Demirkan Besim Gursel

  • 574 Citations
19972022
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Research Output 1997 2019

  • 574 Citations
  • 20 Article
  • 4 Comment/debate
  • 2 Short survey
  • 2 Review article
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Article
2019
1 Citation (Scopus)

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer

Liu, Q., Wang, G., Li, Q., Jiang, W., Kim, J. S., Wang, R., Zhu, S., Wang, X., Yan, L., Yi, Y., Zhang, L., Meng, Q., Li, C., Zhao, D., Qiao, Y., Li, Y., Gursel, D. B., Chinnaiyan, A. M., Chen, K. & Cao, Q., Jul 15 2019, In : International Journal of Cancer. 145, 2, p. 415-426 12 p.

Research output: Contribution to journalArticle

Polycomb-Group Proteins
Ectoderm
Androgen Receptors
Embryonic Development
Prostatic Neoplasms
2017
5 Citations (Scopus)

Disease and region specificity of granulin immunopositivities in Alzheimer disease and frontotemporal lobar degeneration

Mao, Q., Wang, D., Li, Y., Kohler, M., Wilson, J., Parton, Z., Shmaltsuyeva, B., Gursel, D. B., Rademakers, R., Weintraub, S., Mesulam, M-M., Xia, H. & Bigio, E. H., Jan 1 2017, In : Journal of neuropathology and experimental neurology. 76, 11, p. 957-968 12 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Alzheimer Disease
TDP-43 Proteinopathies
Microglia
Haploinsufficiency
6 Citations (Scopus)

Overexpression of lipid metabolism genes and PBX1 in the contralateral breasts of women with estrogen receptor-negative breast cancer

Wang, J., Shidfar, A., Ivancic, D., Ranjan, M., Liu, L., Choi, M. R., Parimi, V., Gursel, D. B., Sullivan, M. E., Najor, M. S., Abukhdeir, A. M., Scholtens, D. M. & Khan, S. A., Jun 1 2017, In : International Journal of Cancer. 140, 11, p. 2484-2497 14 p.

Research output: Contribution to journalArticle

Lipid Metabolism
Estrogen Receptors
Breast
Breast Neoplasms
Genes
3 Citations (Scopus)

The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells

Liu, X., Sun, L., Gursel, D. B., Cheng, C., Huang, S., Rademaker, A. W., Khan, S. A., Yin, J. & Kiyokawa, H., Jan 1 2017, In : Oncotarget. 8, 50, p. 87480-87493 14 p.

Research output: Contribution to journalArticle

Ubiquitin-Activating Enzymes
Epithelial-Mesenchymal Transition
Ubiquitination
Breast
Epithelial Cells
2015
34 Citations (Scopus)

Patient-derived tumor xenografts are susceptible to formation of human lymphocytic tumors

Bondarenko, G., Ugolkov, A., Rohan, S., Kulesza, P., Dubrovskyi, O., Gursel, D., Mathews, J., O'Halloran, T. V., Wei, J. J. & Mazar, A. P., Jan 1 2015, In : Neoplasia. 17, 9, p. 735-741 7 p.

Research output: Contribution to journalArticle

Heterografts
Neoplasms
B-Lymphocytes
Pancreatic Neoplasms
Adenocarcinoma
16 Citations (Scopus)

Role of the biomarker p16 in downgrading-IN 2 diagnoses and predicting higher-grade lesions

Maniar, K. P., Sanchez, B., Paintal, A., Gursel, D. B. & Nayar, R., Jan 1 2015, In : American Journal of Surgical Pathology. 39, 12, p. 1708-1718 11 p.

Research output: Contribution to journalArticle

Biomarkers
Terminology
Papillomaviridae
Pathology
Unnecessary Procedures
13 Citations (Scopus)

Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling

Gürsel, D. B., Banu, M. A., Berry, N., Marongiu, R., Burkhardt, J. K., Kobylarz, K., Kaplitt, M. G., Rafii, S. & Boockvar, J. A., Jan 1 2015, In : Journal of Neuro-Oncology. 121, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Glioblastoma
Cell Survival
Cell Death
Stem Cells
2013
91 Citations (Scopus)

Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche

Infanger, D. W., Cho, Y., Lopez, B. S., Mohanan, S., Liu, S. C., Gursel, D., Boockvar, J. A. & Fischbach, C., Dec 1 2013, In : Cancer Research. 73, 23, p. 7079-7089 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Interleukin-8
Stem Cells
Neoplastic Stem Cells
Endothelial Cells
2012
25 Citations (Scopus)

FTY720, sphingosine 1-phosphate receptor modulator, selectively radioprotects hippocampal neural stem cells

Stessin, A. M., Gursel, D. B., Schwartz, A., Parashar, B., Kulidzhanov, F. G., Sabbas, A. M., Boockvar, J., Nori, D. & Wernicke, A. G., May 16 2012, In : Neuroscience Letters. 516, 2, p. 253-258 6 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
Neural Stem Cells
Cranial Irradiation
Hippocampus
Cell Line
4 Citations (Scopus)

Intra-arterial bevacizumab with blood brain barrier disruption in a glioblastoma xenograft model

Burkhardt, J. K., Santillan, A., Hofstetter, C. P., Christos, P., Berry, N., Shin, B. J., Foley, C. P., Gürsel, D. B., Ballon, D. J., Gobin, Y. P. & Boockvar, J. A., Aug 3 2012, In : Journal of Experimental Therapeutics and Oncology. 10, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Glioblastoma
Blood-Brain Barrier
Heterografts
Bevacizumab
Neoplasms
37 Citations (Scopus)

Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia

Hofstetter, C. P., Burkhardt, J. K., Shin, B. J., Gürsel, D. B., Mubita, L., Gorrepati, R., Brennan, C., Holland, E. C. & Boockvar, J. A., Jan 11 2012, In : PLoS One. 7, 1, e30059.

Research output: Contribution to journalArticle

Cell Hypoxia
Protein Phosphatase 2
phosphoprotein phosphatase
Neoplastic Stem Cells
Glioblastoma
5 Citations (Scopus)
Animal Disease Models
Drug Carriers
Neural Stem Cells
Stem Cell Transplantation
Brain Neoplasms
2011
19 Citations (Scopus)

Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies

Gürsel, D. B., Connell-Albert, Y. S., Tuskan, R. G., Anastassiadis, T., Walrath, J. C., Hawes, J. J., Schaick, J. C. A. V. & Reilly, K. M., Jun 1 2011, In : Neuro-oncology. 13, 6, p. 610-621 12 p.

Research output: Contribution to journalArticle

Astrocytoma
Receptor Protein-Tyrosine Kinases
Phosphatidylinositol 3-Kinases
Glioblastoma
Platelet-Derived Growth Factor Receptors
13 Citations (Scopus)

Optimization of glioblastoma multiforme stem cell isolation, transfection, and transduction

Gürsel, D. B., Beyene, R. T., Hofstetter, C., Greenfield, J. P., Souweidane, M. M., Kaplitt, M., Arango-Lievano, M., Howard, B. & Boockvar, J. A., Sep 1 2011, In : Journal of Neuro-Oncology. 104, 2, p. 509-522 14 p.

Research output: Contribution to journalArticle

Cell Separation
Glioblastoma
Transfection
Stem Cells
Neoplastic Stem Cells
2010
15 Citations (Scopus)

EGFR signaling is differentially activated in patient-derived glioblastoma stem cells

Howard, B. M., Gursel, D. B., Bleau, A. M., Beyene, R. T., Holland, E. C. & Boockvar, J. A., Jul 13 2010, In : Journal of Experimental Therapeutics and Oncology. 8, 3, p. 247-260 14 p.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Stem Cells
Apoptosis
Therapeutics
26 Citations (Scopus)

Schweinfurthin a selectively inhibits proliferation and rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner

Turbyville, T. J., Gürsel, D. B., Tuskan, R. G., Walrath, J. C., Lipschultz, C. A., Lockett, S. J., Wiemer, D. F., Beutler, J. A. & Reilly, K. M., May 1 2010, In : Molecular Cancer Therapeutics. 9, 5, p. 1234-1243 10 p.

Research output: Contribution to journalArticle

Neurofibromatosis 1
Glioma
Glioblastoma
Neoplasms
Neurilemmoma
2008
25 Citations (Scopus)

New strategy for the analysis of phenotypic marker antigens in brain tumor-derived neurospheres and mice and humans

Bleau, A. M., Howard, B. M., Taylor, L. A., Gursel, D., Greenfield, J. P., Tung, H. Y. L., Holland, E. C. & Boockvar, J. A., Mar 1 2008, In : Neurosurgical focus. 24, 3-4, E27.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Differentiation Antigens
Brain Neoplasms
Glioma
Cryoultramicrotomy
9 Citations (Scopus)

Overexpression of high molecular weight FGF-2 forms inhibits glioma growth by acting on cell-cycle progression and protein translation

Lemiere, S., Azar, R., Belloc, F., Gürsel, D., Pyronnet, S., Bikfalvi, A. & Auguste, P., Dec 10 2008, In : Experimental Cell Research. 314, 20, p. 3701-3711 11 p.

Research output: Contribution to journalArticle

Cell Cycle Proteins
Protein Biosynthesis
Fibroblast Growth Factor 2
Glioma
Molecular Weight
2001
125 Citations (Scopus)

Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms

Auguste, P., Gürsel, D. B., Lemière, S., Reimers, D., Cuevas, P., Carceller, F., Di Santo, J. P. & Bikfalvi, A., Feb 15 2001, In : Cancer Research. 61, 4, p. 1717-1726 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
Glioma
Growth
Neoplasms
1997
43 Citations (Scopus)

Requirement for transcription factor IIA (TFIIA)-TFIID recruitment by an activator depends on promoter structure and template competition

Lieberman, P. M., Ozer, J. & Gürsel, D. B., Jan 1 1997, In : Molecular and cellular biology. 17, 11, p. 6624-6632 9 p.

Research output: Contribution to journalArticle

Transcription Factor TFIID
TATA-Box Binding Protein
Transcription Factors
Human Herpesvirus 4
TATA-Binding Protein Associated Factors