Grants per year
Personal profile
Research Interests
I was one of the first students to obtain an undergraduate degree in Bioinformatics and Computational Biology at University of Toronto. Then, I trained as a computational biologist at Duke University (PhD) under Drs. Greg Crawford and Terry Furey focusing on gene regulation, specifically, using high-throughput sequencing assays to study chromatin dynamics across diverse human cell lines. For my postdoc, I joined Ido Amit's lab in Immunogenomics at the Weizmann Institute of Science in Israel where I applied genomic approaches to the study of immunology. My landmark paper showed that tissue-resident macrophages are capable of adopting tissue-specific functions by reprogramming their chromatin landscape in response to signal from the local environment.
As a computational immunologist, I interested in mapping the gene regulatory networks of immune cells in health and disease, particularly macrophages in rheumatic disease. As a plastic immune cell type, macrophages are found throughout the body where they play an important role in both homeostatic functions and immune response. The are critical to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and systemic sclerosis. Using high-throughput sequencing assays and computational techniques, I seek to profile the transcriptional and epigenomic profile of macrophages in different tissues in mouse models and patients with these diseases. We believe that a better understanding of the function and malfunction of macrophages we enable to develop more precise and effective treatments.
Education/Academic qualification
PhD, Duke University
… → 2013
Research interests
- Arthritis - Rheumatoid
- Big Data
- Bioinformatics
- Chromatin
- Computational Biology
- Epigenetics
- Gene Regulation
- Genomics
- Immunology
- Rheumatology
- Scleroderma
- Systems Biology
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Grants
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Defining an epigenomic signature of myeloid skewing in hematopoietic stem cells as a risk factor for disease in aging.
9/1/20 → 8/31/23
Project: Research project
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Microglia-Specific Transcriptional Signatures in Neuropsychiatric Symptoms of SLE
Cuda, C. M., Grebenciucova, E., Ramsey-Goldman, R. & Winter, D. R.
Rheumatology Research Foundation
7/1/20 → 6/30/22
Project: Research project
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Defining the epigenomic signatures of myeloid skewing in aging (postdoctoral fellowship for Monica Gutierrez)
Perlman, H. R. & Winter, D. R.
6/1/20 → 5/31/22
Project: Research project
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The Role of Microglial Subsets in Driving Neuropsychiatric Symptoms of SLE
Cuda, C. M., Grebenciucova, E. & Winter, D. R.
3/1/20 → 2/28/22
Project: Research project
Research Output
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Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease
Stevens, W. W., Staudacher, A. G., Hulse, K. E., Carter, R. G., Winter, D. R., Kato, A., Suh, L., Norton, J. E., Huang, J. H., Peters, A. T., Grammer, L. C., Price, C. P. E., Conley, D. B., Shintani-Smith, S., Tan, B. K., Welch, K. C., Kern, R. C. & Schleimer, R. P., 2020, (Accepted/In press) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A genome-based model to predict the virulence of pseudomonas aeruginosa isolates
Pincus, N. B., Ozer, E. A., Allen, J. P., Nguyen, M., Davis, J. J., Winter, D. R., Chuang, C. H., Chiu, C. H., Zamorano, L., Oliver, A. & Hauser, A. R., Jul 1 2020, In: mBio. 11, 4, p. 1-19 19 p., e01527-20.Research output: Contribution to journal › Article › peer-review
Open Access -
A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus
Makinde, H. M., Winter, D. R., Procissi, D., Mike, E. V., Stock, A. D., Kando, M. J., Gadhvi, G. T., Droho, S., Bloomfield, C. L., Dominguez, S. T., Mayr, M. G., Lavine, J. A., Putterman, C. & Cuda, C. M., Feb 26 2020, In: Frontiers in immunology. 11, 230.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Microglia Adopt Longitudinal Transcriptional Changes After Traumatic Brain Injury
Makinde, H. M., Just, T. B., Gadhvi, G. T., Winter, D. R. & Schwulst, S. J., Feb 1 2020, In: Journal of Surgical Research. 246, p. 113-122 10 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus
Mike, E. V., Makinde, H. M., Gulinello, M., Vanarsa, K., Herlitz, L., Gadhvi, G., Winter, D. R., Mohan, C., Hanly, J. G., Mok, C. C., Cuda, C. M. & Putterman, C., Jan 2019, In: Journal of Autoimmunity. 96, p. 59-73 15 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations