations
2008

A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening

Rader, J. S., Malone, J. P., Gross, J., Gilmore, P., Brooks, R. A., Nguyen, L., Crimmins, D. L., Feng, S., Wright, J. D., Taylor, N., Zighelboim, I., Funk, M. C., Huettner, P. C., Ledenson, J. H., Gius, D. & Townsend, R. R., Dec 1 2008, In : Proteomics - Clinical Applications. 2, 12, p. 1658-1669 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression

Nguyen, P., Bar-Sela, G., Sun, L., Bisht, K. S., Cui, H., Kohn, E., Feinberg, A. P. & Gius, D., Nov 1 2008, In : Molecular and cellular biology. 28, 21, p. 6720-6729 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region

Nguyen, P., Cui, H., Bisht, K. S., Sun, L., Patel, K., Lee, R. S., Kugoh, H., Oshimura, M., Feinberg, A. P. & Gius, D., Jul 15 2008, In : Cancer Research. 68, 14, p. 5546-5551 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16ink4A down-regulation

Guo, Z., Tsai, M. H., Shiao, Y. H., Chen, L. H., Wei, M. L., Lv, X., Gius, D., Little, J. B., Mitchell, J. B. & Chuang, E. Y., Mar 1 2008, In : Journal of Biomedical Science. 15, 2, p. 163-168 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation

Sun, L., Huang, L., Nguyen, P., Bisht, K. S., Bar-Sela, G., Ho, A. S., Bradbury, C. M., Yu, W., Cui, H., Lee, S., Trepel, J. B., Feinberg, A. P. & Gius, D., Apr 15 2008, In : Cancer Research. 68, 8, p. 2726-2735 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells

Mishra, M. V., Bisht, K. S., Sun, L., Muldoon-Jacobs, K., Awwad, R., Kaushal, A., Nguyen, P., Huang, L., Pennington, J. D., Markovina, S., Bradbury, C. M. & Gius, D., Feb 1 2008, In : Molecular Cancer Research. 6, 2, p. 243-249 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

Yu, W., Gius, D., Onyango, P., Muldoon-Jacobs, K., Karp, J., Feinberg, A. P. & Cui, H., Jan 10 2008, In : Nature. 451, 7175, p. 202-206 5 p.

Research output: Contribution to journalArticle

671 Scopus citations

High incidence of oral dysesthesias on a trial of gefitinib, paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers

Sharp, H., Morris, J. C., Van Waes, C., Gius, D., Cooley-Zgela, T. & Singh, A. K., Dec 2008, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 31, 6, p. 557-560 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Patterns of care for women with cervical cancer in the United States

Trimble, E. L., Harlan, L. C., Gius, D., Stevens, J. & Schwartz, S. M., Aug 15 2008, In : Cancer. 113, 4, p. 743-749 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression

Jacobs, K. M., Pennington, J. D., Bisht, K. S., Aykin-Burns, N., Kim, H. S., Mishra, M., Sun, L., Nguyen, P., Ahn, B. H., Leclerc, J., Deng, C. X., Spitz, D. R. & Gius, D., Sep 5 2008, In : International Journal of Biological Sciences. 4, 5, p. 291-299 9 p.

Research output: Contribution to journalArticle

170 Scopus citations
2007

BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer

Annunziata, C. M., Kleinberg, L., Davidson, B., Berner, A., Gius, D., Tchabo, N., Steinberg, S. M. & Kohn, E. C., Nov 15 2007, In : Clinical Cancer Research. 13, 22, p. 6585-6592 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Histone deacetylase inhibitor and demethylating agent chromatin compaction and the radiation response by cancer cells

Bar-Sela, G., Jacobs, K. M. & Gius, D., Jan 1 2007, In : Cancer Journal. 13, 1, p. 65-69 5 p.

Research output: Contribution to journalReview article

15 Scopus citations

Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenesis accommodating for covariates

Gius, D., Funk, M. C., Chuang, E. Y., Feng, S., Huettner, P. C., Nguyen, L., Bradbury, C. M., Mishra, M., Gao, S., Buttin, B. M., Cohn, D. E., Powell, M. A., Horowitz, N. S., Whitcomb, B. P. & Rader, J., Aug 1 2007, In : Cancer Research. 67, 15, p. 7113-7123 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy

Pennington, J. D., Jacobs, K. M., Sun, L., Bar-Sela, G., Mishra, M. & Gius, D., Nov 2007, In : Current Pharmaceutical Design. 13, 33, p. 3368-3377 10 p.

Research output: Contribution to journalReview article

57 Scopus citations
2006

Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression

Zhao, W., Chuang, E. Y., Mishra, M., Awwad, R., Bisht, K., Sun, L., Nguyen, P., Pennington, J. D., Wang, T. J. C., Bradbury, C. M., Huang, L., Chen, Z., Bar-Sela, G., Robbins, M. E. C. & Gius, D., Jun 15 2006, In : Clinical Cancer Research. 12, 12, p. 3823-3830 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Identification of chromosomal alterations important in the development of cervical intraepithelial neoplasia and invasive carcinoma using alignment of DNA microarray data

Fitzpatrick, M. A., Funk, M. C., Gius, D., Huettner, P. C., Zhang, Z., Bidder, M., Ma, D., Powell, M. A. & Rader, J. S., Nov 1 2006, In : Gynecologic oncology. 103, 2, p. 458-462 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone)

Barker, C. A., Burgan, W. E., Carter, D. J., Cerna, D., Gius, D., Hollingshead, M. G., Camphausen, K. & Tofilon, P. J., May 1 2006, In : Clinical Cancer Research. 12, 9, p. 2912-2918 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Redox signaling in cancer biology

Gius, D. & Spitz, D. R., Jul 1 2006, In : Antioxidants and Redox Signaling. 8, 7-8, p. 1249-1252 4 p.

Research output: Contribution to journalReview article

141 Scopus citations

Thioredoxin reductase as a novel molecular target for cancer therapy

Nguyen, P., Awwad, R. T., Smart, D. D. K., Spitz, D. R. & Gius, D., May 18 2006, In : Cancer Letters. 236, 2, p. 164-174 11 p.

Research output: Contribution to journalShort survey

121 Scopus citations
2005

Co-activation of ERK, NF-κβ, and GADD45β in response to ionizing radiation

Wang, T., Hui, Y. C., Dong, S., Fan, M., Tamae, D., Ozeki, M., Gao, Q., Gius, D. & Jian, J. L., Apr 1 2005, In : Journal of Biological Chemistry. 280, 13, p. 12593-12601 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Inhibition of nuclear factor-κB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma

Van Waes, C., Chang, A. A., Lebowitz, P. F., Druzgal, C. H., Chen, Z., Elsayed, Y. A., Sunwoo, J. B., Rudy, S. F., Morris, J. C., Mitchell, J. B., Camphausen, K., Gius, D., Adams, J., Sausville, E. A. & Conley, B. A., Dec 1 2005, In : International Journal of Radiation Oncology Biology Physics. 63, 5, p. 1400-1412 13 p.

Research output: Contribution to journalArticle

105 Scopus citations

Redox-sensitive signaling factors as a novel molecular targets for cancer therapy

Pennington, J. D., Wang, T. J. C., Nguyen, P., Sun, L., Bisht, K., Smart, D. & Gius, D., Oct 2005, In : Drug Resistance Updates. 8, 5, p. 322-330 9 p.

Research output: Contribution to journalArticle

66 Scopus citations

The epigenome as a molecular marker and target: Implications for cancer

Gius, D., Bradbury, C. M., Sun, L., Awwad, R. T., Huang, L., Smart, D. D. K., Bisht, K. S., Ho, A. S. & Nguyen, P., Oct 26 2005, In : Cancer. 104, 9, p. 1789-1793 5 p.

Research output: Contribution to journalReview article

20 Scopus citations

Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols

Stoyanovsky, D. A., Tyurina, Y. Y., Tyurin, V. A., Anand, D., Mandavia, D. N., Gius, D., Ivanova, J., Pitt, B., Billiar, T. R. & Kagan, V. E., Nov 16 2005, In : Journal of the American Chemical Society. 127, 45, p. 15815-15823 9 p.

Research output: Contribution to journalArticle

123 Scopus citations
2004

Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach

Gius, D., Cui, H., Bradbury, C. M., Cook, J., Smart, D. D. K., Zhao, S., Young, L., Brandenburg, S. A., Hu, Y., Bisht, K. S., Ho, A. S., Mattson, D., Sun, L., Munson, P. J., Chuang, E. Y., Mitchell, J. B. & Feinberg, A. P., Oct 1 2004, In : Cancer Cell. 6, 4, p. 361-371 11 p.

Research output: Contribution to journalArticle

147 Scopus citations

Heat shock and the activation of AP-1 and inhibition of NF-κB DNA-binding activity: Possible role of intracellular redox status

Mattson, D., Bradbury, C. M., Bisht, K. S., Curry, H. A., Spitz, D. R. & Gius, D., Mar 1 2004, In : International Journal of Hyperthermia. 20, 2, p. 224-233 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells

Lagunas, L., Bradbury, C. M., Laszlo, A., Hunt, C. R. & Gius, D., Jan 23 2004, In : Biochemical and Biophysical Research Communications. 313, 4, p. 863-870 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

Spitz, D. R., Azzam, E. I., Li, J. J. & Gius, D., Aug 1 2004, In : Cancer and Metastasis Reviews. 23, 3-4, p. 311-322 12 p.

Research output: Contribution to journalReview article

443 Scopus citations