• 9965 Citations
1988 …2020

Research output per year

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Research Output

2004

Oxidative stress, redox, and the tumor microenvironment

Cook, J. A., Gius, D., Wink, D. A., Krishna, M. C., Russo, A. & Mitchell, J. B., Jul 2004, In : Seminars in Radiation Oncology. 14, 3, p. 259-266 8 p.

Research output: Contribution to journalArticle

194 Scopus citations
16 Scopus citations

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity

Mimnaugh, E. G., Xu, W., Vos, M., Yuan, X., Isaacs, J. S., Bisht, K. S., Gius, D. & Neckers, L., May 1 2004, In : Molecular cancer therapeutics. 3, 5, p. 551-566 16 p.

Research output: Contribution to journalReview article

183 Scopus citations

The new field of epigenomics: Implications for cancer and other common disease research

Bjornsson, H. T., Cui, H., Gius, D., Fallin, M. D. & Feinberg, A. P., 2004, In : Cold Spring Harbor symposia on quantitative biology. 69, p. 447-456 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation: Possible role in radiosensitization

Gius, D., Mattson, D., Bradbury, C. M., Smart, D. K. & Spitz, D. R., Mar 1 2004, In : International Journal of Hyperthermia. 20, 2, p. 213-223 11 p.

Research output: Contribution to journalReview article

10 Scopus citations

Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress

Smart, D. D. K., Ortiz, K. L., Mattson, D., Bradbury, C. M., Bisht, K. S., Sieck, L. K., Brechbiel, M. W. & Gius, D., Sep 15 2004, In : Cancer Research. 64, 18, p. 6716-6724 9 p.

Research output: Contribution to journalArticle

99 Scopus citations
2003

2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism

Lin, X., Zhang, F., Bradbury, C. M., Kaushal, A., Li, L., Spitz, D. R., Aft, R. L. & Gius, D., Jun 15 2003, In : Cancer Research. 63, 12, p. 3413-3417 5 p.

Research output: Contribution to journalArticle

119 Scopus citations

Clinical Trials Referral Resource. Clinical trials in cervical cancer.

Trimble, E. L., Schoenfeldt, M., Streicher, H., Gius, D. & Cornelison, T. L., Jan 2003, In : Oncology (Williston Park, N.Y.). 17, 1, p. 84-89 6 p.

Research output: Contribution to journalArticle

Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin Potentiate the in Vitro and in Vivo Radiation Response of Cervical Tumor Cells via the Heat Shock Protein 90-Mediated Intracellular Signaling and Cytotoxicity

Bisht, K. S., Bradbury, C. M., Mattson, D., Kaushal, A., Sowers, A., Markovina, S., Ortiz, K. L., Sieck, L. K., Isaacs, J. S., Brechbiel, M. W., Mitchell, J. B., Neckers, L. M. & Gius, D., Dec 15 2003, In : Cancer Research. 63, 24, p. 8984-8995 12 p.

Research output: Contribution to journalArticle

158 Scopus citations

Inhibition of cyclooxygenase-2 with NS-398 and the prevention of radiation-induced transformation, micronuclei formation and clonogenic cell death in C3H 10T1/2 cells

Bisht, K. S., Bradbury, C. M., Zoberi, I., Curry, H. A., Kaushal, A., Roti Roti, J. L. & Gius, D., Nov 1 2003, In : International Journal of Radiation Biology. 79, 11, p. 879-888 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53

Ohiro, Y., Usheva, A., Kobayashi, S., Duffy, S. L., Nantz, R., Gius, D. & Horikoshi, N., Jan 1 2003, In : Molecular and cellular biology. 23, 1, p. 322-334 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

The holy grail of radiation oncology: Lessons learned from hyperthermia

Karimpour, S. & Gius, D., Jan 1 2003, In : International Journal of Radiation Oncology Biology Physics. 55, 1, p. 3-4 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Those in gene therapy should pay closer attention to lessons from hyperthermia [5] (multiple letter)

Dewhirst, M. W., Sneed, P. K., Karimpour, S. & Gius, D., Oct 1 2003, In : International Journal of Radiation Oncology Biology Physics. 57, 2, p. 597-599 3 p.

Research output: Contribution to journalLetter

26 Scopus citations
2002

A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)

Ohiro, Y., Garkavtsev, I., Kobayashi, S., Sreekumar, K. R., Nantz, R., Higashikubo, B. T., Duffy, S. L., Higashikubo, R., Usheva, A., Gius, D., Kley, N. & Horikoshi, N., Jul 31 2002, In : FEBS Letters. 524, 1-3, p. 163-171 9 p.

Research output: Contribution to journalArticle

61 Scopus citations

Erratum: Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of γ-glutamylcysteine synthetase (Free Radical Biology and Medicine (2002) 32 (650-662) PII: S089158490200755)

Sekhar, K. R., Spitz, D. R., Harris, S., Nguyen, T. T., Meredith, M. J., Holt, J. T., Gius, D., Marnett, L. J., Summar, M. L. & Freeman, M. L., Jul 1 2002, In : Free Radical Biology and Medicine. 33, 1, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death

Aft, R. L., Zhang, F. W. & Gius, D., Jan 1 2002, In : British Journal of Cancer. 87, 7, p. 805-812 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Indomethacin lowers the threshold thermal exposure for hyperthermic radiosensitization and heat-shock inhibition of ionizing radiation-induced activation of NF-κB

Locke, J. E., Bradbury, C. M., Wei, S. J., Shah, S., Rene, L. M., Clemens, R. A., Roti, J. R., Horikoshi, N. & Gius, D., Jul 4 2002, In : International Journal of Radiation Biology. 78, 6, p. 493-502 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines

Zoberi, I., Bradbury, C. M., Curry, H. A., Bisht, K. S., Goswami, P. C., Roti Roti, J. L. & Gius, D., Jan 25 2002, In : Cancer Letters. 175, 2, p. 165-173 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of γ-glutamylcysteine synthetase

Sekhar, K. R., Spitz, D. R., Harris, S., Nguyen, T. T., Meredith, M. J., Holt, J. T., Guis, D., Marnett, L. J., Summar, M. L. & Freeman, M. L., Apr 1 2002, In : Free Radical Biology and Medicine. 32, 7, p. 650-662 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation

Karimpour, S., Lou, J., Lin, L. L., Rene, L. M., Lagunas, L., Ma, X., Karra, S., Bradbury, C. M., Markovina, S., Goswami, P. C., Spitz, D. R., Hirota, K., Kalvakolanu, D. V., Yodoi, J. & Gius, D., Jan 1 2002, In : Oncogene. 21, 41, p. 6317-6327 11 p.

Research output: Contribution to journalArticle

100 Scopus citations

Treatment of nasopharyngeal cancer: Raising the "Barr"

Gius, D. & Coleman, C. N., Nov 6 2002, In : Journal of the National Cancer Institute. 94, 21, p. 1594-1595 2 p.

Research output: Contribution to journalEditorial

2 Scopus citations
2001

Increased activator protein 1 activity as well as resistance to heat-induced radiosensitization, hydrogen peroxide, and cisplatin are inhibited by indomethacin in oxidative stress-resistant cells

Bradbury, C. M., Locke, J. E., Wei, S. J., Rene, L. M., Karimpour, S., Hunt, C., Spitz, D. R. & Gius, D., Apr 15 2001, In : Cancer Research. 61, 8, p. 3486-3492 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-κB activation in HeLa cells occur via a mechanism involving p38 MAP kinase

Markovina, S., Wei, S. J., Rene, L. M., Zoberi, I., Horikoshi, N., Bradbury, C. M. & Gius, D., Oct 15 2001, In : Cancer Research. 61, 20, p. 7689-7696 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
2000

Cell cycle-coupled variation in topoisomerase IIα mRNA is regulated by the 3′-untranslated region: Possible role of redox-sensitive protein binding in mRNA accumulation

Goswami, P. C., Sheren, J., Albee, L. D., Parsian, A., Sim, J. E., Ridnour, L. A., Higashikubo, R., Gius, D., Hunt, C. R. & Spitz, D. R., Dec 8 2000, In : Journal of Biological Chemistry. 275, 49, p. 38384-38392 9 p.

Research output: Contribution to journalArticle

63 Scopus citations

Changes in sub-nuclear structures and functional perturbations: implications for radiotherapy.

Roti Roti, J. L., Gius, D., VanderWaal, R. P. & Xu, M., Jan 1 2000, In : Journal of cellular biochemistry. Supplement. Suppl 35, p. 142-150 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Rearrangement of chromatin domains in cancer and development

Roti Roti, J. L., Gius, D., VanderWaal, R. P. & Xu, M., Dec 1 2000, In : Journal of Cellular Biochemistry. 80, SUPPL. 35, p. 54-60 7 p.

Research output: Contribution to journalReview article

1 Scopus citations

Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation

Wei, S. J., Botero, A., Hirota, K., Bradbury, C. M., Markovina, S., Laszlo, A., Spitz, D. R., Goswami, P. C., Yodoi, J. & Gius, D., Dec 1 2000, In : Cancer Research. 60, 23, p. 6688-6695 8 p.

Research output: Contribution to journalArticle

168 Scopus citations
1999

Heat shock inhibits radiation-induced activation of NF-κB via inhibition of I-κB kinase

Curry, H. A., Clemens, R. A., Shah, S., Bradbury, C. M., Botero, A., Goswami, P. & Gius, D., Aug 13 1999, In : Journal of Biological Chemistry. 274, 33, p. 23061-23067 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1

Gius, D., Botero, A., Shah, S. & Curry, H. A., Jun 1 1999, In : Toxicology Letters. 106, 2-3, p. 93-106 14 p.

Research output: Contribution to journalReview article

243 Scopus citations

Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock

Diamond, D. A., Parsian, A., Hunt, C. R., Lofgren, S., Spitz, D. R., Goswami, P. C. & Gius, D., Jun 11 1999, In : Journal of Biological Chemistry. 274, 24, p. 16959-16964 6 p.

Research output: Contribution to journalArticle

62 Scopus citations

Transduced p16(INK4a) peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cycle progression prior to activation of Cdk2 complexes in late G1

Gius, D. R., Ezhevsky, S. A., Becker-Hapak, M., Nagahara, H., Wei, M. C. & Dowdy, S. F., Jun 1 1999, In : Cancer Research. 59, 11, p. 2577-2580 4 p.

Research output: Contribution to journalArticle

113 Scopus citations
1997

Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

Ezhevsky, S. A., Nagahara, H., Vocero-Akbani, A. M., Gius, D. R., Wei, M. C. & Dowdy, S. F., Sep 30 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 20, p. 10699-10704 6 p.

Research output: Contribution to journalArticle

237 Scopus citations
1993

Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor

Hallahan, D. E., Gius, D., Kuchibhotla, J., Sukhatme, V., Kufe, D. W. & Weichselbaum, R. R., Jan 1 1993, In : Journal of Biological Chemistry. 268, 7, p. 4903-4907 5 p.

Research output: Contribution to journalArticle

53 Scopus citations
1992

Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements

Rim, M., Qureshi, S. A., Gius, D., Nho, J., Sukhatme, V. P. & Foster, D. A., Oct 1 1992, In : Oncogene. 7, 10, p. 2069-2072 4 p.

Research output: Contribution to journalArticle

22 Scopus citations
1990

Transcriptional activation and repression by fos are independent functions: The C terminus represses immediate-early gene expression via CArG elements

Gius, D., Cao, X., Rauscher, F. J., Cohen, D. R., Curran, T. & Sukhatme, V. P., Jan 1 1990, In : Molecular and Cellular Biology. 10, 8, p. 4243-4255 13 p.

Research output: Contribution to journalArticle

169 Scopus citations
1989
Open Access
40 Scopus citations
1988

Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18

Gius, D., Grossman, S., Bedell, M. A. & Laimins, L. A., 1988, In : Journal of virology. 62, 3, p. 665-672 8 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations