Grants per year
Personal profile
Research Interests
I was one of the first students to obtain an undergraduate degree in Bioinformatics and Computational Biology at University of Toronto. Then, I trained as a computational biologist at Duke University (PhD) under Drs. Greg Crawford and Terry Furey focusing on gene regulation, specifically, using high-throughput sequencing assays to study chromatin dynamics across diverse human cell lines. For my postdoc, I joined Ido Amit's lab in Immunogenomics at the Weizmann Institute of Science in Israel where I applied genomic approaches to the study of immunology. My landmark paper showed that tissue-resident macrophages are capable of adopting tissue-specific functions by reprogramming their chromatin landscape in response to signal from the local environment.
As a computational immunologist, I interested in mapping the gene regulatory networks of immune cells in health and disease, particularly macrophages in rheumatic disease. As a plastic immune cell type, macrophages are found throughout the body where they play an important role in both homeostatic functions and immune response. The are critical to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and systemic sclerosis. Using high-throughput sequencing assays and computational techniques, I seek to profile the transcriptional and epigenomic profile of macrophages in different tissues in mouse models and patients with these diseases. We believe that a better understanding of the function and malfunction of macrophages we enable to develop more precise and effective treatments.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Computational Biology & Bioinformatics, Duke University
… → 2013
Research interests keywords
- Arthritis - Rheumatoid
- Big Data
- Bioinformatics
- Chromatin
- Computational Biology
- Epigenetics
- Gene Regulation
- Genomics
- Immunology
- Rheumatology
- Scleroderma
- Systems Biology
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Collaborations and top research areas from the last five years
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TLR Transduction of Dysbiotic Pelvic Pain
Klumpp, D., Schaeffer, A. J. & Winter, D. R.
National Institute of Diabetes and Digestive and Kidney Diseases
8/21/23 → 6/30/27
Project: Research project
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Core Center for Clinical Research at Northwestern University
Sharma, L., Sharma, L., Bass, M., Brown, C. H., Chmiel, J. S., Cuda, C. M., Franklin, P. D., Ghomrawi, H., Holmes, K., Holmes, K., Kershaw, K. N., Kershaw, K. N., Lattie, E. G., Muhammad, L. N., Pope, R. M., Pope, R. M., Spring, B., Tandon, D., Van Horn, L., Wehbe, F., Winter, D. R., Chang, R. W., Lee, Y. C., Lee, J., Lee, Y. C., Ramsey-Goldman, R. & Rothrock, N.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/21/22 → 8/31/27
Project: Research project
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Methodologic Core
Chmiel, J. S., Chmiel, J. S., Franklin, P. D., Franklin, P. D., Ghomrawi, H., Ghomrawi, H., Muhammad, L. N., Muhammad, L. N., Spring, B., Starren, J., Van Horn, L., Van Horn, L., Winter, D. R., Winter, D. R., Chang, R. W., Chang, R. W., Lee, J., Lee, J. & Starren, J.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9/21/22 → 8/31/27
Project: Research project
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The Relationship Between Brain Macrophages and Cognitive Dysfunction in Systemic Lupus Erythematosus
Cuda, C. M., Cuda, C. M., Grebenciucova, E., Grebenciucova, E., Muhammad, L. N., Muhammad, L. N., Ramsey-Goldman, R., Ramsey-Goldman, R., Weiss, C., Weiss, C., Winter, D. R. & Winter, D. R.
National Institute of Allergy and Infectious Diseases
7/5/22 → 6/30/27
Project: Research project
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Transcriptional Profiles of Circulating Monocytes and their Association with Pain Centralization and DMARD response in Rheumatoid Arthritis
Lee, Y. C., Lee, Y. C., Cuda, C. M., Cuda, C. M., Muhammad, L. N., Muhammad, L. N., Winter, D. R. & Winter, D. R.
Rheumatology Research Foundation
7/1/22 → 6/30/24
Project: Research project
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A Novel MIP-1-Expressing Macrophage Subtype in BAL Fluid from Healthy Volunteers
Reyfman, P. A., Malsin, E. S., Khuder, B., Joshi, N., Gadhvi, G., Flozak, A. S., Carns, M. A., Aren, K., Goldberg, I. A., Kim, S., Alexander, M. J., Sporn, P. H. S., Misharin, A. V., Budinger, G. R. S., Lam, A. P., Hinchcliff, M. E., Gottardi, C. J. & Winter, D. R., Feb 1 2023, In: American journal of respiratory cell and molecular biology. 68, 2, p. 176-185 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
MAGNET: A web-based application for gene set enrichment analysis using macrophage data sets
Chen, S. Y., Gadhvi, G. & Winter, D. R., Jan 2023, In: PloS one. 18, 1 January, e0272166.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell sequencing of a novel model of neonatal bile duct ligation in mice identifies macrophage heterogeneity in obstructive cholestasis
Antala, S., Gromer, K. D., Gadhvi, G., Kriegermeier, A., Wang, J. J., Abdala-Valencia, H., Wechsler, J. B., Perlman, H., Winter, D. R., Zhang, Z. J., Green, R. M. & Taylor, S. A., Dec 2023, In: Scientific reports. 13, 1, 14104.Research output: Contribution to journal › Article › peer-review
Open Access -
Suprabasal cells retain progenitor cell identity programs in eosinophilic esophagitis–driven basal cell hyperplasia
Clevenger, M. H., Karami, A. L., Carlson, D. A., Kahrilas, P. J., Gonsalves, N., Pandolfino, J. E., Winter, D. R., Whelan, K. A. & Tétreault, M. P., Oct 2023, In: JCI Insight. 8, 19, e171765.Research output: Contribution to journal › Article › peer-review
Open Access -
Three Distinct Transcriptional Profiles of Monocytes Associate with Disease Activity in Scleroderma Patients
Makinde, H. K. M., Dunn, J. L. M., Gadhvi, G., Carns, M., Aren, K., Chung, A. H., Muhammad, L. N., Song, J., Cuda, C. M., Dominguez, S., Pandolfino, J. E., Dematte D'Amico, J. E., Budinger, G. S., Assassi, S., Frech, T. M., Khanna, D., Shaeffer, A., Perlman, H., Hinchcliff, M. & Winter, D. R., Apr 2023, In: Arthritis and Rheumatology. 75, 4, p. 595-608 14 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations