Grants per year
Personal profile
Research Interests
I was one of the first students to obtain an undergraduate degree in Bioinformatics and Computational Biology at University of Toronto. Then, I trained as a computational biologist at Duke University (PhD) under Drs. Greg Crawford and Terry Furey focusing on gene regulation, specifically, using high-throughput sequencing assays to study chromatin dynamics across diverse human cell lines. For my postdoc, I joined Ido Amit's lab in Immunogenomics at the Weizmann Institute of Science in Israel where I applied genomic approaches to the study of immunology. My landmark paper showed that tissue-resident macrophages are capable of adopting tissue-specific functions by reprogramming their chromatin landscape in response to signal from the local environment.
As a computational immunologist, I interested in mapping the gene regulatory networks of immune cells in health and disease, particularly macrophages in rheumatic disease. As a plastic immune cell type, macrophages are found throughout the body where they play an important role in both homeostatic functions and immune response. The are critical to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and systemic sclerosis. Using high-throughput sequencing assays and computational techniques, I seek to profile the transcriptional and epigenomic profile of macrophages in different tissues in mouse models and patients with these diseases. We believe that a better understanding of the function and malfunction of macrophages we enable to develop more precise and effective treatments.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Computational Biology & Bioinformatics, Duke University
… → 2013
Research interests keywords
- Arthritis - Rheumatoid
- Big Data
- Bioinformatics
- Chromatin
- Computational Biology
- Epigenetics
- Gene Regulation
- Genomics
- Immunology
- Rheumatology
- Scleroderma
- Systems Biology
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Collaborations and top research areas from the last five years
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Understanding the role of noisy chromatin deregulation in aging macrophages
Winter, D. R. (PD/PI), Cuda, C. M. (Co-Investigator) & Makinde, H.-K. M. (Other)
American Federation for Aging Research
12/31/24 → 12/31/27
Project: Research project
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Elucidating the Role of cGAS-STING in Lung Tissue Repair and Remodeling
Ridge, K. M. (PD/PI), Gottardi, C. J. (Co-Investigator), Winter, D. R. (Co-Investigator) & Ma, R. (Other)
National Heart, Lung, and Blood Institute
2/1/24 → 1/31/28
Project: Research project
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TLR Transduction of Dysbiotic Pelvic Pain
Klumpp, D. (PD/PI), Schaeffer, A. J. (Co-Investigator) & Winter, D. R. (Co-Investigator)
National Institute of Diabetes and Digestive and Kidney Diseases
8/21/23 → 6/30/27
Project: Research project
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Methodologic Core
Chmiel, J. S. (Co-Investigator), Chmiel, J. S. (Co-Investigator), Chmiel, J. S. (Co-Investigator), Franklin, P. D. (Co-Investigator), Franklin, P. D. (Co-Investigator), Ghomrawi, H. (Co-Investigator), Ghomrawi, H. (Co-Investigator), Kwasny, M. J. (Co-Investigator), Muhammad, L. N. (Co-Investigator), Muhammad, L. N. (Co-Investigator), Spring, B. (Co-Investigator), Starren, J. (Co-Investigator), Starren, J. (Co-Investigator), Van Horn, L. (Co-Investigator), Van Horn, L. (Co-Investigator), Walunas, T. L. (Co-Investigator), Winter, D. R. (Co-Investigator), Winter, D. R. (Co-Investigator), Chang, R. W. (Other), Chang, R. W. (Other), Lee, J. (Other), Lee, J. (Other) & Starren, J. (Other)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/21/22 → 8/31/27
Project: Research project
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Core Center for Clinical Research at Northwestern University
Sharma, L. (PD/PI), Sharma, L. (PD/PI), Bass, M. (Co-Investigator), Brown, C. H. (Co-Investigator), Chmiel, J. S. (Co-Investigator), Cuda, C. M. (Co-Investigator), Franklin, P. D. (Co-Investigator), Ghomrawi, H. (Co-Investigator), Holmes, K. (Co-Investigator), Holmes, K. (Co-Investigator), Kershaw, K. N. (Co-Investigator), Kershaw, K. N. (Co-Investigator), Lattie, E. G. (Co-Investigator), Muhammad, L. N. (Co-Investigator), Pope, R. M. (Co-Investigator), Pope, R. M. (Co-Investigator), Spring, B. (Co-Investigator), Tandon, D. (Co-Investigator), Van Horn, L. (Co-Investigator), Wehbe, F. (Co-Investigator), Winter, D. R. (Co-Investigator), Chang, R. W. (Other), Lee, Y. C. (Other), Lee, J. (Other), Lee, Y. C. (Other), Ramsey-Goldman, R. (Other) & Rothrock, N. (Other)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/21/22 → 8/31/27
Project: Research project
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Esophageal epithelial Ikkβ deletion promotes eosinophilic esophagitis in experimental allergy mouse model
Clevenger, M. H., Wei, C., Karami, A. L., Tsikretsis, L. E., Carlson, D. A., Pandolfino, J. E., Gonsalves, N., Winter, D. R., Whelan, K. A. & Tétreault, M. P., Apr 2025, In: Journal of Allergy and Clinical Immunology. 155, 4, p. 1276-1289 14 p.Research output: Contribution to journal › Article › peer-review
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Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions
Gromer, K. D., Chen, S. Y., Gadhvi, G., Feng, L., Shearn, C., Antala, S., Wechsler, J. B., Cuda, C. M., Mack, C. L., Sokol, R. J., Janssen, W. J., Green, R. M., Perlman, H., Winter, D. R. & Taylor, S. A., 2025, In: Frontiers in immunology. 16, 1506195.Research output: Contribution to journal › Article › peer-review
Open Access -
Distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia
The NU SCRIPT Study Investigators, 2024, (Accepted/In press) In: Nature Immunology. 25, 9, p. 1607-1622 16 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Retinal microglia express more MHC class I and promote greater T-cell-driven inflammation than brain microglia
Bloomfield, C. L., Gong, J., Droho, S., Makinde, H. M., Gurra, M. G., Stumpf, C. H., Kharel, A., Gadhvi, G., Winter, D. R., Cui, W., Cuda, C. M. & Lavine, J. A., 2024, In: Frontiers in immunology. 15, 1399989.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
A Novel MIP-1–Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers
Reyfman, P. A., Malsin, E. S., Khuder, B., Joshi, N., Gadhvi, G., Flozak, A. S., Carns, M. A., Aren, K., Goldberg, I. A., Kim, S., Alexander, M. J., Sporn, P. H. S., Misharin, A. V., Budinger, G. R. S., Lam, A. P., Hinchcliff, M. E., Gottardi, C. J. & Winter, D. R., Feb 2023, In: American journal of respiratory cell and molecular biology. 68, 2, p. 176-185 10 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations