Grants per year
Personal profile
Research Interests
Debra E. Weese-Mayer, M.D. is the Beatrice Cummings Mayer Professor in Pediatric Autonomic Medicine at Northwestern University Feinberg School of Medicine and Chief of the first Center for Autonomic Medicine in Pediatrics (CAMP) at Lurie Children’s Hospital. Dr. Weese-Mayer is recognized internationally for her clinical and research work in the emerging discipline of pediatric autonomic medicine and is a lead translational researcher at Ann & Robert H. Lurie Children’s Hospital and the Stanley Manne Children’s Research Institute. She is recognized internationally for her expertise as a leader in clinical and research advances in respiratory and autonomic disorders of infancy, childhood, and adulthood (RADICA)--including Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD), Rett Syndrome, Sudden Infant Death Syndrome (SIDS), Congenital Central Hypoventilation Syndrome (CCHS), and Familial Dysautonomia. She has authored more than 250 peer-reviewed articles, reviews, chapters, and abstracts. Her clinical and research programs have grown to include a wide-ranging referral base (48 states; 50 foreign countries). Dr. Weese-Mayer was awarded the March of Dimes Jonas Salk Health Leadership Award in Research for 2005. She patented a genetic test to diagnose CCHS, allowing early confirmation of diagnosis, and prenatal testing (patent proceeds support CCHS research). Dr. Weese-Mayer’s long term career objectives are to 1)build the model Pediatric Autonomic Medicine section---with wholly innovative protocols and technology for in and out-patient application; 2)develop norms for all age groups, ethnicities, and by gender for pediatric-friendly autonomic testing protocols; 3)expand the Centers of Excellence in CCHS and ROHHAD; 4)identify the genetic or epigenetic basis of ROHHAD, SIDS, and stillbirth; 5)advance the Neurocristopathy Consortium to expand knowledge of rare disorders in the context of related disorders to improve visibility of Rare Disease Medicine and value of study of rare diseases to understand basic systems in health; 6)non-invasive study of the maturation of the autonomic nervous system from perinatal origins, through pediatrics, and into adulthood, with aim to relate the maturational trajectory of (dys)regulation to outcome and health risk; 6)build a cross University Autonomic Medicine Department that includes prenatal origins through senescence in its overall domain; and 7)train the next generation of experts in respiratory and autonomic control.
Dr. Weese-Mayer is recognized internationally for her clinical and research work in the emerging discipline of pediatric autonomic medicine and is a lead translational researcher at Ann & Robert H. Lurie Children’s Hospital and the Stanley Manne Children’s Research Institute. Dr. Weese-Mayer’s research and clinical work focuses on respiratory and autonomic disorders of infancy, childhood, and adulthood including Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD), Rett Syndrome, Congenital Central Hypoventilation Syndrome (CCHS), Familial Dysautonomia, and Sudden Infant Death Syndrome (SIDS). Her collaboration with the Rogers group and a growing number of other talented specialists within Northwestern University is expanding focus to non-invasive study of the maturation of the autonomic nervous system from perinatal origins, through pediatrics, and into adulthood, with aim to relate the trajectory of (dys)regulation to outcome and health risk.
Dr. Weese-Mayer's clinical focus includes patients with rare neurocristopathies (Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) and Congenital Central Hypoventilation Syndrome (CCHS)), patients with more common diseases that include a component of autonomic dysregulation, and patients who might benefit from thoracoscopic phrenic nerve-diaphragm pacer implantation.
Certifications and Licenses
General Pediatrics | |
Neonatal-Perinatal Medicine |
Training Experience
1979 | Internship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
1981 | Residency, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
1986 | Fellowship, Northwestern University, McGaw Medical Center (Children’s Memorial Hospital) |
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, MD, University of Chicago
… → 1978
Research interests keywords
- Autonomic Medicine
- Circadian Rhythms
- Developmental Genetics
- Developmental Neurobiology
- Endocrine Genetics
- Pacemakers
- Pediatrics
- Premature Infants
- Prenatal Environment and Developmental Outcomes
- Respiratory Diseases
- Sleep Disorders
- Sudden Cardiac Death
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Collaborations and top research areas from the last five years
Grants
- 20 Finished
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RAPID-ONSET OBESITY WITH HYPOTHALAMIC DYSFUNCTION, HYPOVENTILATION, AND AUTONOMIC DYSREGULATION (ROHHAD): STEM CELL MODELS TO INVESTIGATE CAUSE AND CONSEQUENCES
Weese-Mayer, D. E. (PD/PI)
11/4/19 → 12/31/21
Project: Research project
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Epidermal Wearable Patch: An Innovative Solution to the Lack of Continuous, Non-Invasive Blood Pressure Monitoring in the NICU
Hamvas, A. (PD/PI) & Weese-Mayer, D. E. (PD/PI)
The Gerber Companies Foundation
3/15/18 → 12/31/21
Project: Research project
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Always-on Imperceptible Infant Monitoring (AIIM) in KMC
Weese-Mayer, D. E. (PD/PI)
11/1/17 → 4/30/19
Project: Research project
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No Strings Attached: Wireless Sensor Technology in the Prentice NICU
Paller, A. (PD/PI), Hamvas, A. (Co-PD/PI), Rogers, J. A. (Co-PD/PI) & Weese-Mayer, D. E. (Co-PD/PI)
Northwestern Memorial Hospital
9/1/17 → 8/31/19
Project: Research project
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Echo PRO Core
Marino, B. S. (PD/PI), Alonso, E. M. (Co-Investigator), Davis, M. M. (Co-Investigator), Garfield, C. (Co-Investigator), Kumar, R. (Co-Investigator), Wainwright, M. (Co-Investigator) & Weese-Mayer, D. E. (Co-Investigator)
Northwestern University, Office of the Director
9/21/16 → 8/31/21
Project: Research project
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Antibodies Against ZSCAN1 in Pediatric and Adult Patients With Non-Paraneoplastic ROHHAD Syndrome
Serafim, A. B., Olivé-Cirera, G., Ortega-González, Á., Kruer, M. C., Weese-Mayer, D., Rand, C. M., Fons, C., Fernández-Ramos, J. A., Clemente, M., Simabukuro, M. M., Embiruçu, E. K., Ibáñez-Micó, S., Dalmau, J. O., Graus, F., Armangué, T. & Sabater, L., Jun 25 2024, In: Neurology: Neuroimmunology and NeuroInflammation. 11, 5Research output: Contribution to journal › Article › peer-review
Open Access -
Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Infants Born Extremely Preterm
the Prematurity-Related Ventilatory Control (Pre-Vent) Investigators, Aug 2024, In: journal of pediatrics. 271, 114042.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Computer-aided diagnostic screen for Congenital Central Hypoventilation Syndrome with facial phenotype
Slattery, S. M., Wilkinson, J., Mittal, A., Zheng, C., Easton, N., Singh, S., Baker, J. J., Rand, C. M., Khaytin, I., Stewart, T. M., Demeter, D. & Weese-Mayer, D. E., Jun 2024, In: Pediatric research. 95, 7, p. 1843-1850 8 p.Research output: Contribution to journal › Article › peer-review
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Highly comparative time series analysis of oxygen saturation and heart rate to predict respiratory outcomes in extremely preterm infants
Qiu, J., Di Fiore, J. M., Krishnamurthi, N., Indic, P., Carroll, J. L., Claure, N., Kemp, J. S., Dennery, P. A., Ambalavanan, N., Weese-Mayer, D. E., Maria Hibbs, A., Martin, R. J., Bancalari, E., Hamvas, A., Randall Moorman, J. & Lake, D. E., May 1 2024, In: Physiological Measurement. 45, 5, 055025.Research output: Contribution to journal › Article › peer-review
Open Access -
Maturation of cardioventilatory physiological trajectories in extremely preterm infants
the Prematurity-Related Ventilatory Control (Pre-Vent) Investigators, Mar 2024, In: Pediatric research. 95, 4, p. 1060-1069 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations
Datasets
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ROHHAD and Prader-Willi syndrome (PWS): clinical and genetic comparison
Barclay, S. F. (Creator), Rand, C. M. (Creator), Nguyen, L. (Creator), Wilson, R. J. A. (Creator), Wevrick, R. (Creator), Gibson, W. T. (Creator), Bech-Hansen, N. T. (Contributor) & Weese-Mayer, D. E. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.c.4173563, https://figshare.com/collections/ROHHAD_and_Prader-Willi_syndrome_PWS_clinical_and_genetic_comparison/4173563
Dataset
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Additional file 1: of Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): exome sequencing of trios, monozygotic twins and tumours
Barclay, S. F. (Creator), Rand, C. M. (Creator), Borch, L. A. (Creator), Nguyen, L. (Creator), Gray, P. A. (Creator), Gibson, W. T. (Creator), Wilson, R. J. A. (Creator), Gordon, P. M. K. (Creator), Aung, Z. (Contributor), Berry-Kravis, E. M. (Creator), Ize-Ludlow, D. (Creator), Weese-Mayer, D. E. (Creator) & Bech-Hansen, N. T. (Contributor), figshare, 2015
DOI: 10.6084/m9.figshare.c.3605780_d1, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_Rapid-Onset_Obesity_with_Hypothalamic_Dysfunction_Hypoventilation_and_Autonomic_Dysregulation_ROHHAD_exome_sequencing_of_trios_monozygotic_twins_and_tumours/4346645
Dataset
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Additional file 2: of Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): exome sequencing of trios, monozygotic twins and tumours
Barclay, S. F. (Creator), Rand, C. M. (Creator), Borch, L. A. (Creator), Nguyen, L. (Creator), Gray, P. A. (Creator), Gibson, W. T. (Creator), Wilson, R. J. A. (Creator), Gordon, P. M. K. (Creator), Aung, Z. (Contributor), Berry-Kravis, E. M. (Creator), Ize-Ludlow, D. (Creator), Weese-Mayer, D. E. (Creator) & Bech-Hansen, N. T. (Contributor), figshare, 2015
DOI: 10.6084/m9.figshare.c.3605780_d2, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_Rapid-Onset_Obesity_with_Hypothalamic_Dysfunction_Hypoventilation_and_Autonomic_Dysregulation_ROHHAD_exome_sequencing_of_trios_monozygotic_twins_and_tumours/4346672
Dataset
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Additional file 1: of ROHHAD and Prader-Willi syndrome (PWS): clinical and genetic comparison
Barclay, S. F. (Creator), Rand, C. M. (Creator), Nguyen, L. (Creator), Wilson, R. J. A. (Creator), Wevrick, R. (Creator), Gibson, W. T. (Creator), Bech-Hansen, N. T. (Contributor) & Weese-Mayer, D. E. (Creator), figshare, 2018
DOI: 10.6084/m9.figshare.6847796, https://springernature.figshare.com/articles/Additional_file_1_of_ROHHAD_and_Prader-Willi_syndrome_PWS_clinical_and_genetic_comparison/6847796
Dataset
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Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): exome sequencing of trios, monozygotic twins and tumours
Barclay, S. F. (Creator), Rand, C. M. (Creator), Borch, L. A. (Creator), Nguyen, L. (Creator), Gray, P. A. (Creator), Gibson, W. T. (Creator), Wilson, R. J. A. (Creator), Gordon, P. M. K. (Creator), Aung, Z. (Contributor), Berry-Kravis, E. M. (Creator), Ize-Ludlow, D. (Creator), Weese-Mayer, D. E. (Creator) & Bech-Hansen, N. T. (Contributor), figshare, 2015
DOI: 10.6084/m9.figshare.c.3605780.v1, https://figshare.com/collections/Rapid-Onset_Obesity_with_Hypothalamic_Dysfunction_Hypoventilation_and_Autonomic_Dysregulation_ROHHAD_exome_sequencing_of_trios_monozygotic_twins_and_tumours/3605780/1
Dataset