• 9010 Citations
1988 …2022
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Research Output 1988 2019

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Review article
2018
13 Citations (Scopus)

Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy

Zhu, Y., Dean, A. E., Horikoshi, N., Heer, C., Spitz, D. R. & Gius, D. R., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3682-3691 10 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Neoplasms
Therapeutics
Electron Transport
NADP
10 Citations (Scopus)

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

Kibria, G., Ramos, E. K., Wan, Y., Gius, D. R. & Liu, H., Sep 4 2018, In : Molecular Pharmaceutics. 15, 9, p. 3625-3633 9 p.

Research output: Contribution to journalReview article

Exosomes
Drug Delivery Systems
Neoplasms
Therapeutics
Pharmaceutical Preparations
2017
23 Citations (Scopus)

Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

Zou, X., Ratti, B. A., O’Brien, J. G., Lautenschlager, S. O., Gius, D. R., Bonini, M. G. & Zhu, Y., Aug 1 2017, In : Journal of Bioenergetics and Biomembranes. 49, 4, p. 325-333 9 p.

Research output: Contribution to journalReview article

Superoxide Dismutase
Oxidation-Reduction
Mitochondria
Selenocysteine
Methionine
2016
17 Citations (Scopus)

Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype

Zou, X., Santa-Maria, C. A., O'Brien, J., Gius, D. R. & Zhu, Y., Aug 20 2016, In : Antioxidants and Redox Signaling. 25, 6, p. 326-336 11 p.

Research output: Contribution to journalReview article

Acetylation
Superoxide Dismutase
Breast
Breast Neoplasms
Phenotype
2014
70 Citations (Scopus)
Superoxide Dismutase
Carcinogenesis
Aging of materials
Mitochondria
Proteins
8 Citations (Scopus)

Strategies of dose escalation in the treatment of locally advanced non-small cell lung cancer: Image guidance and beyond

Chi, A., Nguyen, N. P., Welsh, J. S., Tse, W., Monga, M., Oduntan, O., Almubarak, M., Rogers, J., Remick, S. C. & Gius, D. R., Jan 1 2014, In : Frontiers in Oncology. 4 JUN, 156.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Radiation
Conformal Radiotherapy
Positron-Emission Tomography
Radiotherapy
2013
8 Citations (Scopus)

Metabolic regulation of Sirtuins upon fasting and the implication for cancer

Zhu, Y., Yan, Y., Gius, D. R. & Vasilopoulos, A., Nov 1 2013, In : Current Opinion in Oncology. 25, 6, p. 630-636 7 p.

Research output: Contribution to journalReview article

Sirtuins
Fasting
Neoplasms
Carcinogenesis
Glycolysis
2012
34 Citations (Scopus)

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity

Zhu, Y., Park, S. H., Ozden, O., Kim, H. S., Jiang, H., Vassilopoulos, A., Spitz, D. R. & Gius, D., Aug 15 2012, In : Free Radical Biology and Medicine. 53, 4, p. 828-833 6 p.

Research output: Contribution to journalReview article

Acetylation
Static Electricity
Superoxide Dismutase
Electrostatics
Reactive Oxygen Species
50 Citations (Scopus)

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Park, S. H., Zhu, Y., Ozden, O., Kim, H. S., Jiang, H., Deng, C. X., Gius, D. & Vassilopoulos, A., Jun 1 2012, In : Translational Cancer Research. 1, 1, p. 15-21 7 p.

Research output: Contribution to journalReview article

Cell Cycle
Carcinogenesis
Neoplasms
Tumor Suppressor Proteins
Medical Oncology
103 Citations (Scopus)

SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis

Haigis, M. C., Deng, C. X., Finley, L. W. S., Kim, H. S. & Gius, D., May 15 2012, In : Cancer Research. 72, 10, p. 2468-2472 5 p.

Research output: Contribution to journalReview article

Reactive Oxygen Species
Carcinogenesis
Neoplasms
Glucose
Hypoxia-Inducible Factor 1
2011
92 Citations (Scopus)

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress

Ozden, O., Park, S. H., Kim, H. S., Jiang, H., Coleman, M. C., Spitz, D. R. & Gius, D., Jan 1 2011, In : Aging. 3, 2, p. 102-107 6 p.

Research output: Contribution to journalReview article

Acetylation
Superoxide Dismutase
Reactive Oxygen Species
Oxidative Stress
Food
55 Citations (Scopus)

Sirt3, mitochondrial ROS, ageing, and carcinogenesis

Park, S. H., Ozden, O., Jiang, H., Cha, Y. I., Pennington, J. D., Aykin-Burns, N., Spitz, D. R., Gius, D. & Kim, H. S., Sep 1 2011, In : International journal of molecular sciences. 12, 9, p. 6226-6239 14 p.

Research output: Contribution to journalReview article

Reactive Oxygen Species
Carcinogenesis
Aging of materials
Oxygen
oxygen
4 Citations (Scopus)

Will targeting insulin growth factor help us or hurt us? An oncologist's perspective

Kamrava, M., Gius, D., Casagrande, G. & Kohn, E., Jan 1 2011, In : Ageing Research Reviews. 10, 1, p. 62-70 9 p.

Research output: Contribution to journalReview article

Intercellular Signaling Peptides and Proteins
Insulin
Oncologists
Aging of materials
Cells
2007
15 Citations (Scopus)

Histone deacetylase inhibitor and demethylating agent chromatin compaction and the radiation response by cancer cells

Bar-Sela, G., Jacobs, K. M. & Gius, D., Jan 1 2007, In : Cancer Journal. 13, 1, p. 65-69 5 p.

Research output: Contribution to journalReview article

Histone Deacetylase Inhibitors
Chromatin
Histone Deacetylases
Radiation
Epigenomics
57 Citations (Scopus)

Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy

Pennington, J. D., Jacobs, K. M., Sun, L., Bar-Sela, G., Mishra, M. & Gius, D., Jan 1 2007, In : Current Pharmaceutical Design. 13, 33, p. 3368-3377 10 p.

Research output: Contribution to journalReview article

Thioredoxin-Disulfide Reductase
Thioredoxins
Oxidation-Reduction
Oxidative Stress
Neoplasms
2006
137 Citations (Scopus)

Redox signaling in cancer biology

Gius, D. & Spitz, D. R., Jul 1 2006, In : Antioxidants and Redox Signaling. 8, 7-8, p. 1249-1252 4 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Redox reactions
Neoplasms
Polycyclic Aromatic Hydrocarbons
Ionizing radiation
2005
64 Citations (Scopus)

Redox-sensitive signaling factors as a novel molecular targets for cancer therapy

Pennington, J. D., Wang, T. J. C., Nguyen, P., Sun, L., Bisht, K., Smart, D. & Gius, D., Oct 1 2005, In : Drug Resistance Updates. 8, 5, p. 322-330 9 p.

Research output: Contribution to journalReview article

Oxidation-Reduction
Neoplasms
Oxidative Stress
Cell Respiration
Drug Discovery
20 Citations (Scopus)

The epigenome as a molecular marker and target: Implications for cancer

Gius, D., Bradbury, C. M., Sun, L., Awwad, R. T., Huang, L., Smart, D. D. K., Bisht, K. S., Ho, A. S. & Nguyen, P., Oct 26 2005, In : Cancer. 104, 9, p. 1789-1793 5 p.

Research output: Contribution to journalReview article

Methylation
Gene Expression
Genes
Neoplasms
Methyltransferases
2004
409 Citations (Scopus)

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

Spitz, D. R., Azzam, E. I., Li, J. J. & Gius, D., Aug 1 2004, In : Cancer and Metastasis Reviews. 23, 3-4, p. 311-322 12 p.

Research output: Contribution to journalReview article

Ionizing Radiation
Oxidation-Reduction
Free Radicals
Bystander Effect
Radiobiology
177 Citations (Scopus)

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity

Mimnaugh, E. G., Xu, W., Vos, M., Yuan, X., Isaacs, J. S., Bisht, K. S., Gius, D. & Neckers, L., May 1 2004, In : Molecular Cancer Therapeutics. 3, 5, p. 551-566 16 p.

Research output: Contribution to journalReview article

Ubiquitination
Proteasome Endopeptidase Complex
Endoplasmic Reticulum
Proteins
Ubiquitinated Proteins
10 Citations (Scopus)

Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation: Possible role in radiosensitization

Gius, D., Mattson, D., Bradbury, C. M., Smart, D. K. & Spitz, D. R., Mar 1 2004, In : International Journal of Hyperthermia. 20, 2, p. 213-223 11 p.

Research output: Contribution to journalReview article

Transcriptional Activation
Oxidation-Reduction
Transcription Factors
Hot Temperature
Shock
2000
1 Citation (Scopus)

Changes in sub-nuclear structures and functional perturbations: implications for radiotherapy.

Roti Roti, J. L., Gius, D., VanderWaal, R. P. & Xu, M., Jan 1 2000, In : Journal of cellular biochemistry. Supplement. Suppl 35, p. 142-150 9 p.

Research output: Contribution to journalReview article

Radiotherapy
Therapeutics
Neoplasms
Genomic Instability
Eukaryotic Cells
1 Citation (Scopus)

Rearrangement of chromatin domains in cancer and development

Roti Roti, J. L., Gius, D., VanderWaal, R. P. & Xu, M., Dec 1 2000, In : Journal of Cellular Biochemistry. 80, SUPPL. 35, p. 54-60 7 p.

Research output: Contribution to journalReview article

Chromatin
Nuclear Matrix-Associated Proteins
DNA
Dermatoglyphics
Neoplasms
1999
239 Citations (Scopus)

Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1

Gius, D., Botero, A., Shah, S. & Curry, H. A., Jun 1 1999, In : Toxicology Letters. 106, 2-3, p. 93-106 14 p.

Research output: Contribution to journalReview article

Transcription Factor AP-1
Oxidation-Reduction
Transcription Factors
Genes
Genetic Phenomena