Demirkan Besim Gursel

  • 641 Citations
19972019

Research output per year

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Research Output

  • 641 Citations
  • 21 Article
  • 4 Comment/debate
  • 2 Short survey
  • 2 Review article
1997

Requirement for transcription factor IIA (TFIIA)-TFIID recruitment by an activator depends on promoter structure and template competition

Lieberman, P. M., Ozer, J. & Gürsel, D. B., Nov 1997, In : Molecular and cellular biology. 17, 11, p. 6624-6632 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2001

Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms

Auguste, P., Gürsel, D. B., Lemière, S., Reimers, D., Cuevas, P., Carceller, F., Di Santo, J. P. & Bikfalvi, A., Feb 15 2001, In : Cancer Research. 61, 4, p. 1717-1726 10 p.

Research output: Contribution to journalArticle

126 Scopus citations
2005

Models of astrocytoma

Gürsel, D. B. & Reilly, K. M., Jul 18 2005, In : Drug Discovery Today: Disease Models. 2, 1, p. 77-83 7 p.

Research output: Contribution to journalReview article

2008

New strategy for the analysis of phenotypic marker antigens in brain tumor-derived neurospheres and mice and humans

Bleau, A. M., Howard, B. M., Taylor, L. A., Gursel, D., Greenfield, J. P., Tung, H. Y. L., Holland, E. C. & Boockvar, J. A., Mar 1 2008, In : Neurosurgical focus. 24, 3-4, E27.

Research output: Contribution to journalArticle

25 Scopus citations

Overexpression of high molecular weight FGF-2 forms inhibits glioma growth by acting on cell-cycle progression and protein translation

Lemiere, S., Azar, R., Belloc, F., Gürsel, D., Pyronnet, S., Bikfalvi, A. & Auguste, P., Dec 10 2008, In : Experimental Cell Research. 314, 20, p. 3701-3711 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2010

EGFR signaling is differentially activated in patient-derived glioblastoma stem cells

Howard, B. M., Gursel, D. B., Bleau, A. M., Beyene, R. T., Holland, E. C. & Boockvar, J. A., Jul 13 2010, In : Journal of Experimental Therapeutics and Oncology. 8, 3, p. 247-260 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Schweinfurthin a selectively inhibits proliferation and rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner

Turbyville, T. J., Gürsel, D. B., Tuskan, R. G., Walrath, J. C., Lipschultz, C. A., Lockett, S. J., Wiemer, D. F., Beutler, J. A. & Reilly, K. M., May 2010, In : Molecular cancer therapeutics. 9, 5, p. 1234-1243 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies

Gürsel, D. B., Connell-Albert, Y. S., Tuskan, R. G., Anastassiadis, T., Walrath, J. C., Hawes, J. J., Schaick, J. C. A. V. & Reilly, K. M., Jun 2011, In : Neuro-oncology. 13, 6, p. 610-621 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Direct conversion of human fibroblasts to functional neurons in one step

Berry, N., Gursel, D. B. & Boockvar, J. A., Dec 1 2011, In : Neurosurgery. 69, 6

Research output: Contribution to journalComment/debate

11 Scopus citations

Glioblastoma stem-like cells-biology and therapeutic implications

Gürsel, D. B., Shin, B. J., Burkhardt, J. K., Kesavabhotla, K., Schlaff, C. D. & Boockvar, J. A., Jun 2011, In : Cancers. 3, 2, p. 2655-2666 12 p.

Research output: Contribution to journalReview article

26 Scopus citations

Optimization of glioblastoma multiforme stem cell isolation, transfection, and transduction

Gürsel, D. B., Beyene, R. T., Hofstetter, C., Greenfield, J. P., Souweidane, M. M., Kaplitt, M., Arango-Lievano, M., Howard, B. & Boockvar, J. A., Sep 1 2011, In : Journal of Neuro-Oncology. 104, 2, p. 509-522 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012

EGFR targeted inhibition resistance: Compensatory activation of ERBB family members in glioblastoma cancer stem-like cells promotes proliferation

Gursel, D. B., Schlaff, C. D. & Boockvar, J. A., Oct 1 2012, In : Neurosurgery. 71, 4

Research output: Contribution to journalShort survey

1 Scopus citations

FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells

Stessin, A. M., Gursel, D. B., Schwartz, A., Parashar, B., Kulidzhanov, F. G., Sabbas, A. M., Boockvar, J., Nori, D. & Wernicke, A. G., May 16 2012, In : Neuroscience Letters. 516, 2, p. 253-258 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Getting a neural stem cell from a fibroblast

Berry, N., Gursel, D. B. & Boockvar, J. A., Aug 1 2012, In : Neurosurgery. 71, 2

Research output: Contribution to journalShort survey

Intra-arterial bevacizumab with blood brain barrier disruption in a glioblastoma xenograft model

Burkhardt, J. K., Santillan, A., Hofstetter, C. P., Christos, P., Berry, N., Shin, B. J., Foley, C. P., Gürsel, D. B., Ballon, D. J., Gobin, Y. P. & Boockvar, J. A., Aug 3 2012, In : Journal of Experimental Therapeutics and Oncology. 10, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Notch inhibition via micro-RNA blocks glioma development

Berry, N., Gursel, D. B. & Boockvar, J. A., Apr 1 2012, In : Neurosurgery. 70, 4, p. N20-N22

Research output: Contribution to journalComment/debate

2 Scopus citations

Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia

Hofstetter, C. P., Burkhardt, J. K., Shin, B. J., Gürsel, D. B., Mubita, L., Gorrepati, R., Brennan, C., Holland, E. C. & Boockvar, J. A., Jan 11 2012, In : PloS one. 7, 1, e30059.

Research output: Contribution to journalArticle

40 Scopus citations

The contribution of Notch signaling to glioblastoma via activation of cancer stem cell self-renewal: the role of the endothelial network.

Gürsel, D. B., Berry, N. & Boockvar, J. A., Feb 1 2012, In : Neurosurgery. 70, 2, p. N19-21

Research output: Contribution to journalComment/debate

21 Scopus citations

Trials and tribulations of cancer immunotherapy: The dendritic cell vaccine shows promise in a phase i glioblastoma multiforme trial

Gürsel, D. B., Schlaff, C. D. & Boockvar, J. A., Dec 1 2012, In : Neurosurgery. 71, 6

Research output: Contribution to journalComment/debate

2 Scopus citations
2013

Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche

Infanger, D. W., Cho, Y., Lopez, B. S., Mohanan, S., Liu, S. C., Gursel, D., Boockvar, J. A. & Fischbach, C., Dec 1 2013, In : Cancer Research. 73, 23, p. 7079-7089 11 p.

Research output: Contribution to journalArticle

103 Scopus citations
2015

Patient-derived tumor xenografts are susceptible to formation of human lymphocytic tumors

Bondarenko, G., Ugolkov, A., Rohan, S., Kulesza, P., Dubrovskyi, O., Gursel, D., Mathews, J., O'Halloran, T. V., Wei, J. J. & Mazar, A. P., Jan 1 2015, In : Neoplasia. 17, 9, p. 735-741 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Role of the biomarker p16 in downgrading-IN 2 diagnoses and predicting higher-grade lesions

Maniar, K. P., Sanchez, B., Paintal, A., Gursel, D. B. & Nayar, R., Dec 1 2015, In : American Journal of Surgical Pathology. 39, 12, p. 1708-1718 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling

Gürsel, D. B., Banu, M. A., Berry, N., Marongiu, R., Burkhardt, J. K., Kobylarz, K., Kaplitt, M. G., Rafii, S. & Boockvar, J. A., Jan 1 2015, In : Journal of Neuro-Oncology. 121, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2017

Disease and region specificity of granulin immunopositivities in Alzheimer disease and frontotemporal lobar degeneration

Mao, Q., Wang, D., Li, Y., Kohler, M., Wilson, J., Parton, Z., Shmaltsuyeva, B., Gursel, D., Rademakers, R., Weintraub, S., Mesulam, M. M., Xia, H. & Bigio, E. H., Jan 1 2017, In : Journal of neuropathology and experimental neurology. 76, 11, p. 957-968 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer

Wang, J., Shidfar, A., Ivancic, D., Ranjan, M., Liu, L., Choi, M. R., Parimi, V., Gursel, D. B., Sullivan, M. E., Najor, M. S., Abukhdeir, A. M., Scholtens, D. M. & Khan, S. A., Jun 1 2017, In : International Journal of Cancer. 140, 11, p. 2484-2497 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells

Liu, X., Sun, L., Gursel, D. B., Cheng, C., Huang, S., Rademaker, A. W., Khan, S. A., Yin, J. & Kiyokawa, H., 2017, In : Oncotarget. 8, 50, p. 87480-87493 14 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

Nivolumab in Metastatic Adrenocortical Carcinoma: Results of a Phase 2 Trial

Carneiro, B. A., Konda, B., Costa, R. B., Costa, R. L. B., Sagar, V., Gursel, D. B., Kirschner, L. S., Chae, Y. K., Abdulkadir, S. A., Rademaker, A., Mahalingam, D., Shah, M. H. & Giles, F. J., Dec 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 6193-6200 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

Liu, Q., Wang, G., Li, Q., Jiang, W., Kim, J. S., Wang, R., Zhu, S., Wang, X., Yan, L., Yi, Y., Zhang, L., Meng, Q., Li, C., Zhao, D., Qiao, Y., Li, Y., Gursel, D. B., Chinnaiyan, A. M., Chen, K. & Cao, Q., Jul 15 2019, In : International Journal of Cancer. 145, 2, p. 415-426 12 p.

Research output: Contribution to journalArticle

6 Scopus citations