Deborah Rachelle Winter

  • 10174 Citations
20072018
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Personal profile

Research Interests

I was one of the first students to obtain an undergraduate degree in Bioinformatics and Computational Biology at University of Toronto. Then, I trained as a computational biologist at Duke University (PhD) under Drs. Greg Crawford and Terry Furey focusing on gene regulation, specifically, using high-throughput sequencing assays to study chromatin dynamics across diverse human cell lines. For my postdoc, I joined Ido Amit's lab in Immunogenomics at the Weizmann Institute of Science in Israel where I applied genomic approaches to the study of immunology. My landmark paper showed that tissue-resident macrophages are capable of adopting tissue-specific functions by reprogramming their chromatin landscape in response to signal from the local environment.

Education/Academic qualification

PhD, Duke University

… → 2013

Keywords

  • Chromatin
  • Genomics
  • Computational Biology
  • Rheumatology
  • Big Data
  • Systems Biology
  • Gene Regulation
  • Immunology
  • Epigenetics
  • Arthritis - Rheumatoid
  • Scleroderma
  • Bioinformatics

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Research Output 2007 2018

  • 10174 Citations
  • 22 Article
  • 3 Review article
  • 2 Short survey
  • 1 Comment/debate

Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus

Mike, E. V., Makinde, H. M., Gulinello, M., Vanarsa, K., Herlitz, L., Gadhvi, G., Winter, D. R., Mohan, C., Hanly, J. G., Mok, C. C., Cuda, C. M. & Putterman, C., Jan 1 2018, (Accepted/In press) In : Journal of Autoimmunity.

Research output: Contribution to journalArticle

Biomarkers
Brain
RNA Sequence Analysis
Lipocalin-2
Memory Disorders
1 Citations

Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Sphingosine-1-Phosphate Signaling

Mike, E. V., Makinde, H. M., Der, E., Stock, A., Gulinello, M., Gadhvi, G. T., Winter, D. R., Cuda, C. M. & Putterman, C., Jan 1 2018, In : Frontiers in immunology. 9, 1 p.

Research output: Contribution to journalArticle

Central Nervous System Lupus Vasculitis
Inbred MRL lpr Mouse
Lysosphingolipid Receptors
Cytokines
Brain

Thinking BIG rheumatology: How to make functional genomics data work for you

Winter, D. R., Feb 12 2018, In : Arthritis Research and Therapy. 20, 1, 29.

Research output: Contribution to journalReview article

Rheumatology
Genomics
Databases
Gene Regulatory Networks
Rheumatic Diseases
2 Citations

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis

Mandelin, A. M., Homan, P. J., Shaffer, A. M., Cuda, C. M., Dominguez, S. T., Bacalao, E., Carns, M., Hinchcliff, M., Lee, J., Aren, K., Thakrar, A., Montgomery, A. B., Bridges, S. L., Bathon, J. M., Atkinson, J. P., Fox, D. A., Matteson, E. L., Buckley, C. D., Pitzalis, C., Parks, D. & 16 othersHughes, L. B., Geraldino-Pardilla, L., Ike, R., Phillips, K., Wright, K., Filer, A., Kelly, S., Ruderman, E. M., Morgan, V., Abdala-Valencia, H., Misharin, A., Budinger, G. R. S., Bartom, E. T., Pope, R. M., Perlman, H. R. & Winter, D. R., Jun 1 2018, In : Arthritis and Rheumatology. 70, 6, p. 841-854 14 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Macrophages
Biopsy
RNA Sequence Analysis
Precision Medicine
2 Citations

Bim suppresses the development of SLE by limiting myeloid inflammatory responses

Tsai, F. N., Homan, P. J., Agrawal, H., Misharin, A., Abdala-Valencia, H., Haines, G. K., Dominguez, S., Bloomfield, C. L., Saber, R., Chang, A., Mohan, C., Hutcheson, J., Davidson, A., Budinger, G. R. S., Bouillet, P., Dorfleutner, A., Stehlik, C., Winter, D. R., Cuda, C. M. & Perlman, H. R., Dec 1 2017, In : Journal of Experimental Medicine. 214, 12, p. 3753-3773 21 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Macrophages
Glomerulonephritis
Kidney
Interferon Type I