• 9869 Citations
1988 …2020

Research output per year

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Research Output

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Review article
2018

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

Zhu, Y., Dean, A. E., Horikoshi, N., Heer, C., Spitz, D. R. & Gius, D., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3682-3691 10 p.

Research output: Contribution to journalReview article

21 Scopus citations

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

Kibria, G., Ramos, E. K., Wan, Y., Gius, D. R. & Liu, H., Sep 4 2018, In : Molecular Pharmaceutics. 15, 9, p. 3625-3633 9 p.

Research output: Contribution to journalReview article

24 Scopus citations
2017

Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

Zou, X., Ratti, B. A., O’Brien, J. G., Lautenschlager, S. O., Gius, D. R., Bonini, M. G. & Zhu, Y., Aug 1 2017, In : Journal of Bioenergetics and Biomembranes. 49, 4, p. 325-333 9 p.

Research output: Contribution to journalReview article

38 Scopus citations
2016

Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype

Zou, X., Santa-Maria, C. A., O'Brien, J., Gius, D. & Zhu, Y., Aug 20 2016, In : Antioxidants and Redox Signaling. 25, 6, p. 326-336 11 p.

Research output: Contribution to journalReview article

22 Scopus citations
2014
87 Scopus citations

Strategies of dose escalation in the treatment of locally advanced non-small cell lung cancer: Image guidance and beyond

Chi, A., Nguyen, N. P., Welsh, J. S., Tse, W., Monga, M., Oduntan, O., Almubarak, M., Rogers, J., Remick, S. C. & Gius, D. R., Jan 1 2014, In : Frontiers in Oncology. 4 JUN, 156.

Research output: Contribution to journalReview article

8 Scopus citations
2013

Metabolic regulation of Sirtuins upon fasting and the implication for cancer

Zhu, Y., Yan, Y., Gius, D. R. & Vassilopoulos, A., Nov 1 2013, In : Current opinion in oncology. 25, 6, p. 630-636 7 p.

Research output: Contribution to journalReview article

13 Scopus citations
2012

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity

Zhu, Y., Park, S. H., Ozden, O., Kim, H. S., Jiang, H., Vassilopoulos, A., Spitz, D. R. & Gius, D., Aug 15 2012, In : Free Radical Biology and Medicine. 53, 4, p. 828-833 6 p.

Research output: Contribution to journalReview article

38 Scopus citations

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Park, S. H., Zhu, Y., Ozden, O., Kim, H. S., Jiang, H., Deng, C. X., Gius, D. & Vassilopoulos, A., Jun 1 2012, In : Translational Cancer Research. 1, 1, p. 15-21 7 p.

Research output: Contribution to journalReview article

63 Scopus citations

SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis

Haigis, M. C., Deng, C. X., Finley, L. W. S., Kim, H. S. & Gius, D., May 15 2012, In : Cancer Research. 72, 10, p. 2468-2472 5 p.

Research output: Contribution to journalReview article

109 Scopus citations
2011

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress

Ozden, O., Park, S. H., Kim, H. S., Jiang, H., Coleman, M. C., Spitz, D. R. & Gius, D., Feb 2011, In : Aging. 3, 2, p. 102-107 6 p.

Research output: Contribution to journalReview article

104 Scopus citations

Sirt3, mitochondrial ROS, ageing, and carcinogenesis

Park, S. H., Ozden, O., Jiang, H., Cha, Y. I., Pennington, J. D., Aykin-Burns, N., Spitz, D. R., Gius, D. & Kim, H. S., Sep 2011, In : International journal of molecular sciences. 12, 9, p. 6226-6239 14 p.

Research output: Contribution to journalReview article

62 Scopus citations

Will targeting insulin growth factor help us or hurt us? An oncologist's perspective

Kamrava, M., Gius, D., Casagrande, G. & Kohn, E., Jan 1 2011, In : Ageing Research Reviews. 10, 1, p. 62-70 9 p.

Research output: Contribution to journalReview article

5 Scopus citations
2007

Histone deacetylase inhibitor and demethylating agent chromatin compaction and the radiation response by cancer cells

Bar-Sela, G., Jacobs, K. M. & Gius, D., Jan 1 2007, In : Cancer Journal. 13, 1, p. 65-69 5 p.

Research output: Contribution to journalReview article

15 Scopus citations

Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy

Pennington, J. D., Jacobs, K. M., Sun, L., Bar-Sela, G., Mishra, M. & Gius, D., Nov 2007, In : Current Pharmaceutical Design. 13, 33, p. 3368-3377 10 p.

Research output: Contribution to journalReview article

57 Scopus citations
2006

Redox signaling in cancer biology

Gius, D. & Spitz, D. R., Jul 1 2006, In : Antioxidants and Redox Signaling. 8, 7-8, p. 1249-1252 4 p.

Research output: Contribution to journalReview article

140 Scopus citations
2005

The epigenome as a molecular marker and target: Implications for cancer

Gius, D., Bradbury, C. M., Sun, L., Awwad, R. T., Huang, L., Smart, D. D. K., Bisht, K. S., Ho, A. S. & Nguyen, P., Oct 26 2005, In : Cancer. 104, 9, p. 1789-1793 5 p.

Research output: Contribution to journalReview article

20 Scopus citations
2004

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

Spitz, D. R., Azzam, E. I., Li, J. J. & Gius, D., Aug 1 2004, In : Cancer and Metastasis Reviews. 23, 3-4, p. 311-322 12 p.

Research output: Contribution to journalReview article

439 Scopus citations

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity

Mimnaugh, E. G., Xu, W., Vos, M., Yuan, X., Isaacs, J. S., Bisht, K. S., Gius, D. & Neckers, L., May 1 2004, In : Molecular cancer therapeutics. 3, 5, p. 551-566 16 p.

Research output: Contribution to journalReview article

183 Scopus citations

Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation: Possible role in radiosensitization

Gius, D., Mattson, D., Bradbury, C. M., Smart, D. K. & Spitz, D. R., Mar 1 2004, In : International Journal of Hyperthermia. 20, 2, p. 213-223 11 p.

Research output: Contribution to journalReview article

10 Scopus citations
2000

Changes in sub-nuclear structures and functional perturbations: implications for radiotherapy.

Roti Roti, J. L., Gius, D., VanderWaal, R. P. & Xu, M., Jan 1 2000, In : Journal of cellular biochemistry. Supplement. Suppl 35, p. 142-150 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Rearrangement of chromatin domains in cancer and development

Roti Roti, J. L., Gius, D., VanderWaal, R. P. & Xu, M., Dec 1 2000, In : Journal of Cellular Biochemistry. 80, SUPPL. 35, p. 54-60 7 p.

Research output: Contribution to journalReview article

1 Scopus citations
1999

Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1

Gius, D., Botero, A., Shah, S. & Curry, H. A., Jun 1 1999, In : Toxicology Letters. 106, 2-3, p. 93-106 14 p.

Research output: Contribution to journalReview article

242 Scopus citations